Longstanding Eccrine Syringofibroadenoma With Evidence of Carcinomatous Transformation

Longstanding Eccrine Syringofibroadenoma With Evidence of Carcinomatous Transformation: Abstract:

Eccrine syringofibroadenoma (ESFA) is a cutaneous proliferation of eccrine ducts, mainly encountered in association with other dermatoses or skin tumors. Although a benign condition, either considered as a hamartoma or a reactive hyperplasia rather than a real neoplasm, some evidence suggests that longstanding ESFA can undergo malignant change. The recognition of such opportunity could have important therapeutic implications. We present a case of ESFA showing areas of carcinomatous transformation, discussing its morphological and immunohistochemical findings.

Correspondence: Andrea Ronchi, Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania “Luigi Vanvitelli,” Via Luciano Armanni 20, Naples 80100, Italy; (e-mail: andrea.ronchi@unicampania.it).

The authors declare no conflicts of interest.

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