Predictors of OSA following Adenotonsillectomy in Children with Trisomy 21

Predictors of OSA following Adenotonsillectomy in Children with Trisomy 21:

Abstract

Objectives

Given that 30‐50% of children with trisomy 21 have persistent obstructive sleep apnea (OSA) after adenotonsillectomy, we evaluated whether demographic, clinical and polysomnographic factors predicted persistent OSA and OSA severity after adenotonsillectomy.

Design

Retrospective study.

Setting

Secondary care hospital.

Participants

Retrospective review of 32 children with the diagnosis of trisomy 21 and OSA by polysomnography who underwent adenotonsillectomy, from January 2010 to December 2018.

Main outcome and measure

Non‐parametric analysis was used to compare pre and postoperative factors, regression was used to model persistent OSA and OSA severity.

Results

Thirty‐two children were included (17 males, median age 10.00 ± 8.00 years, median body mass index z‐score 0.89 ± 1.25). Overall, adenotonsillectomy resulted in a significant improvement in median obstructive apnea‐hypopnea index (oAHI) from 7.5 ± 8.95 to 4.40 ± 4.38 events per hour (p<0.001) and in median OSA‐18 score from 85.00 ± 12.00 to 61.00 ± 37.75 (p<0.001). Persistent OSA was found in 56.25% of the children. Univariate regression suggests that postoperative OSA‐18 score was associated with persistent OSA after adenotonsillectomy. Preoperative oAHI, preoperative oxygen desaturation index, pre and postoperative OSA‐18 scores correlated with OSA severity after adenotonsillectomy. However, in a multivariate model only the postoperative OSA‐18 score correlated with OSA severity after adenotonsillectomy.

Conclusions

Although adenotonsillectomy results in a significant improvement of OSA in children with trisomy 21, more than half of the children had persistent OSA. The postoperative OSA‐18 score was associated both with persistent OSA and OSA severity after adenotonsillectomy.