Mitigating risk of aldosterone in diabetic kidney diseasePurpose of review Diabetic kidney disease is a growing problem leading to end-stage kidney disease but also atherosclerotic cardiovascular disease and heart failure. Aldosterone is a key risk factor promoting inflammation and fibrosis causing cardio-renal failure. Current options and challenges with mitigating the risk of aldosterone are reviewed. Recent findings More aggressive renin–angiotensin–aldosterone system (RAAS) blockade can be maintained...
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Parental Proxy PROMIS Pain Interference Scores are only Modestly Concordant with their Child's Scores: An Effect of Child CatastrophizingObjectives: Pediatric patients with chronic musculoskeletal conditions such as idiopathic scoliosis awaiting surgical correction can experience pain that interferes with their daily functioning. Reports of this interference are commonly gathered from patients through the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference Scale and...
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Enamel surface loss after erosive and abrasive cycling with different periods of immersion in human salivaPublication date: January 2020Source: Archives of Oral Biology, Volume 109Author(s): Raquel Marianna Lopes, Juliana Sant' Anna da Silva, Samira Helena João-Souza, Vinícius Maximiano, Alana Cristina Machado, Taís Scaramucci, Ana Cecília Correa AranhaAbstractObjectiveThis in vitro study aimed to evaluate different periods of exposure to clarified human saliva for the ability to protect enamel against...
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Web-Based Tailored Nursing Intervention to Support Medication Self-management: A Qualitative Study of the Experience of Kidney Transplant RecipientsOptimal adherence to immunosuppressive medication is essential to kidney graft success. A Web-based tailored virtual nursing intervention was developed to promote medication adherence and support self-management among kidney transplant recipients. A qualitative study was undertaken in a hospital setting in Montreal (Canada) to document how users experience...
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Clinical and Genetic Contributors to New-Onset Atrial Fibrillation in Critically Ill AdultsObjectives: New-onset atrial fibrillation during critical illness is an independent risk factor for mortality. The ability to identify patients at high risk for new-onset atrial fibrillation is limited. We hypothesized that genetic susceptibility contributes to risk of new-onset atrial fibrillation in the ICU. Design: Retrospective sub-study of a prospective observational cohort study. Setting: Medical and...
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Enamel surface loss after erosive and abrasive cycling with different periods of immersion in human salivaPublication date: January 2020Source: Archives of Oral Biology, Volume 109Author(s): Raquel Marianna Lopes, Juliana Sant' Anna da Silva, Samira Helena João-Souza, Vinícius Maximiano, Alana Cristina Machado, Taís Scaramucci, Ana Cecília Correa AranhaAbstractObjectiveThis in vitro study aimed to evaluate different periods of exposure to clarified human saliva for the ability to protect enamel against...
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Augmented reality in prosthodonticsN Gopi ChanderThe Journal of Indian Prosthodontic Society 2019 19(4):281-282Evaluation of peri-implant condition in periodontally compromised patientsGuilherme Da Rocha Scalzer Lopes, Alfredo Carlos Rodrigues Feitosa, Fabricia Ferreira Suaid, Jefferson David Melo De Matos, John Eversong Lucena De Vasconcelos, Sergio Lins De Azevedo Vaz, Valdir Cabral Andrade, Renato Sussumu Nishioka, Selva Maria Gonçalves GuerraThe Journal of Indian Prosthodontic Society 2019 19(4):283-289Aims:...
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Mulberry leaf aqueous extract ameliorates blood glucose and enhances energy expenditure in obese C57BL/6J micePublication date: December 2019Source: Journal of Functional Foods, Volume 63Author(s): Xiaoyun He, Haoyu Li, Ruxin Gao, Chuanhai Zhang, Fei Liang, Yao Sheng, Shujuan Zheng, Jia Xu, Wentao Xu, Kunlun HuangAbstractMulberry leaf garners much attention from researchers because of its hypoglycemic effect. This study's objective was to determine the impact of mulberry leaf aqueous extract (MLAE)...
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Neural network methodology for real-time modelling of bio-heat transfer during thermo-therapeutic applicationsPublication date: November 2019Source: Artificial Intelligence in Medicine, Volume 101Author(s): Jinao Zhang, Sunita ChauhanAbstractReal-time simulation of bio-heat transfer can improve surgical feedback in thermo-therapeutic treatment, leading to technical innovations to surgical process and improvements to patient outcomes; however, it is challenging to achieve real-time computational performance...
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Emerging role of myeloid-derived suppressor cells in the biology of transplantation toleranceMDSCs, a heterogeneous population of myeloid cells, are characterized by their immunosuppressive abilities through the secretion of various cytokines such as iNOS, NO, ROS, TGF-β, and Arg-1. Accumulating evidence highlights its potential role in maintaining immune tolerance in solid organ and hematopoietic stem cell transplantation (HSCT). Mechanistically, MDSCs induced transplant tolerance is mainly dependent...
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A Pilot Study of Postoperative Animal Welfare as a Guidance Tool in the Development of a Kidney Autotransplantation Model With Extended Warm IschemiaBackground. This pilot study aimed to maintain acceptable animal welfare in the development of a porcine autotransplantation model with severe and incremental renal ischemic injury, a model for usage in future intervention studies. Secondary aims were to develop and test methods to collect blood and urine without the need to restrain or use sedative...
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Potent nonopioid antinociceptive activity of telocinobufagin in models of acute pain in miceIntroduction: In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been used for the development of new analgesics. Objective: The aims of this study were to evaluate the antinociceptive effects of telocinobufagin (TCB), a bufadienolide isolated from Rhinella...
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Free-viewing multi-stimulus eye tracking task to index attention bias for alcohol versus soda cues: Satisfactory reliability and criterion validityPublication date: January 2020Source: Addictive Behaviors, Volume 100Author(s): Ali Soleymani, Yavor Ivanov, Sebastiaan Mathot, Peter J. de JongAbstractCognitive -motivational models point to attention bias (AB) as an important factor in the persistence of problematic drinking behavior. Unfortunately, the measures that have been used to examine AB in addiction...
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Effect of General Anesthetics on Caspase-3 Levels in Patients With Aneurysmal Subarachnoid Hemorrhage: A Preliminary StudyBackground: General anesthesia has been associated with neuronal apoptosis and activation of caspases. Apoptosis is a crucial factor in early brain injury following aneurysmal subarachnoid hemorrhage (aSAH). We conducted a double-blind, prospective, randomized pilot study to evaluate the effect of 4 anesthetic agents on cerebrospinal fluid (CSF) and serum caspase-3 levels in aSAH...
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T2-highlighted U-fibres and rapid parenchymal volume loss in AESD: an under-recognised subtype of paediatric acute encephalopathy syndromesPublication date: Available online 4 October 2019Source: Journal of NeuroradiologyAuthor(s): Saipriya Ramji, Gary McCullagh, Dipak Ram, Grace Vassallo, Julija PavaineAbstractAcute Encephalopathy with Reduced Subcortical Diffusion or AED is a unique subtype of acute paediatric encephalopathy which presents with altered mental status, prolonged seizures and developing...
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Strategies in myopia prevention and managementYazan Sultan GammohSudanese Journal of Ophthalmology 2019 11(1):1-7It has been estimated that more than half of the population residing in the Eastern Mediterranean region (EMR) will have myopia by 2050. With recent evidence from the EMR revealing that myopia is becoming more prevalent in children and presenting at a younger age than seen before, it is of importance to investigate the strategies employed in myopia control. Various intervention strategies...
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The burden of corticosteroid overload in severe and difficult to treat asthma: how to reduce this?Purpose of review Severe asthma is a serious condition that requires an individualized approach combining several treatment agents administered simultaneously in order to reach adequate control. Glucocorticosteroid treatment, as the cornerstone of asthma pharmacotherapy, has great disease-controlling capability, although it may induce a vast amount of severe adverse effects. This review describes our...
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Tensile characteristics of carbene-functionalized CNTs subjected to physisorption of polymer chains: a molecular dynamics studyAbstractTensile properties such as Young's modulus and ultimate tensile force are important properties in understanding the characteristics of nanocomposites. Besides, the importance of functionalization methods in modification of the unique mechanical and elastic properties of carbon nanotubes (CNTs) is being widely recognized. In this paper, the tensile properties of CNTs...
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National Latinx AIDS Awareness Day — October 15, 2019 ,Trends in Sexual Risk Behaviors Among Hispanic/Latino Men Who Have Sex with Men — 19 Urban Areas, 2011–2017Lindsay Trujillo, MPH; Johanna Chapin-Bardales, PhD; Emilio J. German, MSHSA; et al.Update: Influenza Activity — United States and Worldwide, May 19–September 28, 2019, and Composition of the 2020 Southern Hemisphere Influenza VaccineScott Epperson, DVM; C. Todd Davis, PhD; Lynnette Brammer, MPH; et al.Vital Signs: Burden and Prevention...
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Complications of thyroidectomy at a tertiary health institution,Sani Ali Samuel, Sani Hauwa RebeccaSub-Saharan African Journal of Medicine 2019 6(1):1-9Introduction: Thyroid surgeries are the most common endocrine surgeries performed all over the world. The procedure has been through tremendous evolution to enhance patient safety. In spite improved techniques, every thyroid surgeon has come across complications with this operation. This is a retrospective study of complications of thyroidectomies...
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Finally, a More Balanced View of Venous Thromboembolism ProphylaxisNo abstract availableHenry Lynch and the Power of Observation in Individual PatientsNo abstract availableProtecting Your Buns: Description of a New Teaching Tool for Total Mesorectal ExcisionNo abstract availableTrying to Keep My Life in TuneNo abstract availableHidradenitis SuppurativaCase Summary: A 66-year-old obese (BMI 34) diabetic man, a former smoker who had quit 4 months ago, had a 20-year history of perianal, inguinal, and...
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Radiographic Outcome and Complication Rate of 34 Graduates After Treatment With Vertical Expandable Prosthetic Titanium Rib (VEPTR): A Single Center ReportBackground: The final strategy for graduates from growth-sparing surgery is challenging. The purpose of this study was to evaluate the radiographic outcome and complications of patients with early onset scoliosis (EOS) who have graduated from vertical expandable prosthetic titanium rib (VEPTR) treatment, either undergoing final fusion surgery or...
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ANSI/HPS N13.56-2012 (R2019): Sampling and Monitoring Releases of Airborne Radioactivity in the WorkplaceNo abstract availableCharacterization of Extrafocal Dose Influence on the Out-of-Field Dose Distribution by Monte Carlo Simulations and Dose MeasurementsOut-of-field scattered and transmitted extrafocal radiation may induce secondary cancer in long-term survivors of external radiotherapy. Pediatric patients have higher life expectancy and tend to receive higher secondary radiation damage due to...
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Certified Basic Life Support Instructors Identify Improper Cardiopulmonary Resuscitation Skills Poorly: Instructor Assessments Versus Resuscitation Manikin DataIntroduction During basic life support (BLS) training, instructors assess learners' cardiopulmonary resuscitation (CPR) skills and correct errors to ensure high-quality performance. This study aimed to investigate certified BLS instructors' assessments of CPR skills. Methods Data were collected at BLS courses for medical students at Aarhus...
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Do NSAIDs increase the risk of congestive heart failure?No abstract availableDevil in the detailsNo abstract availableExamination of the risk of relapse and time to relapse after discontinuation of antidepressants in patients with anxiety disordersNo abstract availableLong-term opioid vs. nonopioid therapies for the treatment of chronic musculoskeletal painNo abstract availableSimplified diagnostic algorithm for suspected pulmonary embolismNo abstract availableSubclinical hypothyroidism: commonly...
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Relationship between atmospheric pollutants and risk of death caused by cardiovascular and respiratory diseases and malignant tumors in Shenyang, China, from 2013 to 2016: an ecological researchBackground: Air pollutants and their pathogenic effects differ among regions and seasons. We aimed to explore the relationship between fine particulate matter (PM2.5), sulfur dioxide (SO2), and ozone-8 hours (O3-8h) concentrations in heating and non-heating seasons and the associated death risk due to cardiovascular...
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Insight Into Illness and Defense Styles in SchizophreniaAlthough the psychological denial model argues that poor insight is a result of defense mechanisms, the direct relationship between the two remains unclear. This study aimed to examine the relationship between insight into illness and defense mechanisms while considering cognitive dysfunction in schizophrenia. A total of 38 patients with schizophrenia were evaluated for level of insight (Schedule for the Assessment of Insight), defense mechanisms...
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Article Summaries for October 2019 Psychosomatic Medicine, Volume 81, Issue 8No abstract availableEmotions in Social Relationships and Their Implications for Health and Disease: Introduction to the Special Issue of: Psychosomatic MedicineSocial relationships and emotions are important to health and disease, but research in this area has largely progressed along parallel and distinct historical paths. These areas are critically linked because relationships are among the most powerful elicitors of...
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Checkpoint Blockade in Combination With Doxorubicin Augments Tumor Cell Apoptosis in OsteosarcomaThe aim of this study was to provide a basis for the theory that the combination of conventional chemotherapy and immunotherapy would be an effective treatment for osteosarcoma. Here, the expression of programmed death ligand 1 (PD-L1) in 26 clinical osteosarcoma tissue samples collected before and after chemotherapy was analyzed. The effects of osteosarcoma cells treated with doxorubicin, a conventional...
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Genitourinary vascularized composite allotransplantation: a review of penile transplantationPurpose of review Vascularized composite allotransplantation (VCA) has developed over the past 20 years, resulting in promising new reconstructive prospects for extensive soft tissue defects. More than 200 VCA's have been performed worldwide, including five genitourinary (GU)VCA's and here we review the most recent literature in this field. Recent findings Developments in GUVCA are continuously evolving to...
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Meaningful measures in cancer cachexia: implications for practice and researchPurpose of review Cancer cachexia is a complex inflammatory syndrome, which presents with a variety of discrete symptoms and signs. This creates a challenge for both clinicians and researchers in recognizing and assessing the syndrome. This review explores the evidence for various measures used in the assessment of cachexia. Recent findings Objectively, cachexia may be assessed using CT-derived measures of skeletal muscle...
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