Iron deficiency and high-intensity running interval training do not impact femoral or tibial bone in young female rats

xlomafota13 shared this article with you from Inoreader Iron deficiency and high-intensity running interval training do not impact femoral or tibial bone in young female rats Via swallowing exercises Br J Nutr. 2021 Nov 11:1-22. doi: 10.1017/S0007114521004426. Online ahead of print. ABSTRACT In the US, as many as 20% of recruits sustain stress fractures during basic training. In addition, approximately one-third of female recruits develop iron deficiency upon completion of training. Iron is a cofactor in bone collagen formation and vitamin D activation, thus we hypothesized iron deficiency may be contributing to altered bone microarchitecture and mechanics during 12-weeks of in creased mechanical loading. Three-week old female Sprague Dawley rats were assigned to one of four groups: iron adequate sedentary, iron deficient sedentary, iron adequate exercise, and iron deficient exercise. Exercise consisted of high-intensity treadmill running (54 min 3×/week). After 12-weeks, serum bone turnover markers, femoral geometry and microarchitecture, mechanical properties and fracture toughness, and tibiae mineral composition and morphometry were measured. Iron deficiency increased the bone resorption markers C-terminal telopeptide type I collagen and tartate-resistant acid phosphatase 5b (TRAcP 5b). In exercised rats, iron deficiency further increased bone TRAcP 5b, while in iron adequate rats, exercise increased the bone formation marker procollagen type I N-terminal propeptide. In the femur, exercise increased cortical thickness and maximum load. In the tibia, iron deficiency increased the rate of bone formation, mineral apposition, and zinc content. These data s how that the femur and tibia structure and mechanical properties are not negatively impacted by iron deficiency despite a decrease in tibiae iron content and increase in serum bone resorption markers during 12-weeks of high-intensity running in young growing female rats. PMID:34758890 | DOI:10.1017/S0007114521004426 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sensitivity of Communicative Participation Item Bank for Measuring Unilateral Vocal Fold Immobility

xlomafota13 shared this article with you from Inoreader Sensitivity of Communicative Participation Item Bank for Measuring Unilateral Vocal Fold Immobility Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This case series examines differences in patients' score s on the Communicative Participation Item Bank before and after treatment of unilateral vocal fold immobility and how the scores compare with qualitative self-reports of treatment outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Persistent Postthyroidectomy Hypoparathyroidism in the Netherlands

xlomafota13 shared this article with you from Inoreader Persistent Postthyroidectomy Hypoparathyroidism in the Netherlands Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cohort study examines the incidence of postoperative , persistent hypoparathyroidism after total or completion thyroidectomy in Dutch patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cystic Neck Mass

xlomafota13 shared this article with you from Inoreader Cystic Neck Mass Via JAMA Otolaryngology–Head & Neck Surgery Current Issue A 44-year-old woman presented with a 6-month history of a right neck mass with compressive symptoms. What is your diagnosis? View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Levels of Triamcinolone Acetonide in Human Perilymph and Plasma After Intratympanic Application

xlomafota13 shared this article with you from Inoreader Levels of Triamcinolone Acetonide in Human Perilymph and Plasma After Intratympanic Application Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This randomized clinical trial compares levels of triamci nolone acetonide in perilymph and plasma after intratympanic injection. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinical Staging to Estimate the Probability of Postoperative Complications in Vestibular Schwannoma

xlomafota13 shared this article with you from Inoreader Clinical Staging to Estimate the Probability of Postoperative Complications in Vestibular Schwannoma Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cohort study presents a staging system to predict se vere surgical complications in patients who undergo surgical resection of vestibular schwannoma. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula After Laryngectomy

xlomafota13 shared this article with you from Inoreader Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula After Laryngectomy Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This multicenter cohort study of adult patients with lary ngeal cancer uses data from a national database to identify nonclinical risks associated with the formation of pharyngocutaneous fistula after total laryngectomy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Unusual Case of Bilateral Chylothorax After Neck Dissection

xlomafota13 shared this article with you from Inoreader An Unusual Case of Bilateral Chylothorax After Neck Dissection Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This case report describes a woman in her 30s who underwe nt total thyroidectomy with modified radical neck dissection due to papillary thyroid cancer and was subsequently diagnosed with bilateral chylothorax secondary to cervical thoracic duct injury. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hearing Loss and Impaired Physical Function, Frailty, and Disability in Older Adults

xlomafota13 shared this article with you from Inoreader Hearing Loss and Impaired Physical Function, Frailty, and Disability in Older Adults Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cross-sectional study examines the association betwe en hearing loss and impaired lower extremity function, frailty syndrome, and disability in older adults. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Long-term Outcomes of Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea

xlomafota13 shared this article with you from Inoreader Long-term Outcomes of Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea Via JAMA Otolaryngology–Head & Neck Surgery Online First This cohort study investigates the association between long-te rm use of hypoglossal nerve stimulation for obstructive sleep apnea and improved patient-reported outcomes, particularly insomnia and depression indices, and compares these outcomes with those for positive airway pressure therapy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Validation of CanAssist Breast immunohistochemistry biomarkers on an automated platform and its applicability in tissue microarray

xlomafota13 shared this article with you from Inoreader Validation of CanAssist Breast immunohistochemistry biomarkers on an automated platform and its applicability in tissue microarray Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Oct 15;14(10):1013-1021. eCollection 2021. ABSTRACT CanAssist Breast (CAB) is a prognostic test for early-stage hormone receptor-positive invasive breast cancer. The test involves performing immunohistochemical (IHC) analysis for five biomarkers, namely CD44, ABCC4, ABCC11, N-cadherin, and pan-cadherin. In addition to IHC grading information, three clinical features, i.e., tumor size, grade, and lymph node status, serve as input into the machine learning-based algorithm to generate the CAB risk score. CAB was developed and initially validated using manual IHC. This study's objectives included: i) automate CAB IHC on an autostainer and establish its performance equivalence with manual IHC ii) validate CAB test using samples in Tissue MicroArray (TMA) format. IHC for CAB biomarkers was standardized on Ventana BenchMark XT autostainer. Two IHC methods were compared for IHC gradings and corresponding CAB risk sc ores/risk categories. A concordance analysis was done using MedCalcTM software. The manual and automated IHC staining methods exhibited a high level of concordance on IHC gradings for 40 cases with an Intra-class Correlation Coefficient (ICC) of >0.85 for 4 of 5 biomarkers. 100% concordance was achieved in risk categorization (low- or high-risk), with very good agreement between the risk scores demonstrated by a kappa statistic of 0.83. TMA versus whole tissue section concordance was analyzed using 45 samples on an autostainer, and the data showed 92% concordance in terms of risk category. The results confirm the equivalence between manual and automated staining methods and demonstrate the utility of TMA as an acceptable format for CanAssist Breast testing. PMID:34760037 | PMC:PMC8569307 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Superiority of sucrase-isomaltase to CD10 for immunohistochemical detection of intestinal absorptive cell phenotype in differentiated-type gastric adenocarcinoma

xlomafota13 shared this article with you from Inoreader Superiority of sucrase-isomaltase to CD10 for immunohistochemical detection of intestinal absorptive cell phenotype in differentiated-type gastric adenocarcinoma Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Oct 15;14(10):1031-1037. eCollection 2021. ABSTRACT Gastric adenocarcinoma (GAC) can be divided immunophenotypically into gastric, intestinal, or mixed gastric and intestinal phenotypes. Cadherin 17 (CDH17) and CD10 have been used as comprehensive markers for intestinal epithelial cells and for small intestinal absorptive cells in GACs, respectively. Sucrase-isomaltase (SI) and CD10 are expressed in small intestinal absorptive cells and SI is more frequently expressed than CD10 in gastric intestinal metaplasia (IM). The aim of this study was to evaluate the potential of SI as a marker for intestinal absorptive cells compared to CD10 in differentiated-type (DT) GACs. We compared the immunohistochemical expression of CDH17, SI, and CD10 in IMs and tissue microarrays of 40 samples of DTGACs. In IMs and DTGACs, CDH17 showed a diffuse lateral cytoplasmic membrane staining both in columnar and goblet cells. SI and CD10 were expressed on the luminal surfaces of the columnar cells. In IMs, SI was positive both in both complete-type IMs and in incomplete-type IMs. CD10 was positive only in complete-type IMs. In DTGACs, CDH17, SI, and CD 10 were positive in 37 (92.5%), 22 (55%), and 11 (27.5%) cases, respectively. In SI-positive cases, the degrees of expression of SI were equal to (7 cases) or less than (15 cases) those of CDH17; the degrees of expression of SI were equal to (5 cases), more than (16 cases), or less than (1 case) those of CD10. In conclusion, SI is a more sensitive immunohistochemical marker for intestinal absorptive cells than CD10 in DTGACs. PMID:34760039 | PMC:PMC8569310 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.