Argyrophilic Nucleolar Organizing Regions in Patients with Xeroderma Pigmentosum Group E

xlomafota13 shared this article with you from Inoreader Argyrophilic Nucleolar Organizing Regions in Patients with Xeroderma Pigmentosum Group E Via Experimental Dermatology Abstract Xeroderma pigmentosum E (XP‐E) is a rare autosomal recessive inherited genodermatosis associated with less severe sun burning with minimal sun exposure. The affected individuals acquire abnormal pigmentation and are at high risk for skin cancer [1]. Notably, the DNA damage‐binding protein 2 (DDB2) gene is responsible for XP‐ E disease [2]. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cortical Stimulation Induces Excitatory Postsynaptic Potentials of Inferior Colliculus Neurons in a Frequency-Specific Manner.

xlomafota13 shared this article with you from Inoreader Cortical Stimulation Induces Excitatory Postsynaptic Potentials of Inferior Colliculus Neurons in a Frequency-Specific Manner. Via cortical auditory Related Articles Cortical Stimulation Induces Excitatory Postsynaptic Potentials of Inferior Colliculus Neurons in a Frequency-Specific Manner. Front Neural Circuits. 2020;14:591986 Authors: Qi J, Zhang Z, He N, Liu X, Zhang C, Yan J Abstract Corticofugal modulation of auditory responses in subcortical nuclei has been extensively studied whereas corticofugal synaptic transmission must still be characterized. This study examined postsynaptic potentials of the corticocollicular system, i.e., the projections from the primary auditory cortex (AI) to the central nucleus of the inferior colliculus (ICc) of the midbrain, in anesthetized C57 mice. We used focal electrical stimulation at the microampere level to activate the AI (ESAI) and in vivo whole-cell current-clamp to record the membrane potentials of ICc neurons. Following the whole-cell patch-clamp recording of 88 ICc neurons, 42 ICc neurons showed ESAI-evoked changes in the membrane potentials. We found that the ESAI induced inhibitory postsynaptic potentials in 6 out of 42 ICc neurons but only when the stimulus current was 96 μA or higher. In the remaining 36 ICc neurons, excitatory postsynaptic potentials (EPSPs) were induced at a much lower stimulus current. T he 36 ICc neurons exhibiting EPSPs were categorized into physiologically matched neurons (n = 12) when the characteristic frequencies of the stimulated AI and recorded ICc neurons were similar (≤1 kHz) and unmatched neurons (n = 24) when they were different (>1 kHz). Compared to unmatched neurons, matched neurons exhibited a significantly lower threshold of evoking noticeable EPSP, greater EPSP amplitude, and shorter EPSP latency. Our data allow us to propose that corticocollicular synaptic transmission is primarily excitatory and that synaptic efficacy is dependent on the relationship of the frequency tunings between AI and ICc neurons. PMID: 33192337 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Application of Wireless Contralateral Routing of Signal (CROS) Technology in Unilateral Cochlear Implant Users

xlomafota13 shared this article with you from Inoreader Application of Wireless Contralateral Routing of Signal (CROS) Technology in Unilateral Cochlear Implant Users Via Acta Otorrinolaringologica English Publication date: November–December 2020 Source: Acta Otorrinolaringologica (English Edition), Volume 71, Issue 6 Author(s): Faustino Núñez-Batalla, Ana Belén Fernández-Junquera, Lorena Súarez-Villanueva, Estefanía Díaz-Fresno, Isabel Sandoval-Menéndez, Justo Gómez Martínez, José Luis Llorente-Pendás View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Fine-needle aspiration cytology in the diagnosis of salivary gland lesions. The role of the Milan system for reporting cytopathology

xlomafota13 shared this article with you from Inoreader Fine-needle aspiration cytology in the diagnosis of salivary gland lesions. The role of the Milan system for reporting cytopathology Via Acta Otorrinolaringologica English Publication date: November–December 2020 Source: Acta Otorrinolaringologica (English Edition), Volume 71, Issue 6 Author(s): José-Fernando Val-Bernal, María Martino, Sara Marcos, Elena Yllera, Belén García-Montesinos View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Expression of E-cadherin and β-catenin in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas

xlomafota13 shared this article with you from Inoreader Expression of E-cadherin and β-catenin in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas Via Acta Otorrinolaringologica English Publication date: November–December 2020 Source: Acta Otorrinolaringologica (English Edition), Volume 71, Issue 6 Author(s): Patricia García-Cabo, Juana María García-Pedrero, M. Ángeles Villaronga, Francisco Hermida-Prado, Rocío Granda-Díaz, Eva Allonca, Fernando López, Juan Pablo Rodrigo View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cavernous Hemangioma of the Tympanic Membrane. Case Report and Review of Literature

xlomafota13 shared this article with you from Inoreader Cavernous Hemangioma of the Tympanic Membrane. Case Report and Review of Literature Via Acta Otorrinolaringologica English Publication date: November–December 2020 Source: Acta Otorrinolaringologica (English Edition), Volume 71, Issue 6 Author(s): Paula Cruz Toro, Margarita Mesa Marrero, Elena Hernández Montero, María Pané Foix View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A giant pseudoaneurysm mimicking a parapharyngeal abscess

xlomafota13 shared this article with you from Inoreader A giant pseudoaneurysm mimicking a parapharyngeal abscess Via Acta Otorrinolaringologica English Publication date: November–December 2020 Source: Acta Otorrinolaringologica (English Edition), Volume 71, Issue 6 Author(s): Manuel Tucciarone, Pascual Elvira Ruiz, Ricardo José González-Orus Álvarez-Morujo View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Factors Associated With the Limitation at Work Because of the Voice: Study With Teachers of Basic Education In Brazil

xlomafota13 shared this article with you from Inoreader Factors Associated With the Limitation at Work Because of the Voice: Study With Teachers of Basic Education In Brazil Via Voice Publication date: Available online 17 November 2020 Source: Journal of Voice Author(s): Bárbara Antunes Rezende, Mery Natali Silva Abreu, Ada Ávila Assunção, Adriane Mesquita de Medeiros View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Management of Laryngopharyngeal Reflux

xlomafota13 shared this article with you from Inoreader Management of Laryngopharyngeal Reflux Around the World: An International Study Via The Laryngoscope Objective To investigate worldwide practices of otolaryngologists in the management of laryngopharyngeal reflux (LPR). Methods An online survey was sent on the management of LPR to members of many otolaryngological societies. The following aspects were evaluated: LPR definition, prevalence, clinical presentation, diagnosis, and treatment. Results A total of 824 otolaryngologists participated, spread over 65 countries. The symptoms most usually attributed to LPR are cough after lying down/meal, throat clearing and globus sensation while LPR‐related findings are arytenoid erythema and posterior commissure hypertrophy. Irrespective to geography, otolaryngologists indicate lack of familiarity with impedance pH monitoring, which they attribute to lack of knowledge in result interpretation. The most common therapeutic regimens significantly vary between world regions, with a higher use of H2 blocker in North America and a lower use of alginate in South America. The duration of treatment also significantly varies between different regions, with West Asia/Africa and East Asia/Oceania otolaryngologists prescribing medication for a shorter period than the others. Only 21.1% of respondents are aware about the existence of nonacid LPR. Overall, only 43.2% of otolaryngologists believe themselves sufficiently knowledgeable about LPR.< /p> Conclusions LPR knowledge and management significantly vary across the world. International guidelines on LPR definition, diagnosis, and treatment are needed to improve knowledge and management around the world. Level of Evidence N.A. Laryngoscope, 2020 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Internal Auditory Canal Diverticula in Children: A Congenital Variant

xlomafota13 shared this article with you from Inoreader Internal Auditory Canal Diverticula in Children: A Congenital Variant Via The Laryngoscope Objectives/Hypothesis Internal auditory diverticula in adults have been found to exist independent of otosclerosis, and in the presence of otosclerosis. We sought to determine the prevalence of internal auditory canal (IAC) diverticula in a pediatric cohort, to assess whether IAC diverticula are a risk factor for hearing loss, and the co‐occurrence of otic capsule hypoattenuation. Study Design Retrospective review. Methods A single‐site retrospective review of high‐resolution temporal bones computed tomography (CT) scans including the presence and size of diverticula and hypoattenuation of the otic capsule. Demographic, imaging, and audiometric data were collected and descriptively analyzed. Bivariate analysis of collected variables was conducted. Comparisons between sides in unilateral cases were also performed. Results 16/600 (2.7%; 95% CI [2.0%, 3.4%]) were found to have IAC diverticula. Six were bilateral. Thirty‐one patients (5.2%) were found to have hypoattenuation of the otic capsule. There were no coincident cases of IAC diverticulum and hypoattenuation of the otic capsule. There was no association between the presence of IAC diverticula and age (P = .13). In six patients with unilateral diverticula, pure tone average (P = .42), and word recognition (P = .27) scores were not significantly different when compared to the normal, contralateral side. Conclusions The prevalence of IAC diverticula in children is lower than the prevalence in adults. IAC diverticula in children likely represent congenital variants of temporal bone anatomy. Similar to adult populations, there is evidence that IAC diverticula in children are likely not an independent risk factor for hearing loss. Level of Evidence 4 Laryngoscope, 2020 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sialographic Analysis of Radioiodine‐Associated Chronic Sialadenitis

xlomafota13 shared this article with you from Inoreader Sialographic Analysis of Radioiodine‐Associated Chronic Sialadenitis Via The Laryngoscope Objectives/Hypothesis To apply a novel sialography classification system to identify parotid and submandibular ductal findings following I‐131 therapy and to assess correlates to dose and duration of symptoms. Study Design Retrospective single‐center case series. Methods Patients who underwent sialography between February 2008 and February 2019 after previously receiving I‐131 treatment were identified via a retrospective chart review. Their sialograms were systematically evaluated and scored by applying the Iowa parotid sialogram scale to also include submandibular gland analysis. Results From 337 sialograms, 30 (five submandibular, 25 parotid) underwent analysis. Ductal stenosis was identified in all sialograms and was graded as moderate (>50%–75%) in 7/30 cases and severe (>75%) in 15/30 cases. The distal (main) duct was narrowed in 23/30 cases. No association was identified between degree of ductal stenosis and I‐131 dose (P = .39), age (P = .81), or time from I‐131 therapy to sialogram (P = .97). Conclusions The Iowa parotid sialogram scale was successfully applied to report abnormalities of the parotid and submandibular ductal system. The most common manifestation of I‐131‐associated sialadenitis was a severe stenosis within the distal salivary duct. No statistically significant association was found between degree of ductal stenosis and dose of I‐131, age, or duration of symptoms. Level of Evidence 4 Laryngoscope, 2020 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Development and Application of the Average Pelvic Shape in Virtual Pelvic Fracture Reconstruction

xlomafota13 shared this article with you from Inoreader Development and Application of the Average Pelvic Shape in Virtual Pelvic Fracture Reconstruction Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background With unilateral pelvic fractures, the contralateral hemipelvis can be used as a template in virtual reconstruction, however, this cannot be applied for bilateral fractures. Therefore, statistical shape modelling was used to build average pelvic shapes that can serve as templates when reconstructing bilaterally fractured pelvises. Methods Four average shape models were created for male and female, left and right hemipelves from 20 male and 20 female subjects. They were used as templates to reconstruct 8 unilaterally fractured pelvises. Results The average root‐mean‐square of deviations between the reconstructed and intact hemipelves was 1.46 ± 0.32 mm, which is less than the 2 mm threshold for causing hip joint complications. Conclusion This indicates that the reconstructions are reliable and the average shape models can be used to reconstruct bilaterally fractured pelvises. The proposed technique can potentially pro vide quick and accurate treatment plans for pelvic fracture patients, which is necessary for recovery. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.