Πέμπτη 14 Μαΐου 2020

Multifocal Parotid Oncocytic Cystadenomatosis: A Rare Process that Can Mimic Malignancy

Multifocal Parotid Oncocytic Cystadenomatosis: A Rare Process that Can Mimic Malignancy:

Abstract

Multifocal cystic oncocytosis (MCO) is a rare, benign process accounting for approximately 0.1% of salivary gland lesions. Salivary oncocytosis is characterized by multiple unencapsulated solid nodules of oncocytic cells derived from transformed striated ducts. MCO is a variant of salivary oncocytosis which manifests as cystically dilated striated ducts. It is difficult to obtain a definitive preoperative diagnosis of MCO; therefore, these lesions are commonly treated with surgery. We report the unique case of a 66-year-old male who previously underwent a superficial left parotidectomy for a pleomorphic adenoma. Four years later, he presented with clinical and radiographic suspicion of a multifocal recurrent pleomorphic adenoma. The patient subsequently underwent a revision parotidectomy. However, final pathology confirmed a diagnosis of MCO. Although MCO is commonly treated with surgery due to lack of a definitive preoperative diagnosis, surgery is unnecessary outside of diagnostic, functional or cosmetic considerations. Thus, if a patient with parotid oncocytosis treated by superficial parotidectomy develops disease re-manifestation in the residual deep lobe, further surgery is not indicated. There is no risk of malignant progression in this process. We report on this unusual entity as it may mimic salivary malignancy or, as in this case, recurrence of benign disease.

68Ga-PSMA PET/CT and 18F-FDG PET/CT in Renal Cell Carcinoma
Recent case reports and series have demonstrated the usefulness of 68Ga/18F-PSMA PET/CT in restaging recurrent renal cancer after nephrectomy. We presented a case of a patient with renal mass who had undergone both 18F-FDG and 68Ga-PSMA PET/CT for diagnosis and staging. Concordant tracer uptake in the primary tumor and metastatic lesions was demonstrated by both radiotracers. Final histopathological reports revealed clear cell renal cell carcinoma. Furthermore, unusual left metacarpal bone metastasis...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Pelvic Leiomyosarcoma With Splenic Metastasis and Response Assessment by 18F-FDG PET/CT
The pelvis is a rare site for the origin of soft tissue sarcomas, and leiomyosarcoma remains the most common soft tissue sarcoma arising in the pelvis. Pelvic leiomyosarcomas are frequently aggressive tumors, and metastatic recurrence rates are high, with the lung, peritoneum, bone, and liver being the most frequent sites. We describe the findings of serial 18F-FDG PET/CT in a 53-year-old woman having pelvic leiomyosarcoma with uncommon site of metastasis, emphasizing the role of 18F-FDG PET/CT in...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Post Contusion Breast Hematoma Mimicking Malignancy on FDG PET/CT
A 32-year-old woman was treated for breast carcinoma. Posttreatment FDG PET/CT scan revealed complete response, but in the contralateral breast, unexpected incidental intense FDG uptake was seen with a differential diagnosis of both malignant and benign causes. Medical history revealed recent breast contusion. The lesion was further evaluated by mammogram and ultrasound, which were compatible with deep breast bruise. Histopathology showed no malignancy. Subsequent FDG PET/CT study showed breast uptake...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Monitoring and Handing of 89Sr Injection Site Extravasation in a Patient With Breast Cancer
Extravasation of various imaging tracers during administration was not a rare complication during nuclear medicine practice. However, the occurrence of extravasation of therapeutic radiopharmaceutical was rarely reported. Here we reported a 60-year-old woman with breast cancer and diffuse painful bone metastases who received strontium chloride (89SrCl2) therapy to palliate her bone pain. Accidental subcutaneous extravasation in the injection site occurred. The extravasated 89Sr was absorbed rapidly...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Fusion 68Ga–Prostate-Specific Membrane Antigen PET/MRI on Postoperative Surveillance of Juvenile Nasal Angiofibroma
Prostate-specific membrane antigen (PSMA) is expressed universally in juvenile nasopharyngeal angiofibroma (JNA). As contrast enhancement of postoperative scar is common with contrast-enhanced MRI (CEMRI), diagnosis of residual/recurrent JNA remains perplexing. Prostate-specific membrane antigen PET targets only the neovasculature and may aid in resolving this dilemma. Positive contrast enhancement on CEMRI was noted in a patient after 30 years of initial surgery, simulating recurrence. However,...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Right Atrial Intimal Sarcoma on 18F-FDG PET/CT
A right atrial mass was discovered with transthoracic cardiac ultrasound in a complaint-free, 81-year-old man at his yearly cardiological checkup. Further investigation of the mass with transesophageal cardiac ultrasound showed a well-defined nodular mass of approximately 3 × 3 cm, in close proximity to the posterior wall of the right atrium. The patient underwent an 18F-FDG PET/CT, which showed a right atrial mass with very high FDG uptake, suggesting a malignant process. The mass was surgically...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Decreased Vision and Headache as the Initial Symptoms of Hepatocellular Carcinoma
Sphenoid sinus metastasis is extremely rare. Herein, we report a case of occult hepatocellular carcinoma with initial symptoms of decreased vision and headache, which were caused by sphenoid sinus metastasis. A 44-year-old man recently complained of bilateral decreased vision and headache. Head MRI showed a soft tissue mass in the sphenoid sinus. Pathological examination of the resected sphenoid sinus mass indicated metastatic carcinoma. Subsequently, 18F-FDG PET/CT and immunohistochemical analysis...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
FDG PET/CT in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma
Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin’s lymphoma, with rearrangements of the anaplastic lymphoma kinase gene in 60%–85% of systemic cases. We report an 11-year-old boy with ALCL in whom serial FDG PET/CT revealed partial response and complete metabolic response at interim and end of treatment, respectively. However, the patient relapsed within 2 weeks, confirmed by cytology. Because of the inherent aggressive nature of ALCL, possibility of an early relapse should always be kept...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
PSMA Expression in the Neovasculature Associated With Rectal Adenocarcinoma: A Potential Stromal Target for Nuclear Theranostics
We report the case of a 63-year-old man who underwent MRI and 68Ga-PSMA-11 PET/CT for biochemical recurrence localization after radical prostatectomy (serum PSA, 0.25 ng/mL) and describe the incidental discovery of a rectal adenocarcinoma. Immunohistochemical analysis showed PSMA staining in the tumor-associated neovasculature, but not in normal vasculature, or tumor cells. After surgical removal, he was treated with salvage radiotherapy to the postoperative prostate bed. This case example has several...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Low ADC in CNS Lymphoma
Patients with primary central nervous system lymphomas (PCNSLs) present with nonspecific clinical symptoms, which makes correct imaging evaluation essential for diagnostic and therapeutic management. In this work, we examined an 81-year-old man with recently discovered PCNSL using 18F-FDG PET/MRI, and we were able to differentiate between 2 lesions—PCNSL lymphoma extension and a recent ischemia. Our work shows that ischemia should be considered as a differential diagnosis for lymphoma progression....
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Emerging Attack and Management Strategies for Nuclear Medicine in Responding to COVID-19—ACNM Member Experience and Advice
As the World Health Organization declared COVID-19 as “global pandemic,” it is important for everyone, including nuclear medicine personnel, to know how to stop transmission, contain, and prevent the spread of COVID-19. We reach out to our ACNM (American College of Nuclear Medicine) international members from Wuhan, China and Singapore, who have participated in dealing with COVID-19 for the last 2 months, to learn from their lessons and experiences, so to provide advice to all ACNM members for their...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Extensive Intraspinal Hypermetabolism Caused by Neurobrucellosis Shown on 18F-FDG PET/CT
A 55-year-old man and a 52-year-old man presenting with neurological symptoms were referred for 18F-FDG PET/CT for the underlying malignancy. In both cases, extensive intraspinal hypermetabolism was observed in 18F-FDG PET/CT. The cerebrospinal fluid culture finally confirmed infection of Brucella. This report illustrates that neurobrucellosis may present as intraspinal hypermetabolism on 18F-FDG PET/CT, and thus it should be added to the differential diagnosis. Received for publication March...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Focal 18F-NaF PET Prostate Activity in the Setting of Prostate Adenocarcinoma
A 72-year-old man with a family history of prostate cancer and initial diagnosis of favorable intermediate risk prostate cancer via biopsy in 2017 elected for active surveillance. Two years later, he underwent prostate biopsy showing intermediate-risk cT1c Nx Mx lesion with Gleason score 3 + 4 = 7 (5 core positive). Transrectal ultrasound showed a prostate volume 28 mL, and the prostate-specific antigen was 8.1. Patient elected to proceed with combination radiation therapy and androgen deprivation...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
18F-FDG PET/CT of a Rare Case of an Adenomatoid Tumor of the Adrenal Gland
A 28-year old man, with previous history of chronic abdominal pain, was referred to our nuclear medicine center for an 18F-FDG PET/CT following the fortuitous discovery of a 48-mm right adrenal gland lesion of heterogeneous density at the CT scan. The PET/CT showed an isolated heterogeneous significant uptake evocative of neoplasia. Surprisingly, the anatomopathological analysis after surgery revealed an adenoid tumor of the adrenal gland. This case of a rare benign tumor can be a source of false-positive...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
Is There Any Clinical Value of Adding 123I-Metaiodobenzylguanidine Myocardial Scintigraphy to 123I-Ioflupane (DaTscan) in the Differential Diagnosis of Parkinsonism?
Purpose The aim of the study is to evaluate the impact of myocardial 123I-metaiodobenzylguanidine (MIBG) in the diagnosis, clinical management, and differential diagnosis of Parkinson disease (PD) and non-PD parkinsonism. Methods The study enrolled 41 patients with parkinsonism. An initial diagnosis was reached after thorough clinical and imaging evaluation. After 2 to 5 years of follow-up, a final diagnosis was established. All patients underwent, soon after their initial visit, presynaptic...
Clinical Nuclear Medicine - Published Ahead-of-Print
Mon May 11, 2020 03:00
[ASAP] Protonation–Suppression-Free LC-MS/MS Analysis for Profiling of DNA Cytosine Modifications in Adult Mice
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00962
Analytical Chemistry
Thu May 14, 2020 07:00
[ASAP] Plasmonic Colloidosome-Coupled MALDI-TOF MS for Bacterial Heteroresistance Study at Single-Cell Level
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00494
Analytical Chemistry
Thu May 14, 2020 07:00
[ASAP] Development and Evaluation of a Microarray Platform for Detection of Serum Antibodies Against <italic toggle="yes">Streptococcus pneumoniae</italic> Capsular Polysaccharides
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01009
Analytical Chemistry
Thu May 14, 2020 07:00
[ASAP] Microfluidic Control of Tumor and Stromal Cell Spheroids Pairing and Merging for Three-Dimensional Metastasis Study
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00408
Analytical Chemistry
Thu May 14, 2020 07:00
[ASAP] Assessment of Embryonic Bioactivity through Changes in the Water Structure Using Near-Infrared Spectroscopy and Imaging
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00076
Analytical Chemistry
Thu May 14, 2020 07:00
[ASAP] Monitoring and Modeling of Living Cell Responses in the Attachment Process and Reaction to the Antitumor Reagent Cisplatin Studied by a Quartz Crystal Microbalance Combined with a Microscope
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01274
Analytical Chemistry
Thu May 14, 2020 07:00
[ASAP] Mediator-Microorganism Interaction in Microbial Solar Cell: a Fluo-Electrochemical Insight
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05808
Analytical Chemistry
Thu May 14, 2020 07:00
[ASAP] Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03708
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Engineering DNA-Functionalized Nanostructures to Bind Nucleic Acid Targets Heteromultivalently with Enhanced Avidity
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01568
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Systematic Modulation of Charge Transport in Molecular Devices through Facile Control of Molecule–Electrode Coupling Using a Double Self-Assembled Monolayer Nanowire Junction
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02215
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Dual Monitoring of Surface Reactions in Real Time by Combined Surface-Plasmon Resonance and Field-Effect Transistor Interrogation
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b11835
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Sulfonated Sub-1-nm Metal–Organic Framework Channels with Ultrahigh Proton Selectivity
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03554
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Optimizing Pore Space for Flexible-Robust Metal–Organic Framework to Boost Trace Acetylene Removal
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02594
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Molecular Factors Controlling the Isomerization of Azobenzenes in the Cavity of a Flexible Coordination Cage
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03444
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Transition State Force Field for the Asymmetric Redox-Relay Heck Reaction
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01979
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
[ASAP] Pd-Catalyzed Enantioselective Syntheses of Trisubstituted Allenes via Coupling of Propargylic Benzoates with Organoboronic Acids
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02876
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Thu May 14, 2020 07:00
Twenty dessert recipes that work better in warm weather
This story originally featured on Saveur.During winter we love rich, hearty desserts to pad our bellies and keep us warm. But once the weather starts to warm up—and with beach season looming on the horizon—we crave lighter and brighter flavors. Our current obsession? Rhubarb desserts are all the rage. But we love any light, seasonal treat that you can pack in your picnic basket. For something visually stunning, look no further than Pinterest. Our users have spoken by choosing these most-pinned spring...
Popular Science
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Planet Nine might not be a planet at all
A ninth planet is one form the solar system’s mysterious mass could take. (Caltech/R. Hurt (IPAC)/)After centuries of watching the skies, the map of our local solar system has grown quite detailed. We live on one of the rocky inner planets. Next there’s a belt of asteroids, two gas giants, two ice giants, and then a second belt of many smaller icy bodies. In the impenetrable outer solar system, however, lies an unseen dragon, researchers have come to suspect. Scanning the darkness, astronomers have...
Popular Science
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We have the tools to contain COVID-19 misinformation, we just aren’t using them
During the 2009 to 2010 H1N1 flu pandemic, the federal government was lauded for the steps it took to tackle false information about both the disease and the vaccine to treat it. (Pixabay/)Nearly 300,000 people globally have died in the ongoing COVID-19 pandemic, and more than 80,000 of them are from the United States. To slow the rate of infections and “flatten the curve”, health officials and scientists worldwide have been working around the clock to better understand the novel virus and spread...
Popular Science
Thu May 14, 2020 19:00
Great sports sunglasses for all outdoor activities
Go hard without losing your shades. (Victor Xok via Unsplash/)A good pair of sports sunglasses are like the perfect running shoes or most comfortable sweat shorts—you’ll wonder how you ever did anything without them before. Whether you’re a hardcore athlete or a weekend warrior, there are options that combine comfort with top flight performance.Choose your weapons, and never squint through a game or running session every again.Put them on, coach. (Amazon /)Not all “sports” sunglasses care if you...
Popular Science
Thu May 14, 2020 18:03

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