Τετάρτη 15 Ιανουαρίου 2020

Journal of Maxillofacial and Oral Surgery

Retraction of Orbital Soft Tissue During Orbital Surgery: A Technical Note

Abstract

Introduction

Orbital fractures may be either isolated or part of midface fractures. These injuries may cause disruption of the orbital walls and herniation or entrapment of orbital contents resulting in enophthalmos or diplopia.

Methods

Surgical exploration of the orbit is the definitive mode of management of such injuries. A common problem encountered during such exploration is the prolapse of orbital soft tissues which hamper the visualization of the defects.

Conclusion

Here, we suggest an adjunct to the orbital retractors in control prolapsing soft tissues.

Long-Term Dislocation of the Mandible: Is there an Algorithm to Success? Intraoperative Decision and Review of Literature

Abstract

Purpose

Long-term TMJ dislocation is a rare condition. It occurs when an acute luxation remains untreated in time.

Methods

A 52-year-old man presented with a long-term TMJ luxation in the context of Steinert’s disease. A discectomy together with condylectomy and eminectomy was performed, obtaining an adequate reduction of the luxated condyle and disc.

Results

Twelve months after the operation, the condition has not recurred at all. A stable and centred occlusion was checked; his MIO was over 30 mm.

Conclusion

The combination of these three techniques could be a good option in cases of Steinert’s myotonia, where the condyle luxation becomes chronic and irreducible due to the altered neuromuscular condition. There is still no consensus regarding the treatment for long-term TMJ dislocations. New and more solid studies may be needed in order to find adequate treatment protocols for this condition.

Intraoperative Image-Guided Retrieval of Foreign Body from Infratemporal Fossa: A Rare Case Report

Abstract

Entrapped foreign bodies in the head and neck region pose a challenge for surgeons, especially when present in areas like infratemporal space. In this case report, a bomb splinter entered through skin below the right infraorbital rim, traversed the maxillary antrum and got entrapped in the infratemporal fossa of the patient, which was initially localized using preoperative two-dimensional and three-dimensional radiographs. The foreign body was exposed via Alkayat Bramley approach and finally retrieved with the help of intraoperative C-arm fluoroscopy.

Maxillofacial Gossypiboma: Case Report, Review of the Literature, and Diagnosis Algorithm

Abstract

Gossypiboma is a retained surgical sponge and represents a rare complication with an uncertain incidence probably due to medical–legal implications. It is an iatrogenic condition solely due to human factors. While the medical literature has previously described cases of this entity after orthopedic, abdominal, otorhinolaryngology, and plastic surgery procedures, gossypibomas in oral and maxillofacial region are uncommon. It can mimic neoplasms or other injuries, which may promote a delayed diagnosis; thus, the differential diagnosis should be based on clinical history in each particular case. Although there are no pathognomonic features of gossypiboma in oral and maxillofacial region, the most common symptoms suggestive of persistent inflammation include pain, fever, swelling, surgical wounds that do not heal, and purulent drainage. The aim of this study was to report a maxillofacial gossypiboma misdiagnosed as third molar surgery-related odontogenic infection and a diagnosis algorithm.

A Rare Case of Hyoid Bone Fracture Concomitant with a Comminuted Mandibular Fracture

Abstract

The hyoid bone fracture secondary to trauma other than strangulation is a rare event, regarding the literature. Hereby, we presented a rare and interesting case of hyoid bone fracture associated with comminuted mandibular fracture following falling-down in a 13-year-old girl. The importance of timely diagnosis and proper treatment plan would be discussed, as well. The maxillofacial surgeon should be aware of the possibility of a hyoid bone fracture in patients who have suffered maxillofacial trauma. Potentially fatal respiratory complications can develop rapidly unless proper care is given to such injuries.

Reconstructing the Nasal Tip After a Human Bite: A Challenge for the Reconstructive Surgeon

Abstract

Background

Human facial bites are uncommon and usually cause a wound that presents major challenges for the reconstructive surgeon.

Purpose

The purpose of this study is to present the advantages and disadvantages of using a superiorly based interpolated nasolabial flap for reconstruction of a nasal tip defect.

Methods

We present a case of serious injury of the nasal tip as a result of a human bite. Early maxillofacial surgical intervention resulted in restoration of the facial anatomy and function of the structures involved.

Results and Conclusion

We present a serious mutilating injury of the tip of the nose in a young patient as a result of a human bite. These injuries can be rather destructive and cause a facial defect which may have a significant adverse psychological impact on the patient. Because of the proximity and the skin colour match of the melolabial fold to the nose, nasolabial flaps are a very attractive and reliable reconstructive choice for nasal tip defects. The relative advantages over other reconstructive options and the limitations of an interpolated superiorly based nasolabial flap are discussed. The elaborated use of a nasolabial peninsular pedicled skin flap may deliver a very satisfactory outcome from a functional and cosmetic point of view.

Single-Skin Paddle Anterolateral Thigh Free Flap with Ileotibial Tract for Internal Lining in Reconstruction of Full-Thickness Cheek Defect

Application of Navigation Surgery in Temporomandibular Joint Ankylosis Case and Review of Literature

Abstract

The aim of this article is to develop a navigation-guided oral and maxillofacial surgery including surgical planning, simulation and navigation in temporomandibular joint ankylosis case practiced in tertiary care hospital. After getting the computed tomographic angiography of head and neck, the special software of Brain lab® is used to mark the arteries and veins of the patient, which was in close approximation to the mandibular condyle. Brain lab® navigation system was used during the surgery to ascertain the middle meningeal artery location, and osteotomy cut was given. Navigation technology use in the neurosurgery is not new. But its use in the subcontinent in the field of maxillofacial surgery is quite rare. First time, it has been used scientifically in temporomandibular joint ankylosis case. Navigation technology use in the maxillofacial surgery requires a holistic imaginative/creative approach to make the surgeries more predictive and safe.

Integration of Perforator Vessels in CAD/CAM Free Fibula Graft Planning: A Clinical Feasibility Study

Abstract

Introduction

Commercial CAD/CAM planning of free osteocutaneous microvascular fibula flap does not support integration of soft tissue structures including perforator vessel anatomy. Therefore, in a clinical trial, a method for such a combined hard- and soft tissue 3D-fibula planning was assessed.

Materials and Methods

In a clinical study on 24 patients needing reconstruction with osteocutaneous fibula graft, skin perforators of the respective leg were detected via Doppler sonography and documented on a measurement device. Each of the perforators’ localization was transferred to a CAD/CAM planning software and included in each planning step as well as in the surgical cutting guide. A comparison between sonography and clinical localization, damage to perforator vessels during surgery as well as a subjective evaluation of feasibility and usefulness of the procedure was carried out.

Results

In total, 19 skin paddles were placed orally, 2 extraorally and 3 at both sites at once. Survival rate was 92% (22/24). In addition, 3 skin paddles were lost complete and 2 partially. Anatomical sites of perforator vessels were never < 1 cm from planned positions and not damaged at all (n = 75). Planning was judged useful for skin paddle design and positioning of osteotomies. In accordance, surgical guides were always implemented successfully without the need of changing planned procedures during surgery.

Conclusion

Integration of skin perforators into 3D planning of microvascular fibular graft is feasible and may even decrease involuntary dissection of perforator vessels. Even so, clinical studies for comparison are needed.

Evaluation of Changes in the Alar Base Width Following Lefort 1 and AMO with Conventional Alar Cinch Suturing: A Photographic Study of 100 Cases

Abstract

Objective

To assess the changes in alar base width in patients who underwent Lefort 1 osteotomy with anterior maxillary osteotomy (AMO), where conventional alar cinch suturing was done to control the alar base widening.

Materials and Methods

This study was conducted on pre-operative and post-operative photographs of 100 female patients aged between 18 and 30 years who underwent Lefort 1 osteotomy with AMO. The derived values were then compared and analysed using t test.

Results

The mean alar base width pre-operatively was 14.11 mm and post-operatively was 15.28 mm. The mean increase in alar base width was 1.176 mm. The result indicated a definitive change between pre-operative and post-operative alar base widths with mean increase in width of 1.176 mm (P = 0.000), which is clinically not very significant.

Conclusion

The effect of Lefort 1 osteotomy on the alar base can be well controlled by the conventional alar cinch suturing without any additional anchorage on the ANS with predictable results.

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, Telephone consultation 11855 int 1193,

Protocol for intubation with introducer guide
If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 12:17
Videolaryngoscopes
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 12:10
Supraglottic Airway Devices (SADs)
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 11:59
Wilson risk score
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 11:28
Airway Assessment
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 11:12
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, Telephone consultation 11855 int 1193,
Environmental Research International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case ReportIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case Report International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020535 Authors: Abdulmalek Alsharidah Yahya Mahli Nayef Alshabyli Mohammed Alsuhaibani Basidiobolomycosis is...
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 10:43
35 JOURNALS
1a6u0b-88krq.html5 ways to connect with Ear, Nose & Throat Journal.eml 2akvsq-nlr70.htmlAnesthesiology Online First.eml 3a1hqh-p5qum.htmlAsian Pac J Trop Biomed - New issue online.eml 4a11r6-gh28h.htmlCancer Research_ January Table of Contents Alert.eml 5ahzkq-fi4ic.htmlClinical Infectious Diseases Advance articles.eml 6afh6m-5rebe.htmlEarly View Alert_ Head & Neck.eml 7a8lut-zyds3.htmlEarly View Alert_ Immunity, Inflammation and Disease.eml 8avzwt-incpw.htmlEarly View Alert_ International...
Medicine by Alexandros G. Sfakianakis
09:19
MDPI
 Journal of Cardiovascular Development and DiseaseJCDD, Vol. 7, Pages 4: The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular DiseasesJCDD, Vol. 7, Pages 4: The Prognostic Importance of TAPSE in Early and in Stable Cardiovascular Diseases Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7010004 Authors: Paolo Giovanardi Enrico Tincani Marco Maioli Stefano Tondi The identification of predictors of major cardiovascular events (MACES) represents a big challenge,...
Medicine by Alexandros G. Sfakianakis
09:08
MDPI
 AntibioticsAntibiotics, Vol. 9, Pages 30: Acknowledgement to Reviewers of Antibiotics in 2019Antibiotics, Vol. 9, Pages 30: Acknowledgement to Reviewers of Antibiotics in 2019 Antibiotics doi: 10.3390/antibiotics9010030 Authors: Antibiotics Editorial OfficeAntibioticsWed Jan 15, 2020 02:00Antibiotics, Vol. 9, Pages 29: Chemical Composition and Antibacterial Activity of Essential Oils from the Algerian Endemic Origanum glandulosum Desf. against Multidrug-Resistant Uropathogenic E. coli IsolatesAntibiotics,...
Medicine by Alexandros G. Sfakianakis
09:06
Frequency and distribution of polyQ disease intermediate-length repeat alleles in healthy Italian population
Frequency and distribution of polyQ disease intermediate-length repeat alleles in healthy Italian population: AbstractBackgroundHuntington disease (HD) and spinocerebellar ataxia type 1-2-17 (SCA1-2-17) are adult-onset autosomal dominant diseases, caused by triplet repeat expansions in the HTT, ATXN1, ATXN2, and TBP genes. Alleles with a repeat number just below the pathological threshold are associated with reduced penetrance and meiotic instability and are defined as intermediate alleles (IAs).ObjectivesWe...
Medicine by Alexandros G. Sfakianakis
09:03
Extraluminal Duodenal Gangliocytic Paraganglioma Presenting with Intractable Back Pain in a Patient with End-Stage Renal Disease
Extraluminal Duodenal Gangliocytic Paraganglioma Presenting with Intractable Back Pain in a Patient with End-Stage Renal Disease: References1.Dahl EV, Waugh JM, Dahlin DC. Gastrointestinal ganglioneuromas: brief review with report of a duodenal ganglioneuroma. Am J Pathol. 1957;33(5):953–65.CASPubMedPubMed CentralGoogle Scholar2.Easwar A, Middleton D, Ligato S. Cytological diagnosis of duodenal gangliocytic paraganglioma on ultrasound-guided fine needle aspirate: a case report with review of the...
Medicine by Alexandros G. Sfakianakis
09:03
Surgical Resection of Multiple Small Bowel Neuroendocrine Tumours Using Intraoperative Fluorescence Angiography with Indocyanine Green Dye
Surgical Resection of Multiple Small Bowel Neuroendocrine Tumours Using Intraoperative Fluorescence Angiography with Indocyanine Green Dye: BackgroundNeuroendocrine tumours (NETs) are a heterogeneous group of malignancies with a small, but increasingly incidence. They usually arise sporadically, with the highest incidence being from the fifth decade onward [1, 2].Small bowel is the third most common site of NETs after the lung and rectum, but is the most common site of NETs that develop distant metastases....
Medicine by Alexandros G. Sfakianakis
09:02
Pyoderma Gangrenosum in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Pyoderma Gangrenosum in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis: AbstractBackgroundPyoderma gangrenosum (PG) is an uncommon but severe extra-intestinal manifestation (EIM) of inflammatory bowel disease (IBD). The incidence and risk factors for PG are disputed.AimsTo assess the incidence of PG and identify factors associated with PG in IBD patients.MethodsA search of electronic databases (Ovid and PubMed) was conducted between 1966 and 2019. Studies that calculated the incidence...
Medicine by Alexandros G. Sfakianakis
09:01
Mutational Mosaics of Cell-Free DNA from Pancreatic Cyst Fluids
Mutational Mosaics of Cell-Free DNA from Pancreatic Cyst Fluids: AbstractBackgroundPancreatic cyst fluids (PCFs) enriched in tumor-derived DNA are a potential source of new biomarkers. The study aimed to analyze germinal variants and mutational profiles of cell-free (cf)DNA shed into the cavity of pancreatic cysts.MethodsThe study cohort consisted of 71 patients who underwent endoscopic ultrasound fine-needle aspiration of PCF. Five malignant cysts, 19 intraductal papillary mucinous neoplasms (IPMNs),...
Medicine by Alexandros G. Sfakianakis
09:01
Polyp Detection Rate Correlates Strongly with Adenoma Detection Rate in Trainee Endoscopists
Polyp Detection Rate Correlates Strongly with Adenoma Detection Rate in Trainee Endoscopists: AbstractBackgroundThe adenoma detection rate (ADR) is a widely accepted quality benchmark for screening colonoscopy but can be burdensome to calculate. Previous studies have shown good correlation between polyp detection rate (PDR) and ADR, but this has not been validated in trainees. Additionally, the correlation between PDR and detection rates for sessile serrated polyps (SSPDR) and advanced neoplasia...
Medicine by Alexandros G. Sfakianakis
09:01
iASPP-Mediated ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma
iASPP-Mediated ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma: AbstractAimsInhibitor for the apoptosis-stimulating protein of p53 (iASPP) has been reported to be correlated with 5-fluorouracil (5-Fu) resistance in renal cell carcinoma. Here, we uncover mechanisms of iASPP-Nrf2-ROS regulation of 5-Fu resistance which are important for the development of alternative treatment strategies for gastric adenocarcinoma treatment.MethodsWe...
Medicine by Alexandros G. Sfakianakis
09:01
Early Treatment Uptake and Cost Burden of Hepatitis C Therapies Among Newly Diagnosed Hepatitis C Patients with a Particular Focus on HIV Coinfection
Early Treatment Uptake and Cost Burden of Hepatitis C Therapies Among Newly Diagnosed Hepatitis C Patients with a Particular Focus on HIV Coinfection: AbstractBackgroundDespite the high efficacy and safety associated with direct-acting antivirals (DAAs), access to HCV treatment has been frequently restricted because of the high DAA drug costs.ObjectivesTo (1) compare HCV treatment initiation rates between HCV monoinfected and HCV/HIV coinfected patients before (pre-DAA period) and after (post-DAA...
Medicine by Alexandros G. Sfakianakis
09:01
IntraMed
Estudio observacional de aleatorización mendeliana | El café protege contra los cálculos biliares sintomáticos en la población generalLa ingesta de café está asociada con un bajo riesgo de enfermedad sintomática por cálculos biliaresIntraMed RSS -2hTiempo del médico empleado en el uso de la historia clínica electrónicaEstudio descriptivo que incluyó datos de aproximadamente 100 millones de encuentros de pacientes con aproximadamente 155.000 médicos durante los encuentros ambulatoriosIntraMed RSS...
Medicine by Alexandros G. Sfakianakis
08:59
Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report
Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report: AbstractTransforming growth factor beta‐1 (TGF‐β1) is expressed in normal epidermis. TGF‐β1 potently inhibits keratinocyte proliferation and immunomodulatory properties, mainly by suppressing immune responses to self‐antigens. Lichen planus (LP) is a form of dermatitis caused by cell‐mediated immune dysfunction, but the exact pathogenic pathways are unknown, which poses therapeutic...
Medicine by Alexandros G. Sfakianakis
08:59
CD10 and P63 Expression in a Sarcomatoid Undifferentiated Melanoma: A Cautionary (and Molecularly Annotated) Tale
CD10 and P63 Expression in a Sarcomatoid Undifferentiated Melanoma: A Cautionary (and Molecularly Annotated) Tale: AbstractUndifferentiated melanoma should be considered in the differential diagnosis of sarcomatoid cutaneous malignancies to ensure that patients receive the correct treatment. Dermatopathologists should recognize the pitfalls of relying too heavily on immunohistochemistry to establish this diagnosis and consider ancillary tests, including single nucleotide polymorphism (SNP) copy number...
Medicine by Alexandros G. Sfakianakis
08:58
Cutaneous "Fibroma‐Like" Perivascular Epithelioid Cell Tumor (PEComa): a case report and review of literature
Cutaneous "Fibroma‐Like" Perivascular Epithelioid Cell Tumor (PEComa): a case report and review of literature: AbstractPerivascular epithelioid cell tumors (PEComas) are a group of lesions sharing the common features of co‐expression of melanocytic and myogenic markers, with focal association of the cells with vascular walls. The PEComa group exhibits a wide range of morphologies. A "fibroma‐like" variant of PEComa has been recently described. The case reported herein is that of an infant with tuberous...
Medicine by Alexandros G. Sfakianakis
08:58
Experimental+Biology+and+Medicine
Morphological Characteristic of Melanoma B16 Progression in C57BL/6 Mice with High and Low Resistance to HypoxiaThe features of B16 melanoma progression in male C57BL/6 mice with initially high and low resistance to hypoxia were studied. To assess the resistance to hypoxia, the mice were placed in a low-pressure chamber at a simulated altitude of 10,000 m. One month after testing, B16 melanoma was inoculated to high- and low-resistant animals. In 19 days after melanoma transplantation, the severity...
Medicine by Alexandros G. Sfakianakis
08:58
Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures
Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures: This paper describes an adhesive hyaluronic acid (HA)‐based hydrogel, which may be suitable for use in minimally invasive procedures to repair maxillofacial tissues. To create hydrogels, HA is modified with methacrylate and 3,4‐dihydroxyphenylalanine (Dopa), forming a material that can be applied under aqueous conditions and gelled with visible light. Upon Dopa oxidation, hydrogels adhere to tissues and...
Medicine by Alexandros G. Sfakianakis
08:57
Improving Quantum Yield of a NIR‐II Dye by Phenylazo Group
Improving Quantum Yield of a NIR‐II Dye by Phenylazo Group: A NIR‐II fluorophore and its three derivatives bearing respectively amino, tert‐butyloxycarbonyl amino and phenylazo groups are synthesized. It is found that the phenylazo groups can significantly enhance its quantum yield (QY). The phenylazo‐containing fluorophore is encapsulated in micelles and a QY of ≈3.51% is achieved in aqueous medium, which is among the highest of the reported organic NIR‐II probes. AbstractUnderstanding structure‐fluorescence...
Medicine by Alexandros G. Sfakianakis
08:57
Synthetic Polymers Provide a Robust Substrate for Functional Neuron Culture
Synthetic Polymers Provide a Robust Substrate for Functional Neuron Culture: Synthetic polymeric substrates for in vitro neuron culture are identified via a high throughput approach. Polymeric substrates are shown to be superior to the current gold standard laminin, showing high levels of neuron and progenitor cell attachment, with the substrate significantly promoting progenitor cell maturation with remarkably high expression of neuron‐related biomarkers in the absence of serum. AbstractSubstrates...
Medicine by Alexandros G. Sfakianakis
08:57
Bioinspired Biomaterials with a Brick‐and‐Mortar Microstructure Combining Mechanical and Biological Performance
Bioinspired Biomaterials with a Brick‐and‐Mortar Microstructure Combining Mechanical and Biological Performance: Advanced silicate‐based bioceramic composites with "brick‐and‐mortar" architecture are shown to possess superior mechanical performances matching with cortical bone, controllable bioactive ions release, and the ability to induce bone integration. AbstractThe fabrication of bone regeneration biomaterials, which simultaneously possess superior mechanical performances and excellent bioactivity,...
Medicine by Alexandros G. Sfakianakis
08:56
Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel
Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel: This work describes the development of a synthetic brain‐mimicking hydrogel. The human brain is characterized mechanically and proteomically, and a modulus and protein composition characteristic of the human brain is defined. Using this brain‐mimicking hydrogel, astrocyte quiescence and activation is controlled via hydrogel composition or soluble cytokines, not possible in other in vitro systems. AbstractBioengineers have...
Medicine by Alexandros G. Sfakianakis
08:56
Design and Analysis of Elimination Surveys for Neglected Tropical Diseases
Design and Analysis of Elimination Surveys for Neglected Tropical Diseases: AbstractAs neglected tropical diseases approach elimination status, there is a need to develop efficient sampling strategies for confirmation (or not) that elimination criteria have been met. This is an inherently difficult task because the relative precision of a prevalence estimate deteriorates as prevalence decreases, and classic survey sampling strategies based on random sampling therefore require increasingly large sample...
Medicine by Alexandros G. Sfakianakis
08:56
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer: AbstractTumor mutations in the gene encoding estrogen receptor alpha (ESR1) have been identified in metastatic breast cancer patients with endocrine therapy resistance. However, relatively little is known about the occurrence of mutations in the progesterone receptor (PGR) gene in this population. The study objective was to determine the frequency and prognostic significance of tumor PGR mutations for patients...
Medicine by Alexandros G. Sfakianakis
08:56
Europe PMC
Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility GeneGenesLatest additions to Europe PMC2hVariants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease PatientsJournal of Clinical MedicineLatest additions to Europe PMC2hHealth in Preconception, Pregnancy and Postpartum Global Alliance: International Network...
Medicine by Alexandros G. Sfakianakis
08:55
Novel technique of fixing intracorneal rings segments after migration
Novel technique of fixing intracorneal rings segments after migration: A 38-year-old patient with a history of non-progressive keratoconus in the left eye presented to us with an uncorrected visual acuity of 20/400, which improved to 20/60 with pinhole. We planned for intracorneal rings segment in the left eye. Postoperatively uncorrected visual acuity improved to 20/30. The patient presented 2 weeks later with severely decreased vision to 20/100 and migration of intracorneal rings were noted with...
Medicine by Alexandros G. Sfakianakis
08:55
Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation
Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation: A 37-year-old male smoker with asthma presented with status asthmaticus refractory to terbutaline, intravenous magnesium, continuous bronchodilators, steroids, heliox and theophylline infusion. He was intubated on hospital day 2 and cannulated for veno-venous extracorporeal membrane oxygenation (V-V ECMO) on hospital day 3 for refractory respiratory acidosis secondary to...
Medicine by Alexandros G. Sfakianakis
08:54
Cyclophosphamide, bortezomib and dexamethasone (CyBorD): a promising regimen for renal light chain deposit disease
Cyclophosphamide, bortezomib and dexamethasone (CyBorD): a promising regimen for renal light chain deposit disease: Renal light chain deposit disease is a rare disease with rapid progression to renal failure when left untreated. There is no standard treatment available. We present a unique case of renal IgA kappa deposit disease who developed severe decline in renal function within a few months of diagnosis. She was started on a single regimen of cyclophosphamide, bortezomib and dexamethasone (CyBorD)...
Medicine by Alexandros G. Sfakianakis
08:54
Successful liver transplantation for drug-induced vanishing bile duct syndrome
Successful liver transplantation for drug-induced vanishing bile duct syndrome: Drug-induced cholestasis has a wide range of clinical presentations, and in a small number of patients, it can progress to severe ductopenia. A 63-year-old woman was referred to our department with progressive cholestasis and hyperbilirubinaemia following a course of flucloxacillin. Despite the comprehensive laboratory, imaging and genetic investigations, no other cause for the cholestasis was demonstrated. Sequential...
Medicine by Alexandros G. Sfakianakis
08:54
Rare case of bilateral wrist and foot drop from SLE-related vasculitic polyneuropathy
Rare case of bilateral wrist and foot drop from SLE-related vasculitic polyneuropathy: Systemic lupus erythematosus (SLE) is a heterogeneous, chronic, inflammatory, autoimmune disease characterised by multiorgan involvement and the production of multiple autoantibodies. Neurological manifestations in SLE patients are frequently reported—the prevalence is 37%–90%. We present a unique case where the patient presented with bilateral wrist and foot drop for 4 days, which later led to the diagnosis of...
Medicine by Alexandros G. Sfakianakis
08:53
Rupture of mitral valve papillary muscle: a rare complication following myocardial infarction
Rupture of mitral valve papillary muscle: a rare complication following myocardial infarction: Here we present a rare clinical presentation of papillary muscle rupture in a 55-year-old man who presented to accident and emergency department with chest pain and was diagnosed as having had a non-ST elevation myocardial infarction. During the admission, he developed papillary muscle rupture due to the myocardial infarction resulting in acute mitral regurgitation. This caused significant haemodynamic...
Medicine by Alexandros G. Sfakianakis
08:53
Terlipressin-induced ischaemic skin necrosis
Terlipressin-induced ischaemic skin necrosis: Terlipressin is a commonly used drug in hepatology practice for the two most serious complications of cirrhosis, that is, acute oesophageal variceal bleed and hepatorenal syndrome. Acute-on-chronic liver failure (ACLF) is a medical emergency and is frequently associated with acute kidney injury (AKI). Two male patients with alcohol-induced ACLF with high MELD (Model for End-Stage Liver Disease) score presented with AKI. Both were treated with terlipressin...
Medicine by Alexandros G. Sfakianakis
08:53
Lung Cancer
Patterns of care for patients with non-operable T1-4 N+ M0 non-small cell lung cancer in the US and outcomes with radiation or chemotherapy monotherapiesTreatment of patients with inoperable locally advanced non-small cell lung cancer (NSCLC), defined as lymph node-positive (N+) non-metastatic (M0), has improved tremendously since the first trial comparing radiation monotherapy (RTmono) to placebo [1]. Randomized trials established concurrent chemoradiation (CRT) as the standard of care for non-operable...
Medicine by Alexandros G. Sfakianakis
08:53
The effect of eHealth-based falls prevention programmes on balance in people aged 65 years and over living in the community: protocol for a systematic review of randomised controlled trials
The effect of eHealth-based falls prevention programmes on balance in people aged 65 years and over living in the community: protocol for a systematic review of randomised controlled trials: IntroductionBetween 20% and 28% of community-dwelling older people experience a fall each year. Falls can result in significant personal and socioeconomic costs, and are the leading cause of admission to hospital for an older person in Australia. Exercise interventions that target balance are the most effective...
Medicine by Alexandros G. Sfakianakis
08:51
Improving the quality of life of patients with breast cancer-related lymphoedema by lymphaticovenous anastomosis (LVA): study protocol of a multicentre randomised controlled trial
Improving the quality of life of patients with breast cancer-related lymphoedema by lymphaticovenous anastomosis (LVA): study protocol of a multicentre randomised controlled trial: IntroductionEarly breast cancer detection and advancements in treatment options have resulted in an increase of breast cancer survivors. An increasing number of women are living with the long-term effects of breast cancer treatment, making the quality of survivorship an increasingly important goal. Breast cancer-related...
Medicine by Alexandros G. Sfakianakis
08:51
Impact of transforming mental health services for young people in England on patient access, resource use and health: a quasi-experimental study
Impact of transforming mental health services for young people in England on patient access, resource use and health: a quasi-experimental study: ObjectiveTo evaluate the impact of child and adolescent mental health services (CAMHS) transformation in South East England on patient access, resource utilisation and health outcomes.DesignIn an observational study, we use difference-in-differences analysis with propensity score matching to analyse routinely collected patient level data.SettingThree CAMHS...
Medicine by Alexandros G. Sfakianakis
08:51
Point-of-care blood tests during home visits by out-of-hours primary care clinicians; a mixed methods evaluation of a service improvement
Point-of-care blood tests during home visits by out-of-hours primary care clinicians; a mixed methods evaluation of a service improvement: ObjectivesWe aimed to evaluate test usage and patient and clinician experience following the introduction of point-of-care (POC) blood tests into a primary care out-of-hours service.DesignA mixed methods service evaluation comprising quantitative records of the clinical contexts of tests taken and qualitative interviews with clinicians. Research permissions and...
Medicine by Alexandros G. Sfakianakis
08:51
Enhanced recovery following hip and knee arthroplasty: a systematic review of cost-effectiveness evidence
Enhanced recovery following hip and knee arthroplasty: a systematic review of cost-effectiveness evidence: AbstractObjectivesTo assess cost-effectiveness of enhanced recovery pathways following total hip and knee arthroplasties. Secondary objectives were to report on quality of studies and identify research gaps for future work.DesignSystematic review of cost–utility analyses.Data sourcesOvid MEDLINE, Embase, the National Health Service Economic Evaluations Database and EconLit, January 2000 to August...
Medicine by Alexandros G. Sfakianakis
08:50
Cost-effectiveness of total knee replacement in addition to non-surgical treatment: a 2-year outcome from a randomised trial in secondary care in Denmark
Cost-effectiveness of total knee replacement in addition to non-surgical treatment: a 2-year outcome from a randomised trial in secondary care in Denmark: ObjectiveTo assess the 24-month cost-effectiveness of total knee replacement (TKR) plus non-surgical treatment compared with non-surgical treatment with the option of later TKR if needed.Methods100 adults with moderate-to-severe knee osteoarthritis found eligible for TKR by an orthopaedic surgeon in secondary care were randomised to TKR plus 12...
Medicine by Alexandros G. Sfakianakis
08:50
Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol
Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol: IntroductionEssential tremor (ET), a tremor disorder, is one of the most common movement disorders. Only oral drugs (propranolol, primidone, topiramate, etc)are still the first-line treatment recommended by the Food and Drug Administration. Propranolol is thought to potentially reduce upper limb action tremor. However, it has a poor effect on axial tremor symptoms, such as essential...
Medicine by Alexandros G. Sfakianakis
08:50
Womens leadership in academic medicine: a systematic review of extent, condition and interventions
Womens leadership in academic medicine: a systematic review of extent, condition and interventions: ObjectivesBecause culture reflects leadership, the making of diverse and inclusive medical schools begins with diversity among leaders. The inclusion of women leaders remains elusive, warranting a systematic exploration of scholarship in this area. We ask: (1) What is the extent of women's leadership in academic medicine? (2) What factors influence women's leadership? (3) What is the impact of leadership...
Medicine by Alexandros G. Sfakianakis
08:50
MedWorm Allergy & Immunology Research
Cytokine Profiles in Human Parechovirus Type 3-induced Sepsis-like SyndromeWe aimed to assess the kinetics of the release of proinflammatory cytokines and to clarify clinical usefulness as an indicator of the disease activity in human parechovirus type 3 virus (HPeV3)-induced sepsis-like syndrome. We measured serum levels of neopterin, interleukin (IL)-6 and the soluble forms of tumor necrosis factor (TNF) receptor types I (sTNF-RI) and II (sTNF-RII). Serum samples were obtained from 12 patients...
Medicine by Alexandros G. Sfakianakis
08:49
Climatic Change
Projecting the urban energy demand for Indiana, USA, in 2050 and 2080Abstract Energy use is one of the largest drivers of climate change, but the large share of energy used for space heating and cooling is also driven by climate change. Demand for energy, particularly cooling, is important for long-range infrastructure planning. Urban areas represent a very small proportion of total land, but usually consume the majority of energy. In this work, statistical, top-down approaches are used to model...
Medicine by Alexandros G. Sfakianakis
08:48
IL-9 blockade attenuates inflammation in a murine model of methicillin-resistant Staphylococcus aureus pneumonia
IL-9 blockade attenuates inflammation in a murine model of methicillin-resistant Staphylococcus aureus pneumonia: AbstractMethicillin-resistant Staphylococcus aureus (MRSA) is an important etiology of pneumonia. Interleukin (IL)-9 is a T helper 9 (Th9) cytokine and participates in the pathogenesis of infectious diseases. Here, we investigated the role of IL-9 by using an MRSA pneumonia animal model. The BALB/c mice underwent nasal inhalation with an ST239 MRSA strain to establish the mouse model...
Medicine by Alexandros G. Sfakianakis
08:47
Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study
Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study: Background: Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. Material and Methods: All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients' demographic and clinical characteristics...
Medicine by Alexandros G. Sfakianakis
08:47
New GEO Series
GSE132237 CRISPR-Cas9 screens to identify regulators of differentiation in Toxoplasma gondiiContributors : Benjamin S Waldman ; Dominic Schwarz ; Marc H Wadsworth II ; Jeroen P Saeij ; Alex K Shalek ; Sebastian LouridoSeries Type : OtherOrganism : Toxoplasma gondiiTargeted gRNA screen against putative nucleic-acid binding proteins in a differentiation reporter strain context. By looking for gRNAs enriched in parasites no longer able to activate reporter expression, we can identify genes essential...
Medicine by Alexandros G. Sfakianakis
08:47
Environmental+Science+and+Pollution
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactionsAbstract Unrefined sea salt originates from seawater, typically by natural evaporation. Being minimally processed, it contains the natural minerals and impurities of seawater. Despite the wide applications of salt for culinary and food preservation purposes, the available composition data is particularly limited. Since seawater often contains...
Medicine by Alexandros G. Sfakianakis
08:45
GEO series published today
GSE132237 CRISPR-Cas9 screens to identify regulators of differentiation in Toxoplasma gondiiContributors : Benjamin S Waldman ; Dominic Schwarz ; Marc H Wadsworth II ; Jeroen P Saeij ; Alex K Shalek ; Sebastian LouridoSeries Type : OtherOrganism : Toxoplasma gondiiTargeted gRNA screen against putative nucleic-acid binding proteins in a differentiation reporter strain context. By looking for gRNAs enriched in parasites no longer able to activate reporter expression, we can identify genes essential...
Medicine by Alexandros G. Sfakianakis
08:43
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactions
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactions: AbstractUnrefined sea salt originates from seawater, typically by natural evaporation. Being minimally processed, it contains the natural minerals and impurities of seawater. Despite the wide applications of salt for culinary and food preservation purposes, the available composition data is particularly limited. Since seawater often contains...
Medicine by Alexandros G. Sfakianakis
08:43
Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke
Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke: AbstractBackgroundThe role of insulin resistance (IR) in stroke prognosis remains largely unknown. This study aimed to investigate the relationship between IR and the risk of early neurological deterioration (END) in non-diabetic patients with acute ischemic stroke.MethodsThis is a retrospective analysis of non-diabetic patients with acute ischemic stroke enrolled...
Medicine by Alexandros G. Sfakianakis
08:42
Subthalamic nucleus deep brain stimulation in two siblings with chorea-acanthocytosis
Subthalamic nucleus deep brain stimulation in two siblings with chorea-acanthocytosis: Dear Editor,Chorea-acanthocytosis (ChAc) is a core neuroacanthocytosis syndrome and a rare neurodegenerative disease that principally affects the basal ganglia. It is caused by autosomal recessive mutations of VPS13A. The characteristic clinical features of ChAc include the appearance of acanthocytes in the peripheral blood smear and mixed movement disorders including, dystonia, chorea, and parkinsonism. Some patients...
Medicine by Alexandros G. Sfakianakis
08:42
Frequency and distribution of polyQ disease intermediate-length repeat alleles in healthy Italian population
Frequency and distribution of polyQ disease intermediate-length repeat alleles in healthy Italian population: AbstractBackgroundHuntington disease (HD) and spinocerebellar ataxia type 1-2-17 (SCA1-2-17) are adult-onset autosomal dominant diseases, caused by triplet repeat expansions in the HTT, ATXN1, ATXN2, and TBP genes. Alleles with a repeat number just below the pathological threshold are associated with reduced penetrance and meiotic instability and are defined as intermediate alleles (IAs).ObjectivesWe...
Medicine by Alexandros G. Sfakianakis
08:41
Novel mutations in SPEF2 causing different defects between flagella and cilia bridge: the phenotypic link between MMAF and PCD
Novel mutations in SPEF2 causing different defects between flagella and cilia bridge: the phenotypic link between MMAF and PCD: AbstractSevere asthenozoospermia is a common cause of male infertility. Recent studies have revealed that SPEF2 mutations lead to multiple morphological abnormalities of the sperm flagella (MMAF) without primary ciliary dyskinesia (PCD) symptoms in males, but PCD phenotype was also found in one female individual. Therefore, whether there is a phenotypic continuum ranging...
Medicine by Alexandros G. Sfakianakis
08:41
Foxn1 and Prkdc genes are important for testis function: evidence from nude and scid adult mice
Foxn1 and Prkdc genes are important for testis function: evidence from nude and scid adult mice: AbstractMutations in Foxn1 and Prkdc genes lead to nude and severe combined immunodeficiency (scid) phenotypes, respectively. Besides being immunodeficient, previous reports have shown that nude mice have lower gonadotropins and testosterone levels, while scid mice present increased pachytene spermatocyte (PS) apoptosis. Therefore, these specific features make them important experimental models for understanding...
Medicine by Alexandros G. Sfakianakis
08:40
A20-OVA Nanoparticles Inhibit Allergic Asthma in a Murine Model
A20-OVA Nanoparticles Inhibit Allergic Asthma in a Murine Model: AbstractThe skewed T helper (Th) 2 response plays a critical role in the pathogenesis of allergic asthma. Regulatory T (Treg) cells and the regulatory cytokines are required in maintaining the homeostasis in the body. This study aims to determine the effects of a poly(lactic-co-glycolic) acid (PLGA)-ovalbumin (OVA)+A20 (a ubiquitin E3 ligase) nanovaccine on inhibiting allergic asthma in a murine model. In this study, A20 and OVA (a...
Medicine by Alexandros G. Sfakianakis
08:39
MicroRNA-486-5p Promotes Acute Lung Injury via Inducing Inflammation and Apoptosis by Targeting OTUD7B
MicroRNA-486-5p Promotes Acute Lung Injury via Inducing Inflammation and Apoptosis by Targeting OTUD7B: Abstract The aim of this article is to study the effect of miR-486-5p in acute lung injury (ALI). MiR-486-5p expression in peripheral blood was determined in ALI patients and healthy volunteers by qRT-PCR. ALI mouse model were reproduced by LPS treatment, and miR-486-5p NC and miRNA-486 inhibitors were injected through trachea. ALI patients' peripheral blood and LPS-induced acute lung injury in...
Medicine by Alexandros G. Sfakianakis
08:39
PNU-282987 Attenuates Intestinal Epithelial Barrier Dysfunction in LPS-Induced Endotoxemia
PNU-282987 Attenuates Intestinal Epithelial Barrier Dysfunction in LPS-Induced Endotoxemia: AbstractPNU-282987, the α7 acetylcholine receptor(α7nAchR) agonist, has been repeatedly reported to play a key role in anti-inflammatory action of multiple disease. However, little is known about its effect on LPS-induced intestinal epithelial barrier dysfunction. This study investigated the protective effects and mechanisms of PNU-282987 on intestinal epithelial barrier dysfunction in lipopolysaccharide(LPS)-induced...
Medicine by Alexandros G. Sfakianakis
08:39
Ossiculoplasty for Tympanosclerosis
Ossiculoplasty for Tympanosclerosis: AbstractPurpose of ReviewThe utility of surgery for tympanosclerosis has been a controversial topic among otologic surgeons for many decades. Knowing the variations in tympanosclerotic involvement, different aspects of surgical technique, and audiologic outcomes data can help inform the discussion of optimal management between surgeon and patient.Recent FindingsTympanosclerosis can involve all structures in the middle ear, and the distribution of that involvement...
Medicine by Alexandros G. Sfakianakis
08:38
Targeted Biologic Therapies in Allergic Disease
Brief Immunology Review for Targeted Biologic Therapies in Allergic Disease: AbstractPurpose of the ReviewThis article provides a concise overview of important aspects of immunology related to atopic disorders and the key inflammatory components that biologic agents target.Recent FindingsOver 15 years ago, the first biologic agent for an allergic disease gained FDA approval. Since then, additional attention has been given to elucidating the underlying pathways involved in these inflammatory disorders...
Medicine by Alexandros G. Sfakianakis
08:38
Elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.
The association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.: Related ArticlesThe association between Chinese patients' elevated omentin-1 levels, their clinicopathological features, and the risk of colorectal cancer.Int J Clin Exp Pathol. 2019;12(6):2264-2274Authors: Zhao X, Zhang Y, Deng L, Wang Y, Li Y, Chen MAbstract To investigate the association between plasma omentin-1 levels and the risk of colorectal cancer...
Medicine by Alexandros G. Sfakianakis
08:38
Recurrent Multifocal Cellulitis
A 67-year-old Man With Recurrent Multifocal Cellulitis: A 67-year-old Caucasian man, an avid traveler with a history of hypertension, depression, and previous morbid obesity treated with bariatric surgery, presented with low-grade fever and recurrent left-ankle painful rash (Figure 1A). The patient noted the first episode 2 months prior to presentation when he presented with a poorly defined painful erythematous patch over his left ankle and leukocytosis. He was treated with cefazolin for suspected...
Medicine by Alexandros G. Sfakianakis
08:37
Cell adhesion in cancer: Beyond the migration of single cells [Signal Transduction]
Cell adhesion in cancer: Beyond the migration of single cells [Signal Transduction]: Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-extracellular matrix interactions. For instance, normal epithelial cells maintain tissue structure by adhering to each other and to the extracellular matrix. The proteins that mediate these distinct interactions are collectively called cell adhesion molecules and are divided into four major groups: cadherins, integrins, selectins,...
Medicine by Alexandros G. Sfakianakis
08:34
Estrogen-induced FOS like 1 regulates matrix metalloproteinase expression and the motility of human endometrial/decidual stromal cells [Cell Biology]
Estrogen-induced FOS like 1 regulates matrix metalloproteinase expression and the motility of human endometrial/decidual stromal cells [Cell Biology]: The regulation mechanisms involved in matrix metalloproteinase (MMP) expression and the motility of human endometrial/decidual stromal cells (ESCs/DSCs) during decidualization remain unclear. DSCs show a significant increased cell motility and expression of FOS like 1 (FOSL1) and MMP-1, -2, -9 when compared with ESCs, whereas a lack of decidualization...
Medicine by Alexandros G. Sfakianakis
08:34
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus [Enzymology]
The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus [Enzymology]: In environments where glucose is limited, some pathogenic bacteria metabolise host derived sialic acid as a nutrient source. N-Acetylmannosamine kinase (NanK) is the second enzyme of the bacterial sialic acid import and degradation pathway and adds phosphate to N-acetylmannosamine using ATP to prime the molecule for future pathway reactions. Sequence alignments reveal...
Medicine by Alexandros G. Sfakianakis
08:34
ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage
ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage: AbstractBackgroundDermic fibroblasts have been proposed as a potential genetic-ALS cellular model. This study aimed to explore whether dermic fibroblasts from patients with sporadic-ALS (sALS) recapitulate alterations typical of ALS motor neurons and exhibit abnormal DNA-damage response.MethodsDermic fibroblasts were obtained from eight sALS patients and four control...
Medicine by Alexandros G. Sfakianakis
08:33
Brain MRI of multiple system atrophy of cerebellar type: a prospective study with implications for diagnosis criteria
Brain MRI of multiple system atrophy of cerebellar type: a prospective study with implications for diagnosis criteria: AbstractAimThe second consensus statement for the diagnosis of multiple system atrophy type cerebellar (MSA-C) includes pons and middle cerebellar peduncle (MCP) atrophy as MRI features. However, other MRI abnormalities such as MCP hyperintensity, hot cross bun sign (HCB), putaminal hypointensity and hyperintense putaminal rim have been described.ObjectivesTo evaluate, in patients...
Medicine by Alexandros G. Sfakianakis
08:33
A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia
A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia: AbstractObjectiveTo analyze deep brain stimulation (DBS) outcomes in patients with cervical dystonia (CD), the relationships between motor and disability/pain outcomes, and the differences in outcomes between globus pallidus internus (GPi) and subthalamic nucleus (STN) DBS, and to identify potential outcome predictors.MethodsA systematic literature search identified individual patient data of CD patients...
Medicine by Alexandros G. Sfakianakis
08:33
Assessing heavy metal pollution by biomonitoring honeybee nectar in Córdoba (Spain)
Assessing heavy metal pollution by biomonitoring honeybee nectar in Córdoba (Spain): AbstractNectar of honeybee colonies has been used in order to identify heavy metals and establish the benefit of this type of studies as a tool for environmental management. For these goals, samples of nectar were obtained from Apis mellifera hives placed in the city of Córdoba (Spain) and its surroundings. Five stations (each with two hives) were selected and samples were collected from May to July of 2007, 2009...
Medicine by Alexandros G. Sfakianakis
08:32
Acute ecotoxicity and genotoxicity assessment of two wastewater treatment units
Acute ecotoxicity and genotoxicity assessment of two wastewater treatment units: AbstractWater contamination by discharge of untreated or poorly treated wastewater into water bodies is a current issue that may cause harm to humans. Water quality assessment targets general parameters, which often misleads to underestimation of their implication in the environment. Acute and genotoxicity assays using Daphnia magna is a reliable tool for testing deleterious effects of wastewater exposure. This paper...
Medicine by Alexandros G. Sfakianakis
08:32
Environmentally relevant exposures of male mice to carbendazim and thiram cause persistent genotoxicity in male mice
Environmentally relevant exposures of male mice to carbendazim and thiram cause persistent genotoxicity in male mice: AbstractCarbendazim and thiram are fungicides used in combination to prevent mold destruction of crops. Studies have demonstrated genotoxicity by these agents, but have not used concentrations below their water solubility limits in drinking water to test for persistence of genotoxicity due to chronic exposure. Ten 8-week old male Swiss-Webster mice were exposed to tap water, or nominal...
Medicine by Alexandros G. Sfakianakis
08:32
"Modern agriculture" transfers many pesticides to watercourses: a case study of a representative rural catchment of southern Brazil
"Modern agriculture" transfers many pesticides to watercourses: a case study of a representative rural catchment of southern Brazil: AbstractThe total cultivated area in Brazil reached to 62 million ha in 2018, with the predominance of genetically modified soybean and corn (36 and 17 million ha, respectively) in no-tillage systems. In 2018, 5.3 × 105 Mg of active ingredient of pesticides was applied in cropfields, representing about 7.3 L of commercial product by habitant. However, the monitoring...
Medicine by Alexandros G. Sfakianakis
08:31
Plastic floating debris along a summer-winter estuarine environmental gradient in a coastal lagoon: how does plastic debris arrive in a conservation unit?
Plastic floating debris along a summer-winter estuarine environmental gradient in a coastal lagoon: how does plastic debris arrive in a conservation unit?: AbstractImproper management of plastic waste is an important contributor to the pollution in water bodies. However, how floating plastic debris is transported to coastal lagoons and marine conservation units is still poorly understood. This work determined the level of contamination due to floating plastic debris in Acaraí Lagoon by establishing...
Medicine by Alexandros G. Sfakianakis
08:30
Phosphorus removal from wastewater by waste concrete: influence of P concentration and temperature on the product
Phosphorus removal from wastewater by waste concrete: influence of P concentration and temperature on the product: AbstractThis study investigated the feature of phosphorus uptake by low-cost waste concrete. Adsorption isotherms, metal dissolution, influence of P concentration and temperature, as well as adsorbent regeneration were investigated. Chemical extraction, SEM, XRD, FTIR, and XPS were employed to determine the products of P sequestration. Results demonstrated that phosphate adsorption fitted...
Medicine by Alexandros G. Sfakianakis
08:30
Exposed to endocrine active riverbed sediments
Embryo/larval toxicity and transcriptional effects in zebrafish ( Danio rerio ) exposed to endocrine active riverbed sediments: AbstractSediment toxicity plays a fundamental role in the health of inland fish communities; however, the assessment of the hazard potential of contaminated sediments is not a common objective in environmental diagnostics or remediation. This study examined the potential of transcriptional endpoints investigated in zebrafish (Danio rerio) exposed to riverbed sediments in...
Medicine by Alexandros G. Sfakianakis
08:30
Influence of graphene oxide nanosheets on the cotransport of cu-tetracycline multi-pollutants in saturated porous media
Influence of graphene oxide nanosheets on the cotransport of cu-tetracycline multi-pollutants in saturated porous media: AbstractAntibiotic-heavy metal multi-pollutants are produced by intensive livestock farming and become an increasingly prominent problem. In this study, the transport behavior of tetracycline (TC) and its chelate with copper ions (Cu-TC) in saturated sand column with and without graphene oxide (GO) prefilled was investigated by laboratory breakthrough experiments. The effects of...
Medicine by Alexandros G. Sfakianakis
08:29
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactions
Trace elements, polycyclic aromatic hydrocarbons, mineral composition, and FT-IR characterization of unrefined sea and rock salts: environmental interactions: AbstractUnrefined sea salt originates from seawater, typically by natural evaporation. Being minimally processed, it contains the natural minerals and impurities of seawater. Despite the wide applications of salt for culinary and food preservation purposes, the available composition data is particularly limited. Since seawater often contains...
Medicine by Alexandros G. Sfakianakis
08:29
Distribution and risk analysis of heavy metals in sediments from the Yangtze River Estuary, China
Distribution and risk analysis of heavy metals in sediments from the Yangtze River Estuary, China: AbstractSediments core within the Yangtze River Estuary was collected for metal and grain size analysis. The vertical distribution characteristics of eight metals along the core were investigated based on 137Cs and 210Pb radionuclide dating. The sediment was mainly composed of sand and silt. The metals concentrations were Al, 4.67–6.83; Fe, 2.3–3.94; Mn, 0.046–0.07; Cr, 69.5–103; Cu, 14.3–32.1; Zn,...
Medicine by Alexandros G. Sfakianakis
08:29
Protocol for intubation with introducer guide
If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 12:17
Videolaryngoscopes
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 12:10
Supraglottic Airway Devices (SADs)
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 11:59
Wilson risk score
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 11:28
Airway Assessment
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 11:12
Ear, Nose & Throat Journal
- Volume: 99, Number: 1 (January 2020)EditorialHuman Subject Research or Quality Improvement Project?Robert T. SataloffImaging ClinicUnilateral Cricoarytenoid Joint Ankylosis in Rheumatoid ArthritisAbdul-Latif Hamdan, Elie Khalifee, and Ghina BerjawiLaryngoscopic ClinicLaryngeal Cryptococcal InfectionJessica R. Winters, Rodolfo E. Manosalva, and Michele P. MorrisonClinical StudyModified Infrahyoid Myocutaneous Flap for Laryngopharyngeal ReconstructionDanqing Yan, Jian Zhang, and Xiang MinEvaluation...
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 10:48
Voice
Amateur Music Theatre Singers' Perceptions of their Current Singing Voice FunctionThe primary aim of this study was to investigate amateur music theatre singers (MTS)' perceptions of their current singing voice function according to evaluation of ability to sing easily (EASE) scores while involved in a musical theatre production, to determine if scores were influenced by demographic or voice-related factors and to compare EASE scores of amateur MTS and previously published professional MTS.Resident...
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 10:47
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, Telephone consultation 11855 int 1193,
Environmental Research International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case ReportIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case Report International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020535 Authors: Abdulmalek Alsharidah Yahya Mahli Nayef Alshabyli Mohammed Alsuhaibani Basidiobolomycosis is...
Medicine by Alexandros G. Sfakianakis
Wed Jan 15, 2020 10:43
Protocol for intubation with introducer guide
If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 12:17
Videolaryngoscopes
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 12:10
Supraglottic Airway Devices (SADs)
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 11:59
Wilson risk score
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 11:28
Airway Assessment
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 11:12
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, Telephone consultation 11855 int 1193,
Environmental Research International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case ReportIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case Report International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020535 Authors: Abdulmalek Alsharidah Yahya Mahli Nayef Alshabyli Mohammed Alsuhaibani Basidiobolomycosis is...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 10:43
Protocol for intubation with introducer guide
If the vocal cords are visible:Insert the introducer guide;Feel palpable vibrations (or clicks);Insert the endotracheal tube over the guide (without removing the laryngoscope);Rotate the endotracheal tube 90° clockwise before passing by vocal cords (keeping the bevel of the tube posteriorly directed eases its positioning and prevents arytenoid injury);Remove the guide, while maintaining the endotracheal tube positioned;Confirm proper endotracheal tube position.If the vocal cords are NOT visible:Insert...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 12:17
Videolaryngoscopes
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 12:10
Supraglottic Airway Devices (SADs)
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 11:59
Wilson risk score
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 11:28
Airway Assessment
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
Wed Jan 15, 2020 11:12

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