Characteristic differences in radiation‐induced DNA damage response in human papillomavirus‐negative and human papillomavirus‐positive head and neck cancers with accumulation of fractional radiation dose

xlomafota13 shared this article with you from Inoreader Characteristic differences in radiation‐induced DNA damage response in human papillomavirus‐negative and human papillomavirus‐positive head and neck cancers with accumulation of fractional radiation dose Via Head & Neck Abstract Background Superior treatment responses by patients with human papillomavirus (HPV) positive head and neck squamous cell carcinoma (HNSCC), compared to patients with HNSCC from other causes, drive biomarker research to optimize treatment. Most HNSCC patients receive radiation therapy delivered as a fractionated course. Changing HPV status in HNSCC from a positive prognostic marker to a predictive one requires biomarkers that capture cellular radiation response to cumulative dose. Methods Nuclear enlargement, γH2AX expression and micronuclei count, were studied in six HNSCC cell lines after 4 Gy fractionated X-irradiation. Results All HNSCC cell lines displayed altered cellular responses, indicating increasing inability to repair radiation damage with subsequent radiation fractions. Increases in nuclear area were significantly greater among HPV positive cell lines (207% and 67% for the HPV positive and HPV negative groups, respectively). Conclusions A different character of DNA repair dysfunction in the HPV positive group suggests greater chromosomal translocation with accumulated radiation dose. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Deep Neck Infections: Demographic and Clinical Factors Associated with Poor Outcomes

xlomafota13 shared this article with you from Inoreader Deep Neck Infections: Demographic and Clinical Factors Associated with Poor Outcomes Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Introduction: Deep neck infections (DNIs) are abscesses located in the profound spaces of the neck and constitute one of the most common otolaryngological life-threatening emergencies. The aim of this study is to review the clinical and demographic data of patients with DNI and identify factors associated with prolonged hospitalization, reoperation, and mortality. Methods: Retrospective review and analysis of 75 patients with DNI admitted from January 2015 to Decem ber 2019 in a tertiary referral hospital. Results: Of 75 patients, 50 (66.6%) were males and 25 (33.3%) females. Age ranged from 18 to 91 years with a mean of 41.79 (±15.48). DNIs were odontogenic in 49 patients (65.3%). History of diabetes mellitus (DM) was positive in 26 patients (34.6%). The submandibular space was involved in 57 patients (76%). Streptococcus spp. were isolated in 35 patients (46%). Intubation for airway preservation was needed in 21 patients (28%) and tracheostomy in 6 (8%). Mediastinitis presented in 8 patients (10.67%), with a mortality rate of 62.5% (n = 5). Mean hospital stay was 9.13 days (±7.2). DM (p = 0.016), age (p = 0.001), BMI classification 3, 4, and 6 (p = 0.041), and intensive care unit (ICU) admission (p = 0.009) were associated with a longer stay. Surgical drainage was performed after 1.71 days (±1.65). Surgical reintervention was needed in 6 cases (8%) and was associated with temporal (< i>p = 0.001) and masticator (p = 0.002) space involvement and DM (p = 0.009). Overall mortality was 8% and decreased to 1.5% when mediastinitis was excluded. Mediastinitis (p = 0.001), ICU admission (p #x3c; 0.0001), Streptococcus spp. (p = 0.019), and low hemoglobin levels (p = 0.004) were associated with mortality. Discussion/Conclusion: DNIs are entities associated with high morbimortality. Mediastinitis and airway obstruction are life-threatening possible complications and should be promptly evaluated. Low HB could be used as a predicting factor for mortality. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Targeted chemodenervation of the posterior belly of the digastric muscle for the management of jaw discomfort in facial synkinesis

xlomafota13 shared this article with you from Inoreader Targeted chemodenervation of the posterior belly of the digastric muscle for the management of jaw discomfort in facial synkinesis Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Jun 9:S1748-6815(21)00297-7. doi: 10.1016/j.bjps.2021.05.045. Online ahead of print. ABSTRACT BACKGROUND: Botulinum toxin (BT-A) chemodenervation has been proved to significantly improve the physical and psychological well-being of patients suffering from facial synkinesis. Despite this, a cohort of patients has persistent tightness and discomfort around the angle of the jaw, which may be caused by synkinesis within the posterior belly of digastric (PBD) muscle. This study was designed to evaluate the benefits of ultrasound-guided BT-A injections into the PBD. METHODS: Thirty-three patients with recalcitrant tightness and discomfort around the angle of the jaw, despite maximal facial therapy and platysmal chemodenervation were selected for inclusion. Patients underwent ultrasound-guided BT-A injection into the ipsilateral PBD muscle (skin puncture site 1 cm inferior and posterior to the angle o f mandible). Outcomes consisted of the Facial Disability Index (FDI), Synkinesis Assessment Questionnaire (SAQ), and a visual analogue scale (VAS) designed to assess tightness and pain around the PBD when moving the jaw, swallowing, and masticating. Questionnaires were completed two weeks before and postinjection. Statistical analysis was performed using a paired t-test. RESULTS: Nineteen patients completed the post-treatment outcome questionnaire. A statistically significant improvement was noted in the physical and social function aspects of the FDI and all aspects of the patient-reported VAS scores apart from tightness and pain on jaw retrusion and swallowing. There was no significant difference in the SAQ. CONCLUSION: This study has demonstrated the patient-perceived benefit of ultrasound-targeted BT-A chemodenervation of PBD. This represents a low-risk treatment option that can be easily added to the repertoire of treatments offered to patients with post paralysis f acial synkinesis. PMID:34233854 | DOI:10.1016/j.bjps.2021.05.045 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Incidental Finding of a Persistent Stapedial Artery in a Patient Presenting With Conductive Hearing Loss

xlomafota13 shared this article with you from Inoreader Incidental Finding of a Persistent Stapedial Artery in a Patient Presenting With Conductive Hearing Loss Via ear nose throat Ear Nose Throat J. 2021 Jul 8:1455613211032005. doi: 10.1177/01455613211032005. Online ahead of print. ABSTRACT A persistent stapedial artery is a congenital vascular malformation that can cause tinnitus and/or conductive hearing loss. Although rare, this case highlights the importance of recognizing aberrant anatomy as a potential cause of patients' symptoms. It also demonstrates how to recognize and treat patients with a symptomatic persistent stapedial artery. PMID: 34233519 | DOI:10.1177/01455613211032005 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nasal Maggot Infection in a Patient With Nasal Non-Hodgkin's Lymphoma

xlomafota13 shared this article with you from Inoreader Nasal Maggot Infection in a Patient With Nasal Non-Hodgkin's Lymphoma Via ear nose throat Ear Nose Throat J. 2021 Jul 8:1455613211031024. doi: 10.1177/01455613211031024. Online ahead of print. ABSTRACT We describe a case of nasal non-Hodgkin's lymphoma in a 79-year-old Chinese patient accompany with nasal myiasis. The first 2 biopsies in this case were false negative. Subsequently, nasal maggots developed in this patient. After removing all maggots under nasal endoscopy, the patient continued to have recurrent fever and was transferred to a higher hospital for fu rther treatment, in which he received a third biopsy. Unfortunately, several hours after the biopsy, the patient died for severe nasal bleeding. The final biopsy result indicated the neoplasm of the left nasal cavity was non-Hodgkin's lymphoma. This case illustrates the importance of repeated biopsies for nasal non-Hodgkin's lymphoma if necessary. Nasal myiasis is a secondary disease of nasal non-Hodgkin's lymphoma in this case. PMID:34233486 | DOI:10.1177/01455613211031024 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nasal Septal Perforation Due to Desmopressin Nasal Spray Use

xlomafota13 shared this article with you from Inoreader Nasal Septal Perforation Due to Desmopressin Nasal Spray Use Via ear nose throat Ear Nose Throat J. 2021 Jul 8:1455613211026425. doi: 10.1177/01455613211026425. Online ahead of print. ABSTRACT Perforations of the nasal septum have many etiologies and occasionally result from intranasal medicated spray use. This case report describes a perforation related to the use of desmopressin nasal spray, which has not been previously reported in the literature. Clinical considerations presented in this article include appropriate technique of nasal spray applicatio n, appropriate monitoring of patients on intranasal sprays, and indications for evaluation by an otolaryngologist. Septal perforation treatment success is improved with an early diagnosis. PMID:34233494 | DOI:10.1177/01455613211026425 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Renin-Angiotensin-Aldosterone System Imbalance and Altered Aquaporin Activity: A New Perspective for COVID-19-Associated Xerostomia

xlomafota13 shared this article with you from Inoreader Renin-Angiotensin-Aldosterone System Imbalance and Altered Aquaporin Activity: A New Perspective for COVID-19-Associated Xerostomia Via ear nose throat Ear Nose Throat J. 2021 Jul 8:1455613211030348. doi: 10.1177/01455613211030348. Online ahead of print. NO ABSTRACT PMID:34233506 | DOI:10.1177/01455613211030348 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pleomorphic Adenoma of the Submandibular Gland in a 10-Year-Old Child: A Case Report

xlomafota13 shared this article with you from Inoreader Pleomorphic Adenoma of the Submandibular Gland in a 10-Year-Old Child: A Case Report Via ear nose throat Ear Nose Throat J. 2021 Jul 8:1455613211022113. doi: 10.1177/01455613211022113. Online ahead of print. ABSTRACT We report the case of a 10-year-old girl with a painless slowly growing mass that had developed over the course of 2 years in the left submandibular area. Physical examination revealed a firm painless submandibular mass with no other associated signs. Ultrasound graphics were in favor of a sebaceous cyst. Fine-needle aspiration and magnetic resonance images (MRI) c oncluded to a pleomorphic adenoma of the submandibular gland. The patient underwent left submandibulectomy. Histopathological examination confirmed the diagnosis of pleomorphic adenoma arising from the submandibular gland. The postoperative course was uneventful. Pleomorphic adenoma of the submandibular gland represents a diagnostic and therapeutic dilemma in children. Preoperative evaluation, including MRI and fine-needle aspiration, is recommended. Total submandibulectomy is also recommended to minimize recurrences and to avoid malignant transformation. PMID:34233518 | DOI:10.1177/01455613211022113 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Otolaryngology-Specific Symptoms May Be Highly Observed in Patients With a History of Covid-19 Infection After Inactivated Coronavirus Vaccination

xlomafota13 shared this article with you from Inoreader Otolaryngology-Specific Symptoms May Be Highly Observed in Patients With a History of Covid-19 Infection After Inactivated Coronavirus Vaccination Via ear nose throat Ear Nose Throat J. 2021 Jul 8:1455613211028493. doi: 10.1177/01455613211028493. Online ahead of print. ABSTRACT OBJECTIVE: To evaluate the otolaryngology-specific symptoms that occur after receiving the Covid-19 vaccine and its possible side effects in patients who had Covid-19 infection in the last 6 months before the vaccination. PATIENTS AND METHODS: The study comprised 3383 health care workers who were vaccinated against Covid 19. After excluding, the study was con ducted with 1710 (51%) participants who agreed to answer the study questions. The participants were divided into 2 groups according to the history of Covid-19 positivity in the last 6 months before vaccination. The presence of symptoms related to otolaryngology practice, including cough, nasal congestion, rhinorrhea, sore throat, hearing loss, dizziness, loss of smell, loss of taste, ear pressure, and facial paralysis was recorded. RESULTS: The mean age of the study population was 35.79 ± 10.2 (19-71) years and 1454 (85%) of the patients had a history of Covid-19 infection in the last 6 months. Regarding otolaryngology-related symptoms, the most common complaints were rhinorrhea (4.4%), sore throat (3.2%), and nasal congestion (2.9%). The presence of smell and taste loss, nasal congestion, rhinorrhea, sore throat, and hearing loss was significantly more common in patients with a history of Covid-19 infection. CONCLUSIONS: The patients with a history of Covid-19 disease might have otolaryngology-specific symptoms more commonly than those without a history of Covid-19 disease in the last 6 months before vaccination. PMID:34233498 | DOI:10.1177/01455613211028493 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nasopharyngeal Approach to a Cholesterol Granuloma of the Petrous Apex

xlomafota13 shared this article with you from Inoreader Nasopharyngeal Approach to a Cholesterol Granuloma of the Petrous Apex Via ear nose throat Ear Nose Throat J. 2021 Jul 8:1455613211028074. doi: 10.1177/01455613211028074. Online ahead of print. ABSTRACT Cholesterol granulomas are rare cystic inflammatory lesions characterized by the formation of cholesterol crystals. They are the most prevalent lesions of the petrous apex and when symptomatic, hearing loss, vertigo, tinnitus, headache, and facial pathology can be present. Surgical management is recommended in symptomatic patients. There are different surgical appr oaches to cholesterol granulomas. The aim of this article is to present and describe an endoscopic endonasal nasopharyngeal approach to a cholesterol granuloma and explain the advantages and disadvantages. PMID:34233514 | DOI:10.1177/01455613211028074 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Solitary vaginal paraganglioma with mature sacrococcygeal teratoma: a rare case report

xlomafota13 shared this article with you from Inoreader Solitary vaginal paraganglioma with mature sacrococcygeal teratoma: a rare case report Via radioactive iodine BMC Endocr Disord. 2021 Jul 7;21(1):145. doi: 10.1186/s12902-021-00806-6. ABSTRACT BACKGROUND: Vaginal paraganglioma are rare, atypical, solitary tumors which originate from the female genital tract. Sacrococcygeal teratoma are also rare neoplasms which derive from one (or more) primordial germ cell layers. Here we report a unique case of vaginal paraganglioma with sacrococcygeal teratoma. CASE PRESENTATION: A 44-year-old female experienced paroxysmal hypertension, palpitatio ns and dizziness for almost six years. Enhanced CT and MRI highlighted two abnormal soft tissue lesions located in the left vaginal wall and coccyx anteriorly, and Iodine-131 metaiodobenzylguanidine (131I-MIBG) demonstrated abnormal radioactive uptake in perineum area. Endocrine tests showed elevated plasma normetanephrine (NMN) and 24 h urine norepinephrine. There was a well-circumscribed soft tissue lesion of approximately 3.5 cm in the left lateral vaginal wall which could be palpated during bimanual examination, together with a 1.5 cm tumor in the posterior wall of the rectum. We completely resected the two lesions in stages with the support of a senior gynecologist and general surgeons. Postoperative histopathological examinations suggested the vaginal paraganglioma and mature sacrococcygeal teratoma. Targeted sanger sequencing for the 36 mostly common paraganglioma-related genes, with a depth of 1000x, revealed no mutations. Post-operatively, plasma NMN and 24 h uri ne norepinephrine returned to the normal range and her symptoms completely disappeared. CONCLUSIONS: We reported an extremely rare case and the successful treatment of functional vaginal paraganglioma coexisting with adult sacrococcygeal teratoma. PMID:34233670 | DOI:10.1186/s12902-021-00806-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.