Publication date: Available online 24 June 2020Source: Medical Image AnalysisAuthor(s): Fan Zhang, Suheyla Cetin Karayumak, Nico Hoffmann, Yogesh Rathi, Alexandra J. Golby, Lauren J. O’Donnell
Wed Jun 24, 2020 13:05
Publication date: Available online 24 June 2020Source: Medical Image AnalysisAuthor(s): Shivam Kalra, H.R. Tizhoosh, Charles Choi, Sultaan Shah, Phedias Diamandis, Clinton J.V. Campbell, Liron Pantanowitz
Wed Jun 24, 2020 13:05
Publication date: Available online 23 June 2020Source: Medical Image AnalysisAuthor(s): Prachi H. Kulkarni, S.N. Merchant, Suyash P. Awate
Wed Jun 24, 2020 13:05
Climate, which sets broad limits for migrating species, is considered a key filter to species migration between contrasting marine environments. The Southeast Mediterranean Sea (SEMS) is one of the regions where ocean temperatures are rising the fastest under recent climate change. Also, it is the most vulnerable marine region to species introductions. Here, we explore the factors which enabled the colonization of the endemic Red Sea octocoral Melithaea erythraea (Ehrenberg, 1834) along the SEMS...
Wed Jun 24, 2020 03:00
Mapping of reads to reference sequences is an essential step in a wide range of biological studies. The large size of datasets generated with next-generation sequencing technologies motivates the development of fast mapping software. Here, I describe URMAP, a new read mapping algorithm. URMAP is an order of magnitude faster than BWA with comparable accuracy on several validation tests. On a Genome in a Bottle (GIAB) variant calling test with 30× coverage 2×150 reads, URMAP achieves high accuracy...
Wed Jun 24, 2020 03:00
During the contact lens (CL) usage, microbial adhesion and biofilm formation are crucial threats for eye health due to the development of mature biofilms on CL surfaces associated with serious eye infections such as keratitis. For CL related eye infections, multi drug resistant Pseudomonas aeruginosa or Staphylococcus aureus (especially MRSA) and Candida albicans are the most common infectious bacteria and yeast, respectively. In this study, CL biofilm models were created by comparing them to reveal...
Wed Jun 24, 2020 03:00
We describe a new, medium-sized species of terrestrial frog of the genus Phrynopus from a single locality in the central Andes of Peru (Departamento de Huánuco) at 3,730 meters of elevation. Phylogenetic analyses supported Phrynopus remotum sp. nov. as an independent lineage, sister to most of its congeners. The new species is morphologically distinguishable by the presence of small tubercles on upper eyelids and heels, an areolate venter, and the absence of dorsolateral folds or ridges. This species...
Wed Jun 24, 2020 03:00
Related Articles Identification of 11 Different HPV Subtypes in Adult Patients With Recurrent Respiratory Papillomatosis. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820931817 Authors: Hoesli RC, Wingo ML, Richardson BE, Bastian RW Abstract OBJECTIVE: To define the human papillomavirus (HPV) subtypes seen in a large adult population with traditionally defined recurrent respiratory papillomatosis. STUDY DESIGN: Retrospective...
Wed Jun 24, 2020 13:00
Related Articles Cricopharyngeal Achalasia: Management and Associated Outcomes-A Scoping Review. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820931470 Authors: Dewan K, Santa Maria C, Noel J Abstract OBJECTIVE: There is little consensus regarding the efficacy and safety of treatment options for cricopharyngeal (CP) achalasia. The purpose of this scoping review is to assess the literature regarding the various treatments for this disease....
Wed Jun 24, 2020 13:00
Related Articles Augmentation of Scarred Vocal Folds With Centrifuged and Emulsified Autologous Fat Grafts. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820932836 Authors: Salmerón-González E, García-Vilariño E, Llópez-Carratalá I, Collado-Martin D, María Perolada-Valmaña J, Armengot-Carceller M Abstract OBJECTIVE: To review the results of a series of patients with glottic insufficiency caused by scarred vocal folds who underwent injection...
Wed Jun 24, 2020 13:00
Related Articles Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820933209 Authors: Lechien JR, Akst LM, Saussez S, Crevier-Buchman L, Hans S, Barillari MR, Calvo-Henriquez C, Bock JM, Carroll TL Abstract OBJECTIVES: To investigate the existing published evidence supporting the role of laryngopharyngeal reflux (LPR) in the development...
Wed Jun 24, 2020 13:00
Related Articles Narrowband Imaging for p16+ Unknown Primary Squamous Cell Carcinoma Prior to Transoral Robotic Surgery. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820933204 Authors: Al-Mulki K, Hamilton J, Kaka AS, Boyce BJ, Baddour HM, El-Deiry M, Solares CA, Magliocca K, Summers K, Aiken A, Saba NF, Beitler JJ, Patel MR Abstract Our purpose was to assess the potential utility of narrowband imaging (NBI) as a tool in diagnosing and...
Wed Jun 24, 2020 13:00
Related Articles Controversies in the Workup and Surgical Management of Parotid Neoplasms. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820932512 Authors: Moore MG, Yueh B, Lin DT, Bradford CR, Smith RV, Khariwala SS Abstract OBJECTIVE: Parotid neoplasms are a rare heterogeneous group of tumors with varied clinical presentation and behavior. Here we provide an evidence-based review of the contemporary approach to evaluation and surgical...
Wed Jun 24, 2020 13:00
Related Articles The Difficult Airway and Aerosol-Generating Procedures in COVID-19: Timeless Principles for Uncertain Times. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820936615 Authors: Smith JD, Chen MM, Balakrishnan K, Sidell DR, di Stadio A, Schechtman SA, Brody RM, Kupfer RA, Rassekh CH, Brenner MJ Abstract The impact of the COVID-19 pandemic on otolaryngology practice is nowhere more evident than in acute airway management. Considerations...
Wed Jun 24, 2020 13:00
Related Articles National Trends in Surgical Resection of Vestibular Schwannomas. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820932148 Authors: Ren Y, Sethi RKV, Stankovic KM Abstract OBJECTIVE: To characterize the national trend for surgical resection of vestibular schwannoma (VS) and to assess changes in demographics, length of stay (LOS), discharge patterns, and hospital charges. STUDY DESIGN: Population-based inpatient...
Wed Jun 24, 2020 13:00
Related Articles The Role of Age and Merkel Cell Polyomavirus in Oral Cavity Cancers. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820932553 Authors: Windon M, Fakhry C, Rooper L, Ha P, Schoppy D, Miles B, Koch W, Vosler P, Eisele D, D'Souza G Abstract The incidence of oral tongue cancer, the majority subsite of oral cavity cancer, is rising among young people with less exposure to tobacco and alcohol. Viral causes have been proposed,...
Wed Jun 24, 2020 13:00
Related Articles Subjective Visual Vertical Testing in Patients With Chronic Suppurative Otitis Media. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820931491 Authors: da Costa Monsanto R, Kasemodel ALP, Tomaz A, de Oliveira Penido N Abstract OBJECTIVE: To analyze the results of the subjective visual vertical test using the "bucket method" in patients with chronic suppurative otitis media (CSOM). STUDY DESIGN: Cross-sectional,...
Wed Jun 24, 2020 13:00
Related Articles Meta-analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820932137 Authors: Chaaban MR, Moffatt D, Wright AE, Cowthran JA, Hsu ES, Kuo YF Abstract OBJECTIVE: The objective of this study is to explore the sinopulmonary outcomes of aspirin desensitization through a systematic review and meta-analysis. DATA...
Wed Jun 24, 2020 13:00
Related Articles Randomized Controlled Trial of Balloon Dilation in Treatment of Subglottic Stenosis With a Rabbit Model. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820931486 Authors: Wistermayer P, McIlwain W, Escalante D, Rogers DJ Abstract OBJECTIVES: Identify the effects of balloon dilation duration and topical ciprofloxacin-dexamethasone application in treatment of subglottic stenosis. STUDY DESIGN: Randomized controlled...
Wed Jun 24, 2020 13:00
Related Articles Identifying Type III Sulcus: Patient Characteristics and Endoscopic Findings. Otolaryngol Head Neck Surg. 2020 Jun 23;:194599820933208 Authors: Varelas EA, Paddle PM, Franco RA, Husain IA Abstract OBJECTIVE: Type III sulcus is a pathologic structural deformity of the vocal folds that is challenging to accurately diagnose without endoscopic examination under anesthesia. This study aims to further define the clinical presentation...
Wed Jun 24, 2020 13:00
Related Articles [Hearing rehabilitation using a cochlear implant - a way of reducing tinnitus in the elderly]. Laryngorhinootologie. 2020 Jun 23;: Authors: Issing C, Baumann U, Pantel J, Stöver T Abstract BACKGROUND: Tinnitus is a common symptom of severe hearing loss or deafness especially in older people. Hearing rehabilitation for these patients is usually only possible with a cochlear implant (CI). In recent years, an increasing number...
Wed Jun 24, 2020 16:56
Positionspapier: Anwendung von Biologika bei chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP) im deutschen Gesundheitssystem – Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC). Laryngorhinootologie. 2020 Jun 23;: Authors: Klimek L, Förster-Ruhrmann U, Becker S,...
Wed Jun 24, 2020 13:00
Related Articles [Importance of machine blood count in the diagnosis of infectious mononucleosis by EBV]. Laryngorhinootologie. 2020 Jun 22;: Authors: Stupp F, Hoffmann TK, Grossi AS, Sommer F, Sieron HL, Lindemann J Abstract INTRODUCTION: EBV serology is recommended for serological diagnosis of mononucleosis. As results of an automated differential blood count is available more quickly, possible differences between an EBV primary infection...
Wed Jun 24, 2020 13:00
Related Articles [Detection rates of chemosensory evoked Potenzials with healthy and anosmic subjects]. Laryngorhinootologie. 2020 Jun 22;: Authors: Gudziol H, Baldow E, Guntinas-Lichius O, Bitter T Abstract BACKGROUND: The detection rate of olfactory chemosensory event-related EEG Potentials (oCSERP) and trigeminal chemosensory event-related EEG Potentials (tCSERP) is also dependent on the stimulants and the evaluator of the averaged EEG curves....
Wed Jun 24, 2020 13:00
Publication date: Available online 24 June 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): D. Wang, T. Gao, L. Liu, Y. Chen, S. Liao, T. Xu, K. Zhang
Wed Jun 24, 2020 12:55
Publication date: Available online 24 June 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Langton, G.C.S. Cousin, A. Plüddemann, C.R. Bankhead
Wed Jun 24, 2020 12:55
Background Insulinoma‐associated protein 1 (INSM1) has recently emerged as a reliable nuclear immunostaining marker for detecting neuroendocrine tumors (NETs) in paraffin‐embedded surgical samples and cytologic cell blocks, but the reliability of INSM1 staining on cytologic smears is understudied. This study investigated the performance of INSM1 staining on cytologic smears for the detection of various NETs in comparison with chromogranin (CG) and synaptophysin (SYN). Methods INSM1, CG, and...
Tue Jun 23, 2020 15:50
Background The indeterminate categories in the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) are diagnostically challenging because of inherent heterogeneity and complexity, with wide interobserver variability (IOV). Herein, the authors explore the concordance rate (CR) between cytopathologists (CPs) and cytotechnologists (CTs) in interpreting indeterminate salivary gland lesions using the MSRSGC. Methods Between 2011 and 2016, 86 indeterminate fine‐needle aspirations had...
Tue Jun 23, 2020 15:50
Publication date: Available online 24 June 2020Source: American Journal of OtolaryngologyAuthor(s): Jian-Yun Peng, Fu-Shun Pan, Wei Wang, Zhu Wang, Quan-Yuan Shan, Jin-Hua Lin, Jia Luo, Yan-Ling Zheng, Hang-Tong Hu, Si-Min Ruan, Jin-Yu Liang, Xiao-Yan Xie, Ming-De Lu
Wed Jun 24, 2020 12:50
Publication date: Available online 23 June 2020Source: American Journal of OtolaryngologyAuthor(s): Erdal Sakalli, Dastan Temirbekov, Esra Bayri, Esra Ergun Alis, Selcuk Cem Erdurak, Mesut Bayraktaroglu
Wed Jun 24, 2020 12:50
The E2 envelope glycoprotein of the hepatitis C virus (HCV) is a major target of broadly neutralizing antibodies that are closely related to a spontaneous cure of HCV infection. There is still no data about the diversity of E2-specific antibodies (Abs) glycosylation. The aim of this study was to analyze the level and sialylation of E2 IgG Abs, the relation of the respective changes to hepatic fibrosis (F) progression and their possible association with the efficacy of interferon-α-2a plus ribavirin...
Wed Jun 24, 2020 08:05
Abstract Objectives Determine whether the insertion site of the recurrent laryngeal nerve (RLN) occurs at a predictable distance from the midline trachea, to help guide safe dissection during thyroid surgery. Design Prospective clinical trial. At the inferior edge of the cricoid cartilage, we measured the distance from mildline trachea to the RLN insertion site. Setting Single institution. Participants 50 consecutive patients undergoing thyroid surgery. Main outcome measures...
Tue Jun 23, 2020 20:51
ABSTRACT Ultrasound (US) has become an integral part of the practice of medicine due in part to its soft tissue resolution, cost effectiveness, ability to measure vessel flow and, perhaps most relevant to head and neck surgeons, ease of use in the clinical setting in conjunction with fine needle aspiration (FNA).
Tue Jun 23, 2020 17:40
Angiopoietin-1 (Ang-1) is a new neuroprotective agent, which can protect neurons from apoptosis. Increased autophagy in neurons subjected to oxygen-glucose deprivation/recovery (OGD/R) injury may lead to autophagic cell death; therefore, the present study investigated the effect of Ang-1 on neurons subjected to OGD/R injury. Neuronal viability was detected by using the Cell Counting Kit-8, which was then used to select the appropriate concentration of Ang-1 and rapamycin used in the OGD/R injury...
Mon Jun 22, 2020 03:00
Calcitonin gene-related peptide (CGRP) and adrenomedullin are structurally similar neuropeptides acting as potent vasodilators of blood pressure and mediator of inflammation in skin. Revealing the expression pattern of their common receptor-Calcitonin gene-related peptide receptor (Calcrl) in their targeted cells is important to explain the functions of CGRP and adrenomedullin in skin. Our immunostaining results showed that Calcrl is enriched in hair follicles bulge stem cells and differentially...
Mon Jun 22, 2020 03:00
Serotonin (5-HT) has an important role in the pathophysiology of the mood disorders like major depression and anxiety disorders in central nervous system. On the one hand, dorsal raphe nucleus (DRN) neurons send serotonergic projections to almost all brain regions. On the other hand, they affect themselves through 5-HT1A autoreceptors. Many electrophysiological studies have investigated the ionic mechanism of the 5-HTs effect on the DRN neurons of the rat. However, there is no study characterizing...
Mon Jun 22, 2020 03:00
Cholinergic systems modulate dopaminergic function in brain pathways are thought to mediate heroin addiction. This study investigated whether huperzine A, an acetylcholinesterase inhibitor, has beneficial effects on heroin reward and heroin-seeking behavior. Rats were trained to self-administer heroin (50 μg/kg/infusion) under the fixed ratio 1 schedule for 14 days and then drug-seeking was extinguished for 10 days, after which reinstatement of drug-seeking was induced by conditioned cues or heroin...
Mon Jun 22, 2020 03:00
Our recent study demonstrated that local perfusion of ethanol (EtOH) and acetaldehyde (AcH) into the hippocampus via microdialysis decreased extracellular glutamate; however, it is not clear whether this effect occurs in the frontal cortex. To address this issue, we investigated the effects of local perfusion of EtOH and AcH on extracellular glutamate in the frontal cortex of Aldh2-knockout (Aldh2-KO) and C57BL/6 N [wild-type (WT)] mice. Dialysates were collected every 20 minutes, and extracellular...
Mon Jun 22, 2020 03:00
Post-stroke cognitive impairment (PSCI) severely affects the quality of a survivor’s life, but its neurophysiological basis remains unknown. Neuroinflammation has been considered as an important contributor to PSCI, which could be induced or exacerbated by system inflammation. NACHT-LRR- and pyrin-domain-containing protein 3 (NLRP3) inflammasome is the most widely studied in the initiation of inflammation. Here, using a mouse model of photothrombotic stroke, we demonstrated that NLRP3 activation...
Mon Jun 22, 2020 03:00
