Pilotstudie zum Einfluss von kaltem atmosphärischem Plasma auf bakterielle Kontamination und Heilungstendenz chronischer Wunden

xloma.fota13 shared this article with you from Inoreader Pilotstudie zum Einfluss von kaltem atmosphärischem Plasma auf bakterielle Kontamination und Heilungstendenz chronischer Wunden Via JDDG: Journal der Deutschen Dermatologischen Gesellschaft Zusammenfassung Hintergrund Wöchentlich dreimalige Anwendung kalten atmosphärischen Plasmas (KAP) wurde bereits erfolgreich zur Wundbehandlung eingesetzt. Jetzt sollte untersucht werden, ob mit nur einmal wöchentlicher Behandlung vergleichbar gute Ergebnisse erzielt werden können. Patienten und Methodik In dieser randomisierten klinischen Pilotstudie (RCT) wurden Patienten mit therapierefraktären chronischen Wunden über maximal zwölf Wochen 1 x/Woche (Gruppe 1) oder 3 x/Woche (Gruppe 2) mit KAP behandelt. Patienten der Gruppe 3 erhielten 1 x/Woche eine Placebotherapie. Ergebnisse Die Wundfläche nahm in Gruppe 1 (n = 14) signifikant um 63,0 % (P = 0,005) und in Gruppe 2 (n = 13) um 46,8 % (P = 0,007) ab. In Gruppe 3 (n = 10) wurden die Wunden durchschnittlich 17,5 % größer. In den beiden mit KAP behandelten Gruppen konnte eine signifikante Schmerzreduktion (Gruppe 1: P = 0,042; Gruppe 2: P = 0,027) gemessen werden. Ausschließlich in der Gruppe 2 zeigte sich eine signifikante Verbesserung der wundspezifischen Lebensqualität (P = 0,005). Nach der zwölfwöchigen KAP‐Behandlung konnte eine Reduktion der Bakterienlast um durchschnittlich 50,4 % (Gruppe 1) beziehungsweise um 35,0 % (Gruppe 2) im Vergleich zum Tag des Studieneinschlusses nachgewiesen werden. Schlussfolgerungen Unserer RCT zeigt, dass durch die Behandlung mit KAP verschiedene Parameter der Wundheilung bei Patienten mit therapierefraktären, chronischen Wunden verbessert werden. Hierbei waren die Ergebnisse bei der Anwendung 1 x/Woche der Anwendung 3 x/Woche nicht unterlegen. Die Behandlung 1 x/Woche ist im klinischen Alltag leichter und wirtschaftlicher zu implementieren. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparative accuracy of cone‐beam CT and conventional multislice computed tomography for real‐time navigation in zygomatic implant surgery

xloma.fota13 shared this article with you from Inoreader Comparative accuracy of cone‐beam CT and conventional multislice computed tomography for real‐time navigation in zygomatic implant surgery Via Clinical Implant Dentistry and Related Research Abstract Background Cone‐beam computed tomography (CBCT) and conventional multislice CT (MSCT) are both used in zygomatic implant navigation surgery but the superiority of one technique versus the other remains unclear. Purpose This study compared the accuracy of CBCT and MSCT in zygomatic implant navigation surgery by calculating the deviations of implants. Material and methods Patients with severely atrophic maxillae were classified into two groups according to the use of CBCT‐ or MSCT‐guided navigation system. The entry and apical distance deviation, and the angle deviation of zygomatic implants were measured on fused operation images. A linear effect model was used for analysis, with statistical significance set at P < .05. Results A total of 72 zygomatic implants were inserted as planned in 23 patients. The comparison of deviations in CBCT and MSCT groups showed a mean (± SD) entry deviation of 1.69 ± 0.59 mm vs 2.04 ± 0.78 mm (P = .146), apical deviation of 2 ± 0.68 mm vs 2.55 ± 0.85 (P < .001), and angle deviation of 2.32 ± 1.02° vs 3.23 ± 1.21° (P = .038). Conclusion Real‐time zygomatic implant navigation surgery with CBCT may result in higher values for accuracy than MSCT. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The right thalamic ventral posterolateral nucleus seems to be determinant for macrosomatognosia: a case report

xloma.fota13 shared this article with you from Inoreader The right thalamic ventral posterolateral nucleus seems to be determinant for macrosomatognosia: a case report Via Latest Results for BMC Neurology Abstract Background Macrosomatognosiais the illusory sensation of a substantially enlarged body part. This disorder of the body schema, also called "Alice in wonderland syndrome" is still poorly understood and requires careful documentation and analysis of cases. The patient presented here is unique owing to his unusual macrosomatognosia phenomenology, but also given the unreported localization of his most significant lesion in the right thalamus that allowed consistent anatomo-clinical analysis. Case presentation This 45-years old man presented mainly with long-lasting and quasi-delusional macrosomatognosia associated to sensory deficits, both involving the left upper-body, in the context of a right thalamic ischemic lesion most presumably located in the ventral posterolateral nucleus. Fine-grained probabilistic and deterministic tractography revealed the most eloquent targets of the lesion projections to be the ipsilateral precuneus, superior parietal lobule,but also the right primary somatosensory cortex and, to a lesser extent, the right primary motor cortex. Under stationary neurorehabilitation, the patient slowly improved his symptoms and could be discharged back home and, later on, partially return to work. Conclusion We discuss deficient neural processing and integration of sensory inputs within the right ventral posterolateral nucleus lesion as possible mechanisms underlying macrosomatognosia in light of observed anatomo-clinical correlations. On the other hand, difficulty to classify this unique constellation of Alice in wonderland syndrome calls for an alternative taxonomy of cognitive and psychic aspects of illusory body-size perceptions. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effect of vitamin A, calcium and vitamin D fortification and supplementation on nutritional status of women: an overview of systematic reviews

xloma.fota13 shared this article with you from Inoreader Effect of vitamin A, calcium and vitamin D fortification and supplementation on nutritional status of women: an overview of systematic reviews Via Systematic Reviews - Latest Articles Micronutrient deficiency affects the health and development of vulnerable population such as children and pregnant women. Measures such as fortification of food and supplementation have been implemented to pre... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Combination of a CD26 Inhibitor, G-CSF, and Short-term Immunosuppressants Modulates Allotransplant Survival and Immunoregulation in a Rodent Hindlimb Allotransplant Model

xloma.fota13 shared this article with you from Inoreader Combination of a CD26 Inhibitor, G-CSF, and Short-term Immunosuppressants Modulates Allotransplant Survival and Immunoregulation in a Rodent Hindlimb Allotransplant Model Via http://journals.lww.com/transplantjournal/_layouts/OAKS.Journals/feed.aspx?FeedType=PublishAheadofPrint&year=9000&issue=00000 Background: Recent studies have demonstrated that inhibition of CD26 potentiates stromal cell-derived factor-1α (SDF-1α) promotes tissue regeneration and suppresses the rejection of organ transplants. This study investigated whether the combination of a CD26 inhibitor (CD26i) with granulocyte colony-stimulating factor (G-CSF) and short-term immunosuppressants modulates vascularized composite tissue allotransplant (VCA) survival in a rodent orthotopic hindlimb allotransplant model. Methods: The hindlimb allotransplantation from Brown-Norway to Lewis rats were divided into 4 groups. Group 1 (controls) did not receive any treatment. Group 2 was treated with short-term antilymphocyte serum (ALS) and cyclosporine-A (CsA). Group 3 was administrated CD26i and G-CSF. Group 4 received a combination of CD26i/G-CSF/ALS/CsA. Each subgroup comprised 10 rats. Peripheral blood and sampling of transplanted tissues were collected for immunological and histological analysis. Results: The results revealed that allotransplant survival was significantly prolonged in group 4 with CD26i/G-CSF/ALS/CsA treatment compared to those in the other groups. The IL-10 and TGF-βl levels, the percentage of CD4+/CD25+/FoxP3+ T cells, as well as the levels of SDF-1α expressions were significantly increased in group 4 compared to those in the other groups. Group 4 revealed a statistical increase of the percentage of donor cells (RT1n) expression in the recipient peripheral blood, and the mixed lymphocyte reaction showed hyporesponsiveness of the T-cells to donor alloantigens. Conclusion: The combination of CD26i/G-CSF and short-term immunosuppressants prolongs allotransplant survival by inducing immunoregulatory effects and enhancing the percentage of SDF-1α expression. This immunomodulatory approach has great potential as a strategy to increase VCA survival. # First 2 authors have equal contribution as co–first author. Financial disclosure: This work was partly supported by grant MOST 108-2314-B-037-084 -MY3 from the Ministry of Science and Technology, Taiwan and MOHW107-TDU-B-212-123006 from the Ministry of Health and Welfare, Taiwan; and in part by grants SA10801, KMUH108-8M18, KMUH108-8M29, and KMUH108-8R31 from Kaohsiung Medical University Hospital, Taiwan; KMU-TC108A02-5 and 105KMUOR06 from Kaohsiung Medical University, Taiwan. Disclaimer: We declare that we have no conflicts of interest. Competing interests: The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation. Availability of supporting data: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Correspondence: Dr Yur-Ren Kuo, MD, PhD Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 100 Tzyou 1st Rd., Kaohsiung 80756, Taiwan. Phone: +886-7-3121101, ext. 7675, Fax: +886-7-7311482 E-mail: kuoyrren@gmail.com Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The right thalamic ventral posterolateral nucleus seems to be determinant for macrosomatognosia: a case report

xloma.fota13 shared this article with you from Inoreader The right thalamic ventral posterolateral nucleus seems to be determinant for macrosomatognosia: a case report Via BMC Neurology - Latest Articles Macrosomatognosiais the illusory sensation of a substantially enlarged body part. This disorder of the body schema, also called "Alice in wonderland syndrome" is still poorly understood and requires careful do... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Trabecular Bone is Increased in a Rat Model of Polycystic Ovary Syndrome

xloma.fota13 shared this article with you from Inoreader Trabecular Bone is Increased in a Rat Model of Polycystic Ovary Syndrome Via Experimental and Clinical Endocrinology & Diabetes Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-5491 Polycystic ovary syndrome (PCOS) in an intricate disorder characterized by reproductive and metabolic abnormalities that may affect bone quality and strength along with the lifespan. The present study analysed the impact of postnatal androgenization (of a single dose of testosterone propionate 1.25 mg subcutaneously at day 5 of life) on bone development and markers of bone metabolism in adult female Wistar rats. Compared with healthy controls, the results of measurements of micro-computed tomography (microCT) of the distal femur of androgenized rats indicated an increased cortical bone volume voxel bone volume to total volume (VOX BV/TV) and higher trabecular number (Tb.n) with reduced trabecular separation (Tb.sp). A large magnitude effect size was observed in the levels of circulating bone formation Procollagen I N-terminal propeptide (P1NP) at day 60 of life; reabsorption cross-linked C-telopeptide of type I collagen (CTX) markers were similar between the androgenized and control rats at days 60 and 110 of life. The analysis of gene expression in bone indicated elements for an increased bone mass such as the reduction of the Dickkopf-1 factor (Dkk1) a negative regulator of osteoblast differentiation (bone formation) and the reduction of Interleukin 1-b (Il1b), an activator of osteoclast differentiation (bone reabsorption). Results from this study highlight the possible role of the developmental programming on bone microarchitecture with reference to young women with PCOS. [...] Georg Thi eme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extrauterine adenomyoma located in the inguinal region

xloma.fota13 shared this article with you from Inoreader Extrauterine adenomyoma located in the inguinal region: a case report of a 44-year-old woman Via Journal of Surgical Case Reports - current issue Abstract Adenomyomas are benign tumours ma de of smooth muscle cells, endometrial glands and stroma. An extrauterine location is extremely rare with an unknown pathogenesis. Preoperative diagnosis is challenging and pathologic examination is necessary to confirm the diagnosis. Here we present a case report of a 44-year-old woman with a painful non-reducible mass in the right inguinal region without fever or other alarming symptoms 2 months after a laparoscopic hysterectomy. She was treated with a surgical resection of the mass. Extrauterine adenomyoma is a very uncommon entity. Preoperative workup is challenging, as confirmation of the diagnosis can only be achieved by histopathological analysis following surgical excision. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A unique case of medulla oblongata epidermoid cyst

xloma.fota13 shared this article with you from Inoreader A unique case of medulla oblongata epidermoid cyst Via Journal of Surgical Case Reports - current issue Abstract Epidermoid cysts (ECs) are slow-g rowing, benign tumors that represent <2% of all intracranial tumors. ECs can be divided into following two types: extra-axial and intra-axial. Extra-axial ECs are most often positioned in the cerebellopontine angle. Intra-axial ECs, which are also referred to as intraparenchymal ECs, are most commonly found in supratentorial structures, such as the frontal and temporal lobes, accounting for <2% of all intracranial ECs and are especially rare in children. In this report, we described a unique case of medulla oblongata EC in a child, to contribute this knowledge to the existing body of literature. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An unusual case of hyalinizing clear cell carcinoma in a sinonasal cavity and cranial base

xloma.fota13 shared this article with you from Inoreader An unusual case of hyalinizing clear cell carcinoma in a sinonasal cavity and cranial base Via Journal of Surgical Case Reports - current issue Abstract Hyalinizing clear cell carcinoma (HCCC) is a rare, predominantly minor salivary gland tumor. Most of these tumors occur in the oral cavity, mainly the palate and tongue. Primary localization of the tumor in the region of the nasal cavity and paranasal sinuses is extremely rare and, with only a few cases reported in the literature so far. We present an extremely rare case of a 61-year-old woman with hyalinizing clear cell carcinoma (HCCC), occupying the left posterior nasal and nasopharyngeal cavity, as a primary tumor location. The patient total recovery was uneventful, and she is now free of disease at three years postoperative follow-up. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clipping of a basilar tip aneurysm using hypothermia and circulatory arrest: a case report

xloma.fota13 shared this article with you from Inoreader Clipping of a basilar tip aneurysm using hypothermia and circulatory arrest: a case report Via Journal of Surgical Case Reports - current issue Abstract Treatment of complex and giant an eurysms remains challenging despite modern endovascular and microsurgical techniques. We report the first case of microsurgical clipping of a complex basilar tip aneurysm under circulatory arrest and hypothermia performed in Greece. A 52-year-old patient presented with a Hunt and Hess Grade 4 subarachnoid hemorrhage. The digital subtraction angiography revealed a complex basilar tip aneurysm. Due to aneurysm complexity, we decided for microsurgical clipping under hypothermia and circulatory arrest. We performed a right pterional craniotomy with orbitozygomatic osteotomy. The patient was then put on heart–lung-machine. Following hypothermia and circulatory arrest, the aneurysm was clipped with its complete occlusion. The patient was discharged with no neurological deficits. Clipping of complex aneurysms under hypothermia and cardiac arrest performed by experienced team is a safe alternative when endovascular therapy or bypass technique is not feasible. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Unusual localizations of hydatid cysts

xloma.fota13 shared this article with you from Inoreader Unusual localizations of hydatid cysts: a rare case report from Syria Via Journal of Surgical Case Reports - current issue Abstract Hydatid disease (HD) is an infect ion with the metacestode stage of the tapeworm Echinococcus. It is commonly seen in South America, The Middle East, Eastern Mediterranean, Africa and China. Hydatid cysts usually affect the liver followed by the lungs. Involvement in other organs has been reported. However, in the majority of the cases, cysts are localized in one organ or one region. We report a rare case of a 36-year-old woman who presented to the hospital in Syria with long-standing history of non-specific abdominal pain. Computerized tomography showed several hydatid cysts in the liver, spleen, left lung, mediastinum (adjacent to the aortic arch), both breasts and above the right gluteal muscles. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.