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Δευτέρα 30 Μαρτίου 2020
The combination of acyclovir and dexamethasone protects against Alzheimer’s disease-related cognitive impairments in mice
The combination of acyclovir and dexamethasone protects against Alzheimer’s disease-related cognitive impairments in mice:
Medicine by Alexandros G. Sfakianakis
pubmed: health technology,Using infrared depth-s...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Telephone consultation 11855 int 1193,
Related ArticlesUsing infrared depth-sensing technology to improve the brachytherapy operating room experience. Brachytherapy. 2020 Mar 24;: Authors: Martell K, Law C, Hasan Y, Taggar A, Barnes E, Ravi A, Leung E Abstract PURPOSE: The purpose of this study was to discuss the merits of using depth-sensing infrared camera technology in the brachytherapy operating room during interstitial brachytherapy for gynecologic malignancies. MATERIALS AND...
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Related ArticlesImpact of Procedure Type, Case Duration, and Adjunctive Equipment on Surgeon Intraoperative Musculoskeletal Discomfort. J Am Coll Surg. 2020 Apr;230(4):554-560 Authors: Yang L, Money SR, Morrow MM, Lowndes BR, Weidner TK, Fortune E, Davila VJ, Meltzer AJ, Stone WM, Hallbeck MS Abstract BACKGROUND: Surgeons are at high risk of developing musculoskeletal disorders. STUDY DESIGN: This study was designed to identify risk factors...
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Related ArticlesUsing a health information technology survey to explore the availability of addiction treatment data in the electronic health records: A National Drug Abuse Treatment Clinical Trials Network study. J Subst Abuse Treat. 2020 Mar;112S:56-62 Authors: Wu LT, Payne EH, Roseman K, Case A, Nelson C, Lindblad R Abstract BACKGROUND: Healthcare data from electronic health records (EHRs) and related health information technology (IT) tools are critical...
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Related ArticlesThe application of digital health to the assessment and treatment of substance use disorders: The past, current, and future role of the National Drug Abuse Treatment Clinical Trials Network. J Subst Abuse Treat. 2020 Mar;112S:4-11 Authors: Marsch LA, Campbell A, Campbell C, Chen CH, Ertin E, Ghitza U, Lambert-Harris C, Hassanpour S, Holtyn AF, Hser YI, Jacobs P, Klausner JD, Lemley S, Kotz D, Meier A, McLeman B, McNeely J, Mishra V, Mooney L, Nunes E,...
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Related ArticlesEconomic evaluation in the National Drug Abuse Treatment Clinical Trials Network: Past, present, and future. J Subst Abuse Treat. 2020 Mar;112S:18-27 Authors: Jalali A, Ryan DA, McCollister KE, Marsch LA, Schackman BR, Murphy SM Abstract Economic evaluations provide evidence that informs stakeholders on how to efficiently allocate real and financial healthcare resources. The purpose of this study was to review and discuss the integration...
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Related ArticlesAssociation between dietary patterns with insulin resistance in an Iranian population. Clin Nutr ESPEN. 2020 Apr;36:45-52 Authors: Ehrampoush E, Nazari N, Homayounfar R, Ghaemi A, Osati S, Tahamtan S, Hashempur MH, Bahmanyar M Abstract AIM: To assess the association between dietary patterns no single food or group, and risk of insulin resistance (Fasting blood sugar (FBS), Fasting insulin, 2h-glucose, 2h-insulin and HOMA-IR). ...
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Related ArticlesThe effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2020 Apr;36:10-16 Authors: Hadi A, Campbell MS, Hassani B, Pourmasoumi M, Salehi-Sahlabadi A, Hosseini SA Abstract BACKGROUND & AIMS: Several clinical trials have shown that cinnamon can reduce blood pressure, but the results are controversial. Therefore, we conducted a systematic...
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Related ArticlesPolypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol. 2020 Mar 13;: Authors: Kaplan A, Andrei SA, van Regteren Altena A, Simas T, Banerjee SL, Kato N, Bisson N, Higuchi Y, Ottmann C, Fournier AE Abstract Targeting protein-protein interactions (PPIs) is a promising approach in the development of drugs for many indications. 14-3-3 proteins are a family of phosphoprotein-binding...
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Related ArticlesImplementation of palliative care consult Service in Hungary - integration barriers and facilitators. BMC Palliat Care. 2020 Mar 27;19(1):41 Authors: Zemplényi AT, Csikós Á, Csanádi M, Mölken MR, Hernandez C, Pitter JG, Czypionka T, Kraus M, Kaló Z Abstract BACKGROUND: The Palliative Care Consult Service (PCCS) programme was among the first initiations in Hungary to provide palliative care for patients admitted to hospital. The PCCS team...
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Related ArticlesInequalities in reproductive health care use in five West-African countries: A decomposition analysis of the wealth-based gaps. Int J Equity Health. 2020 Mar 27;19(1):44 Authors: Ogundele OJ, Pavlova M, Groot W Abstract BACKGROUND: Family planning and maternal care services have become increasingly available in West Africa but the level of non-use remains high. This unfavorable outcome may be partly due to the unaffordability of reproductive...
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Related ArticlesCorrection to: Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy. Mol Brain. 2020 Mar 27;13(1):50 Authors: Bai YF, Chiu M, Chan ES, Axerio-Cilies P, Lu J, Huh L, Connolly MB, Guella I, Farrer MJ, Xu ZD, Liu L, Demos M, Wang YT Abstract Following publication of the original article [1], the authors reported errors in Figure 4.PMID: 32220239 [PubMed - as supplied by publisher]
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Related ArticlesAnti-Inflammatory Activity of Limonene in Prevention and Control of Injuries in the Respiratory System: A Systematic Review. Curr Pharm Des. 2020 Mar 20;: Authors: Santana H, Carvalho F, Silva E, Santos N, Santos D, Wisniewski J, Júnior JC, Nunes P, Shanmugam S, de Albuquerque Júnior RL, Araújo A, Roberto M Abstract INTRODUCTION: The pulmonary inflammatory response results of an injurious factor exposure and is associated with oxidative...
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Related ArticlesDevelopment and evaluation of an electronic hospital referral system: a human factors approach. Ergonomics. 2020 Mar 27;:1-20 Authors: Woodward M, De Pennington N, Grandidge C, McCulloch P, Morgan L Abstract Coordinating care across hospital organisations has been identified as a risk factor for patient safety as referrals are often paper-based and poorly documented. Electronic referral systems have the potential to improve the situation...
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Abstract Backgrounds Local recurrence after definitive chemoradiotherapy, if diagnosed early, can be cured by salvage endoscopic therapy, which allows organ preservation and contributes to maintaining patient quality of life. This study aimed to investigate early endoscopic findings of local recurrence in post-definitive chemoradiotherapy patients. Methods ...
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Related ArticlesCreating Space for Feminist Ethics in Medical School. HEC Forum. 2020 Mar 27;: Authors: Campelia GD, Feinsinger A Abstract Alongside clinical practice, medical schools now confront mounting reasons to examine nontraditional approaches to ethics. Increasing awareness of systems of oppression and their effects on the experiences of trainees, patients, professionals, and generally on medical care, is pushing medical curriculum into an unfamiliar...
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Related ArticlesConscientious Objection in Medicine: Making it Public. HEC Forum. 2020 Mar 27;: Authors: Ben-Moshe N Abstract The literature on conscientious objection in medicine presents two key problems that remain unresolved: (a) Which conscientious objections in medicine are justified, if it is not feasible for individual medical practitioners to conclusively demonstrate the genuineness or reasonableness of their objections ("the justification problem")?...
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Abstract Purpose We evaluated the expression of proteasome subunits to assess whether the proteasome could be a therapeutic target in cisplatin-resistant lung cancer cells. Methods Cisplatin-resistant (CR) variants were established from three non-small cell lung cancer (NSCLC) cell lines (A549, H1299, and H1975) and two small cell lung cancer (SCLC) cell...
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This update on chronic urticaria (CU) focuses on the prevalence and pathogenesis of chronic spontaneous urticaria (CSU), the expanding spectrum of patient-reported outcome measures (PROMs) for assessing CU disease activity, impact, and control, as well as future treatment options for CU. This update is needed, as several recently reported findings have led to significant advances in these areas. Some of these key discoveries were first presented at past meetings of the Collegium Internationale Allergologicum...
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Zusammenfassung In der jüngeren Vergangenheit ist vermehrt Kritik am Einsatz von Glaubhaftigkeitsbegutachtungen in Verfahren zu Sexualdelikten formuliert worden. Ein Tenor dieser Kritik lautet, dass die wissenschaftlichen Grundlagen der Aussagepsychologie für ihren praktischen Einsatz bei einigen relevanten Fragestellungen für Glaubhaftigkeitsbeurteilungen nicht ausreichend seien. Diese nichtfundierte Kritik stellt keine Herausforderung für die Aussagepsychologie dar, wie der vorliegende...
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Abstract Epidermal growth factor receptor (EGFR) expression and activation are the major causes of metastasis in cancers such as head and neck squamous cell carcinoma (HNSCC). However, the reciprocal effect of EGF‐induced cyclooxygenase‐2 (COX‐2) and angiopoietin‐like 4 (ANGPTL4) on HNSCC metastasis remains unclear. In this study, we revealed that the expression of ANGPTL4 is essential for COX‐2‐derived prostaglandin E2 (PGE2)‐induced tumor cell metastasis. We showed that EGF‐induced ANGPTL4 expression...
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Abstract Chemotherapy‐induced alopecia is one of the most difficult adverse events of cancer treatment for patients. However, it is still unknown why anticancer drugs cause hair loss. We aimed to clarify the mechanism of chemotherapy‐induced alopecia in mice using an in vivo imaging technique with a two‐photon microscope, which enables observation of the deep reaction in the living body in real time. In this study, ICR mice were injected intraperitoneally with cyclophosphamide (120 µg/g). Changes...
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Abstract Both ceritinib (CER) and PD‐1/PD‐L1 have brought significant breakthrough for ALK‐rearranged non‐small‐cell lung cancer (NSCLC). However, the overall clinical efficacy of either CER or PD‐1/PD‐L1 inhibitor monotherapy has been limited to a large extent. Besides, the antitumor effect of combined CER with PD‐L1 inhibitor in ALK‐rearranged NSCLC are not fully understood. In H2228 cells, we examined the tumor killing effect of CER plus PD‐L1 inhibitor in vitro by quantitative RT‐PCR, flow...
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Abstract Background Despite being largely preventable, many occupational diseases continue to be highly prevalent and extremely costly. Effective strategies are required to reduce their human, economic, and social impacts. Methods To better understand which approaches are most likely to lead to progress in preventing noise‐related hearing loss, occupational contact dermatitis, occupational cancers, and occupational asthma, we undertook a scoping review and consulted with a number...
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Abstract Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene–multiple lifestyle exposure interactions to find novel BP loci. For each of 6,254 Framingham Heart Study participants, we computed lifestyle risk score (LRS) value by aggregating the risk of four lifestyle exposures (smoking, alcohol, education, and physical activity)...
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Biosensors, Vol. 10, Pages 31: Competitive HRP-Linked Colorimetric Aptasensor for the Detection of Fumonisin B1 in Food based on Dual Biotin-Streptavidin Interaction Biosensors doi: 10.3390/bios10040031 Authors: Zui Tao You Zhou Xiang Li Zhouping Wang Fumonisin B1 (FB1) is the most prevalent and toxic form among fumonisin homologues which are produced by fusarium species and it contaminates various types of food products, posing serious health hazards for humans and...
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Deficiencies in methyl donor status may render DNA methylation changes and DNA damage, leading to carcinogenesis. Epidemiological studies reported that higher dietary intake of choline is associated with lower risk of pancreatic cancer, but no study has examined the association of serum choline and its metabolites with risk of pancreatic cancer. Two parallel case–control studies, one nested within the Shanghai Cohort Study (129 cases and 258 controls) and the other within the Singapore Chinese Health...
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Angiopoietin‐2 (ANGPT2) is a prognostic factor in metastatic colorectal cancer (CRC). Nevertheless, it remains to be elucidated which molecular characteristics make up the ANGPT2‐related poor‐prognosis CRC subset. Public transcriptomic datasets were collected from Gene Expression Omnibus GEO and with the TCGAbiolinks R‐package for the TCGA. After appropriate normalization, differential expression analysis was performed using Benjamini and Hochberg method for false discovery rate. Plasma from two...
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Abstract Knowledge about variations in mylohyoid muscle and submental artery is essential for maxillofacial surgeons, as these structures are commonly encountered in maxillofacial ablative and reconstructive surgery. While cadaveric and radiologic studies on mylohyoid variations have been documented in the literature, we report an intraoperative variation observed in relation to mylohyoid muscle and submental artery.
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Abstract Heavy metals in groups 3–16 in periods 4 and greater. They exist naturally in the earth’s crust. People are exposed to heavy metals by the inhalation of polluted air and via the intake of contaminated food. People are exposed to lead (Pb), one of heavy metals, by consuming foods that are contaminated from the environment. Pb is ubiquitous in the environment and accumulates in plants and animals that eat contaminated plants. The Pb in foods before and after processing...
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Abstract The effects of extraction conditions on the acrylamide/furan content, antioxidant activity, and sensory properties of cold brew coffee were probed for samples prepared by steeping and dripping at various temperatures and for different times. Sensory properties were evaluated using a nine-point hedonic scale and an overall preference ranking test. Samples prepared by 3-h extraction featured the lowest acrylamide levels, while the lowest furan contents were observed for...
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Abstract Whey, a by-product of cheese making, is a collection of several milk proteins and has functional and nutritional values. Whey protein concentrate (WPC) exhibits various functional effects by glycation. Studies to find sugar-binding sites in a protein having a functional effect are reported. However, it is rarely clear whether it confirms that glycated single protein exhibits the same effect of protein cluster. This study confirmed which protein sites are responsible for...
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Abstract Pregnane X receptor (PXR) is activated by chemicals to transcriptionally regulate drug disposition and possibly decrease drug efficacy and increase resistance, suggesting therapeutic value for PXR antagonists. We previously reported the antagonist SPA70 and its analog SJB7, which unexpectedly is an agonist. Here, we describe another unexpected observation: mutating a single residue (W299A) within the PXR ligand-binding domain converts SPA70 to an agonist. After characterizing...
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