Long‐term outcomes in sinonasal squamous cell carcinoma arising from inverted papilloma: Systematic review

xlomafota13 shared this article with you from Inoreader Long‐term outcomes in sinonasal squamous cell carcinoma arising from inverted papilloma: Systematic review Via Head & Neck Abstract Long-term survival and recurrence patterns of squamous cell carcinoma arising from inverted papilloma (IP-SCC) have not been thoroughly investigated. Four electronic databases were searched and primary studies describing overall survival (OS), recurrence, and mean time to recurrence of patients with IP-SCC were included for review. Our search yielded 662 studies. The 28 studies selected for inclusion identified 663 patients with IP-SCC. In 596 patients with reported T classification, 439 (73.7%) were T3/T4 on presentation. Of the 650 participants with recurrence data (local, regional, and distant), 155 (23.8%) experienced a recurrence, with an aggregate mean time-to-recurrence of 24.3 months. In 565 patients with 5-year OS rates, the aggregate 5-year OS was 62%. Based on the literature to date, IP-SCC is associated with a 5-year OS rate of 62%. 23.8% of patients experienced recurrence at a mean time of 24.3 months, suggesting the need for long-term surveillance. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effect of cosmetic surgery on mental self-image and life satisfaction in women undergoing breast augmentation: An intermediate role of evaluating the surgery as one of the most important life events

xlomafota13 shared this article with you from Inoreader The effect of cosmetic surgery on mental self-image and life satisfaction in women undergoing breast augmentation: An intermediate role of evaluating the surgery as one of the most important life events Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Jan 21:S1748-6815(22)00033-X. doi: 10.1016/j.bjps.2022.01.018. Online ahead of print. ABSTRACT AIM: To estimate changes in self-perception and satisfaction in women undegoing breast augmentation surgery (BAS). METHODS: Using a quasi-experimental questionnaire study design, we enrolled a cohort of BAS women treated at a private clinic during a 5-year interval. The primary predictor variable was treatment (before/after). The main outcome variables included effect of considering breast augmentation as one of the most important life events on self-image (BAOMILE), and subjective evaluation of physical appearance and life satisfaction. Other study variables were demographic data. The Mann-Whitney and the Wilcoxon signed-rank tests were used to compare the outcomes between before and after the surgery. The Spearman rank correlation and the Pearson chi-squared test were computed to analyze the relatio nships among variables. RESULTS: The sample consisted of 53 subjects (52.3% married; 40.9% from medium-sized towns) with a mean age of 33.2 ± 6.4 years (range, 21-46). Life satisfaction was significantly increased after BAS in the whole cohort (preop., 7.83 vs. postop., 8.42; P = .003; 95% CI, -0.95 to -0.22) as well as in the BAOMILE subgroup (preop., 7.87 vs. postop., 8.56; P = .011; 95% CI, -1.20 to -0.17). Within the BAOMILE subgroup, there was a positive correlation between the appearance assessment and the number of positive traits before surgery (ρ = 0.63; P = .002; 95% CI, 0.27-0.83) and life satisfaction after surgery (ρ = 0.480; P = .03; 95% CI, 0.06-0.74). CONCLUSIONS: The results of this study suggest that BAS improves self-perception and life satisfaction of the patients. The psychologist's role in understating patient's motivation for cosmetic surgery and the revision of their attitudes towards expected effects require further investigations. PMID: 35140045 | DOI:10.1016/j.bjps.2022.01.018 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Revised donor site skin incision technique for a multivector functioning muscle transfer using the serratus anterior muscle for smile reanimation

xlomafota13 shared this article with you from Inoreader Revised donor site skin incision technique for a multivector functioning muscle transfer using the serratus anterior muscle for smile reanimation Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Jan 31:S1748-6815(22)00064-X. doi: 10.1016/j.bjps.2022.01.049. Online ahead of print. NO ABSTRACT PMID:35140039 | DOI:10.1016/j.bjps.2022.01.049 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mitochondrial DHODH regulates hypoxia-inducible factor 1 expression in OTSCC

xlomafota13 shared this article with you from Inoreader Mitochondrial DHODH regulates hypoxia-inducible factor 1 expression in OTSCC Via American Journal of Cancer Research Am J Cancer Res. 2022 Jan 15;12(1):48-67. eCollection 2022. ABSTRACT Oral tongue squamous cell carcinoma (OTSCC) was one of the most hypoxic tumors with unfavorable outcomes. Hypoxia-inducible factor-1 (HIF-1) signaling was associated with cancer proliferation, lymph node metastasis, angiogenesis and poor prognosis of OTSCC. Dihydroorotate dehydrogenase (DHODH) catalyzed the rate-limiting step in the de novo pyrimidine biosynthesis. The aim of the study was to explore the biological function of DHODH and investigate whether DHODH regulated HIF-1 signaling in OTSCC. Proliferation, migration and anoikis resistance were used to determine the function of DHODH. Western blot and luciferase activity assays were used to determine the regulatory role of DHODH on HIF-1. We found that increased DHODH expression was associated with advanced tumor stage and poorly differentiated tumor in head and neck cancer patients in The Cancer Genome Atlas (TC GA). DHODH enhanced the proliferation and aggressiveness of OTSCC. Moreover, DHODH prompted tumor growth and metastasis in vivo. DHODH promoted transcription, protein stability, and transactivation activity of HIF1A. DHODH-induced HIF1A upregulation in OTSCC can be reversed by reactive oxygen species (ROS) scavenger, indicating that DHODH enhanced HIF1A expression via ROS production. DHODH inhibitor suppressed DHODH-mediated ROS generation and HIF1A upregulation. Targeting DHODH using clinically available inhibitor, atovaquone, might provide a new strategy to treat OTSCC. PMID:35141004 | PMC:PMC8822278 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers

xlomafota13 shared this article with you from Inoreader Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers Via American Journal of Cancer Research Am J Cancer Res. 2022 Jan 15;12(1):17-47. eCollection 2022. ABSTRACT BRCA1 mutation carriers have a greater risk of developing cancers in hormone-responsive tissues like breasts and ovaries. However, this tissue-specific incidence of BRCA1 related cancers remains elusive. The majority of the BRCA1 mutated breast cancers exhibit typical histopathological features of high-grade tumors, with basal epithelial phenotype, classified as triple-negative molecular subtype and have a higher percentage of DNA damage and chromosomal abnormality. Though there are many studies relating BRCA1 with ER-α (Estrogen receptor-α), it has not been reported whether E2 (Estrogen) -ER-α signaling can modulate the DNA repair activities of BRCA1. The present study analyzes whether deregulation of ER-α signaling, arising as a result of E2/ER-α deficiency, could impact the BRCA1 dependent DDR (DNA Damage Response) pathways, predominantly those of DNA-DSB (Dou ble Strand break) repair and oxidative damage response. We demonstrate that E2/E2-stimulated ER-α can augment BRCA1 mediated high fidelity repairs like HRR (Homologous Recombination Repair) and BER (Base Excision Repair) in breast cancer cells. Conversely, a condition of ER-α deficiency itself or any interruption in ligand-dependent ER-α transactivation resulted in delayed DNA damage repair, leading to persistent activation of γH2AX and retention of unrepaired DNA lesions, thereby triggering tumor progression. ER-α deficiency not only limited the HRR in cells but also facilitated the DSB repair through error prone pathways like NHEJ (Non Homologous End Joining). ER-α deficiency associated persistence of DNA lesions and reduced expression of DDR proteins were validated in human mammary tumors. PMID:35141003 | PMC:PMC8822286 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Definitive radiation therapy and liver local therapy in de novo liver metastatic nasopharyngeal carcinoma: Large cohort study

xlomafota13 shared this article with you from Inoreader Definitive radiation therapy and liver local therapy in de novo liver metastatic nasopharyngeal carcinoma: Large cohort study Via Head & Neck Abstract Background We aimed to evaluate patients suitable for definitive radiation therapy (DRT) and liver local therapy (LLT) in addition to palliative chemotherapy (PCT) among those with de novo liver metastatic nasopharyngeal carcinoma (lmNPC). Methods The overall survival (OS) and progression-free survival (PFS) rates were calculated and compared in 610 patients with lmNPC. Results Both the PCT+DRT and PCT+DRT+LLT groups had better survival outcomes than the PCT group. Among patients with complete response/partial response (CR/PR) after PCT, no significant differences in survival rates were observed between those treated with PCT+DRT and PCT+DRT+LLT (2-year PFS: 27.0% vs. 32.9%, p = 0.263). Among patients with progressive disease/stable disease (PD/SD) after PCT, significantly better survival rates were observed in patients treated with PCT+DRT+LLT. Conclusions DRT might benefit patients with lmNPC regardless of the tumor response after PCT. For patients with CR/PR, LLT might not be needed. For patients with PD/SD, LLT might improve survival outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Trends in Subglottic Stenosis Management: Resource Utilization and Pediatric Otolaryngology Training

xlomafota13 shared this article with you from Inoreader Trends in Subglottic Stenosis Management: Resource Utilization and Pediatric Otolaryngology Training Via The Laryngoscope Objectives/Hypothesis The role for endoscopic management in children with subglottic stenosis (SGS) has grown, but there are no data on resource utilization or the impact on surgical training in pediatric otolaryngology. This study hypothesizes that this shift has increased resource utilization and has impacted surgical training by shifting the focus toward more endoscopic techniques. Study Design Retrospective database review. Methods The Kids' Inpatient Database for 2003, 2006, 2009, and 2012 was queried for admissions with the diagnosis of SGS. Surgical caseload was studied using the Accreditation Council for Graduate Medical Education Accreditation data system for 2010 to 2017. Results Admissions with SGS remained constant between 2003 and 2012. Hospital charges per admission did not change between 2003 and 2009 but increased in 2012. Tracheostomy decreased from 10.5% of admissions in 2003 to 6.8% in 2012. The percentage requiring repair of the larynx did not change; other operations on the larynx increased from 4.5% in 2003 to 11.6% in 2012. The median number of laryngoplasties performed per trainee decreased from 14 to nine between 2010 and 2017, whereas the number of laryngoscopy with intervention procedures increased from 34 to 56. Conclusions The evolution of SGS management appears to have led to a decrease in tracheostomy and an increase in certain procedures that may include endoscopic procedures. Recently, there has been a shift in airway surgical training, with trainees logging less open laryngotracheoplasty and more interventional laryngoscopy. Although these trends cannot be directly linked, the changes in trainee surgical experience may be justified by the decrease in larger open procedures and associated resource utilization. Level of Evidence 2c Laryngoscope, 132:S1–S9, 2022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nasal reconstruction with local flaps versus grafts: Long term perspectives

xlomafota13 shared this article with you from Inoreader Nasal reconstruction with local flaps versus grafts: Long term perspectives Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2022 Feb 1:S1748-6815(22)00025-0. doi: 10.1016/j.bjps.2022.01.010. Online ahead of print. NO ABSTRACT PMID:35144904 | DOI:10.1016/j.bjps.2022.01.010 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bacterial meningitis due to the Streptococcus mitis group in children with cerebrospinal fluid leak

xlomafota13 shared this article with you from Inoreader Bacterial meningitis due to the Streptococcus mitis group in children with cerebrospinal fluid leak Via leak of cerebrospinal fluid IDCases. 2022 Jan 13;27:e01406. doi: 10.1016/j.idcr.2022.e01406. eCollection 2022. ABSTRACT The Streptococcus mitis group constitutes a part of the oral flora in humans and has been reported to cause infective endocarditis, brain abscesses, sepsis, pneumonia, and peritonitis. However, the S. mitis group rarely causes meningitis in children. We experienced a case of bacterial meningitis due to the S. mitis group in a 14-year-old girl with Gorham-Stout disease undergoing treatment with sirolimus for skull base osteolysis and cerebrospinal fluid (CSF) leak. Antibiotic treatment was initiated with linezolid and levofloxacin due to allergies against β-lactam antibiotics. On the third treatment day, antibiotics were switched to penicillin G according to CSF culture results, which were positive for penicillin-susceptible S. mitis group. Antibiotic therapy was successfully completed after 14 days without any neurological sequelae. There have apparently been no reports of S. mitis meningitis in pediatric patients with skull base osteolysis and CSF leak as in our case. Our findings suggest that clinicians should be aware of the possibility of S. mitis meningitis for patients with skull base osteolysis and/or CSF leakage. PMID:35145856 | PMC:PMC8801995 | DOI:10.1016/j. idcr.2022.e01406 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Human telomerase reverse transcriptase protein expression is associated with survival in patients with oral squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Human telomerase reverse transcriptase protein expression is associated with survival in patients with oral squamous cell carcinoma Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2022 Jan 15;15(1):29-37. eCollection 2022. ABSTRACT Despite improvements in diagnosis and treatment, the 5-year survival of oral squamous cell carcinoma (OSCC), no matter the location, remains low, averaging 50%. Telomerase is expressed in 85% of malignancies and may play an important role in human carcinogenesis. Its catalytic component is human telomerase reverse transcriptase (hTERT), which has been thought, but not proven, to be involved in survival with OSCC. We investigated whether hTERT protein was a prognostic factor in OSCC by evaluating its association with clinicopathologic findings and OSCC survival. We found that in comparison to patients with high hTERT expression, patients with low hTERT expression survived significantly longer, including a longer 5-year overall survival. In addition, overall survival was significantly correlated to hTERT expression and the histologic grade and N status of the tumo r. Disease-free survival was significantly related to hTERT expression, the histologic grade and N status of the tumor, and mode of invasion. These results suggest that hTERT protein is involved in cervical lymph node metastasis, that its levels may be increased during carcinogenesis, and that it may influence tumor invasion. We believe that this study is the first to demonstrate that OSCC with high hTERT expression carries a worse prognosis than cases with low hTERT expression. PMID:35145581 | PMC:PMC8822205 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of manual and automated digital image analysis systems for quantification of cellular protein expression

xlomafota13 shared this article with you from Inoreader Comparison of manual and automated digital image analysis systems for quantification of cellular protein expression Via Cellular and Molecular Biology Histol Histopathol. 2022 Feb 11:18434. doi: 10.14670/HH-18-434. Online ahead of print. ABSTRACT OBJECTIVE: Quantifying protein expression in immunohistochemically stained histological slides is an important tool for oncologic research. The use of computer-aided evaluation of IHC-stained slides significantly contributes to objectify measurements. Manual digital image analysis (mDIA) requires a user-dependent annotation of the region of interest (ROI). Others have built-in machine learning algorithms with automated digital image analysis (aDIA) and can detect the ROIs automatically. We aimed to investigate the agreement between the results obtained by aDIA and those derived from mDIA systems. METHODS: We quantified chromogenic intensity (CI) and calculated the positive index (PI) in cohorts of tissue microarrays (TMA) using mDIA and aDIA. To consider the different distributions of staining within cellular sub-compartments and diffe rent tumor architecture our study encompassed nuclear and cytoplasmatic stainings in adenocarcinomas and squamous cell carcinomas. RESULTS: Within all cohorts, we were able to show a high correlation between mDIA and aDIA for the CI (p<0.001) along with high agreement for the PI. Moreover, we were able to show that the cell detections of the programs were comparable as well and both proved to be reliable when compared to manual counting. CONCLUSION: mDIA and aDIA show a high correlation in acquired IHC data. Both proved to be suitable to stratify patients for evaluation with clinical data. As both produce the same level of information, aDIA might be preferable as it is time-saving, can easily be reproduced, and enables regular and efficient output in large studies in a reasonable time period. PMID:35146728 | DOI:10.14670/HH-18-434 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.