Ten-year trends in the incidence of microtia: a nationwide population-based study from Taiwan

xlomafota13 shared this article with you from Inoreader Ten-year trends in the incidence of microtia: a nationwide population-based study from Taiwan Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jul 26. doi: 10.1007/s00405-021-07014-x. Online ahead of print. ABSTRACT PURPOSE: Few studies have explored population-based incidence rates of microtia using nationwide data. The aim of this study was to analyze the 10-year secular trends in the incidence of microtia and/or anotia in Taiwan from 2008 to 2017 using nationwide population-based data. METHODS: Patient data were retrieved from Taiwan's National Health Insurance Dataset, after identifying 1152 children aged ≤ 1 year with a first-time diagnosis of microtia or anotia between January 2008 and December 2017. The annual microtia-anotia incidence rate was the sum of new microtia-anotia cases in a year divided by total infant population in the year. Furthermore, we used the annual percent change (APC) to study the secular trend in microtia-anotia incidence rate. RESULTS: The annual incidence rate of microtia-anotia averaged across the 10-year period was 57.7 per 100,000 infants (standard deviation = 8.6). The annual incidence rates of microtia and anotia were 53.3 and 4.4 per 100,000 infants, respectively, during this period. Furthermore, female infants had a higher incidence than males (63.3 vs. 52.4 per 100,000). The incidence of microtia-anotia gradually decreased between 2008 and 2017 with an APC of - 5.64% (95% CI - 9.31 ~ - 1.18%, p = 0.004). Since 2011, females had a significantly higher annual incidence rate of microtia-anotia than males. CONCLUSIONS: The incidence of microtia-anotia was 57.7 per 100,000 infants in Taiwan, which declined during the study period 2008-2017. The female-to-male incidence ratio was 1.21:1. PMID:34309752 | DOI:10.1007/s00405-021-07014-x View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Correlation between functional outcome and the SAMEO-ATO framework

xlomafota13 shared this article with you from Inoreader Correlation between functional outcome and the SAMEO-ATO framework Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jul 26. doi: 10.1007/s00405-021-07000-3. Online ahead of print. ABSTRACT PURPOSE: To evaluate the recently proposed SAMEO-ATO framework for middle ear and mastoid surgery, by correlating it with the functional outcome in a large cohort of patients operated for middle ear and mastoid cholesteatoma in a tertiary referral center. METHODS: We retrospectively included all surgeries for middle ear and mastoid cholesteatoma undergone in our Department between January 2009 and December 2014, by excluding revision surgeries, congenital and petrous bone cholesteatoma. All surgeries were classified according to the SAMEO-ATO framework. The post-operative air bone gap (ABG) was calculated and chosen as benchmark parameter for the correlation analysis. RESULTS: 282 consecutive surgeries for middle ear and mastoid cholesteatoma were released in the study period on a total of 273 patients, with a mean age o f 41.2 years. All patients were followed for an average period of 55.3 months. 54% of patients underwent M2c mastoidectomy (Canal Wall Down, CWD), while the remaining underwent Canal Wall Up (CWU) procedures, being M1b2a mastoidectomy the most common one (33%). Mean pre-operative and post-operative ABGs were 29.2 and 23.5 dB, with a significant improvement (p < 0.0001). 'Mastoidectomy' and 'Ossicular reconstruction' parameters of SAMEO-ATO showed significant association with postoperative ABG, with smaller residual gaps for the classes Mx and On, and worse hearing results for M3a and Ox. CONCLUSION: Our results show the utility of SAMEO-ATO framework, and in particular of 'M' (Mastoidectomy) and 'O' (Ossicular reconstruction) parameters, in predicting the hearing outcome. PMID:34309753 | DOI:10.1007/s00405-021-07000-3 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The influence of dissection on clinical anatomical knowledge for surgical needs

xlomafota13 shared this article with you from Inoreader The influence of dissection on clinical anatomical knowledge for surgical needs Via radiol anat Surg Radiol Anat. 2021 Jul 26. doi: 10.1007/s00276-021-02802-w. Online ahead of print. ABSTRACT PURPOSE: Due to the ongoing discussion of the usefulness of dissection on human bodies in medical curricula, we investigated the influence of anatomical knowledge collected in the dissection course and requested for modules of visceral surgery. METHODS: Students attending the dissection course of topographic anatomy had to answer a questionnaire of 22 questions with focus on anatomical knowledge required for visceral surgical modules. Failure was defined as 13 or fewer correct answers, success categorized as high, good or moderate. The same questionnaire was handed out to 245 students prior to the module on visceral surgery. Students provided information on which regions they had dissected during the course or prior to the module. The results were compared to the result of a written Multiple Choice Question (MCQ) exam of the module visceral surgery (n = 160 students) with an unannounced primary focus on anatomy. RESULTS: Students who dissected the truncal regions of the human body succeeded in answering the questionnaire with high success. Students dissecting regions of the Head/Neck or Limbs had a high failure rate, and none of them reached the "high" success level. In the MCQ exam, students dissecting truncal regions had a high success rate, while those who had not dissected or who dissected the Head/Neck or Limbs had a high failure rate. CONCLUSION: Dissections support and improve the required knowledge for surgical modules. For the visceral surgical module, students dissecting the region prior to the module greatly benefited. Therefore, entire human body dissection assumes to be preferable. PMID:34309713 | DOI:10.1007/s00276-021-02802-w View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prognostic Significance of E-Cadherin, B-Catenin and Cyclin D1 in Oral Squamous Cell Carcinoma: a tissue microarray study

xlomafota13 shared this article with you from Inoreader Prognostic Significance of E-Cadherin, B-Catenin and Cyclin D1 in Oral Squamous Cell Carcinoma: a tissue microarray study Via Cellular and Molecular Biology Histol Histopathol. 2021 Jul 26:18363. doi: 10.14670/HH-18-363. Online ahead of print. ABSTRACT OBJECTIVE: To study the prognostic significance of E-cadherin, B-catenin, and Cyclin D1 expression in oral squamous cell carcinoma. SUBJECTS AND METHODS: The study included 65 subjects with histologically confirmed squamous cell carcinoma. TMA blocks were prepared for immunohistochemical quantification of the expression of the three markers using IHC profiler and Immune ratio plugin of Image J. RESULTS: E-cadherin expression was significantly correlated with histological grades and the metastasis status (p<0.05), whereas B-catenin expression was significantly correlated with smoking and tumor recurrence (P<0.05). Cyclin D1 expression was significantly correlated with depth of invasion and tumor recurrence. (p<0.05). Advanced tumor stage and depth of tumor invasion increases the risk of recurrence or death by 2.5 times (O R= 2.53 and 0.84 respectively). CONCLUSION: High expression of B- Catenin and Cyclin D1 are significantly correlated with tumor recurrence and old age. Depth of invasion , low histological grade and old age were a significant predictor for the risk of having tumor recurrence and cancer related death. PMID:34309825 | DOI:10.14670/HH-18-363 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Use of monopolar microelectrodes and radiofrequency in the treatment of arytenoid edema after partial horizontal laryngectomy and radiotherapy

xlomafota13 shared this article with you from Inoreader Use of monopolar microelectrodes and radiofrequency in the treatment of arytenoid edema after partial horizontal laryngectomy and radiotherapy Via Head & Neck Abstract We evaluated the tissue reduction effects using monopolar microelectrodes (MME) coupled to a radiofrequency (RF) generator in arytenoid edema caused by postoperative radiotherapy in larynx. This is a retrospective transversal study, which included 15 patients with supraglottic laryngeal carcinoma. All the patients had undergone a partial horizontal laryngectomy and bilateral neck dissection followed by postoperative radiotherapy. The studied group of patients presented laryngeal stenosis defined by arytenoid edema as a complication, requiring permanent tracheostomy for mean of 12 months. The surgical procedure for treating the edema was the transoral approach of the larynx by microlaryngoscopy under general anesthesia; using 180° MME coupled to a 4-MHz RF generator delivering 15 W using coagulation mode. A total of 11 (73%) patients were decannulated. The median time for decannulation was 10 weeks. No complications were reported. After 2 years of follow-ups, no case of re -stenosis was found. MME coupled to RF is a very efficient method to treat arytenoid edema after adjuvant radiotherapy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Modeling Recurrence in Idiopathic Subglottic Stenosis With Mobile Peak Expiratory Flow

xlomafota13 shared this article with you from Inoreader Modeling Recurrence in Idiopathic Subglottic Stenosis With Mobile Peak Expiratory Flow Via The Laryngoscope Objectives/Hypothesis We sought to establish normative peak expiratory flow (PEF) data for patients with idiopathic subglottic stenosis (iSGS), evaluate whether immediate changes in PEF after a procedure predict long-term treatment response, and test if a decline in longitudinal PEF is associated with disease recurrence. Study Design International, prospective, 3-year multicenter cohort study of 810 patients with untreated, newly diagnosed, or previously treated iSGS. Methods iSGS patients consented and enrolled in the North American Airway Collaborative (NoAAC) iSGS1000 cohort recorded PEF data on a mobile smartphone app. Cox regression tested the associations between the magnitude of postoperative PEF improvement and longitudinal 90-day PEF decline with the risk of disease recurrence. Results Within the NoAAC iSGS1000 cohort, 810 patients participated in a 3-year prospective study comparing surgical treatment efficacy and 385 had appropriate PEF measurements and follow-up data. Of those patients, 42% (161/385) required at least one operation during study follow-up. The mean PEF preceding operative intervention was 241 L/min (95% confidence interval [CI]: 120–380) corresponding to a predicted PEF of 52%. The mean increase in PEF following a procedure was 111 L/min (95% CI: 96–125 L/min). Interestingly, the magnitude of immediate PEF improvement was not predictive of disease recurrence (hazard ratio [HR] for 100 L/min increase = 0.90, 95% CI: 0.60–1.00). However, recurrence was associated with the magnitude of PEF decline over 90 days (30% vs. 10% decline, HR = 2.2, 95% CI: 1.5–3.0). Conclusions We provide normative PEF data on a large iSGS patient cohort. The degree of PEF improvement immediately after surgery was not associated with a longer procedure-free interval. However, a 30% decline in PEF over 90 days was associated with elevated risk of disease recurrence. Level of Evidence 2 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effectiveness of Mitomycin C in Otolaryngology procedures: A systematic review

xlomafota13 shared this article with you from Inoreader The effectiveness of Mitomycin C in Otolaryngology procedures: A systematic review Via Clinical Otolaryngology Abstract Objective Many studies have evaluated the effectiveness of topical intraoperative mitomycin (MCC) usage in a wide range of Otolaryngologic procedures with variable conclusions on effectiveness. This systematic review aims to provide a qualitative estimation of mitomycin C's treatment effectiveness in maintaining or preventing stenosis after surgical interventions. Design and Main outcome measures Following the PRISMA guideline, a comprehensive systematic search of MEDLINE, EMBASE, and CINAHL databases was performed including hand-searching and cross-reference checking. The search was limited to humans, sample size greater than two, and study designs including a comparative arm. Results 571 unique abstracts and 109 full articles were reviewed. 77 studies were included in the final analysis. The available evidence ranged from case series to randomized control studies. Meta-analysis was deemed inappropriate due to heterogeneity of study design. 38 studies assessed the effective of MCC in dacryocystorhinostomy, which is reported in a separate meta-analysis. All other studies were categorized into otolaryngologic site and pathology including: choanal atresia (n=5), endoscopic sinus surgery (n=12), airway procedures (n=9), esophageal procedures (n=8), and other (n=2). Conclusions The published literature on the effectiveness of MMC was mixed, but suggested topical MMC improved surgical outcomes in many Otolaryngologic procedures compared to controls. This was the first review to assemble literature on MMC usage for different surgical procedures. Comprehensive interpretation of the data was limited due to heterogeneity in primary outcome, procedure type, and study quality. High quality prospective and randomized controlled studies are required to further confirm the positive effect of MMC use on surgical outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Minimally invasive fully ROBOT‐assisted cochlear implantation in humans: preliminary results in five consecutive patients

xlomafota13 shared this article with you from Inoreader Minimally invasive fully ROBOT‐assisted cochlear implantation in humans: preliminary results in five consecutive patients Via Clinical Otolaryngology Abstract - Cochlear implants are medical devices indispensable for the treatment of severe-to-profound bilateral sensorineural hearing loss - The most commonly used surgical procedure for cochlear implantation involves temporal bone drilling associating mastoidectomy with a facial recess approach - Improvements in robot-assisted surgery since 2010 have raised questions about the possibility of "simplifying" cochlear implant surgery - This study showed that the use of robotic assistance coupled to CT guidance for cochlear implantation is possible and apparently safe for the entire procedure using a Robot that is already available worldwide. - Several improvements are required to optimize this procedure View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

“Topical pentoxifylline can be an effective and safe adjunctive therapy to NBUVB therapy in treating vitiligo: a split‐side clinical trial”

xlomafota13 shared this article with you from Inoreader "Topical pentoxifylline can be an effective and safe adjunctive therapy to NBUVB therapy in treating vitiligo: a split‐side clinical trial" Via Experimental Dermatology View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Antimicrobial peptides and proteins: Interaction with the skin microbiota

xlomafota13 shared this article with you from Inoreader Antimicrobial peptides and proteins: Interaction with the skin microbiota Via Experimental Dermatology Abstract The cutaneous microbiota comprises all living skin microorganisms. There is increasing evidence that the microbiota plays a crucial role in skin homeostasis. Accordingly, a dysbiosis of the microbiota may trigger cutaneous inflammation. The need for a balanced microbiota requires specific regulatory mechanisms that control and shape the microbiota. In this review we highlight the present knowledge suggesting that antimicrobial peptides (AMPs) may exert a substantial influence on the microbiota by controlling their growth. This is supported by own data showing the differential influence of principal skin-derived AMPs on commensal staphylococci. Vice versa we also illuminate how the cutaneous microbiota interacts with skin-derived AMPs by modulating AMP expression and how microbiota members protect themselves from the antimicrobial activity of AMPs. Taken together, the current picture suggests that a fine-tuned and well-balanced AMP-microbiota interplay on the skin surface may be cr ucial for skin health. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multimodality‐based knee joint modeling method with bone and cartilage structures for total knee arthroplasty

xlomafota13 shared this article with you from Inoreader Multimodality‐based knee joint modeling method with bone and cartilage structures for total knee arthroplasty Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Objective We propose a robust and accurate knee joint modeling method with bone and cartilage structures to enable accurate surgical guidance for knee surgery. Methods A multimodality registration strategy is proposed to fuse MR and CT images of the femur and tibia separately to remove spatial inconsistency caused by knee bending in CT/MR scans. Automatic segmentation of the femur, tibia, and cartilages is carried out with ROI clustering and intensity analysis based on the multimodal fusion of images. Results Experimental results show that the registration error is 1.13 ± 0.30 mm. The Dice similarity coefficient (DSC) values of the proposed segmentation method of the femur, tibia, femoral and tibial cartilages are 0.969, 0.966, 0.910, and 0.872, respectively. Conclusions This study demonstrates the feasibility and effectiveness of multimodality-based registration and segmentation methods for knee joint modeling. The proposed metho d can provide users with 3D anatomical models of the femur, tibia, and cartilages with few human inputs. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Single assistant vs dual assistant robotic surgery for robot‐assisted laparoscopic hysterectomy using da Vinci Xi or X

xlomafota13 shared this article with you from Inoreader Single assistant vs dual assistant robotic surgery for robot‐assisted laparoscopic hysterectomy using da Vinci Xi or X Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background To verify the usefulness of single assistant robotic surgery (SA-RS) using da Vinci Xi or X performed for total hysterectomy. Methods The SA-RS group (S-group) includes surgeries in which the surgeon performed all surgical operations other than that of the uterine manipulator, while the dual assistant robotic surgery group (D-group) includes surgeries performed by the surgeon with two assistants. In S-group, the forceps and camera were replaced during surgery in cases of a large uterus with limited range of motion of the instrument. A comparative study of patient background, intraoperative and postoperative results and surgery-related cost was performed between the two groups. Results No significant differences were observed between the two groups. On the contrary, S-group showed a significant reduction in preparation time and wound closure time, and a savings of $768. Conclusion SA-RS for total hysterectomy was possible , which is excellent in terms of cost, esthetics, and manpower This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.