Images: Unilateral rhinorrhea in a patient starting autotitrating positive airway pressure therapy for obstructive sleep apnea

xlomafota13 shared this article with you from Inoreader Images: Unilateral rhinorrhea in a patient starting autotitrating positive airway pressure therapy for obstructive sleep apnea Via leak of cerebrospinal fluid J Clin Sleep Med. 2021 Jun 22. doi: 10.5664/jcsm.9470. Online ahead of print. ABSTRACT We rerpot a case of a 65-year-old obese female who developed a unilateral nasal cerebrospinal fluid (CSF) leak after starting autotitrating positive airway pressure therapy for obstructive sleep apnea. The CSF leak was confirmed by beta-2 transferrin testing of the nasal fluid, as well as by identification of the leak through the anterior cribriform plate after administration of intrathecal fluorescein. The CSF leak was successfully repaired endoscopically, and autotitrating positive airway pressure was reinitiated one month postoperatively. PMID:34170244 | DOI:10.5664/jcsm.9470 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Proceedings of the Canadian Thyroid Cancer Active Surveillance Study Group 2019 national investigator meeting

xlomafota13 shared this article with you from Inoreader Proceedings of the Canadian Thyroid Cancer Active Surveillance Study Group 2019 national investigator meeting Via Journal of Otolaryngology - Head & Neck Surgery Active surveillance (AS) in the management of small, low risk papillary thyroid cancer (PTC) as an alternative option to thyroidectomy, is an area of active research. A national Canadian study is proposed to e... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Fixed vs Measured Length of Stapes Prosthesis in Stapes Surgery

xlomafota13 shared this article with you from Inoreader Fixed vs Measured Length of Stapes Prosthesis in Stapes Surgery Via Otolaryngology Indian Abstract Aims The aim of this study is to assess the relationship between the prosthesis length and the outcome of the primary stapes surgery in patients with otosclerosis. Material and Methods This was a retrospective cohort study. We reviewed medical records of 218 patients between January 2015 and August 2020 in two different referral centers. It was conducted in two hospitals by two different well experienced otologic surgeons that one of them believes in fixed length (4.75 mm) of stapes prosthesis (group A) and, the other one believes in measuring the distance between the footplate and incus long process to choose the proper length of prosthesis (group B). The surgery success rates and complications between these two groups were compared 3 months postoperatively. Results Mean age, preoperative bone conduction (BC) audiometric threshold and air-bone gap, postoperative BC and air-bone gap were similar in both groups (All p� ��> 0.05). Vertigo frequency was not significantly different between the two groups (p = 0.303). There were no significant differences regarding the number of favorable postoperative outcomes between group A and B (70 (97.2%) vs. 142(97.3%) respectively) (p = 0.632). Conclusion This study found no significant difference regarding the hearing outcomes between fixed length vs measured length of stapes prosthesis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Survival and toxicity in patients with human papilloma virus‐associated oropharyngeal squamous cell cancer receiving trimodality therapy including transoral robotic surgery

xlomafota13 shared this article with you from Inoreader Survival and toxicity in patients with human papilloma virus‐associated oropharyngeal squamous cell cancer receiving trimodality therapy including transoral robotic surgery Via Head & Neck Abstract Background Patients with oropharyngeal cancer who undergo transoral robotic surgery (TORS) and have high-risk features generally receive adjuvant chemoradiotherapy or trimodality therapy (TMT). The notion that TMT leads to high toxicity is largely based on studies that included human papilloma virus (HPV)-negative cancers and/or nonrobotic surgery; we sought to describe outcomes in HPV-associated oropharyngeal squamous cell cancer (HPV + OPSCC) undergoing TORS-TMT. Methods In consecutive patients with HPV + OPSCC receiving TMT at an academic center from 2010 to 2017, survival was estimated using Kaplan–Meier methodology, and toxicities were ascertained via chart review. Results In our cohort of 178 patients, 5-year survival was 93.6%. Feeding tube rates were 25.8% at therapy completion and 0.7% at 1 year. Rates of grade ≥ 3 kidney injury, anemia, and neutropenia in cisplatin-treated patients were 2.7%, 3.4%, and 11.0%, respectively. Conclusions Patients with HPV + OPSCC who underwent TORS-TMT had excellent survival and low rates of toxicity and feeding tube dependence. These outcomes compare favorably to historical cohorts treated with definitive chemoradiotherapy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Surgical Outcome of Potassium-Titanyl-Phosphate (KTP) Laser Photocoagulation for Vocal Fold Vascular Lesions

xlomafota13 shared this article with you from Inoreader Surgical Outcome of Potassium-Titanyl-Phosphate (KTP) Laser Photocoagulation for Vocal Fold Vascular Lesions Via Voice Publication date: Available online 25 June 2021 Source: Journal of Voice Author(s): Bailey Balouch, Heather Yeakel, Ghiath Alnouri, Matthew Brennan, Vishnu Martha, Robert T. Sataloff View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Acid Test: Proton Pump Inhibitors in Persistent Throat Symptoms: A Systematic Review of Systematic Reviews

xlomafota13 shared this article with you from Inoreader The Acid Test: Proton Pump Inhibitors in Persistent Throat Symptoms: A Systematic Review of Systematic Reviews Via Clinical Otolaryngology Abstract Introduction Proton pump inhibitors (PPIs) have evolved to become a frequent treatment option for patients with persistent throat symptoms. The evidence for their use in this context is, however, conflicting. This review assesses the quality of the published systematic reviews and meta-analyses evaluating PPIs in persistent throat symptoms. Methods Following a literature search, meta-analyses were evaluated using the Reporting of Bias in Systematic Reviews (ROBIS) tool and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Outcome measures were analysed using the 'checklist to operationalize measurement characteristics of patient reported outcome measures'. Results 10 systematic reviews were assessed. All but one were at high risk of bias. No review met the PRISMA checklist criteria. No identified PROM met the checklist requirements for validation. Significant methodological concerns include inappropriate selection of studies for inclusion, poor selection of outcome measures, a lack of appropriate bias assessments and inconsistent reporting of reviews. Conclusion The quality of evidence concerning the role of PPIs in persistent throat symptoms gives serious cause for concern. Collectively, nine studies at high risk of bias have been cited 714 times. Systematic reviews typically attract these high numbers of citations and, if their premises and conclusions do not withstand scrutiny, they are open to widespread misinterpretation, perpetuation of misunderstanding and negative clinical impact. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Characterization of otologic involvement in patients with X‐Linked Hypophosphatemia

xlomafota13 shared this article with you from Inoreader Characterization of otologic involvement in patients with X‐Linked Hypophosphatemia Via Clinical Otolaryngology Abstract In this report of otological involvement in XLH patients, 23% of them presented hearing loss. Patients with hearing loss had higher prevalence of tinnitus and lower serum phosphate compared to patients without hearing loss. Otologic involvement was not significantly associated to the severity of other XLH manifestations. Special attention should be given to children, considering that none of them reported symptoms of hearing loss, but up to one third of them had audiometric abnormalities. An active search strategy of otological involvement is needed in patients with XLH View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The diagnostic utility of clinical exome sequencing in 60 patients with hearing loss disorders: A single‐institution experience

xlomafota13 shared this article with you from Inoreader The diagnostic utility of clinical exome sequencing in 60 patients with hearing loss disorders: A single‐institution experience Via Clinical Otolaryngology Abstract Genetic aetiologies are an important cause of congenital ear anomalies and hearing impairment. Next-generation sequencing (NGS) strategies, such as targeted gene panels or clinical exome sequencing (CES) are effective tools in the diagnosis of patients with inherited hearing impairment, with clear advantages over previous genetic testing approaches. CES in our cohort shows the genetic heterogeneity of syndromic and non-syndromic congenital ear and hearing disorders, highlighting the clinical utility of undergoing genomic investigations. Multidisciplinary decision-making for diagnostic workup and management, including close collaboration between Genetics, Otolaryngology, Audiology and other allied specialties, is key in the investigation of congenital ear and hearing disorders. Timely molecular genetic diagnosis can streamline patient care and potentially improve clinical outcomes. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Role of the Skin Microbiota in the Modulation of Cutaneous Inflammation‐ Lessons from the Gut

xlomafota13 shared this article with you from Inoreader The Role of the Skin Microbiota in the Modulation of Cutaneous Inflammation‐ Lessons from the Gut Via Experimental Dermatology Abstract Inflammation is a vital defence mechanism used to protect the body from invading pathogens, but dysregulation can lead to chronic inflammatory disorders such as psoriasis and atopic dermatitis. Differences in microbiota composition have been observed in patients with inflammatory skin conditions compared with healthy individuals, particularly within lesions. There is also increasing evidence accumulating to support the notion that the microbiome contributes to the onset or modulates the severity of inflammatory diseases. Despite the known protective effects of orally administered lactic acid bacteria against inflammation, few studies have investigated the potential protective effects of topical application of bacteria on skin health and even fewer have looked at the potential anti-inflammatory effects of skin commensals. If lack of diversity and reduction in the abundance of specific commensal strains is observed in inflammatory skin lesions, and it is known that commensal bacteri a can produce anti-inflammatory compounds, we suggest that certain members of the skin microbiota have anti-inflammatory properties that can be harnessed for use as topical therapeutics in inflammatory skin disorders. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Can plantar fibroblast implantation protect amputees from skin injury? A recipe for skin augmentation

xlomafota13 shared this article with you from Inoreader Can plantar fibroblast implantation protect amputees from skin injury? A recipe for skin augmentation Via Experimental Dermatology Abstract Skin injuries remain a persistent problem for users of lower-limb prostheses despite sustained progress in prosthesis design. One factor limiting the prevention of skin injuries is that skin on the residual limb is not suited to bear the mechanical loads of ambulation. One part of the body that is suited to this task is the sole of the foot. Here, we propose a novel strategy to actively augment skin's tolerance to load, increasing its resistance to mechanically induced injuries. We hypothesise that the load tolerance of skin can be augmented by autologous transplantation of plantar fibroblasts into the residual limb dermis. We expect that introducing plantar fibroblasts will induce the overlying keratinocytes to express plantar-specific keratins leading to a tougher epidermis. Using a computational finite element model of a weight-bearing residual limb, we estimate that skin deformation (a key driver of pressure ulcer injuries) could be halved by reprogramming skin to a plantar- like phenotype. We believe this strategy could yield new progress in pressure ulcer prevention for amputees, facilitating rehabilitation and improving quality of life for patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Severe acute orthostatic headache: spontaneous intracranial hypotension (SIH)

xlomafota13 shared this article with you from Inoreader Severe acute orthostatic headache: spontaneous intracranial hypotension (SIH) Via leak of cerebrospinal fluid BMJ Case Rep. 2021 Jun 25;14(6):e243179. doi: 10.1136/bcr-2021-243179. ABSTRACT The most common cause of spontaneous intracranial hypotension headache is a cerebrospinal fluid (CSF) leakage, but the underlying mechanisms remain unknown. Intracranial hypotension is characterised by diffuse pachymeningeal enhancement on cranial MRI features, low CSF pressure and orthostatic headaches mostly caused by the dural puncture. We report a 31-year-old woman who presented to our services with reports of continuous severe bifrontal headache, which increased on sitting up and resolved on lying down. MRI of the cervical and lumbosacral spine showed signs of CSF leak; hence, patient was diagnosed with spontaneous intracranial hypotension headache. A CT-guided epidural blood patch was done at L4-5 with fibrin glue injected at the site of leak. The patient's signs and symptoms improved after the procedure. PMID:34172480 | DOI:10.1136/bcr-2021-243179 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Perceptual awareness negativity: a physiological correlate of sensory consciousness

xlomafota13 shared this article with you from Inoreader Perceptual awareness negativity: a physiological correlate of sensory consciousness Via cortical auditory Trends Cogn Sci. 2021 Jun 22:S1364-6613(21)00146-7. doi: 10.1016/j.tics.2021.05.009. Online ahead of print. ABSTRACT Much research on the neural correlates of consciousness (NCC) has focused on two evoked potentials, the P3b and the visual or auditory awareness negativity (VAN, AAN). Surveying a broad range of recent experimental evidence, we find that repeated failures to observe the P3b during conscious perception eliminate it as a putative NCC. Neither the VAN nor the AAN have been dissociated from consciousness; furthermore, a similar neural signal correlates with tactile consciousness. These awareness negativities can be maximal contralateral to the evoking stimulus, are likely generated in underlying sensory cortices, and point to the existence of a generalized perceptual awareness negativity (PAN) reflecting the onset of sensory consciousness. PMID:34172384 | DOI:10.1016/j.tics.2021.05.009 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.