Glandular Stem Cells in the Skin during Development, Homeostasis, Wound Repair and Regeneration

xlomafota13 shared this article with you from Inoreader Glandular Stem Cells in the Skin during Development, Homeostasis, Wound Repair and Regeneration Via Experimental Dermatology Abstract Glands in the skin are essential for various physiological functions involving exocrine secretion. Like other tissues and organs, they possess the ability to repair injury and self‐renew during homeostasis. Progenitor cells in glands are mostly unipotent but include some multipotent stem cells that function when extensive remodeling or regeneration is required. In this review, using two glandular models in skin, mouse sweat gland and mammary gland, we discuss lineage restriction that develops during glandular morphogenesis, as well as the mechanisms regulating cell fate and plasticity during wound repair and regeneration. Understanding the intrinsic and extrinsic factors that control the behaviors of glandular stem cell and maintain glandular functions will provide insight into future prospects for glandular regeneration. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

NKG2D and its ligands as cytotoxic factors in cutaneous lupus erythematosus

xlomafota13 shared this article with you from Inoreader NKG2D and its ligands as cytotoxic factors in cutaneous lupus erythematosus Via Experimental Dermatology Abstract Cutaneous lupus erythematosus (CLE) is an autoimmune skin disorder that is characterized by an anti‐epidermal lymphocytic infiltrate invading the dermo‐epidermal junction, causing an interface dermatitis (ID). Pathogenesis of CLE has been linked to activation of innate immunity. NKG2D is an innate immune receptor on NK cells and distinct T‐cell populations. The NKG2D ligands MHC class I polypeptide‐related sequence A and B (MICA, MICB) have been associated to CLE susceptibility. Our gene microarray analyses of chronic discoid lupus erythematosus (CDLE) skin lesions, separated in epidermal, junctional and dermal skin areas via laser microdissection, revealed a high expression of NKG2D in the lymphocytic infiltrate and led us to further investigate the role of NKG2D in CLE. Pathway analyses showed a strong "interferon (IFN) signature" and vast activation of innate immune response pathways (TLR, RIG‐I, cytosolic DNA sensing, JAK/STAT) in CDLE, that expressed the high NK G2D signal. Immunohistochemistry (IHC) confirmed the presence of NKG2D and its ligand MICB in CDLE and subacute cutaneous lupus erythematosus (SCLE) lesions. Finally, HaCaT cells were stimulated with nucleic acids and extracted RNA was sequenced with Illumina HiSeq and showed that stressed keratinocytes express typical NKG2D ligands MICA/B and ULBP2. This study provides first evidence that NKG2D is present in CDLE and SCLE skin lesions and could be relevant for cytotoxicity in IFN‐driven skin lesions with upregulated innate immune response pathways present in CLE. It could furthermore play a role in CLE inflammation promoted by keratinocytes under cell stress. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Exclusive Two Handed Endoscopic Cartilage Type 3 Tympanoplasty with Endoscope Holders

xlomafota13 shared this article with you from Inoreader Exclusive Two Handed Endoscopic Cartilage Type 3 Tympanoplasty with Endoscope Holders Via Otolaryngology Indian Abstract In present world of contemporary techniques of microscopic ear surgery and single handed endoscopic ear surgery, we propose the technique of two handed endoscopic tympanoplasty using endoscope holders. The aim of the study  is to evaluate the functional and anatomical results of our technique of endoscopic type 3 cartilage tympanoplasty using endoscope holder. It is a Retrospective Non Randomized Clinical Study. A total of 67 endoscope holder assisted exclusively two handed endoscopic type 3 cartilage tympanoplasties performed from December 2014 to March 2017 with our technique were included in the study. Patients with pars tensa retractions and perforations with absent incus were included in the study. Those with cholesteatoma were excluded from the study. Full thickness tragal cartilage disc of 3 × 3 mm dimensions with a circular slot of 1 mm to fit onto the head of the stapes was used for reconstruction. Tympanic membrane reconstr uction was done along with attic reconstruction, using sliced tragal cartilage of 0.5 mm thickness. Patients were assessed at 6, 12 and 24 months for graft status. In early follow up period ranging from 24 to 52 months, the graft take up was seen in 64 ears with three perforations giving a success rate of 95.52%. The pre-operative air-bone gap was 42.6 ± 3.26 dB and the post-operative air-bone gap at 6 months, 1 and 2 years was 18.36 ± 3.46 dB, 19.42 ± 4.32 dB and 19.53 ± 4.33 dB respectively. The study reports good air-bone closure to 20 dB postoperatively following type 3 endoscopic tympanoplasty using endoscope holder. Slotted cartilage graft is definitely an excellent option for ossiculoplasty in cases of absent incus providing a stable assembly. Level of evidence: Level 4. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Síndrome vestibular agudo paraneoplásico: qué, cuándo y cómo

xlomafota13 shared this article with you from Inoreader Síndrome vestibular agudo paraneoplásico: qué, cuándo y cómo Via Acta Otorrinolaringológica Española Publication date: Available online 9 March 2021 Source: Acta Otorrinolaringológica Española Author(s): Carolina Moreno-de-Jesús, Lucía Prieto-Sánchez-de-Puerta, Irene Mármol-Szombathy, Emilio Domínguez-Durán View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The intraoral growth patterns of parapharyngeal tumors: A proposed classification system

xlomafota13 shared this article with you from Inoreader The intraoral growth patterns of parapharyngeal tumors: A proposed classification system Via ear nose throat Ear Nose Throat J. 2021 Mar 9:145561321997557. doi: 10.1177/0145561321997557. Online ahead of print. ABSTRACT OBJECTIVE: Nearly half of parapharyngeal space (PPS) tumors present as an intraoral mass, which is diagnostically challenging. In this study, we studied whether preoperative growth patterns were associated with histopathological diagnosis for planning surgery. METHODS: We performed a cross-sectional study in patients with PPS tumors. A simplified classification scheme based on intraoral tumor growth patterns (patterns 1 and 2) was then proposed. In pattern 1, tumors bulge submucosally to the oropharynx from the soft palate, with the center convexity above the uvula. In pattern 2, tumors bulge submucosally to the oropharynx from the lateral oropharynx wall, with the center convexity below the uvula. The association of this classification with postoperative histopathological diagnosis and surgical-related events was studied. RESULTS: Twenty-two patients were enrolled in this study (12 with pattern 1, 10 with pattern 2). Of these, 91.7% (11/12) of pattern 1 tumors were salivary gland tumors (P < .001), and 90% (9/10) of pattern 2 tumors were neurogenic (P < .001). Pattern 2 tumors had fewer bleeding complications or needed external approaches when a transoral approach was chosen. CONCLUSIONS: This new classification of PPS tumors facilitates the prediction of salivary gland and neurogenic tumors and can improv e the accuracy of preoperative radiologic diagnosis. This system will be helpful for planning surgical interventions, such as implementing transoral approaches. PMID:33685250 | DOI:10.1177/0145561321997557 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Role of H2B mono-ubiquitination in the initiation and progression of cancer

xlomafota13 shared this article with you from Inoreader Role of H2B mono-ubiquitination in the initiation and progression of cancer Via Association française pour l'étude du cancer Bull Cancer. 2021 Mar 5:S0007-4551(21)00049-7. doi: 10.1016/j.bulcan.2020.12.007. Online ahead of print. ABSTRACT Numerous epigenetic alterations are observed in cancer cells, and dysregulation of mono-ubiquitination of histone H2B (H2Bub1) has often been linked to tumorigenesis. H2Bub1 is a dynamic post-translational histone modification associated with transcriptional elongation and DNA damage response. Histone H2B monoubiquitination occurs in the site of lysine 120, written predominantly by E3 ubiquitin ligases RNF20/RNF40 and deubiquitinated by ubiquitin specific peptidase 22 (USP22). RNF20/40 is often altered in the primary tumors including colorectal cancer, breast cancer, ovarian cancer, prostate cancer, and lung cancer, and the loss of H2Bub1 is usually associated with poor prognosis in tumor patients. The purpose of this review is to summarize the current knowledge of H2Bub1 in transcription, DNA damage response and primary tu mors. This review also provides novel options for exploiting the potential therapeutic target H2Bub1 in personalized cancer therapy. PMID:33685627 | DOI:10.1016/j.bulcan.2020.12.007 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Presbylarynx: stratifying endoscopic signs for future researches

xlomafota13 shared this article with you from Inoreader Presbylarynx: stratifying endoscopic signs for future researches Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 8. doi: 10.1007/s00405-021-06735-3. Online ahead of print. NO ABSTRACT PMID:33686485 | DOI:10.1007/s00405-021-06735-3 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Free and total vitamin d in psoriatic patients treated with biological drugs

xlomafota13 shared this article with you from Inoreader Free and total vitamin d in psoriatic patients treated with biological drugs Via Experimental Dermatology Abstract Data regarding the association between psoriasis and vitamin D levels are controversial [S1‐S2], maybe due to the choice of dosing serum total 25(OH)D in order to assess the vitamin D nutritional state both at its basal levels and after supplementation [S3‐S4]. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Free and total vitamin d in psoriatic patients treated with biological drugs

xlomafota13 shared this article with you from Inoreader Free and total vitamin d in psoriatic patients treated with biological drugs Via Experimental Dermatology Abstract Data regarding the association between psoriasis and vitamin D levels are controversial [S1‐S2], maybe due to the choice of dosing serum total 25(OH)D in order to assess the vitamin D nutritional state both at its basal levels and after supplementation [S3‐S4]. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Uvula Manipulation and Resonance (UMAR) Treatment for Puberphonia

xlomafota13 shared this article with you from Inoreader Uvula Manipulation and Resonance (UMAR) Treatment for Puberphonia Via Otolaryngology Indian Abstract Otolaryngologists and speech therapist can be experts in managing specific puberphonia lesions to improve voice. However, not all voice problems have lesions amenable to surgical or medical therapies. Many are associated with maladaptive speech behaviors. We may employ a variety of techniques to improve vocal quality and function in patients with and without structural or neurologic laryngeal pathology. There is an alarming increase in cases of puberphonia and it's after effects. Otolaryngologists can partner to manage a constellation of puberphonia voice problems with directed voice evaluation and therapy. We, in a small Otorhinolarygolist center in a small city, Chennai has registered and treated 600 cases of puberphonia. We are able to register the devastating problems of puberphonia. Regarding the treatment of puberphonia, in which laryngeal massage, outside the neck, is consistently highlighted as being an effective therapy technique for treating it. In ad dition, there have been several individual studies conducted to examine the effectiveness of laryngo pharyngeal manipulation inside the vocal tract, which also yielded positive results. A basic review of UMAR techniques and this partnership with yoga breathing trainers is presented which give almost immediate low pitch speech and give a good follow up. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Letter to Editor on “Changes in Acoustic Aspects of Voice Function in Children After Adenotonsillectomy”

xlomafota13 shared this article with you from Inoreader Letter to Editor on "Changes in Acoustic Aspects of Voice Function in Children After Adenotonsillectomy" Via Journal of Voice We read with great interest the article by Brkic et al on changes in Acoustic Aspects of Vocal Function in Children After Adenotonsillectomy.1 They have reported significant differences in the fundamental frequency, jitter, shimmer and harmonic noise ratio immediately after surgery.1 Of these the fundamental frequency was the earliest to return to normal in one month. This finding is used to allay the concerns of the parents regarding voice change. We commend the authors for sharing their valuable experience with voice change after adenotonsillectomy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The clinical anatomy of variations of the pectoralis minor

xlomafota13 shared this article with you from Inoreader The clinical anatomy of variations of the pectoralis minor Via radiol anat Surg Radiol Anat. 2021 Mar 9. doi: 10.1007/s00276-021-02703-y. Online ahead of print. ABSTRACT Shoulder pathology is a very common medical presentation and can be due to anatomical variations. Therefore, knowledge of variants is important for the clinician treating patients with such complaints so that misdiagnosis is minimized and iatrogenic injury prevented. A review of the literature was performed of the variant anatomy of the pectoralis minor muscle. The aim of this revi ew is to better inform clinicians who might treat patients with shoulder pathology so that if identified, variants of the pectoralis minor muscle are better appreciated. PMID:33687490 | DOI:10.1007/s00276-021-02703-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.