De Novo vs Inverted Papilloma–Associated Sinonasal Squamous Cell Carcinoma Survival Outcomes

Greek DailyNews shared this article with you from Inoreader De Novo vs Inverted Papilloma–Associated Sinonasal Squamous Cell Carcinoma Survival Outcomes Via JAMA Otolaryngology–Head & Neck Surgery Online First This systematic review and meta-analysis uses data from studies retrieved f rom an Ovid Medline, Embase, Scopus, and Cochrane Library database search to investigate survival differences between de novo and inverted papilloma–associated sinonasal squamous cell carcinoma pathogenesis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prevalence of anemia among patients with solid cancers at diagnosis

Greek DailyNews shared this article with you from Inoreader Prevalence of anemia among Saudi patients with solid cancers at diagnosis in King Faisal Hospital, Taif Province, Kingdom of Saudi Arabia Via Head and neck cancers by Mazen Almehmadi, Magdi Salih, Tariq E. Elmissbah, Abdulaziz Alsharif, Naif Alsiwiehri, Khalid Alzahrani, Alaa Shafie, Haytham Dahlawi Objectives The aim of this study was to estimate the prevalence of anemia among patients newly diagnosed with solid malignancies at King Faisal Hospital in Taif Province, Kingdom of Saudi Arabia. Methods A descriptive, cross-sectional, hospital-based study was conducted from December 2017 to March 2020. A total of 320 patients newly diagnosed with solid malignancy were examined to assess anemia prevalence. Results Of 320 patients with solid cancers, 245 (76.6%) were female and 75 (23.4%) were male. The median (interquartile range) age of 57 (45 ─ 66) years, range between 16 and 108 years. The types of cancer included were breast (29.1%), female genital tract (20.0%), colorectal (25.3%), head and neck (10.3%), urinary bladder (4.7%), prostate (5.0%), lung (2.5%), liver (2.2%) and lymphoma (0.9%). The prevalence of anemia at diagnosis of cancer was 44.1% across all cancer types. A higher anemia prevalence was noted in colorectal (n = 46/81, 56.8%) (p = 0.047). Conclusion Patients with colorectal or female genital tract cancers had a higher anemia prevalence (56.8% and 43.8%, respectively) than did patients with other cancers. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Possible Role of Sclerostin in the Pathogenesis of Tympanosclerosis

Greek DailyNews shared this article with you from Inoreader The Possible Role of Sclerostin in the Pathogenesis of Tympanosclerosis Via AUD : Last 10 articles Objective: The aim of this study was to investigate sclerostin (SOST) expression in a rat model of experimental tympanosclerosis (TS) and its possible role in the formation of TS. Materials and Methods: Thirty-four SD rats were randomly divided into 2 groups: experimental group (n = 17) and normal group (n = 17). The left tympanic cavities in the experimental group were inoculated with methicillin-resistant Staphylococcus aureus. The changes of t ympanic membranes were examined and recorded under otoendoscope. Haematoxylin-eosin staining was adopted to detect the morphological changes in the tympanic membrane and middle ear mucosa. Immunohistochemistry and Western blot analysis were used to observe the expression of SOST, Wnt3a, β-catenin, and P-ERK1/2. Results: In the experimental group, sclerotic lesions were observed in 54.5% ears in the end of 6 weeks. Morphological changes such as mucosa incrassation, inflammatory cells infiltration, fibrous tissue proliferation, and interstitial tissue incrassation prominently appeared in the tympanic membrane and middle ear mucosa. SOST protein was mainly distributed in the cytoplasm of epithelial cells and gland cells, the expression of which increased significantly in the calcified experimental ears. In addition, expression levels of Wnt3a, β-catenin, and P-ERK1/2 increased significantly in the calcified group too. Conclusion: The upregulated expression level of SOST may be involved in the formation of TS, first, through the pro-phosphorylation of ERK1/2 in the inflammatory stage, and then through the enhancement of Wnt3a in the osteogenic stage. Audiol Neurotol View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art

Greek DailyNews shared this article with you from Inoreader Stem Cells and Gene Therapy in Progressive Hearing Loss: the State of the Art Via Journal of the Association for Research in Otolaryngology Abstract Progressive non-syndromic sensorineural hearing loss (PNSHL) is the most common cause of sensory impairment, affecting more than a third of individuals over the age of 65. PNSHL includes noise-induced hearing loss (NIHL) and inherited forms of deafness, among which is delayed-onset autosomal dominant hearing loss (AD PNSHL). PNSHL is a prime candidate for genetic therapies due to the fact that PNSHL has been studied extensively, and there is a potentially wide window between identification of the disorder and the onset of hearing loss. Several gene therapy strategies exist that show potential for targeting PNSHL, including viral and non-viral approaches, and gene editing versus gene-modulating approaches. To fully explore the potential of these therapy strategies, a faithful in vitro model of the human inner ear is needed. Such models may come from induced pluripotent stem cells (iPSCs). The development of new treatment modalities by combining iPSC modeling with novel and innovative gene therapy approaches will pave the way for future applications leading to improved quality of life for many affected individuals and their families. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

5 things to know about capnography and respiratory distress

Greek DailyNews shared this article with you from Inoreader 5 things to know about capnography and respiratory distress Via Airway Management RSS Feed Understand how monitoring end-tidal carbon dioxide helps assess and treat a patient in respiratory distress Attachments: View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma

xloma.fota13 shared this article with you from Inoreader The systemic inflammation response index predicts the survival of patients with clinical T1‐2N0 oral squamous cell carcinoma Via Oral Diseases Abstract Objective The systemic inflammation response index (SIRI) is an independent prognostic factor for many malignant tumors. However, the value of this factor in patients with clinical T1‐2N0 (cT1‐2N0) oral squamous cell carcinoma (OSCC) is still unclear. Methods We calculated SIRI of 235 cT1‐2N0 OSCC patients from 2013 to 2017. Multivariate cox regression analysis was applied to verify the prognostic significance of SIRI. Kaplan‐Meier curves were plotted to analyze the overall survival (OS) and disease‐specific survival (DSS) for cT1‐2N0 OSCC patients. Results According to the optimal cutoff point of SIRI, we divided cT1‐2N0 OSCC patients into high SIRI group (SIRI ≥ 1.3) and low SIRI group (SIRI < 1.3). SIRI was an independent prognostic indicator for OS (HR = 2.87; 95% CI = 1.35‐6.10; P = 0.006) and DSS (HR = 2.17; 95% CI = 1.10‐4.27; P = 0.025). High SIRI had a significantly poorer OS (P = 0.001) and DSS (P = 0.007) in survival analysis than the low SIRI. Moreover, the prognostic value of SIRI was significantly stronger than neutrophil‐to‐lymphocyte ratio (NLR) and monocyte‐to‐lymphocyte ratio (MLR). Conclusions Preoperative SIRI can be regarded as a meaningful indicator for poor survival of cT1‐2N0 OSCC patients, and it is a promising tool to formulate the best individualized treatment for high‐risk patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Age‐related dental phenotypes and tooth characteristics of FAM83H‐associated hypocalcified amelogenesis imperfect

xloma.fota13 shared this article with you from Inoreader Age‐related dental phenotypes and tooth characteristics of FAM83H‐associated hypocalcified amelogenesis imperfect Via Oral Diseases Abstract Objectives Autosomal‐dominant hypocalcified amelogenesis imperfecta (ADHCAI) shows phenotypic heterogeneity. Our aim was to characterise the ADHCAI phenotypes, tooth properties, and genotypes. Methods Three unrelated ADHCAI probands and seven additional affected members of the three families were recruited. Mutations were identified by exome and Sanger sequencing, and haplotypes by SNP array. Tooth colour, roughness, density, nanohardness, minerals, and ultrastructure were investigated. Results Ten participants were heterozygous for the FAM83H mutation c.1387C>T (p.Gln463*). All shared a 3.43 Mbp region on chromosome 8q24.3 encompassing the FAM83H variant, indicating a common ancestry. The c.1387C>T was estimated to be 23.8 generations or 600 years. The FAM83H enamel had higher roughness and lower lightness, density, nanohardness, and calcium and phosphorus levels than controls. Blunted enamel rods, wide interrod spaces, and disorganized dentinoenamel junctions were observed. Evaluating the patients with the same mutation and reviewing others with different mutations in FAM83H revealed that the FAM83H heterogeneous phenotypes are age‐influenced. Tooth colour and surface texture change with aging. Conclusions FAM83H enamel demonstrated decreased lightness, density, hardness, calcium, phosphorus, and defective ultrastructure. We have identified that the phenotypic variation in FAM83H‐associated ADHCAI is age‐related. Awareness of the correlation between age and clinical features of FAM83H‐ADHCAI can help dentists make an accurate diagnosis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.