Brief Communication PD1-related Nephrotoxicity: Optimizing Its Clinical Management Through Histopathologic Features

alwin shared this article with you from Inoreader Brief Communication PD1-related Nephrotoxicity: Optimizing Its Clinical Management Through Histopathologic Features Via Journal of Immunotherapy Immune-related nephrotoxicity (ir-N) is a rare adverse event of immune-checkpoint(s) inhibitors (ICI) therapy and its clinical management is still debated. Among 501 consecutive ICI-treated patients at our Institution, 6 who developed an ir-N with clinical signs suggestive for an acute kidney injury underwent kidney biopsy. Histology showed an acute tubule-interstitial nephritis, simulating the scenario of acute T-cell–mediated kidney transplant rejection. Thus, the management of allograft kidney rejection routinely utilized at our clinic was implemented, leading to rapid renal function improvement. Histologic features supporting the definition of an immune-mediated acute kidney injury in ICI-treated patients may help optimizing the clinical management of ir-N. (Source: Journal of Immuno... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A novel antimicrobial peptide derived from human BPIFA1 protein protects against < em > Candida albicans < /em > infection

alwin shared this article with you from Inoreader A novel antimicrobial peptide derived from human BPIFA1 protein protects against < em > Candida albicans < /em > infection Via Innate Immunity Innate Immun. 2022 Feb 24:17534259221080543. doi: 10.1177/17534259221080543. Online ahead of print.ABSTRACTBactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is an innate immunity defense protein. Our previous studies proved its antibacterial and antiviral effects, but its role in fungi remains unknown. The study aimed to identify antifungal peptides (AFP) derived from BPIFA1, and three antimicrobial peptides (AMP1-3) were designed. The antifungal effects were proved by growth inhibition assay. AMP3 activity was confirmed by germ tube growth experiment and XTT assay. Its effects on cell wall and membrane of Candida albicans were assessed by tannic acid and Annexin V-FITC/PI double staining, respectively. Additionally, scanning electron microscope (SEM) and tra... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol

alwin shared this article with you from Inoreader Hyperbaric Oxygen as Adjunctive Therapeutic in Management of Craniocervical Necrotizing Fasciitis: Case Series and Treatment Protocol Via Journal of Oral and Maxillofacial Surgery Odontogenic infections are commonly encountered in OMS practices. Rarely, odontogenic infections can progress into craniocervical necrotizing fasciitis (CCNF). CCNF of the head and neck is a rare, potentially lethal disease process involving infection and subsequent destruction of fascial planes. Mortality ranges from 33% to 50% if the mediastinum is involved.1,2 CCNF diagnosis is based on clinical suspicion. Typical findings include dishwater-like purulence and easy spread of fascial planes using fingers.3 Treatment for CCNF usually consists of aggressive surgical debridement, source control, and intravenous antibiotics. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Can Positioning an Oral Endotracheal Tube in the Retromolar Space Allow Maxillomandibular Fixation without Occlusal Interference?

alwin shared this article with you from Inoreader Can Positioning an Oral Endotracheal Tube in the Retromolar Space Allow Maxillomandibular Fixation without Occlusal Interference? Via Journal of Oral and Maxillofacial Surgery Traumatic maxillofacial injuries requiring maxillomandibular fixation (MMF) traditionally necessitate airway management via tracheostomy or submental intubation. The aim of this study is to understand whether the retromolar space can accommodate passage of a reinforced endotracheal tube (ETT) without interfering with establishing MMF, a technique previously described as retromolar intubation. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Improved Quality of Living following Simultaneous Condylectomy and Orthognathic Surgery: A Retrospective Analysis for Active Unilateral Condylar Hyperplasia

alwin shared this article with you from Inoreader Improved Quality of Living following Simultaneous Condylectomy and Orthognathic Surgery: A Retrospective Analysis for Active Unilateral Condylar Hyperplasia Via Journal of Oral and Maxillofacial Surgery The objective was to assess quality of life in patients who underwent simultaneous condylectomy and orthognathic surgery in conjunction with orthodontic treatment for active unilateral condylar (TMJ) hyperplasia. This pathologic process leads to the development of esthetic and functional concerns. High condylectomy (7-10mm of bone removed from condylar process) simultaneously performed with orthognathic surgery is the treatment studied1, but currently, there is no published literature that analyzes patient satisfaction. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions?

alwin shared this article with you from Inoreader Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions? Via Journal of Oral and Maxillofacial Surgery It is unclear whether certain bacteria initiate the development of inflammatory jaw conditions, or whether these diseases create a milieu for dysbiosis and secondary colonization of indigenous flora. At present, there are no comparative studies on the types of bacteria that colonize different inflammatory jaw conditions. Accordingly, this study aims to identify and compare the types of bacteria isolated in osteomyelitis, osteoradionecrosis, and MRONJ. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.