IgG4-Related Disease and the Salivary Glands

xlomafota13 shared this article with you from Inoreader IgG4-Related Disease and the Salivary Glands Via Otolaryngologic Clinics of North America IgG4-related disease is a rare, immune-mediated, systemic disease that is characterized by soft tissue lymphocyte infiltration and resultant fibrosis. The salivary glands are among the most commonly affected organs. Patients present with subacute submandibular and/or parotid swelling and sialadenitis. Diagnosis incorporates clinical, serologic, radiologic, and pathologic findings. Most cases respond quickly to systemic glucocorticoids. IgG4-related disease mimics many infectious, inflammatory, and neoplastic diseases. Therefore, IgG4-related disease is frequently misdiagnosed. A knowledge of the pathophysiology, diagnosis, and management of IgG4-related disease is important for providers who treat salivary gland diseases. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extent and Indications for Elective and Therapeutic Neck Dissection for Salivary Carcinoma

xlomafota13 shared this article with you from Inoreader Extent and Indications for Elective and Therapeutic Neck Dissection for Salivary Carcinoma Via Otolaryngologic Clinics of North America Although salivary gland malignancies account for only a small percentage of all head and neck cancers, the incidence is increasing. Furthermore, there is a wide variety of histologic subtypes which must be taken into account in the context of their location. Each is associated with a different rate of regional metastasis and overall survival. This article examines the incidence of salivary gland malignancies and provides evidence for the indications for and extent of elective or therapeutic neck dissection based on location, pathologic type, and histopathologic characteristics. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Observation Rather than Surgery for Benign Parotid Tumors

xlomafota13 shared this article with you from Inoreader Observation Rather than Surgery for Benign Parotid Tumors Via Otolaryngologic Clinics of North America Surgery is the preferred treatment of benign parotid lesions, but it carries a risk of complications. Therefore, the approach toward the surgery of these lesions should seek to avoid complications. There are no guidelines or recommendations for when not to operate. Integration of comorbidities and other factors shift the scales from surgery toward observation in a small subset of patients presenting with parotid tumors. When observation is chosen, the patient should be followed frequently and cautiously, and the surgeon should be prepared to change strategy to surgical excision if in doubt. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Practical Salivary Ultrasound Imaging Tips and Pearls

xlomafota13 shared this article with you from Inoreader Practical Salivary Ultrasound Imaging Tips and Pearls Via Otolaryngologic Clinics of North America Ultrasound imaging is a valuable and effective clinical tool for salivary gland disorder evaluation and management. Pathologies including salivary duct stenosis, sialolithiasis, neoplasms, and autoimmune disorders have characteristic sonographic features. Maneuvers such as bimanual palpation and oral administration of sialagogues during the ultrasound examination can enhance examination findings. Ultrasound guidance is useful for targeting needle biopsies of neoplasms, ensuring appropriate intraparenchymal gland injections, and augmenting salivary duct instrumentation and intraoperative management. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Olig2 knockdown alleviates hypoxic-ischemic brain damage in newborn rats

xlomafota13 shared this article with you from Inoreader Olig2 knockdown alleviates hypoxic-ischemic brain damage in newborn rats Via Cellular and Molecular Biology Histol Histopathol. 2021 May 20:18344. doi: 10.14670/HH-18-344. Online ahead of print. ABSTRACT OBJECTIVES: Neuronal damage is an important pathological mechanism in neonatal hypoxic-ischemic brain damage (HIBD). We found in our previous studies that oligodendrocyte transcription factor 2 (Olig2) downregulation was able to increase cell survival in the brain. However, the specific mechanism has yet to be clarified. METHODS: Sprague-Dawley rats aged 3 d were randomly divided into three groups: the normal control group, the Olig2-RNAi group, and the RNAi-negative control group. The normal control group received no treatment, the Olig2-RNAi group received the Olig2 RNAi adenovirus, and the RNAi-negative control group was given the control adenovirus after the completion of the HIBD model. Infarct lesions and their volumes were observed by triphenyltetrazolium chloride (TTC) staining 3 d after the completion of the adenovirus local i njection. The condition of the tissue was characterized by hematoxylin-eosin staining 7 d after the model was established, and cell viability was determined by azure methylene blue staining. Subcellular damage was analyzed by transmission electron microscopy. Rotarod analysis was performed to detect moving behavior ability and an MWM assay was conducted to evaluate the memory. RESULTS: TTC staining showed a smaller brain injury area in the Olig2-RNAi group than in the RNAi-negative control group. Hematoxylin-eosin staining indicated the presence of severe cell injury in the hippocampal region after HIBD, which improved after Olig2 knockdown. Azure methylene blue staining and electron microscopy results suggested that the cells improved after Olig2 knockdown. The rats stayed longer on the rotating rod, and their latency in the water maze test was gradually shortened relative to that of the rats in the Olig2-RNAi negative control group. CONCLUSION: Olig2 knockdown can prom ote the repair of hypoxic-ischemic brain damage in newborn rats. PMID:34013967 | DOI:10.14670/HH-18-344 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The displacement technique: a simple method for clearing maxillary sinus stubborn mucus

xlomafota13 shared this article with you from Inoreader The displacement technique: a simple method for clearing maxillary sinus stubborn mucus Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 May 20. doi: 10.1007/s00405-021-06874-7. Online ahead of print. ABSTRACT BACKGROUND: Clearing thick secretions from the hidden crevices of the maxillary sinus can be challenging and can increase operative time during endoscopic sinus surgery. METHODS: We demonstrate the Displacement Technique as a user-friendly technique to address thick secretions within the maxillary sinus barring no orbital floor dehiscence. First, a wide maxillary antrostomy is performed. Then, a surgical pledget is placed in the maxillary sinus to displace the inspissated content into the nasal cavity using a curved suction. This process is repeated as necessary. CONCLUSION: The displacement technique is a simple and inexpensive method for addressing stubborn secretions. PMID:34014361 | DOI:10.1007/s00405-021-06874-7 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prognostic value of MTA1, SOX4 and EZH2 expression in esophageal squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Prognostic value of MTA1, SOX4 and EZH2 expression in esophageal squamous cell carcinoma Via Experimental and therapeutic medicine Exp Ther Med. 2021 Jul;22(1):722. doi: 10.3892/etm.2021.10154. Epub 2021 May 3. ABSTRACT Esophageal cancer has always been one of the major malignant tumor types affecting the health of the Chinese population. Metastasis-associated protein 1 (MTA1), SOX4 and enhancer of zeste homolog 2 (EZH2) are all potent inducers of invasion and metastasis in esophageal squamous cell carcinoma (ESCC). However, the role of these signaling molecules and their implication in ESCC have remained largely elusive. In the present study, the effects of MTA1, SOX4 and EZH2 on the prognosis of patients with ESCC were explored. Immunohistochemistry was used to examine the expression levels of MTA1, SOX4 and EZH2. The χ2 test was used to analyze the association between protein expression and clinicopathological parameters. Kaplan-Meier curves and Cox proportional hazards model survival analysis was performed to investigate the effects of the three pr oteins examined on disease prognosis. The results indicated that MTA1 may be used as a prognostic and diagnostic marker for ESCC. To the best of our knowledge, the present study was the first to demonstrate that MTA1-SOX4 signaling is associated with prognosis in ESCC. However, no significant association was noted between SOX4 and EZH2 in the present study, which was inconsistent with previously reported findings. The function of the MTA1-SOX4-EZH2 axis and the interactions of the proteins involved require further investigation. PMID:34007331 | PMC:PMC8120658 | DOI:10.3892/etm.2021.10154 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.