Δευτέρα 22 Νοεμβρίου 2021

Cochlear implantation in LEOPARD syndrome: our experience with three patients

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Abstract

LEOPARD syndrome is a rare hereditary disease characterized by several congenital defects in multiple organs, including sensorineural hearing impairment. LEOPARD syndrome is caused by mutations in the PTPN11 gene, and different PTPN11 mutations are associated with different clinical features. Cochlear implantation (CI) can potentially benefit LEOPARD syndrome patients with profound sensorineural hearing impairment. The CI outcomes in LEOPARD syndrome patients are influenced by the PTPN11 genotypes, because different PTPN11 mutations confer different pathogenicity on neurocognitive development. Genetic testing is of prognostic value in the management of LEOPARD syndrome.

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Assessment of swallow function pre and post‐endoscopic CO2 laser medial arytenoidectomy: a case series

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Abstract

Endoscopic CO2 laser medial arytenoidectomy is performed for glottic stenosis however post-operative aspiration remains a risk Pre-operative and post-operative objective and subjective assessments of swallow function were evaluated There was no statistically significant difference when comparing pre- and post-operative penetration-aspiration scores or subjective swallow function If baseline swallow is impaired, this should not preclude the patient from arytenoidectomy; baseline FEES is essential to aid surgical planning and inform patient consent 'Staged arytenoidectomy' should be performed as a swallow-preserving procedure

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The Value of Diversity, Equity, and Inclusion in Otolaryngology

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Diversity impacts performance of our teams, fosters innovation, and improves outcomes of our patients in otolaryngology head and neck surgery. In addition to the moral imperative, increasing the otolaryngology diversity workforce will decrease health care disparities while equity and justice can increase the culture humility to take care of an increasingly diverse patient population. To move toward justice, otolaryngology departments need to end biases in faculty hiring, development, research evaluations, and publication practices. The more intentional our efforts, the more benefit to our patients, providers, staff, learners, and society.
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Honesty and Transparency, Indispensable to the Clinical Mission—Part III

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The hidden epidemic of burnout exacts a staggering toll on professionals and patients, reflected in increased risk of medical errors, complications, and staff turnover. For surgeons, nurses, and other team members working at the sharp end of care, adverse events can amplify work exhaustion, interpersonal disengagement, and risk of moral adversity. Visionary leaders are not content to mitigate burnout and moral injury; they elevate the human experience throughout health care by modeling wellness, fostering moral courage, promoting safety of professionals, and restoring joy in work. Part 3, Health Professional Wellness and Resilience, introduces the final pillar for advancing the clinical mission.
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“Business” Is not a Four-Letter Word

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Remember back to when you decided you wanted to be a physician? You made the conscious decision to study instead of going out, to spend your weekends and evenings buried in books and memorization, maybe even foregoing that really interesting humanities course because you had to "ace" organic chemistry. You did this because you wanted to be a doctor to help people and make a difference in this world, and that's what you told your medical school interviewers. Me, too. Not one of us said, "I want to be a doctor and make sure I run my business profitably so that I can pay my staff and myself fairly and stay in business to continue to help more patients and provide for my family and retire comfortably." Likewise, our curricula in medical school were rich in basic and clinical sciences, and more recently in ethics and communication, but, all along training, information continues to be sparse regarding business basics, employment and insurance negotiations, the intricacies o f human resource management, billing, coding and getting paid, what to do in case you are sued, and how to plan for your and your family's financial future.
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The log odds of positive neck lymph nodes is a superior lymph node predictor for overall survival in head and neck cancer: a population-based analysis in Germany

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Eur Arch Otorhinolaryngol. 2021 Nov 22. doi: 10.1007/s00405-021-07176-8. Online ahead of print.

ABSTRACT

BACKGROUND: This population-based study investigated the influence of different lymph node (LN) classifications on overall survival (OS) in head and neck cancer (HNC).

METHODS: 401 patients (median age: 57 years; 47% stage IV) of the Thuringian cancer registries with diagnosis of a primary HNC receiving a neck dissection (ND) in 2009 and 2010 were included. OS was assessed in relation to total number of LN removed, number of positive LN, LN ratio, and log odds of positive LN (LODDS).

RESULTS: Mean number of LODDS was 0-0.96 ± 0.57. When limiting the multivariate analysis to TNM stage, only the UICC staging (stage IV: HR 9.218; 95% CI 2.721-31.224; p < 0.001) and LODDS > - 1.0 (HR 2.120; 95% CI 1.129-3.982; p = 0.019) were independently associated with lower OS.

CONCLUSION: LODDS was an independent and superi or predictor for OS in HNC in a population-based setting with representative real-life data.

PMID:34807283 | DOI:10.1007/s00405-021-07176-8

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The log odds of positive neck lymph nodes is a superior lymph node predictor for overall survival in head and neck cancer: a population-based analysis in Germany

xlomafota13 shared this article with you from Inoreader

Eur Arch Otorhinolaryngol. 2021 Nov 22. doi: 10.1007/s00405-021-07176-8. Online ahead of print.

ABSTRACT

BACKGROUND: This population-based study investigated the influence of different lymph node (LN) classifications on overall survival (OS) in head and neck cancer (HNC).

METHODS: 401 patients (median age: 57 years; 47% stage IV) of the Thuringian cancer registries with diagnosis of a primary HNC receiving a neck dissection (ND) in 2009 and 2010 were included. OS was assessed in relation to total number of LN removed, number of positive LN, LN ratio, and log odds of positive LN (LODDS).

RESULTS: Mean number of LODDS was 0-0.96 ± 0.57. When limiting the multivariate analysis to TNM stage, only the UICC staging (stage IV: HR 9.218; 95% CI 2.721-31.224; p < 0.001) and LODDS > - 1.0 (HR 2.120; 95% CI 1.129-3.982; p = 0.019) were independently associated with lower OS.

CONCLUSION: LODDS was an independent and superi or predictor for OS in HNC in a population-based setting with representative real-life data.

PMID:34807283 | DOI:10.1007/s00405-021-07176-8

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