Activated pyrin domain containing 3 (NLRP3) inflammasome in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP).

Activated pyrin domain containing 3 (NLRP3) inflammasome in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP).:

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Activated pyrin domain containing 3 (NLRP3) inflammasome in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP).

J Allergy Clin Immunol. 2020 Jan 22;:

Authors: Wei Y, Zhang J, Wu X, Sun W, Wei F, Liu W, Lu T, Ji W, Li H, Wen W

Abstract

NLRP3 inflammasome and IL-1β were significantly correlated and upregulated in high neutrophil infiltrated CRSwNP. The antigen and proinflammatory cytokines chemotaxis neutrophil infiltration by the NLRP3-IL-1β axis in polyp tissues, although glucocorticoid treatment alleviates it.

PMID: 31981626 [PubMed - as supplied by publisher]