Genomic Destabilization and its Associated Mutagenesis Increase with Senescence‐Associated Phenotype Expression

xloma.fota13 shared this article with you from Inoreader Genomic Destabilization and its Associated Mutagenesis Increase with Senescence‐Associated Phenotype Expression Via Cancer Science Abstract Cancer develops through multiple rounds of clonal evolution of cells with abrogated defense systems. Such clonal evolution is triggered by genomic destabilization with associated mutagenesis. However, it remains unclear what increases the risk of genomic destabilization. Genomic instability is usually the result of erroneous repair of DNA double‐strand breaks (DSBs); paradoxically, however, most cancers develop with genomic instability but lack mutations in DNA repair systems. In this manuscript, we review current knowledge regarding a cellular state that increases the risk of genomic destabilization, in which cells exhibit phenotypes often observed during senescence. In addition, we also explore the pathways that lead to genomic destabilization and its associated mutagenesis, which ultimately result in cancer. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.