Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study

xlomafota13 shared this article with you from Inoreader Expression of clec9a in the oral cancer microenvironment. A preliminary immunohistochemical pilot study Via pubmed: "med oral patol oral... Med Oral Patol Oral Cir Bucal. 2021 Aug 20:24659. doi: 10.4317/medoral.24659. Online ahead of print. ABSTRACT BACKGROUND: The search for treatments to improve cancer survival has led to the emergence of immunotherapy and the study of the tumour microenvironment existing in neoplasms. This preliminary study aims to understand the clinical and pathological relationship of clec9a expression in oral cancer and to explore survival models for future studies. MATERIAL AND METHODS: Immunohistochemical study that included 26 patients with a diagnosis of oral squamous cell carcinoma (OSCC) in mobile tongue and floor of the mouth. Clinical and histopathological variables were recorded, and the biomarkers clec9a for dendritic cells and CD8 and CD4 for lymphocytes were used. RESULTS: Clec9a was expressed in 58% of the sample. It was more common in cases with low lymphoplasmacytic infiltration and in type 2 invasion patterns. It was sign ificantly related to CD8 expression (p=0.055 and p=0.007). No prognostic risks were evident in the survival models studied (overall survival, disease-specific survival, disease-free survival). CONCLUSIONS: CLEC9A expression is present in the OSCC microenvironment and is mainly related to the presence of CD8 lymphocytes. The relationship of its expression with survival prognosis in OSCC could not be confirmed; however, this needs to be confirmed through future studies with larger sample size. PMID:34415004 | DOI:10.4317/medoral.24659 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.