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Τρίτη 19 Οκτωβρίου 2021

Concurrent Chemoradiotherapy with Cisplatin and Docetaxel for Head and Neck Squamous Cell Carcinoma

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Abstract

Objectives

Concurrent chemoradiotherapy (CCRT) with high-dose cisplatin is considered as the global standard therapy to treat patients with advanced head and neck cancer (HNSCC). High doses of cisplatin (100mg/m2) induce severe adverse effects that hinder the completion of therapy, and late toxicity, including renal dysfunction, may prevent patients from receiving treatment with second-line chemotherapies.

Design

We retrospectively analyzed the effect of CCRT combined with moderate-dose cisplatin (4x15 mg/m2) and docetaxel (50 mg/m2) in 83 patients with locally advanced HNSCC.

Results

The median follow-up period was 31 months (range 3-100 months). Radiotherapy was completed in 98% of patients including 36 patients (43%) aged 70 or older. The overall complete response rate was 87% with preserving renal function. The 3-year overall survival, disease-specific survival and progression-free survival rates were 71%, 81% and 70%, respectively. The 3-year disease-specific survival with organ preservation was 79%.

Conclusion

CCRT with a combination of moderate-dose cisplatin and docetaxel in HNSCC patients was well tolerated; it also demonstrated comparable clinical responses to CCRT using high-dose cisplatin

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