Abstract
Objectives
Three-dimensional inversion-recovery sequence with real reconstruction (3D-real IR) magnetic resonance imaging (MRI) can detect endolymphatic hydrops of the inner ear. We aimed to explore a appropriate dose for intravenous gadolinium injection.
Design
Observational prospective study.
Setting
Tertiary referral center.
Participants
We collected 90 unilateral definite Meniere's disease patients.
Main outcome measures
All enrolled patients were divided into three groups randomly (patients in group A, B and C received gadolinium injection in 1/1.5/2 times doses, respectively). After 4 hours, inner ear MRI scans were applied.
Results
The signal intensities of B-affected ears and C-affected ears were significantly higher than A-affected ears (p < 0.05), however, no difference was found between B-affected ears and C-affected ears (p=0.267). The same conditions also appeared in the three unaffected-ear groups. Moreover, the signal intensities of affected-ear in group A, B and C were significantly higher than that of the corresponding unaffected-ear groups (p < 0.05). Besides, the subjective visual evaluation scores of group B and C were significantly better than that of group A (p < 0.05).
Conclusions
Intravenous injection of gadolinium in a single dose may be unbefitting for the inner ear imaging based on 3D-real IR MRI, both the applications of gadolinium in 1.5 times and double doses can have a good perilymphatic enhancement effect of inner ear. In order to minimize the use of dose for avoiding or mitigating the adverse reactions and renal damage, 1.5 times dose may be preferred in clinical practice.
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