Κυριακή 6 Μαρτίου 2022

Investigation of the Mechanism of Impaired Skin Barrier Function in Dogs With Malignant Tumors

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In Vivo. 2022 Mar-Apr;36(2):743-752. doi: 10.21873/invivo.12761.

ABSTRACT

BACKGROUND/AIM: No study has investigated skin barrier dysfunction with systemic diseases in veterinary medicine. We investigated the mechanism of disturbed skin barrier function in dogs with internal diseases.

MATERIALS AND METHODS: Healthy controls and dogs with systemic diseases were enrolled in three different disease groups: malignant tumor, hyperadrenocorticism and kidney disease. Transepidermal water loss (TEWL), serum levels of five selective pro-inflammatory cytokines and claudin-1, and complete blood count were measured.

RESULTS: TEWL was significantly increased in the malignant tumor group while serum claudin-1 concentrations were significantly lower compared to controls. Tumor necrosis factor-α was also significantly increased in the cancer group. In addition, the malignant tumor group showed significantly higher monocyte chemotactic prot ein-1 after chemotherapy, but lower interleukin-6 levels, compared to dogs with no chemotherapy.

CONCLUSION: Skin barrier function was decreased in dogs with malignant tumors compared to dogs with other systemic diseases by oxidative stress and a reduction in tight junction proteins.

PMID:35241530 | DOI:10.21873/invivo.12761

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