Infant Growth Trajectories and Lipid Levels in Adolescence: Evidence from a Chilean Infancy Cohort

alexandrossfakianakis shared this article with you from Inoreader Infant Growth Trajectories and Lipid Levels in Adolescence: Evidence from a Chilean Infancy Cohort Via American Journal of Epidemiology - Advance Access Abstract Growth in early infancy is hypothesized to affect chronic disease risk factors later in life. To date, most reports draw on European ancestry cohorts with few repeated observations in early infancy. We investigated the association between infant growth before six months and lipid levels in adolescents in a Hispanic/Latino cohort. We characterized infant growth from birth to five months in males (n=311) and females (n=285) from the Santiago Longitudinal Study (1991-1996) using three metrics: weight (kg), length (cm) and weight-for-length (WFL) (g/cm). SuperImposition by Translation and Rotation (SITAR) and latent growth mixture models (LGMM) were used to estimate the association between infant growth characteristics and lipid levels at 17 years. We found a positive relationship between the SITAR length velocity parameter before six months of age and high-density lipoprotein cholesterol levels in adolescence (11.5, standard error=4.1) indicating hi gher high-density lipoprotein cholesterol levels occurring with faster length growth. The strongest associations from the LGMM models were between higher low-density lipoprotein cholesterol and slower WFL growth, following a pattern of associations between slower growth and adverse lipid profiles. Further research in this window of time can confirm the association between early infant growth as an exposure and adolescent cardiovascular disease risk factors. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.