ABSTRACT
Data on sofosbuvir-based therapy for pregnant women and infant with severe chronic hepatitis C (CHC) are lacking. Two late pregnant women and one female infant with severe CHC were enrolled for treatment. Pregnant women 1 and 2 and infant 3 were 30, 33, and 1.2 years old, respectively; the gestational ages of pregnant women 1 and 2 were 31 and 26 weeks, respectively. Notably, pregnant women 1 and 2 and infant 3 had hepatitis C virus (HCV) RNA levels of 139000, 198000, and 8450000 IU/ml; alanine aminotransferase levels of 420, 781, and 220 U/L; and received sofosbuvir/ledipasvir, sofosbuvir/velpatasvir, and sofosbuvir/ledipasvir for 12 weeks, respectively. All three patients were safely cured with favorable tolerance, and two newborns were both breastfeeding and were consistently negative for the anti-HCV antibody during the one-year follow-up after birth. Additionally, two newborns and infant 3 had normal growth parameters during the follow-up year one. In c onclusion, this case series study found that sofosbuvir-based therapy for pregnant women and infant with severe CHC is safe and effective. The data may fill the gap and provide evidence of the use of sofosbuvir-based therapy as a reference when similar severe CHC situations are encountered during clinical practice.
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