Emergence of S gene‐based quasispecies explains an optimal adaptation of Omicron BA.5 subvariant in the immunocompetent vaccinated human host

alexandrossfakianakis shared this article with you from Inoreader Emergence of S gene‐based quasispecies explains an optimal adaptation of Omicron BA.5 subvariant in the immunocompetent vaccinated human host via Journal of Medical Virology Abstract In this study, we collected two subsequent swabs from 7 immunocompetent up to date vaccinated healthcare workers undergoing mild symptomatic SARS-CoV-2 infection, and applied a next generation sequencing approach to establish the intra-host dynamics of SARS-CoV-2 quasispecies. Data obtained show that complex dynamics of viral quasispecies occur over a short period of time in patients infected with BA.1 and BA.2. as compared to patients infected with BA.2.3 and BA.5. The low frequency of quasispecies in BA.2.3- and BA.5-infected patients supports the hypothesis that these omicron sub-lineages are adapted to vaccine-elicited immune responses. This article is protected by copyright. All rights reserved. View on Web

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