The UK government is to launch a major clinical trial of the novel cholesterol lowering drug inclisiran later this year and aims to make it available to NHS patients from 2021.Inclisiran, an...
8h
Cook and colleagues summarise many deficiencies in the care of people with dementia but do not mention hearing loss or deafness.1How can I follow instructions if I can’t hear what you are saying? In...
8h
The UK government is to launch a major clinical trial of the novel cholesterol lowering drug inclisiran later this year and aims to make it available to NHS patients from 2021.Inclisiran, an...
11h
Cook and colleagues summarise many deficiencies in the care of people with dementia but do not mention hearing loss or deafness.1How can I follow instructions if I can’t hear what you are saying? In...
13h
What you need to knowThelarche and increased growth velocity before age 8 in girls and genital development in boys before age 9 suggests precocious pubertyPrecocious puberty in boys represents a...
14h
bmj;368/jan13_7/m106/FAF1faIn December 2019 I attended a symposium in the Vatican on religion and medical ethics, hosted by the World Innovation Summit for Health and the Pontifical Academy for Life....
14h
NHS England now requires that prisoners must be registered with a general practitioner before their release. It says this is because “release from custody can be a crisis situation for some and can...
14h
Paediatricians and other health professionals should talk to patients and families about how they can reduce exposure and contribution to air pollution, the Royal College of Paediatrics and Child...
14h
A national audit shows that only one in four men with advanced prostate cancer receives life prolonging chemotherapy despite its recommendation by the National Institute for Health and Care...
14h
Leaders in the pharmaceutical and biotechnology industries have signed a commitment to pricing that enables “broad” and “uninterrupted” patient access in the face of action from US lawmakers to drive...
14h
What you need to knowThelarche and increased growth velocity before age 8 in girls and genital development in boys before age 9 suggests precocious pubertyPrecocious puberty in boys represents a...
17h
bmj;368/jan13_7/m106/FAF1faIn December 2019 I attended a symposium in the Vatican on religion and medical ethics, hosted by the World Innovation Summit for Health and the Pontifical Academy for Life....
17h
NHS England now requires that prisoners must be registered with a general practitioner before their release. It says this is because “release from custody can be a crisis situation for some and can...
17h
Paediatricians and other health professionals should talk to patients and families about how they can reduce exposure and contribution to air pollution, the Royal College of Paediatrics and Child...
18h
A national audit shows that only one in four men with advanced prostate cancer receives life prolonging chemotherapy despite its recommendation by the National Institute for Health and Care...
18h
In October 2018, the UK government announced that it would be reclassifying gabapentin and pregabalin1—known collectively as gabapentinoids—after experts pointed out the rising numbers of deaths...
19h
Leaders in the pharmaceutical and biotechnology industries have signed a commitment to pricing that enables “broad” and “uninterrupted” patient access in the face of action from US lawmakers to drive...
19h
Background There is substantial variation in head and neck cancer (HNC) mortality and competing mortality among patients with HNC. In this study, the authors characterize the causes and risks of short‐term mortality among patients with oropharynx cancer (OPC) and how these risks differ by human papillomavirus (HPV) status. Methods A custom Surveillance, Epidemiology, and End Results (SEER) data set with HPV status was used to identify 4930 patients with OPC who were diagnosed with nonmetastatic...
21h
AbstractBoth the onset of various malignancies as well as the treatment of cancer can lead to neurologic symptoms which can be difficult to diagnose. In this review, we highlight the varied ways in which neurologic sequelae of cancer and its treatment manifest in children. Initial neurologic presentation may be secondary to mass effect or to immune-mediated paraneoplastic syndromes. Treatment effects on the nervous system may arise from surgery, chemotherapy, radiation, or bone marrow transplantation....
9h
Abstract Both the onset of various malignancies as well as the treatment of cancer can lead to neurologic symptoms which can be difficult to diagnose. In this review, we highlight the varied ways in which neurologic sequelae of cancer and its treatment manifest in children. Initial neurologic presentation may be secondary to mass effect or to immune-mediated paraneoplastic syndromes. Treatment effects on the nervous system may arise from surgery, chemotherapy, radiation, or bone...
21h
Abstract Lactate dehydrogenase C (LDHC) is an archetypical cancer testis antigen with limited expression in adult tissues and re-expression in tumors. This restricted expression pattern together with the important role of LDHC in cancer metabolism renders LDHC a potential target for immunotherapy. This study is the first to investigate the immunogenicity of LDHC using T cells from healthy individuals. LDHC-specific T cell responses were induced by in vitro stimulation with synthetic...
10h
Smoking duration and intensity but not age at initiation are NPC risk factors, and anti‐EBV VCA IgA seropositivity rate was higher in current than never smokers among controls. Mediation analyses show that NPC and EBV association may be explained by the interplay between smoking and EBV antibodies serostatus. Abstract Background The study aims are to evaluate the associations between nasopharyngeal carcinoma (NPC) risk and cigarette smoking and to explore the effects of cigarette smoking on...
8h
Our nomograms provided reliable prognostic values in predicting PFS and OS in stage II‐IVa NPC patients. These nomograms could robustly estimate individual benefit from CCT, which strengthens decision‐making around prognosis. Abstract Objective We aimed to establish and validate two nomograms that predict progression‐free survival (PFS) and overall survival (OS) in patients with stage II–IVa nasopharyngeal carcinoma (NPC) while evaluating the benefit of concurrent chemotherapy. Patients...
8h
Abstract Increasing evidence indicates that extracellular vesicle (EV) play an important role in cancer cell‐to‐cell communication. The Epstein–Barr virus (EBV) encoded latent membrane protein 1 (LMP1), which is closely associated with nasopharyngeal carcinoma (NPC) pathogenesis, can trigger multiple cell signaling pathways that affect cell progression. Several reports have shown that LMP1 promotes EV secretion, and LMP1 trafficking by EVs can enhances cancer progression and metastasis. However,...
20h
Cancers, Vol. 12, Pages 199: Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer Cancers doi: 10.3390/cancers12010199 Authors: Maria Karmella Apaya Pei-Wen Hsiao Yu-Chih Yang Lie-Fen Shyur Recurrence and metastasis are the main causes of triple-negative breast cancer (TNBC) mortality. On the basis of our clinical cohorts and integrative omics analyses, we hypothesized...
17h
Cancers, Vol. 12, Pages 197: Potential of Exosomal microRNA-200b as Liquid Biopsy Marker in Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12010197 Authors: Moritz Reese Isabelle Flammang Zixuan Yang Sameer A. Dhayat Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor entity, characterized by rapid disease progression, early metastatic dissemination, and late diagnosis at advanced tumor stages. Recently, we explored the clinical impact of several...
19h
Cancers, Vol. 12, Pages 195: Sitravatinib Sensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs Cancers doi: 10.3390/cancers12010195 Authors: Chung-Pu Wu Sung-Han Hsiao Yang-Hui Huang Lang-Cheng Hung Yi-Jou Yu Yu-Tzu Chang Tai-Ho Hung Yu-Shan Wu The development of multidrug resistance (MDR) in cancer patients driven by the overexpression of ATP-binding cassette (ABC) transporter ABCB1 or ABCG2 in cancer cells presents...
19h
Cancers, Vol. 12, Pages 196: Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells Cancers doi: 10.3390/cancers12010196 Authors: Jan Skoda Jakub Neradil Iva Staniczkova Zambo Alena Nunukova Peter Macsek Karolina Borankova Viera Dobrotkova Pavel Nemec Jaroslav Sterba Renata Veselska Serial xenotransplantation of sorted cancer cells in immunodeficient mice remains the most...
19h
Cancers, Vol. 12, Pages 198: Molecular Classification of Gastric Cancer among Alaska Native People Cancers doi: 10.3390/cancers12010198 Authors: Holly A. Martinson Dominic Mallari Christine Richter Tsung-Teh Wu James Tiesinga Steven R. Alberts Matthew J. Olnes Gastric cancer is an aggressive and heterogeneous malignancy that often varies in presentation and disease among racial and ethnic groups. The Alaska Native (AN) people have the highest incidence and mortality...
19h
Cancers, Vol. 12, Pages 192: Current Status and Future Perspectives of Immunotherapy for Locally Advanced or Metastatic Urothelial Carcinoma: A Comprehensive Review Cancers doi: 10.3390/cancers12010192 Authors: Tae Jin Kim Kang Su Cho Kyo Chul Koo Advancements in the understanding of tumor immunology in urothelial carcinoma (UC) have led to U.S Food and Drug Administration (FDA) approval of five novel anti-programmed cell death protein-1/ligand 1 (PD-1/L1) checkpoint inhibitors....
20h
Cancers, Vol. 12, Pages 194: Systemic Actions of Breast Cancer Facilitate Functional Limitations Cancers doi: 10.3390/cancers12010194 Authors: Ruizhong Wang Harikrishna Nakshatri Breast cancer is a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of breast cancer can lead to functional limitations in patients who suffer from muscle weakness, fatigue, pain, fibromyalgia, or many other dysfunctions, which hasten cancer-associated death....
20h
Cancers, Vol. 12, Pages 193: Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12010193 Authors: Jin-Feng Teng Qi-Bing Mei Xiao-Gang Zhou Yong Tang Rui Xiong Wen-Qiao Qiu Rong Pan Betty Yuen-Kwan Law Vincent Kam-Wai Wong Chong-Lin Yu Han-An Long Xiu-Li Xiao Feng Zhang Jian-Ming Wu Da-Lian Qin An-Guo Wu Trillium tschonoskii Maxim...
20h
Populations differ with respect to their cancer risk and screening preferences, which may influence the performance of colorectal cancer (CRC) screening programs. This review aims to systematically compare the mortality effect of CRC screening across European regions.
10h
The aim of this study was to quantify the impact of organised mammography screening on breast cancer mortality across European regions. Therefore, a systematic review was performed including different types of studies from all European regions and stringently used clearly defined quality appraisal to summarise the best evidence.
10h
The European interdisciplinary guidelines on the diagnosis and treatment of basal cell carcinoma (BCC) are a thorough updated and expanded review of the literature [1]. The guidelines provide guidance for physicians to optimise BCC care. We strongly agree with emphasising personalised care and an individualised approach for each patient and tumour. In addition, we would like to comment on the extensive safety margins advised for conventional (2D) surgical excision of high-risk BCCs and the proposed...
10h
European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics – Update 2019
Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumor and causes 90% of skin cancer mortality. A unique collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on CM diagnosis and treatment, based on systematic literature reviews and the experts' experience. The diagnosis of melanoma can...
10h
Abstract Purpose We quantified cytotoxic T cells in nonmalignant breast tissues from women with and without subsequent breast cancer to assess evidence of whether immunosurveillance may be suppressed prior to tumor development. Methods We used an age-matched set of breast tissues from women with benign breast disease (BBD) who subsequently developed breast...
12h
Abstract Purpose A growing amount of research has successfully incorporated Fitbit devices and other wearable activity trackers into technology-oriented lifestyle interventions to increase physical activity among cancer survivors. Methods The present review of this literature is based upon bibliographic searches in PubMed and CINAHL and relevant search terms....
20h
Abstract Background Chemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportunity to impede tumor through combination or sequential therapy, while the accurate effect is vague. Methods The efficacy...
15h
Abstract Background Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated kinase (PAK), hypoxia or epithelial-mesenchymal transition (EMT) contributed to the VM potential. However, the details underlying these biological behaviors have not been completely elucidated. ...
15h
Abstract Background Histone lysine demethylase 4B (KDM4B) has been implicated in various pathological processes and human diseases. Glucose metabolism is the main pattern of energy supply in cells and its dysfunction is closely related to tumorigenesis. Recent study shows that KDM4B protects against obesity and metabolic dysfunction. We realized the significant role of KDM4B in metabolism. However, the role of KDM4B in glucose metabolism...
12h
Abstract Background Mounting evidence suggests that complement components promote tumor progression via modulating immune suppression, angiogenesis, or tumor cell proliferation. However, the role of C3a-C3aR signaling in regulating lung metastasis of breast cancer remains unknown. Methods We performed various ex-vivo and in-vivo assays. Genetic...
15h
In the original publication of this article [1], labelling within Fig. 7a was incorrect. The updated figure is shown below, with ‘DMT1’ now corrected to read ‘DNMT1’.
19h
Abstract Background The current guidelines in Sweden regarding individuals with a clinically actionable (i.e. pathogenic or likely pathogenic) germline TP53 variant recommend patients to take part of the national Swedish P53 Study (SWEP53). Methods The study comprises a patient registry (mandatory for all participants) and three optional...
9h
Population‐based evidence regarding risk of ovarian cancer after a borderline ovarian tumor (BOT) is sparse. We aimed to examine the incidence of specific types of ovarian cancer in women with serous or mucinous BOTs in a nationwide cohort study with up to 36 years of follow‐up. Using the nationwide Danish Pathology Data Bank, we identified 4281 women with a BOT (2058 serous BOTs and 2223 mucinous BOTs) in Denmark during 1978–2012. We computed standardized incidence ratios (SIRs) to compare the incidence...
22h
AbstractBackgroundNeoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) is the standard treatment for locally-advanced rectal cancer. There is interest in de-escalating local therapy after a clinical complete response (cCR) to CRT. We hypothesized that a watch-and-wait (WW) strategy offers comparable cancer-specific survival (CSS), superior quality-adjusted survival, and reduced cost compared to upfront TME.MethodsWe developed a decision-analytic model to compare WW, low...
15h
Abstract Background Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown. Methods SS patients < 21 years registered in consecutive CWS trials over the period of 1981–2018 were evaluated. Characteristics were analyzed according to age groups...
15h
Abstract Purpose We set out to determine whether clinically tested epigenetic drugs against class I histone deacetylases (HDACs) affect hallmarks of the metastatic process. Methods We treated permanent and primary renal, lung, and breast cancer cells with the class I histone deacetylase inhibitors (HDACi) entinostat (MS-275) and valproic acid (VPA), the replicative...
21h
Donglan Xiong, Rui Feng, Sheng Yang, Tingyan Lin, Xiangqi ChenJournal of Cancer Research and Therapeutics 2019 15(7):1635-1641 Objective: In this study, we investigated the antitumor activity of interleukin (IL)-18 on A549 human lung cancer cell line and evaluated the potential of IL-18 therapy in lung cancer. Materials and Methods: We generated a human IL-18 lentiviral expression vector and examined three groups of A549 cells, including nontransduced cells and cells transduced with either...
15h
Hongling Li, Xiaohuan Wang, Lingfang Zhang, Xuemei Yi, Yujie Qiao, Qianqian JinJournal of Cancer Research and Therapeutics 2019 15(7):1581-1588 Objectives: The aim of the current study was to investigate whether the maximum standardized uptake value (SUVmax) measured by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) could discriminate between aggressive and indolent non-Hodgkin lymphomas (NHLs) and correlations between the SUVmax and clinical variables...
15h
Junjie Wang, Shude Chai, Ruoyu Wang, Guangjun Zheng, Kaixian Zhang, Bin Huo, Xiaodong Huo, Yuliang Jiang, Zhe Ji, Ping Jiang, Ran PengJournal of Cancer Research and Therapeutics 2019 15(7):1430-1434 Interstitial permanent radioactive seed implantation delivers a high local dose to tumors and sharply drops off at surrounding normal tissues. Radioactive seeds implanted via ultrasound or computed tomography (CT) guidance are minimally invasive and facilitate quick recovery. Transrectal ultrasound-guided...
15h
Zhaomin Song, Jiacheng Ye, Yongzheng Wang, Yuliang Li, Wujie WangJournal of Cancer Research and Therapeutics 2019 15(7):1553-1560 Purpose: This study aimed to retrospectively assess the outcome of interstitial iodine-125 brachytherapy for unresectable hepatocellular carcinoma (HCC). Materials and Methods: Between February 2013 and March 2019, 57 patients with 108 unresectable HCC lesions treated with computed tomography (CT)-guided iodine-125 seed brachytherapy were retrospectively analyzed....
15h
Zhiwei Wang, Xiao Yang, Jitao Wang, Shuai Wang, Xiaorong Mao, Mingxing Li, Yongzhao Zhao, Weidong Wang, Xiaolong Qi, Tongwei WuJournal of Cancer Research and Therapeutics 2019 15(7):1435-1449 Molecular target anticancer drugs are commonly used in various forms of cancers. It is a concern that the risk of serious adverse events (SAEs) and fatal adverse events (FAEs) of molecular target drugs are increasing. An up-to-date meta-analysis of all Phase II/III/IV randomized trials of molecular target...
15h
Jian Chen, Jin Chen, Xiu-Hua Lin, Rui-Xiang Lin, Yuan Yan, Qing-Feng Lin, Zheng-Yu LinJournal of Cancer Research and Therapeutics 2019 15(7):1611-1616 Aim: This study aimed to investigate the technical procedure, safety, and clinical value of the transosseous approach for computed tomography (CT)-guided radioactive 125-iodine (125I) seed implantation for the treatment of thoracic and abdominal lymph node metastases. Subjects and Methods: This was a retrospective study that Nine lymph node...
15h
Hua Qiu, Jun-Hua Ai, Jun Shi, Ren-Feng Shan, Dong-Jun YuJournal of Cancer Research and Therapeutics 2019 15(7):1450-1463 Gastrectomy is considered the gold standard treatment for gastric cancer patients. Currently, there are two minimally invasive surgical methods to choose from, robotic gastrectomy (RG) and laparoscopic gastrectomy (LG). Nevertheless, it is still unclear which is superior between the two. This meta-analysis aimed to investigate the effectiveness and safety of RG and LG for gastric...
15h
Min Yang, Jiang Li, Rui Sun, Yanfeng Wang, Haiyan Xu, Boyan Yang, Xiaoming Wu, Lei YuJournal of Cancer Research and Therapeutics 2019 15(7):1541-1546 Aim of the Study: The role of direct-acting oral anticoagulants in the treatment of venous thromboembolism (VTE) in cancer patients compared with the current standard of low-molecular-weight heparin (LMWH) treatment remains unclear. This meta-analysis aimed to evaluate the efficacy and safety of direct factor Xa inhibitors compared with those of...
15h
Yu-Fei Fu, Li-Hua Jiang, Tao Wang, Guang-Chao Li, Wei Cao, Yi-Bing ShiJournal of Cancer Research and Therapeutics 2019 15(7):1464-1470 Objective: The aim of this study is to develop a predictive model for identifying true negatives among nonspecific benign results on computed tomography-guided lung biopsy. Materials and Methods: This was a single-center retrospective study. Between December 2013 and May 2016, a total of 126 patients with nonspecific benign biopsy results were used as the...
15h
Fuxin Kou, Song Gao, Shaoxing Liu, Xiaodong Wang, Hui Chen, Xu Zhu, Jianhai Guo, Xin Zhang, Aiwei Feng, Baojiang LiuJournal of Cancer Research and Therapeutics 2019 15(7):1567-1573 Aims: This study aims to observe the preliminary clinical efficacy of percutaneous interstitial brachytherapy using iodine-125 seeds for the treatment of advanced malignant lung tumors. Subjects and Methods: This retrospective study enrolled 24 patients in our hospital with advanced malignant lung tumors between...
15h
Xianqi Feng, Xiangyun Chen, Shumin Nie, Yanyan Chang, Fanjun Meng, Jingjing Zhou, Chunxia Mao, Tianlan Li, Xueshen Yan, Junxia Huang, Shanshan Liu, Yan Gao, Shuxin XiaoJournal of Cancer Research and Therapeutics 2019 15(7):1471-1476 Objective: Decitabine is reported to be valuable in treating multiple malignant blood diseases. However, the application of decitabine in myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) has not been fully examined. Thus, our study aimed to investigate...
15h
Xueqi Ou, Guanfeng Gao, Meiheban Bazhabayi, Kaiming Zhang, Feng Liu, Xiangsheng XiaoJournal of Cancer Research and Therapeutics 2019 15(7):1597-1602 Aims: The purpose of this study was to investigate the potential correlation between metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the transcription factor BTB and CNC homology 1 (BACH1) and their clinicopathological significance in triple-negative breast cancer (TNBC). Subjects and Methods: MALAT1 and BACH1 were detected...
15h
Songsong Wu, Xin Li, Jie Yu, Xiaoling Yu, Zhigang Cheng, Fangyi Liu, Zhiyu Han, Shaobo Duan, Ping LiangJournal of Cancer Research and Therapeutics 2019 15(7):1477-1483 Objective: The objective of this study is to assess the clinical effect and safety of ultrasound-guided percutaneous microwave ablation (US-PMWA) assisted by three-dimensional (3D) visualization operative treatment planning system in larger adrenal metastasis (LAM) (D ≥ 4 cm). Materials and Methods: From Dec 2011 to Dec 2017,...
15h
Wenhong Li, Zhigang Wei, Xia Yang, Guanghui Huang, Xiaoying Han, Yang Ni, Jiao Wang, Min Meng, Zhigeng Zou, Qiang Wen, Xin YeJournal of Cancer Research and Therapeutics 2019 15(7):1624-1628 Background: Camrelizumab is a promising anti-programmed cell death-1 agent for non-small cell lung cancer (NSCLC) and induces reactive capillary hemangiomas (RCHs). Routine clinical management of this unique and prevalent toxicity has been summarized in previous studies. The objective of this study was to...
15h
Dongdong Wang, Bin Li, Zhixin Bie, Yuanming Li, Xiaoguang LiJournal of Cancer Research and Therapeutics 2019 15(7):1484-1489 Aims: This study aimed to evaluate the safety and feasibility of computed tomography (CT)-guided synchronous percutaneous core-needle biopsy and microwave ablation (MWA) for highly suspicious malignant pulmonary nodules. Materials and Methods: This retrospective study evaluated medical records of 54 consecutive patients (mean age, 65.5 ± 11.2 years) with 62 highly suspicious...
15h
Xiaoguang Li, Xin YeJournal of Cancer Research and Therapeutics 2019 15(7):1427-1429
15h
Chuan-Cai Xu, Wei Lei, Jun-Hong Jiang, Zi-Rui Wang, Chong-Jun Ni, Jian-An HuangJournal of Cancer Research and Therapeutics 2019 15(7):1490-1495 Context: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and positron emission tomography/computed tomography (PET/CT) are the two most extensively used methods for the diagnosis and staging of lung cancer. Aims: The present study was designed to compare the diagnostic performance of EBUS-TBNA with that of PET/CT in patients...
15h
Haibo Cai, Wei Lu, Yueying Zhang, Hengyao Liu, Zhaopeng Wang, Yi ShenJournal of Cancer Research and Therapeutics 2019 15(7):1547-1552 Objective: Lung cancer is the leading cause of cancer-related death worldwide with a relatively low 5-year relative survival rate of 16%. Novel and efficient therapeutic approach for lung cancer is desperately needed. Materials and Methods: Targeting cancer stem cells (CSCs) provides a promising strategy to eradicate malignancies. The Notch signaling pathway...
15h
Li Chuang, Wang Ruoyu, Wang Zhe, Zhao Guangsheng, Zhou JunJournal of Cancer Research and Therapeutics 2019 15(7):1496-1500 Objective: The objective of the study was to evaluate computed tomography (CT)-guided 125I implantation for the treatment of recurrent and malignant pelvic tumors. Materials and Methods: Fifteen cases of pelvic malignant tumors were studied. Tumor length/diameter was 4–10 cm (average: 6.8 ± 2.3 cm). In patients with pelvic recurrence or metastasis of malignant tumors,...
15h
Miaomiao Yang, Huajun Qu, Aina Liu, Jiannan Liu, Ping Sun, Hua LiJournal of Cancer Research and Therapeutics 2019 15(7):1561-1566 Context: Nanoparticle albumin-bound paclitaxel (Nab-PTX) is a form of paclitaxel bound to albumin nanoparticles and is used widely in a neoadjuvant setting for patients with breast cancer. Aims: We conducted a retrospective study to compare the efficacy and safety of Nab-PTX to PTX as neoadjuvant chemotherapy for patients with operable HER2-negative breast cancer....
15h
Fei Cao, Lin Xie, Han Qi, Song Ze, Shuanggang Chen, Lujun Shen, Xiaoshi Zhang, Weijun FanJournal of Cancer Research and Therapeutics 2019 15(7):1501-1507 Purpose: To evaluate the technical feasibility of microwave ablation (MWA) for melanoma liver metastases with persistent high signal on magnetic resonance imaging (MRI). Materials and Methods: Seven patients with 22 target melanoma liver metastases who underwent MWA treatment were included. All procedure-related complications were observed...
15h
Shanshan Yu, Xingchen Wang, Xiaoyan Wang, Xueyuan Wu, Rongrong Xu, Xiaoqi Wang, Xue Zhang, Chunhong Zhang, Kun Chen, Dezhi Cheng, Li WenfengJournal of Cancer Research and Therapeutics 2019 15(7):1574-1580 Context: Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) play an indispensable role in the treatment of non-small cell lung cancer (NSCLC), leading to a survival major breakthrough, but there remains no uniform standard for predicting the efficacy of TKI therapy....
15h
Ling Long, Haiping Zhang, Xiaojing He, Jun Zhou, Dajing Guo, Xinjie LiuJournal of Cancer Research and Therapeutics 2019 15(7):1508-1515 Background: Conventional magnetic resonance imaging (MRI) does not accurately evaluate lymph node (LN) status, which is essential for the treatment and prognosis assessment in patients with rectal cancer. Objective: The aim of this study is to evaluate the diagnostic value of intravoxel incoherent motion (IVIM) MRI in differentiating metastatic and nonmetastatic...
15h
Daguang Zhang, Zhiyong Yang, Shan Jiang, Lin Zhou, Zeyang Zhou, Wei WangJournal of Cancer Research and Therapeutics 2019 15(7):1589-1596 Objectives: The aim of this study is to address the limitation of combined intracavitary-interstitial (IC/IS) brachytherapy (BT) in locally advanced cervical cancer using standardized applicators and to determine the optimal dose distribution in patients with challenging tumors, innovative methods of customizing and optimizing the IS needle configuration for combined...
15h
Hanyue Ding, Ayan Mao, Lian Wen, Pei Dong, Yujie Yang, Xuan Cheng, Wuqi QiuJournal of Cancer Research and Therapeutics 2019 15(7):1516-1521 Objective: To provide an objective cost–utility evaluation of a colorectal cancer screening program in a hypothetical general population. Materials and Methods: A cost–utility analysis was conducted comparing screened individuals with the general population. Patients were evaluated as part of the screening program which conducted colorectal cancer risk...
15h
Ke-Fen Zhang, Jun Wang, Jiao Guo, Yue-Ying Huang, Tian-Ren HuangJournal of Cancer Research and Therapeutics 2019 15(7):1603-1610 Objective: Radiotherapy becomes more and more important in hepatocellular carcinoma (HCC) due to the development of technology, especially in unresectable cases. Metformin has a synergistic benefit with radiotherapy in some cancers, but remains unclear in HCC. This study aims to investigate the effect of metformin on radiosensitivity of HCC cells and the roles of specificity...
15h
Liping Wang, Dong Xu, Yan Yang, Mingkui Li, Chuanming Zheng, Xinguang Qiu, Bin HuangJournal of Cancer Research and Therapeutics 2019 15(7):1522-1529 Objective: This study aimed to evaluate the safety and efficacy of thermal ablation in treating low-risk unifocal papillary thyroid microcarcinoma (PTMC). Materials and Methods: Patients with unifocal PTMC were enrolled in this study, and thermal ablations were performed. Contrast-enhanced ultrasound was used to estimate the extent of ablation...
15h
Hongye Wang, Yihai Liu, Kangjie Shen, Yuxiang Dong, Jinyu Sun, Yimei Shu, Xiaojie Wan, Xiaohan Ren, Xiyi Wei, Bo ZhaiJournal of Cancer Research and Therapeutics 2019 15(7):1617-1623 Objective: This study determined whether the effect of combination therapy for hepatic carcinoma (HCC) is comparable to surgical resection (SR). According to the guidelines of the American Association for the Study of Liver Disease, radiofrequency ablation (RFA) and SR are recommended for early HCC. However, patients...
15h
Hua Qiu, Ren-Feng Shan, Jun-Hua Ai, Shan-Ping Ye, Jun ShiJournal of Cancer Research and Therapeutics 2019 15(7):1530-1534 Objective: The purpose of this study was to investigate the rate and reasons and also the risk factors for unplanned reoperation after pancreatoduodenectomy (PD) in a single center. Patients and Methods: This retrospective analysis included patients who underwent PD in the First Affiliated Hospital of Nanchang University between January 2010 and January 2018. The patients...
15h
Zhigang Wei, Xia Yang, Xin Ye, Guanghui Huang, Wenhong Li, Xiaoying Han, Jiao Wang, Min Meng, Yang Ni, Zhigeng Zou, Qiang WenJournal of Cancer Research and Therapeutics 2019 15(7):1629-1634 Aim: The present study evaluated the safety and efficacy of camrelizumab (a programmed death-1 antibody) in combination with microwave ablation (MWA) in advanced non-small cell lung cancer (NSCLC). Materials and Methods: A total of 21 patients were prospectively enrolled. MWA was performed in 25 pulmonary...
15h
Ke Hu, Jingjing Wu, Yi Dong, Zhiping Yan, Zhiqiang Lu, Lingxiao LiuJournal of Cancer Research and Therapeutics 2019 15(7):1535-1540 Objective: The purpose of this study was to compare the efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) for the treatment of benign thyroid nodules (BTNs). Methods: Patients with BTNs were treated in our hospital, including 72 patients treated with RFA and 100 patients treated with MWA from June 2016 to March 2019. The volume reduction...
15h
Bingqiang Li, Guofeng QuJournal of Cancer Research and Therapeutics 2019 15(7):1642-1646 Objective: The aim of this study is to probe in the inhibitory effects of ginsenoside Rg3 on the expression of hypoxia-induced factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human gastric cancer cells. Materials and Methods: Human gastric cancer BGC823 cells were divided into the control group and experiment group, and expression levels of HIF-1α and VEGF were detected by immunocytochemistry...
15h
In the original publication of this article [1], labelling within Fig. 7a was incorrect. The updated figure is shown below, with ‘DMT1’ now corrected to read ‘DNMT1’.
17h
Localized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition an...
17h
Circular RNAs (circRNAs) have recently emerged as a new family of noncoding RNAs that are involved in the causation and progression of various cancers. However, the roles of circRNAs in the tumorigenesis of ga...
17h
Abstract Introduction Appropriate management of patients with Alzheimer’s disease (AD) helps preserve their independence and time at home. We explored physician behavior in the management of AD, focusing on diagnosis. Methods Online questionnaires and patient record forms (PRFs) were created by an independent market research agency and completed by participating...
14h
Abstract Objective Timely initiation of Alzheimer’s disease (AD)-specific treatment may postpone cognitive deterioration and preserve patient independence. We explored real-world physician behavior in the treatment of AD. Methods Online questionnaires and patient record forms (PRFs) were completed by participating physicians. The physicians included general...
14h
In the original article. The third author name is incorrect. The correct name is Nicholas J. Leeper.
18h
Abstract Purpose In breast cancer, FoxP3-positive tumor-infiltrating lymphocytes (FoxP3+ TILs) vary depending on lymph node status, histological grade, and subtype. All these studies have compared the numbers of FoxP3+ TILs among different hosts, but recruitment of FoxP3+ TILs might depend on each individual’s immune environment and each tumor’s biological characteristics. In the present study, FoxP3+ TIL numbers were investigated in patients...
10h
Abstract The modified round block technique (MRBT) is a level I oncoplastic breast-conserving surgery (OBCS), which contains a very wide glandular flap created by extensive dual-plane undermining that is achieved by entire subcutaneous dissection and approximately 50% dissection of the breast parenchyma from the pectoralis muscle. A retrospective analysis was performed for 100 patients who underwent OBCS using MRBT from February 2009 to October 2017. The incidence of positive margin...
20h
Abstract Background Whole-body diffusion weighted imaging (WB-DWI) has proven value to detect multiple myeloma (MM) lesions. However, the large volume of imaging data and the presence of numerous lesions makes the reading process challenging. The aim of the current study was to develop a semi-automatic lesion segmentation algorithm for WB-DWI images in MM patients and to evaluate this smart-algorithm (SA) performance by comparing...
10h
Abstract Background Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the digestive system, are treated varyingly according to the malignancy. The purpose of this study is to develop and validate a nomogram for preoperative prediction of the malignant potential in patients with GIST. Methods A total of...
16h
Abstract Background Postoperative cognitive dysfunction (POCD) had a great relationship with anesthesia during surgery, and miRNAs have been found involved in anesthesia-induced cognitive impairment. Objective To explore the role and potential mechanism of miR-106a in isoflurane anesthesia-induced cognitive impairment. ...
14h
Abstract To visualize transfer of plasmid in Streptomyces during conjugation, we constructed a conjugative plasmid that harbored melC operon encoding an extracellular tyrosinase and placed it in Streptomyces hosts which were defective in expressing the operon. Hyphae of these donors were mixed with hyphae of a plasmidless recipient, which could express melC, and plated on a solid medium supplemented with tyrosine. After 8 to 9 h of incubation, melanin started to appear in the mating...
20h
Abstract Although numerous prevention efforts have been implemented, marijuana remains the most commonly used illicit substance among Hispanic adolescents nationwide. We sought to determine the influence authoritative parenting behaviors have on lifetime, past year, and past month marijuana use among Hispanic adolescents overall, and then based on age (i.e., 12–13, 14–15, and 16–17 years). We conducted a secondary analysis of the 2012 National Survey on Drug Use and Health (N = 3457)....
14h
Abstract We tested the effects of emotional eating in long-term weight-loss so that both treatment processes and theory could be improved. Women with obesity participated in treatments of either high interpersonal contact and behavioral methods (n = 39) or low interpersonal contact and educational methods (n = 36) through community-based settings. We assessed mood, emotional eating, self-regulation, self-efficacy, and weight. Changes in the psychosocial measures were significantly...
14h
Nature Reviews Cancer, Published online: 13 January 2020; doi:10.1038/s41568-019-0231-8This Perspective discusses how cell competition between tumour cells and neighbouring epithelial host cells may dictate tumorigenesis and proposes that manipulating the strength and direction of cell competition could form the basis of an orthogonal therapeutic strategy.
9h
Publication date: February 2020Source: European Journal of Cancer, Volume 126Author(s): Roch Houot, Aurélien Marabelle, Stéphane Champiat
11h
Part protocol, part memoir, recipes can bring together the how and why -- Read more on ScientificAmerican.com
11h
It would be a huge win in fighting the opioid crisis -- Read more on ScientificAmerican.com
13h
A complex natural signaling system could help address impulse-control disorders -- Read more on ScientificAmerican.com
18h
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου