Decreased DNA Damage Repair in Response to Targeted Therapies Facilitates the Emergence of Drug-Resistant Clones.

This Is Our Cells Under Pressure: Decreased DNA Damage Repair in Response to Targeted Therapies Facilitates the Emergence of Drug-Resistant Clones.:

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This Is Our Cells Under Pressure: Decreased DNA Damage Repair in Response to Targeted Therapies Facilitates the Emergence of Drug-Resistant Clones.

Cancer Cell. 2020 Jan 13;37(1):5-7

Authors: Gay CM, Parseghian CM, Byers LA

Abstract

In a recent issue of Science, Russo et al. observe that colorectal cancer cells, when exposed to the pressure of EGFR- and BRAF-targeted therapies, transiently alter their transcriptional profiles to foster mutagenesis, thereby enhancing the stochastic development of acquired resistance mutations.

PMID: 31951562 [PubMed - in process]