IJMS, Vol. 21, Pages 634: Genome-Wide Identification and Characterization of the NAC Transcription Factor Family in Musa Acuminata and Expression Analysis during Fruit Ripening International Journal of Molecular Sciences doi: 10.3390/ijms21020634 Authors: Bin Li Ruiyi Fan Qiaosong Yang Chunhua Hu Ou Sheng Guiming Deng Tao Dong Chunyu Li Xinxiang Peng Fangcheng Bi Ganjun Yi Banana (Musa acuminata, AAA group) is a representative climacteric fruit with essential...
Sat Jan 18, 2020 02:00
IJMS, Vol. 21, Pages 636: Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding International Journal of Molecular Sciences doi: 10.3390/ijms21020636 Authors: Marta Spodzieja Katarzyna Kuncewicz Adam Sieradzan Agnieszka Karczyńska Justyna Iwaszkiewicz Valérie Cesson Katarzyna Węgrzyn Igor Zhukov Martyna Maszota-Zieleniak Olivier Michielin Daniel E. Speiser Vincent Zoete Laurent Derré Sylwia Rodziewicz-Motowidło Immune checkpoints are crucial...
Sat Jan 18, 2020 02:00
IJMS, Vol. 21, Pages 631: Relaxin Positively Influences Ischemia—Reperfusion Injury in Solid Organ Transplantation: A Comprehensive Review International Journal of Molecular Sciences doi: 10.3390/ijms21020631 Authors: Jakubauskiene Jakubauskas Leber Strupas Stiegler Schemmer In recent decades, solid organ transplantation (SOT) has increased the survival and quality of life for patients with end-stage organ failure by providing a potentially long-term treatment option....
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 633: Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: an in Vitro and in Silico Study International Journal of Molecular Sciences doi: 10.3390/ijms21020633 Authors: Di Sotto Irannejad Eufemi Mancinelli Abete Mammola Altieri Mazzanti Di Giacomo Doxorubicin represents a valuable choice for different cancers, although the severe side effects occurring at...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 630: Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21020630 Authors: Mario Zurita Juan Manuel Murillo-Maldonado Human mutations in the transcription and nucleotide excision repair (NER) factor TFIIH are linked with three human syndromes: xeroderma pigmentosum (XP), trichothiodystrophy (TTD) and Cockayne syndrome (CS). In particular, different...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 627: Association of α/β-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition International Journal of Molecular Sciences doi: 10.3390/ijms21020627 Authors: Shan Xu Bleyer Becker Melbaum Wemheuer Hirschfeld Wacker Zhao Schütz Brenig We have identified a Holstein sire named Tarantino who had been approved for artificial insemination that is based on normal semen characteristics (i.e., morphology,...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 628: Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia International Journal of Molecular Sciences doi: 10.3390/ijms21020628 Authors: Szilagyi Gelencser Romero Xu Kiraly Demeter Palhalmi Gyorffy Juhasz Hupuczi Kekesi Meinhardt Papp Draghici Erez Tarca Knöfler Than The human placenta maintains pregnancy and supports the...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 629: Isolation and Identification of a TaTDR-Like Wheat Gene Encoding a bHLH Domain Protein, Which Negatively Regulates Chlorophyll Biosynthesis in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21020629 Authors: Yu Xia Zheng Li Junwei Wang Yanhong Li Yang Ren Jingjing Du Qilu Song Shoucai Ma Yulong Song Huiyan Zhao Zhiquan Yang Gaisheng Zhang Na Niu Chlorophyll biosynthesis plays a vital role in chloroplast...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 632: Review of Chitosan-Based Polymers as Proton Exchange Membranes and Roles of Chitosan-Supported Ionic Liquids International Journal of Molecular Sciences doi: 10.3390/ijms21020632 Authors: Nur Adiera Hanna Rosli Kee Shyuan Loh Wai Yin Wong Rozan Mohamad Yunus Tian Khoon Lee Azizan Ahmad Seng Tong Chong Perfluorosulphonic acid-based membranes such as Nafion are widely used in fuel cell applications. However, these membranes have several drawbacks,...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 625: Immunological Memory of Psoriatic Lesions International Journal of Molecular Sciences doi: 10.3390/ijms21020625 Authors: Owczarczyk Saczonek Krajewska-Włodarczyk Kasprowicz-Furmańczyk Placek The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 624: Wound Dressing Selection Is Critical to Enhance Platelet-Rich Fibrin Activities in Wound Care International Journal of Molecular Sciences doi: 10.3390/ijms21020624 Authors: Cristina Del Amo Arantza Perez-Valle Elena Perez-Zabala Karmele Perez-del-Pecho Ainara Larrazabal Andima Basterretxea Paola Bully Isabel Andia The use of platelet-rich fibrin (PRF) is investigated in ulcer management because it provides a healing milieu rich in growth...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 626: Age-Associated TET2 Mutations: Common Drivers of Myeloid Dysfunction, Cancer and Cardiovascular Disease International Journal of Molecular Sciences doi: 10.3390/ijms21020626 Authors: Ferrone Blydt-Hansen Rauh Acquired, inactivating mutations in Tet methylcytosine dioxygenase 2 (TET2) are detected in peripheral blood cells of a remarkable 5%–10% of adults greater than 65 years of age. They impart a hematopoietic stem cell advantage and resultant...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 623: Influence of Cardiometabolic Risk Factors on Platelet Function International Journal of Molecular Sciences doi: 10.3390/ijms21020623 Authors: Cristina Barale Isabella Russo Platelets are key players in the thrombotic processes. The alterations of platelet function due to the occurrence of metabolic disorders contribute to an increased trend to thrombus formation and arterial occlusion, thus playing a major role in the increased risk of atherothrombotic events...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 622: Specific Heat and Transport Functions ofWater International Journal of Molecular Sciences doi: 10.3390/ijms21020622 Authors: Mallamace Corsaro Mallamace Fazio Chen Cupane Numerous water characteristics are essentially ascribed to its peculiarity to form stronghydrogen bonds that become progressively more stable on decreasing the temperature. However, thestructural and dynamical implications of the molecular rearrangement are still subject...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 620: Identification of (Z)-8-Heptadecene and n-Pentadecane as Electrophysiologically Active Compounds in Ophrys insectifera and Its Argogorytes Pollinator International Journal of Molecular Sciences doi: 10.3390/ijms21020620 Authors: Björn Bohman Alyssa M. Weinstein Raimondas Mozuraitis Gavin R. Flematti Anna-Karin Borg-Karlson Sexually deceptive orchids typically depend on specific insect species for pollination, which are lured by sex pheromone mimicry....
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 619: Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms21020619 Authors: Yu-Ting Kang Wen-Cheng Hsu Chu-Chyn Ou Hui-Chun Tai Hui-Ting Hsu Kun-Tu Yeh Jiunn-Liang Ko Nickel (Ni), which is a carcinogenic workplace hazard, increases the risk of lung cancer. Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine that is...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 618: Effect of Drought Stress during Soybean R2–R6 Growth Stages on Sucrose Metabolism in Leaf and Seed International Journal of Molecular Sciences doi: 10.3390/ijms21020618 Authors: Yanli Du Qiang Zhao Liru Chen Xingdong Yao Huijun Zhang Junjiang Wu Futi Xie Sucrose is the main photosynthesis product of plants and the fundamental carbon skeleton monomer and energy supply for seed formation and development. Drought stress induces decreased photosynthetic...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 621: Jasmonic Acid Signaling Pathway in Response to Abiotic Stresses in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21020621 Authors: Md. Sarafat Ali Kwang-Hyun Baek Plants as immovable organisms sense the stressors in their environment and respond to them by means of dedicated stress response pathways. In response to stress, jasmonates (jasmonic acid, its precursors and derivatives), a class of polyunsaturated fatty acid-derived phytohormones,...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 616: The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model International Journal of Molecular Sciences doi: 10.3390/ijms21020616 Authors: Magdalena Gorska-Ponikowska Alicja Kuban-Jankowska Antonella Marino Gammazza Agnieszka Daca Justyna M. Wierzbicka Michal A. Zmijewski Hue H. Luu Michal Wozniak Francesco Cappello 2-Methoxyestradiol is one of the natural 17β-estradiol derivatives...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 615: Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity International Journal of Molecular Sciences doi: 10.3390/ijms21020615 Authors: Danielle Gutman Elina Rivkin Almog Fadida Lital Sharvit Vered Hermush Elad Rubin Dani Kirshner Irina Sabin Tzvi Dwolatzky Gil Atzmon Exceptionally long-lived individuals (ELLI) who are the focus of many...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 614: Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21020614 Authors: Hyun Jin Jung Ju-Hee Kang Seongwon Pak Keunwook Lee Je Kyung Seong Seung Hyun Oh Nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a cell-surface adhesion molecule that regulates cell migration and attachment. This study demonstrates the increase in Ninj1...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 617: Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses International Journal of Molecular Sciences doi: 10.3390/ijms21020617 Authors: Dongsheng Jiang Yuval Rinkevich Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring–regeneration...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 612: Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells International Journal of Molecular Sciences doi: 10.3390/ijms21020612 Authors: Linzhi Cai Sabrina V. Kirchleitner Dongxu Zhao Min Li Jörg-Christian Tonn Rainer Glass Roland E. Kälin Molecular imaging is essential for diagnosis and treatment planning for glioblastoma patients. Positron emission tomography (PET) with tracers for...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 609: Mild Hyperthermia Aggravates Glucose Metabolic Consequences in Repetitive Concussion International Journal of Molecular Sciences doi: 10.3390/ijms21020609 Authors: Meghan Blaya Jessie Truettner Weizhao Zhao Helen Bramlett William Dalton Dietrich Traumatic brain injury (TBI) is one of the leading causes of mortality and disability around the world. Mild TBI (mTBI) makes up approximately 80% of reported cases and often results in transient psychological...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 611: Report for the Sixth Meeting of the International Society for Zinc Biology (ISZB-2019) International Journal of Molecular Sciences doi: 10.3390/ijms21020611 Authors: Toshiyuki Fukada Taiho Kambe The sixth meeting of the International Society for Zinc Biology (ISZB-2019) was held on September 9–13, 2019 in Kyoto, Japan. The meeting attracted 215 participants, had four plenary speakers, ten scientific symposia, two oral sessions, and one poster discussion...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 610: Aquaglyceroporins Are Differentially Expressed in Beige and White Adipocytes International Journal of Molecular Sciences doi: 10.3390/ijms21020610 Authors: Inês Vieira da Silva Francisco Díaz-Sáez António Zorzano Anna Gumà Marta Camps Graça Soveral Browning of white adipocytes has been proposed as a powerful strategy to overcome metabolic complications, since brown adipocytes are more catabolic, expending energy as a heat form. However, the biological...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 613: Bone Marrow Stromal Cells-Induced Drug Resistance in Multiple Myeloma International Journal of Molecular Sciences doi: 10.3390/ijms21020613 Authors: Roberto Ria Angelo Vacca Multiple myeloma is a B-cell lineage cancer in which neoplastic plasma cells expand in the bone marrow and pathophysiological interactions with components of microenvironment influence many biological aspects of the malignant phenotype, including apoptosis, survival, proliferation, and...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 607: TBX1 and Basal Cell Carcinoma: Expression and Interactions with Gli2 and Dvl2 Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21020607 Authors: Cinzia Caprio Silvia Varricchio Marchesa Bilio Federica Feo Rosa Ferrentino Daniela Russo Stefania Staibano Daniela Alfano Caterina Missero Gennaro Ilardi Antonio Baldini Early events of basal cell carcinoma (BCC) tumorigenesis are triggered by inappropriate activation...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 608: Genome-Wide Investigation of Heat Shock Transcription Factor Family in Wheat (Triticum aestivum L.) and Possible Roles in Anther Development International Journal of Molecular Sciences doi: 10.3390/ijms21020608 Authors: Jiali Ye Xuetong Yang Gan Hu Qi Liu Wei Li Lingli Zhang Xiyue Song Heat shock transcription factors (HSFs) play crucial roles in resisting heat stress and regulating plant development. Recently, HSFs have been shown to play...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 606: Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area International Journal of Molecular Sciences doi: 10.3390/ijms21020606 Authors: Sonia Sanchez-Bezanilla N. David Åberg Patricia Crock Frederick R. Walker Michael Nilsson Jörgen Isgaard Lin Kooi Ong Motor impairment is the most common and widely recognised clinical outcome after stroke. Current clinical practice...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 603: The Subtilisin-Like Protease Bcser2 Affects the Sclerotial Formation, Conidiation and Virulence of Botrytis cinerea International Journal of Molecular Sciences doi: 10.3390/ijms21020603 Authors: Xinqiang Liu Jiatao Xie Yanping Fu Daohong Jiang Tao Chen Jiasen Cheng Botrytis cinerea, a ubiquitous necrotrophic plant-pathogenic fungus, is responsible for grey mold and rot disease in a very wide range of plant species. Subtilisin-like proteases (or...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 604: The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology International Journal of Molecular Sciences doi: 10.3390/ijms21020604 Authors: Olubadewa A. Fatunde Sherry-Ann Brown As many novel cancer therapies continue to emerge, the field of Cardio-Oncology (or onco-cardiology) has become crucial to prevent, monitor and treat cancer therapy-related cardiovascular toxicity. Furthermore, given the narrow therapeutic window of most cancer therapies, drug-drug...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 605: The Effects of TiO2 Nanoparticles on Cisplatin Cytotoxicity in Cancer Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21020605 Authors: Basma Salama El-Said El-Sherbini Gehad El-Sayed Mohamed El-Adl Koki Kanehira Akiyoshi Taniguchi There have been many studies on improving the efficacy of cisplatin and on identifying safe compounds that can overcome multi-drug resistance (MDR) acquired by cancer cells. Our previous research...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 602: Mechanisms of Tumor-Lymphatic Interactions in Invasive Breast and Prostate Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21020602 Authors: Leticia Oliveira-Ferrer Karin Milde-Langosch Kathrin Eylmann Maila Rossberg Volkmar Müller Barbara Schmalfeldt Isabell Witzel Jasmin Wellbrock Walter Fiedler During the last few years, diverse studies have shown that tumors can actively interact with the lymphatic system and...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 601: The Role and Function of HDL in Patients with Chronic Kidney Disease and the Risk of Cardiovascular Disease International Journal of Molecular Sciences doi: 10.3390/ijms21020601 Authors: Jacek Rysz Anna Gluba-Brzózka Magdalena Rysz-Górzyńska Beata Franczyk Chronic kidney disease (CKD) is a worldwide health problem with steadily increasing occurrence. Significantly elevated cardiovascular morbidity and mortality have been observed in CKD. Cardiovascular...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 600: GABAA Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets International Journal of Molecular Sciences doi: 10.3390/ijms21020600 Authors: Sergiy V. Korol Zhe Jin Bryndis Birnir In pancreatic islets, the major cell-types are α, β and δ cells. The γ-aminobutyric acid (GABA) signalling system is expressed in human pancreatic islets. In single...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 598: Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria International Journal of Molecular Sciences doi: 10.3390/ijms21020598 Authors: Andrea Angeli Mariana Pinteala Stelian S. Maier Bogdan C. Simionescu Andrea Milaneschi Ghulam Abbas Sonia del Prete Clemente Capasso Antonella Capperucci Damiano Tanini Fabrizio Carta Claudiu T. Supuran A series...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 599: Cadmium-Related Effects on Cellular Immunity Comprises Altered Metabolism in Earthworm Coelomocytes International Journal of Molecular Sciences doi: 10.3390/ijms21020599 Authors: Martina Höckner Claudio Adriano Piechnik Birgit Fiechtner Birgit Weinberger Lars Tomanek The heavy metal cadmium (Cd) is known to modulate the immune system, challenging soil-dwelling organisms where environmental Cd pollution is high. Since earthworms lack adaptive immunity,...
Fri Jan 17, 2020 02:00
IJMS, Vol. 21, Pages 597: Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges International Journal of Molecular Sciences doi: 10.3390/ijms21020597 Authors: Kei Kunimasa Taichiro Goto The immune system plays a dual role in tumor evolution—it can identify and control nascent tumor cells in a process called immunosurveillance and can promote tumor progression through immunosuppression via various mechanisms. Thus, bilateral host-protective...
Fri Jan 17, 2020 02:00
IJNS, Vol. 6, Pages 3: Acknowledgement to Reviewers of International Journal of Neonatal Screening in 2019 International Journal of Neonatal Screening doi: 10.3390/ijns6010003 Authors: International Journal of Neonatal Screening Editorial Office
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 265: Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up—A CLARICOR Trial Sub-Study Journal of Clinical Medicine doi: 10.3390/jcm9010265 Authors: Nilsson Kastrup Sajadieh Boje Jensen Kjøller Kolmos Wuopio Nowak Larsson Jakobsen Winkel Gluud Iversen Ärnlöv Carlsson Elevated pregnancy-associated plasma protein A (PAPP-A)...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 278: Bone Marrow-Derived Mesenchymal Stromal Cells (MSCs) Modulate the Inflammatory Character of Alveolar Macrophages from Sarcoidosis Patients Journal of Clinical Medicine doi: 10.3390/jcm9010278 Authors: Ian McClain Caldwell Christopher Hogden Krisztian Nemeth Michael Boyajian Miklos Krepuska Gergely Szombath Sandra MacDonald Mehrnoosh Abshari Joel Moss Lynn Vitale-Cross Joseph R Fontana Eva Mezey Sarcoidosis is a devastating inflammatory...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 276: Expression Patterns of Circulating MicroRNAs in the Risk Stratification of Bicuspid Aortopathy Journal of Clinical Medicine doi: 10.3390/jcm9010276 Authors: Evaldas Girdauskas Niklas Neumann Johannes Petersen Tatiana Sequeira-Gross Shiho Naito Maria von Stumm Yskert von Kodolitsch Hermann Reichenspurner Tanja Zeller Objective: Aortic size-based criteria are of limited value in the prediction of aortic events, while most aortic events occur...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 275: Epidemiology, Treatment, and Prevention of Nosocomial Bacterial Pneumonia Journal of Clinical Medicine doi: 10.3390/jcm9010275 Authors: Jean Chang Lin Lee Hsueh Hsu Septicaemia likely results in high case-fatality rates in the present multidrug-resistant (MDR) era. Amongst them are hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), two frequent fatal septicaemic entities amongst hospitalised patients. We reviewed...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 277: Safety of Abatacept in Italian Patients with Rheumatoid Arthritis and Interstitial Lung Disease: A Multicenter Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm9010277 Authors: Giulia Cassone Andreina Manfredi Fabiola Atzeni Vincenzo Venerito Caterina Vacchi Valentina Picerno Federica Furini Gian Luca Erre Paola Tomietto Anna Laura Fedele Giovanni Della Casa Valeria Nucera Chiara Giannitti Carlo Salvarani Marco...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 272: Could IL-17A Be a Novel Therapeutic Target in Diabetic Nephropathy? Journal of Clinical Medicine doi: 10.3390/jcm9010272 Authors: Lavoz Rayego-Mateos Orejudo Opazo-Ríos Marchant Marquez-Exposito Tejera-Muñoz Navarro-González Droguett Ortiz Egido Mezzano Rodrigues-Diez Ruiz-Ortega Chronic kidney disease has become a major medical issue in recent years due to its high prevalence worldwide, its association with...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 273: Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Systematic Review of a Controversial and Underestimated Diagnosis Journal of Clinical Medicine doi: 10.3390/jcm9010273 Authors: Frizziero Chakrabarty Nagy Lamarca Hubner Valle McNamara Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature regarding their epidemiology, biology,...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 274: Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31 Journal of Clinical Medicine doi: 10.3390/jcm9010274 Authors: Labonne Driessen Harris Kong Brakta Theisen Sangare Layman Kim Lim Kim We report a genomic and phenotypic delineation for two chromosome regions with candidate genes for syndromic intellectual...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 271: Highly Sensitive Detection of IDH2 Mutations in Acute Myeloid Leukemia Journal of Clinical Medicine doi: 10.3390/jcm9010271 Authors: Jessica Petiti Valentina Rosso Eleonora Croce Vanessa Franceschi Giacomo Andreani Matteo Dragani Marco De Gobbi Monia Lunghi Giuseppe Saglio Carmen Fava Marco Lo Iacono Daniela Cilloni Background: Acute myeloid leukemia is a heterogeneous hematological disease, characterized by karyotypic and molecular...
Sun Jan 19, 2020 02:00
JCM, Vol. 9, Pages 269: Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions Journal of Clinical Medicine doi: 10.3390/jcm9010269 Authors: Viola Huang Negin Karimian Danielle Detelich Siavash Raigani Sharon Geerts Irene Beijert Fermin M. Fontan Mohamed M. Aburawi Sinan Ozer Peony Banik Florence Lin Murat Karabacak Ehab O.A. Hafiz Robert J. Porte Korkut Uygun James F. Markmann Heidi...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 268: Serum Cartilage Oligomeric Matrix Protein in Late-Stage Osteoarthritis: Association with Clinical Features, Renal Function, and Cardiovascular Biomarkers Journal of Clinical Medicine doi: 10.3390/jcm9010268 Authors: Jana Riegger Martin Rehm Gisela Büchele Hermann Brenner Klaus-Peter Günther Dietrich Rothenbacher Rolf E. Brenner This study aimed to assess associations between serum cartilage oligomeric matrix protein (sCOMP) and phenotypic characteristics...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 267: The Vasoactive Mas Receptor in Essential Hypertension Journal of Clinical Medicine doi: 10.3390/jcm9010267 Authors: Amalie L. Povlsen Daniela Grimm Markus Wehland Manfred Infanger Marcus Krüger The renin–angiotensin–aldosterone system (RAAS) has been studied extensively, and with the inclusion of novel components, it has become evident that the system is much more complex than originally anticipated. According to current knowledge,...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 266: Exogenous Gonadotrophin Stimulation Induces Partial Maturation of Human Sertoli Cells in a Testicular Xenotransplantation Model for Fertility Preservation Journal of Clinical Medicine doi: 10.3390/jcm9010266 Authors: Hutka Smith Goossens Wallace Stukenborg Mitchell The future fertility of prepubertal boys with cancer may be irreversibly compromised by chemotherapy and/or radiotherapy. Successful spermatogenesis has not been achieved following...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 270: The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in Apc-Mutant Mice Journal of Clinical Medicine doi: 10.3390/jcm9010270 Authors: Kurokawa Fujii Tomono Miyamoto Hamoya Takahashi Narita Komiya Kobayashi Higami Mutoh Colorectal cancer is the fourth leading cause of cancer death worldwide, and it is important to establish effective methods for preventing colorectal cancer. One effective prevention strategy...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 264: Expression of Taste Receptor 2 Subtypes in Human Testis and Sperm Journal of Clinical Medicine doi: 10.3390/jcm9010264 Authors: Laura Governini Bianca Semplici Valentina Pavone Laura Crifasi Camilla Marrocco Vincenzo De Leo Elisabeth Arlt Thomas Gudermann Ingrid Boekhoff Alice Luddi Paola Piomboni Taste receptors (TASRs) are expressed not only in the oral cavity but also throughout the body, thus suggesting that they may play different...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 260: Clinical Factors Associated with Adherence to the Follow-Up Examination after Positive Fecal Occult Blood Test in National Colorectal Cancer Screening Journal of Clinical Medicine doi: 10.3390/jcm9010260 Authors: Kim Kang Park Shim Kang Lee Tchoe Kong Kim Kim Choi Moon Background: The compliance with the follow-up examination after a positive fecal occult blood test (FOBT) is lower than expected. We aimed to evaluate...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 263: Ringer’s Lactate Prevents Early Organ Failure by Providing Extracellular Calcium Journal of Clinical Medicine doi: 10.3390/jcm9010263 Authors: Khatua Yaron El-Kurdi Kostenko Papachristou Singh Objective: Ringer’s lactate may improve early systemic inflammation during critical illnesses like severe acute pancreatitis, which are associated with hypocalcemia. Ringer’s lactate is buffered and contains lactate and calcium. We,...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 261: Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment
JCM, Vol. 9, Pages 261: Glial Cells—The Strategic Targets in Amyotrophic Lateral Sclerosis Treatment Journal of Clinical Medicine doi: 10.3390/jcm9010261 Authors: Filipi Hermanova Tureckova Vanatko Anderova Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease, which is characterized by the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently by muscle atrophy. To date, numerous gene mutations have been linked to both sporadic...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 262: Effect of Le Fort I Maxillary Advancement and Clockwise Rotation on the Anteromedial Cheek Soft Tissue Change in Patients with Skeletal Class III Pattern and Midface Deficiency: A 3D Imaging-Based Prediction Study Journal of Clinical Medicine doi: 10.3390/jcm9010262 Authors: Hsin-Chih Lai Rafael Denadai Cheng-Ting Ho Hsiu-Hsia Lin Lun-Jou Lo Patients with a skeletal Class III deformity may present with a concave contour of the anteromedial cheek region....
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 258: The Effect of Proton Pump Inhibitor Use on Renal Function in Kidney Transplanted Patients Journal of Clinical Medicine doi: 10.3390/jcm9010258 Authors: Dominik J. G. Flothow Barbara Suwelack Hermann Pavenstädt Katharina Schütte-Nütgen Stefan Reuter Recently, proton pump inhibitor (PPI) intake has been linked to acute kidney injury and chronic kidney disease. The objective of this study was to assess the effect of PPIs on renal function and rejection...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 259: Ipragliflozin Additively Ameliorates Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Controlled with Metformin and Pioglitazone: A 24-Week Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9010259 Authors: Eugene Han Yong-ho Lee Byung-Wan Lee Eun Seok Kang Bong-Soo Cha Despite the benefits of pioglitazone in the treatment of non-alcoholic fatty liver disease (NAFLD), many treated patients continue to experience...
Sat Jan 18, 2020 02:00
JCM, Vol. 9, Pages 257: Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson’s Disease Journal of Clinical Medicine doi: 10.3390/jcm9010257 Authors: Jin Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic neurons of the substantia nigra and plays a critical...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 254: The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function? Journal of Clinical Medicine doi: 10.3390/jcm9010254 Authors: Julia Sarant David Harris Peter Busby Paul Maruff Adrian Schembri Ulrike Lemke Stefan Launer Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 255: Serum Zinc Level and non-Protein Respiratory Quotient in Patients with Chronic Liver Diseases Journal of Clinical Medicine doi: 10.3390/jcm9010255 Authors: Hiroki Nishikawa Ryo Takata Hirayuki Enomoto Kazunori Yoh Yoshinori Iwata Yoshiyuki Sakai Kyohei Kishino Yoshihiro Shimono Naoto Ikeda Tomoyuki Takashima Nobuhiro Aizawa Kunihiro Hasegawa Noriko Ishii Yukihisa Yuri Takashi Nishimura Hiroko Iijima Shuhei Nishiguchi ...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 253: Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair Journal of Clinical Medicine doi: 10.3390/jcm9010253 Authors: Gertrude J. Nieuwenhuijs-Moeke Søren E. Pischke Stefan P. Berger Jan Stephan F. Sanders Robert A. Pol Michel M. R. F. Struys Rutger J. Ploeg Henri G. D. Leuvenink Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 256: Outcome of Femoral Varus Derotational Osteotomy for the Spastic Hip Displacement: Implication for the Indication of Concomitant Pelvic Osteotomy Journal of Clinical Medicine doi: 10.3390/jcm9010256 Authors: Hoon Park Sharkawy Wagih Abdel-Baki Kun-Bo Park Byoung Kyu Park Isaac Rhee Seung-Pyo Hong Hyun Woo Kim No previous studies have suggested a reliable criterion for determining the addition of a concomitant pelvic osteotomy by using a large...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 251: High On-Treatment Platelet Reactivity Affects the Extent of Ischemic Lesions in Stroke Patients Due to Large-Vessel Disease Journal of Clinical Medicine doi: 10.3390/jcm9010251 Authors: Adam Wiśniewski Joanna Sikora Agata Sławińska Karolina Filipska Aleksandra Karczmarska-Wódzka Zbigniew Serafin Grzegorz Kozera Background: Excessive platelet activation and aggregation plays an important role in the pathogenesis of ischemic stroke. Correlation...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 250: Associated Lichen Sclerosis Increases the Risk of Lymph Node Metastases of Vulvar Cancer Journal of Clinical Medicine doi: 10.3390/jcm9010250 Authors: Yohann Dabi Marie Gosset Sylvie Bastuji-Garin Rana Mitri-Frangieh Sofiane Bendifallah Emile Darai Bernard Jean Paniel Roman Rouzier Bassam Haddad Cyril Touboul The most important prognostic factor in vulvar cancer is inguinal lymph node status at the time of diagnosis, even in locally...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 249: Periodontal Behavior Around Teeth Prepared with Finishing Line for Restoration with Fixed Prostheses. A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9010249 Authors: Raquel León-Martínez Jose María Montiel-Company Carlos Bellot-Arcís María Fernanda Solá-Ruíz Eduardo Selva-Otaolaurruchi Rubén Agustín-Panadero Background: The objective of this systematic review and meta-analysis was to analyze the periodontal behavior...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 247: Incremental Value of ePLAR—The Echocardiographic Pulmonary to Left Atrial Ratio in the Assessment of Sub-Massive Pulmonary Emboli Journal of Clinical Medicine doi: 10.3390/jcm9010247 Authors: Isabel G. Scalia William M. Scalia Jonathon Hunter Andrea Z. Riha David Wong Yael Celermajer David G. Platts Benjamin T. Fitzgerald Gregory M. Scalia Background: Acute pulmonary embolism (PE) is characterized hemodynamically by abrupt obstruction in...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 246: Association between On-Treatment Haemoglobin A1c and All-Cause Mortality in Individuals with Type 2 Diabetes: Importance of Personalized Goals and Type of Anti-Hyperglycaemic Treatment Journal of Clinical Medicine doi: 10.3390/jcm9010246 Authors: Emanuela Orsi Enzo Bonora Anna Solini Cecilia Fondelli Roberto Trevisan Monica Vedovato Franco Cavalot Gianpaolo Zerbini Susanna Morano Antonio Nicolucci Giuseppe Penno Giuseppe Pugliese ...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 248: Can Artificial Intelligence Improve the Management of Pneumonia Journal of Clinical Medicine doi: 10.3390/jcm9010248 Authors: Mariana Chumbita Catia Cillóniz Pedro Puerta-Alcalde Estela Moreno-García Gemma Sanjuan Nicole Garcia-Pouton Alex Soriano Antoni Torres Carolina Garcia-Vidal The use of artificial intelligence (AI) to support clinical medical decisions is a rather promising concept. There are two important factors that have driven...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 252: Cytomegalovirus Viremia after Living and Deceased Donation in Kidney Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9010252 Authors: Ulrich Jehn Katharina Schütte-Nütgen Joachim Bautz Hermann Pavenstädt Barbara Suwelack Gerold Thölking Hauke Heinzow Stefan Reuter Despite screening, effective anti-viral drugs and risk-balanced prophylaxis, cytomegalovirus (CMV) remains a major cause of morbidity in transplant patients. The objective...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 245: Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy Journal of Clinical Medicine doi: 10.3390/jcm9010245 Authors: Manila Hada Hannah Oh Shaoqi Fan Roni T. Falk Berta Geller Pamela Vacek Donald Weaver John Shepherd Jeff Wang Bo Fan Sally Herschorn Louise A. Brinton Xia Xu Mark E. Sherman Britton...
Fri Jan 17, 2020 02:00
JCM, Vol. 9, Pages 244: Circulating PCSK9 Level and Risk of Cardiovascular Events and Death in Hemodialysis Patients Journal of Clinical Medicine doi: 10.3390/jcm9010244 Authors: Hyeon Seok Hwang Jin Sug Kim Yang Gyun Kim So-Young Lee Shin Young Ahn Hong Joo Lee Dong-Young Lee Sang Ho Lee Ju Young Moon Kyung Hwan Jeong Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for the prevention of cardiovascular (CV) events. However, the...
Fri Jan 17, 2020 02:00
JDB, Vol. 8, Pages 1: Acknowledgement to Reviewers of JDB in 2019 Journal of Developmental Biology doi: 10.3390/jdb8010001 Authors: JDB Editorial Office
Thu Jan 16, 2020 02:00
JFB, Vol. 11, Pages 5: In Vitro Evaluation of the Influence of Substrate Mechanics on Matrix-Assisted Human Chondrocyte Transplantation Journal of Functional Biomaterials doi: 10.3390/jfb11010005 Authors: Yang Ogando Barabino Matrix-assisted chondrocyte transplantation (MACT) is of great interest for the treatment of patients with cartilage lesions. However, the roles of the matrix properties in modulating cartilage tissue integration during MACT recovery have not been fully...
Sat Jan 18, 2020 02:00
JFMK, Vol. 5, Pages 6: The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Utility and Advantages of the Eccentric Training through the Isoinertial System Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010006 Authors: Fisher Ravalli Carlson Bridgeman Roggio Scuderi Maniaci Cortis Fusco Musumeci We are glad to introduce the first Journal Club of volume five, the first issue. This edition is focused on relevant...
Sun Jan 19, 2020 02:00
JFMK, Vol. 5, Pages 5: Acknowledgement to Reviewers of Journal of Functional Morphology and Kinesiology in 2019 Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010005 Authors: Journal Of Functional Morphology And Kinesiology Editorial
Fri Jan 17, 2020 02:00
JoF, Vol. 6, Pages 16: On Commensalism of Candida Journal of Fungi doi: 10.3390/jof6010016 Authors: Jesus A. Romo Carol A. Kumamoto Candida species are both opportunistic fungal pathogens and common members of the human mycobiome. Over the years, the main focus of the fungal field has been on understanding the pathogenic potential and disease manifestation of these organisms. Therefore, understanding of their commensal lifestyle, interactions with host epithelial barriers, and initial...
Fri Jan 17, 2020 02:00
J. Imaging, Vol. 6, Pages 3: Acknowledgement to Reviewers of Journal of Imaging in 2019 Journal of Imaging doi: 10.3390/jimaging6010003 Authors: Journal of Imaging Editorial Office
Fri Jan 17, 2020 02:00
J. Imaging, Vol. 6, Pages 2: Multiple Query Content-Based Image Retrieval Using Relevance Feature Weight Learning Journal of Imaging doi: 10.3390/jimaging6010002 Authors: Abeer Al-Mohamade Ouiem Bchir Mohamed Maher Ben Ismail We propose a novel multiple query retrieval approach, named weight-learner, which relies on visual feature discrimination to estimate the distances between the query images and images in the database. For each query image, this discrimination consists of learning,...
Fri Jan 17, 2020 02:00
Life, Vol. 10, Pages 6: Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry Life doi: 10.3390/life10010006 Authors: Chandru Mamajanov Cleaves Jia A variety of organic chemicals were likely available on prebiotic Earth. These derived from diverse processes including atmospheric and geochemical synthesis and extraterrestrial input, and were delivered to environments including oceans, lakes, and subaerial hot springs. Prebiotic...
Sun Jan 19, 2020 02:00
Life, Vol. 10, Pages 5: Life in The Context of Order and Complexity Life doi: 10.3390/life10010005 Authors: Mayer It is generally accepted that life requires structural complexity. However, a chaotic mixture of organic compounds like the one formed by extensive reaction sequences over time may be extremely complex, but could just represent a static asphalt-like dead end situation. Likewise, it is accepted that life requires a certain degree of structural order. However, even extremely...
Sat Jan 18, 2020 02:00
Life, Vol. 10, Pages 4: Acknowledgement to Reviewers of Life in 2019 Life doi: 10.3390/life10010004 Authors: Life Editorial Office
Fri Jan 17, 2020 02:00
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