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FEBS Open Bio. 2020 Feb 25;:
Authors: Gao K, Li Y, Yue Z, Han J, Zhou X, Wang X
Abstract
Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring, and obstructive sleep apnea (OSA). Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immune responses may play an important role in AH. Tumor necrosis factor-alpha-induced protein-8 like-2 (TIPE2) is a newly identified protein which negatively regulates the activation of inflammatory pathways. Here, we investigated the effect of TIPE2 in AH in children. We observed that the levels of TNF-α and IL-6 were greater in the adenoid tissue of AH children than in healthy controls (p < 0.01), and this increase was positively correlated with the severity of AH. The level of TIPE2 expression was decreased compared with control and negatively correlated with AH. TIPE2 overexpression in primary human monocytes (isolated from adenoid tissue of AH children) inhibited the activation of NF-κB and expression of TNF-α and IL-6. These results suggest that overexpression of TIPE2 may attenuate AH through inactivation of the NF-κB signaling pathway.
PMID: 32100476 [PubMed - as supplied by publisher]
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