Antibiotics, Vol. 9, Pages 356: Structural Modifications of 3-triazeneindoles and Their Increased Activity Against Mycobacterium tuberculosis Antibiotics doi: 10.3390/antibiotics9060356 Authors: Majorov Nikonenko Ivanov Telegina Apt Velezheva We synthesized 100 novel indole-based compounds with polyaza-functionalities, including 3-triazeneindoles, and tested their activity in vitro against laboratory M. tuberculosis H37Rv and clinical izoniazid-resistant CN-40 isolates,...
Wed Jun 24, 2020 03:00
Antibiotics, Vol. 9, Pages 355: Helicobacter Pylori Biofilm Confers Antibiotic Tolerance in Part via A Protein-Dependent Mechanism Antibiotics doi: 10.3390/antibiotics9060355 Authors: Hathroubi Zerebinski Clarke Ottemann Helicobacter pylori, a WHO class I carcinogen, is one of the most successful human pathogens colonizing the stomach of over 4.4 billion of the world’s population. Antibiotic therapy represents the best solution but poor response rates have hampered...
Wed Jun 24, 2020 03:00
Antioxidants, Vol. 9, Pages 550: Impact of the APE1 Redox Function Inhibitor E3330 in Non-small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion Antioxidants doi: 10.3390/antiox9060550 Authors: Rita Manguinhas Ana S. Fernandes João G. Costa Nuno Saraiva Sérgio P. Camões Nuno Gil Rafael Rosell Matilde Castro Joana P. Miranda Nuno G. Oliveira Elevated expression levels of the apurinic/apyrimidinic...
Wed Jun 24, 2020 03:00
Antioxidants, Vol. 9, Pages 549: Reversible Oxidative Modifications in Myoglobin and Functional Implications Antioxidants doi: 10.3390/antiox9060549 Authors: Mark H. Mannino Rishi S. Patel Amanda M. Eccardt Blythe E. Janowiak David C. Wood Fahu He Jonathan S. Fisher Myoglobin (Mb), an oxygen-binding heme protein highly expressed in heart and skeletal muscle, has been shown to undergo oxidative modifications on both an inter- and intramolecular level when exposed to...
Wed Jun 24, 2020 03:00
Biology, Vol. 9, Pages 135: On a Coupled Time-Dependent SIR Models Fitting with New York and New-Jersey States COVID-19 Data Biology doi: 10.3390/biology9060135 Authors: Benjamin Ambrosio M. A. Aziz-Alaoui This article describes a simple Susceptible Infected Recovered (SIR) model fitting with COVID-19 data for the month of March 2020 in New York (NY) state. The model is a classical SIR, but is non-autonomous; the rate of susceptible people becoming infected is adjusted over time in...
Wed Jun 24, 2020 03:00
Biomedicines, Vol. 8, Pages 172: False Myths versus Medical Facts: Ten Common Misconceptions Related to Dry Eye Disease Biomedicines doi: 10.3390/biomedicines8060172 Authors: Giuseppe Giannaccare Vincenzo Scorcia Since the first definition of dry eye, rapid progress has been made in this field over the past decades that has guided profound changes in the definition, classification, diagnosis and management of the disease. Although dry eye is one of the most frequently encountered...
Wed Jun 24, 2020 03:00
Biomolecules, Vol. 10, Pages 954: Class A G Protein-Coupled Receptor Antagonist Famotidine as a Therapeutic Alternative Against SARS-CoV2: An In Silico Analysis Biomolecules doi: 10.3390/biom10060954 Authors: Joseph T. Ortega Maria Luisa Serrano Beata Jastrzebska The pandemic associated with Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV2) and its disease named COVID-19 challenged the scientific community to discover effective therapeutic solutions in a short period....
Wed Jun 24, 2020 03:00
Biomolecules, Vol. 10, Pages 953: Pathogenesis of Preeclampsia and Therapeutic Approaches Targeting the Placenta Biomolecules doi: 10.3390/biom10060953 Authors: Manoj Kumar Jena Neeta Raj Sharma Matthew Petitt Devika Maulik Nihar Ranjan Nayak Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of pregnancies worldwide and is characterized by hypertension and damage to multiple maternal organs, primarily the liver and kidneys. PE usually begins...
Wed Jun 24, 2020 03:00
Biomolecules, Vol. 10, Pages 952: The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ NaV1.5 Mutant of the Long QT Type 3 Syndrome Biomolecules doi: 10.3390/biom10060952 Authors: Julio Alvarez-Collazo Alejandro López-Requena Julio L. Alvarez Karel Talavera Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na+ channel (hNaV1.5). The citrus flavanone hesperetin (HSP) was...
Wed Jun 24, 2020 03:00
Biosensors, Vol. 10, Pages 72: Detection of Cardiovascular CRP Protein Biomarker Using a Novel Nanofibrous Substrate Biosensors doi: 10.3390/bios10060072 Authors: Isaac Macwan Ashish Aphale Prathamesh Bhagvath Shalini Prasad Prabir Patra It is known that different diseases have characteristic biomarkers that are secreted very early on, even before the symptoms have developed. Before any kind of therapeutic approach can be used, it is necessary that such biomarkers be detected...
Wed Jun 24, 2020 03:00
Biosensors, Vol. 10, Pages 71: A Capillary-Perfused, Nanocalorimeter Platform for Thermometric Enzyme-Linked Immunosorbent Assay with Femtomole Sensitivity Biosensors doi: 10.3390/bios10060071 Authors: Evan Kazura Ray Mernaugh Franz Baudenbacher Enzyme-catalyzed chemical reactions produce heat. We developed an enclosed, capillary-perfused nanocalorimeter platform for thermometric enzyme-linked immunosorbent assay (TELISA). We used catalase as enzymes to model the thermal characteristics...
Wed Jun 24, 2020 03:00
Brain Sciences, Vol. 10, Pages 402: Increased Neural Reward Responsivity in Adolescents with ASD after Social Skills Intervention Brain Sciences doi: 10.3390/brainsci10060402 Authors: Baker Veytsman Martin Blacher Stavropoulos The reward system has been implicated as a potential neural mechanism underlying social-communication deficits in individuals with autism spectrum disorder (ASD). However, it remains unclear whether the neural reward system in ASD is sensitive...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1685: Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12061685 Authors: Stefanie Schatz Markus Falk Balázs Jóri Hayat O. Ramdani Stefanie Schmidt Eva-Maria Willing Roopika Menon Harry J. M. Groen Linda Diehl Matthias Kröger Claas Wesseler Frank Griesinger Petra Hoffknecht Markus Tiemann Lukas C. Heukamp In recent years, Non-small...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1683: Role of Colposcopy after Treatment for Cervical Intraepithelial Neoplasia Cancers doi: 10.3390/cancers12061683 Authors: Annu Heinonen Maija Jakobsson Mari Kiviharju Seppo Virtanen Karoliina Aro Maria Kyrgiou Pekka Nieminen Ilkka Kalliala Colposcopy is often used in follow-up after treatment for cervical intraepithelial neoplasia (CIN) despite its marked inter-observer variability and low sensitivity. Our objective was to assess the role...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1684: A Clinically Applicable Approach to the Classification of B-Cell Non-Hodgkin Lymphomas with Flow Cytometry and Machine Learning Cancers doi: 10.3390/cancers12061684 Authors: Valentina Gaidano Valerio Tenace Nathalie Santoro Silvia Varvello Alessandro Cignetti Giuseppina Prato Giuseppe Saglio Giovanni De De Rosa Massimo Geuna The immunophenotype is a key element to classify B-cell Non-Hodgkin Lymphomas (B-NHL); while it is routinely...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1677: Integrating the Tumor Microenvironment into Cancer Therapy Cancers doi: 10.3390/cancers12061677 Authors: Sabina Sanegre Federico Lucantoni Rebeca Burgos-Panadero Luis de La Cruz-Merino Rosa Noguera Tomás Álvaro Naranjo Tumor progression is mediated by reciprocal interaction between tumor cells and their surrounding tumor microenvironment (TME), which among other factors encompasses the extracellular milieu, immune cells, fibroblasts, and the...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1676: Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy Cancers doi: 10.3390/cancers12061676 Authors: Kosuke Murakami Yasushi Kotani Hidekatsu Nakai Noriomi Matsumura Endometrial cysts (ECs) are thought to be the origin of endometriosis-associated ovarian cancer (EAOC). A hypothesis that the oxidative stress of iron in cysts causes “malignant transformation of ECs” has been proposed, but this has not been verified....
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1680: The Double-Edged Sword Role of Viruses in Gastric Cancer Cancers doi: 10.3390/cancers12061680 Authors: Paulina Niedźwiedzka-Rystwej Ewelina Grywalska Rafał Hrynkiewicz Mikołaj Wołącewicz Rafał Becht Jacek Roliński Due to its high morbidity and mortality, gastric cancer is a topic of a great concern throughout the world. Major ways of treatment are gastrectomy and chemotherapy, unfortunately they are not always successful. In a search for more...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1681: Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up of Exocrine Pancreatic Ductal Adenocarcinoma: Evidence Evaluation and Recommendations by the Italian Association of Medical Oncology (AIOM) Cancers doi: 10.3390/cancers12061681 Authors: Nicola Silvestris Oronzo Brunetti Alessandro Bittoni Ivana Cataldo Domenico Corsi Stefano Crippa Mirko D’Onofrio Michele Fiore Elisa Giommoni Michele Milella Raffaele Pezzilli Enrico...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1678: Intensive Care Outcomes of Patients after High Dose Chemotherapy and Subsequent Autologous Stem Cell Transplantation: A Retrospective, Single Centre Analysis Cancers doi: 10.3390/cancers12061678 Authors: Panagiotis Karagiannis Lena Sänger Winfried Alsdorf Katja Weisel Walter Fiedler Stefan Kluge Dominic Wichmann Carsten Bokemeyer Valentin Fuhrmann High dose chemotherapy (HDT) followed by autologous peripheral blood stem cell transplantation...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1679: Telomerase Biogenesis and Activities from the Perspective of its Direct Interacting Partners Cancers doi: 10.3390/cancers12061679 Authors: Kathryn T. T. T. Nguyen Judy M. Y. Wong Telomerase reverse transcriptase (TERT)—the catalytic subunit of telomerase—is reactivated in up to 90% of all human cancers. TERT is observed in heterogenous populations of protein complexes, which are dynamically regulated in a cell type- and cell cycle-specific...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1682: Multiparametric Analysis of Longitudinal Quantitative MRI data to Identify Distinct Tumor Habitats in Preclinical Models of Breast Cancer Cancers doi: 10.3390/cancers12061682 Authors: Anum K. Syed Jennifer G. Whisenant Stephanie L. Barnes Anna G. Sorace Thomas E. Yankeelov This study identifies physiological tumor habitats from quantitative magnetic resonance imaging (MRI) data and evaluates their alterations in response to therapy. Two models...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1675: Primary and Metastatic Intracranial Ewing Sarcoma at Diagnosis: Retrospective International Study and Systematic Review Cancers doi: 10.3390/cancers12061675 Authors: Lianne M. Haveman Andreas Ranft Henk van den Berg Stephanie Klco-Brosius Ruth Ladenstein Michael Paulussen Heribert Juergens Uta Dirksen Johannes H.M. Merks Intracranial Ewing sarcoma (EwS) is rare and publications on primary or metastatic intracranial EwS are minimal....
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1671: Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation Cancers doi: 10.3390/cancers12061671 Authors: Yasaman Alaghband Samantha N. Cheeks Barrett D. Allen Pierre Montay-Gruel Ngoc-Lien Doan Benoit Petit Patrik Goncalves Jorge Erich Giedzinski Munjal M. Acharya Marie-Catherine Vozenin Charles L. Limoli Major advances in high precision treatment delivery and imaging have greatly improved the...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1674: Inhibition of FGF2-Mediated Signaling in GIST—Promising Approach for Overcoming Resistance to Imatinib Cancers doi: 10.3390/cancers12061674 Authors: Sergei Boichuk Aigul Galembikova Ekaterina Mikheeva Firuza Bikinieva Aida Aukhadieva Pavel Dunaev Dinar Khalikov Semen Petrov Refat Kurtasanov Elena Valeeva Igor Kireev Vera Dugina Anna Lushnikova Maria Novikova Pavel Kopnin Inhibition of KIT-signaling is a major molecular...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1672: Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe Cancers doi: 10.3390/cancers12061672 Authors: Giulia Veronesi David R. Baldwin Claudia I. Henschke Simone Ghislandi Sergio Iavicoli Matthijs Oudkerk Harry J. De Koning Joseph Shemesh John K. Field Javier J. Zulueta Denis Horgan Lucia Fiestas Navarrete Maurizio Valentino Infante Pierluigi Novellis Rachael L. Murray Nir...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1673: Comparative Efficacy of First-Line Immune-Based Combination Therapies in Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-Analysis Cancers doi: 10.3390/cancers12061673 Authors: Reza Elaidi Letuan Phan Delphine Borchiellini Philippe Barthelemy Alain Ravaud Stéphane Oudard Yann Vano Three drug combinations, ipilimumab-nivolumab (Ipi-Nivo), pembrolizumab-axitinib (Pembro-Axi), and avelumab-axitinib (Ave-Axi), have received...
Wed Jun 24, 2020 03:00
Cancers, Vol. 12, Pages 1670: Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress Cancers doi: 10.3390/cancers12061670 Authors: Wangjie Yu Yunyun Chen Nagireddy Putluri Cristian Coarfa Matthew J. Robertson Vasanta Putluri Fabio Stossi Julien Dubrulle Michael A. Mancini Jonathan C. Pang Trung Nguyen Dodge Baluya Jeffrey N. Myers Stephen Y. Lai Vlad C. Sandulache Background:...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1539: Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis Cells doi: 10.3390/cells9061539 Authors: Peter Ping Lin Hematogenous and lymphogenous cancer metastases are significantly impacted by tumor neovascularization, which predominantly consists of blood vessel-relevant angiogenesis, vasculogenesis, vasculogenic mimicry, and lymphatic vessel-related lymphangiogenesis. Among the endothelial...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1541: Early Onset of Sex-Dependent Mitochondrial Deficits in the Cortex of 3xTg Alzheimer’s Mice Cells doi: 10.3390/cells9061541 Authors: Jelena Djordjevic Subir Roy Chowdhury Wanda M. Snow Claudia Perez Chris Cadonic Paul Fernyhough Benedict C. Albensi Alzheimer’s disease (AD) is a major public health concern worldwide. Advanced age and female sex are two of the most prominent risk factors for AD. AD is characterized by progressive neuronal...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1540: Methylation-Based Therapies for Colorectal Cancer Cells doi: 10.3390/cells9061540 Authors: Klara Cervena Anna Siskova Tomas Buchler Pavel Vodicka Veronika Vymetalkova Colorectal carcinogenesis (CRC) is caused by the gradual long-term accumulation of both genetic and epigenetic changes. Recently, epigenetic alterations have been included in the classification of the CRC molecular subtype, and this points out their prognostic impact. As epigenetic...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1538: Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas Cells doi: 10.3390/cells9061538 Authors: Marta Mellai Laura Annovazzi Ilaria Bisogno Cristiano Corona Paola Crociara Barbara Iulini Paola Cassoni Cristina Casalone Renzo Boldorini Davide Schiffer Background: Neuron glial antigen 2 or chondroitin sulphate proteoglycan 4 (NG2/CSPG4) is expressed by immature precursors/progenitor cells and is...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1542: Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis Cells doi: 10.3390/cells9061542 Authors: Marko Sesartić Kristian Ikenberg Sun-Young Yoon Michael Detmar Podoplanin is a small transmembrane mucin-like glycoprotein that plays a crucial role in the development of the lung, heart and lymphatic vascular system. Its expression is upregulated in several types of human carcinomas and podoplanin levels in squamous cell carcinomas...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1537: Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers Cells doi: 10.3390/cells9061537 Authors: Ghita Chabab Florence Boissière-Michot Caroline Mollevi Jeanne Ramos Evelyne Lopez-Crapez Pierre-Emmanuel Colombo William Jacot Nathalie Bonnefoy Virginie Lafont γδ T-cells contribute to the immune response against many tumor types through their direct cytolytic functions and their capacity to recruit and...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1536: Lessons from the Endoplasmic Reticulum Ca2+ Transporters—A Cancer Connection Cells doi: 10.3390/cells9061536 Authors: Xingjian Zhai Andra Mihaela Sterea Yassine El Hiani Ca2+ is an integral mediator of intracellular signaling, impacting almost every aspect of cellular life. The Ca2+-conducting transporters located on the endoplasmic reticulum (ER) membrane shoulder the responsibility of constructing the global Ca2+ signaling landscape. These transporters...
Wed Jun 24, 2020 03:00
Cells, Vol. 9, Pages 1535: Macrophage Modification Strategies for Efficient Cell Therapy Cells doi: 10.3390/cells9061535 Authors: Anastasiya S. Poltavets Polina A. Vishnyakova Andrey V. Elchaninov Gennady T. Sukhikh Timur Kh. Fatkhudinov Macrophages, important cells of innate immunity, are known for their phagocytic activity, capability for antigen presentation, and flexible phenotypes. Macrophages are found in all tissues and therefore represent an attractive therapeutic...
Wed Jun 24, 2020 03:00
Cosmetics, Vol. 7, Pages 50: To Play or Not to Play: Can an Instrument Really Impact Lip and Tongue Performance? Cosmetics doi: 10.3390/cosmetics7020050 Authors: Robert S. Thiebaud Takashi Abe W. Matt Denning Jeremy P. Loenneke Micah J. Okerlund Joe S. J. Ryan Whitney Boyce Maggie McBride Jared Hernandez (1) Background: Increasing tongue and lip strength may help improve various speech and swallowing disorders, but it is unclear if instrumentalists who use these...
Wed Jun 24, 2020 03:00
Dentistry Journal, Vol. 8, Pages 60: Minimally Invasive Diastema Restoration with Prefabricated Sectional Veneers Dentistry Journal doi: 10.3390/dj8020060 Authors: Claudio Novelli Andrea Scribante This case report presents a new technique for sectional veneer fabrication and diastema restoration with a prefabricated composite veneer. For the purpose of diastema restoration, a prefabricated sectional veneer provides the same benefits of a traditional ceramic sectional veneer (highly...
Wed Jun 24, 2020 03:00
Diagnostics, Vol. 10, Pages 429: Budget Impact Analysis of EGFR Mutation Liquid Biopsy for First- and Second-Line Treatment of Metastatic Non-Small Cell Lung Cancer in Greece Diagnostics doi: 10.3390/diagnostics10060429 Authors: Mindy Cheng Athanasios Akalestos Sidney Scudder Within the European Union, Greece has the highest incidence of lung cancer among people under 45 years of age. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are indicated for the treatment...
Wed Jun 24, 2020 03:00
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