JCM, Vol. 9, Pages 3163: 18F-FDG PET/MR versus MR Alone in Whole-Body Primary Staging and Restaging of Patients with Rectal Cancer: What Is the Benefit of PET?
Journal of Clinical Medicine doi: 10.3390/jcm9103163
Authors:
Li
Mueller
Neuhaus
Bertram
Schaarschmidt
Demircioglu
Ludwig
Kirchner
Rischpler
Herrmann
Catalano
Umutlu
Background: To investigate and compare the diagnostic performance of 18F-Fluorodeoxyglucose (18F-FDG) PET/MR and MR alone in whole-body primary staging and restaging of patients with rectal cancer. Methods: A retrospective analysis was performed to evaluate diagnostic accuracies of combined reading of PET/MR and MR alone in T, N and M staging against the reference standard. Inter-observer agreement regarding TNM staging was calculated separately for PET/MR and MR alone. Results: A total of 39 studies of 34 patients could be evaluated. Diagnostic accuracies of PET/MR and MR alone were the same in locoregional T staging. For predicting N+ stage, the specificity of combined reading of PET and MR (0.917 and 0.833 for reader 1 and 2, respectively) was slightly higher than MR alone (0.833 and 0.75) without significantly increasing the overall accuracy (0.783 vs. 0.783 and 0.783 vs. 0.739). For detecting distant metastasis, the sensitivities of PET/MR and MR alone were shown equal (1.0 vs. 1.0 and 0.938 vs. 0.938), while the specificity of PET/MR was marginally lower (0.87 vs. 0.913 and 0.826 vs. 0.87). The inter-observer agreements were good to excellent in M (κ = 0.64 and 0.637 for PET/MR and MR alone, p < 0.001) and N staging (0.819 and 0.738, p < 0.001).Conclusion: PET did not yield a significant improvement in diagnostic accuracy of PET/MR in TNM staging of rectal cancer, since MR alone facilitated accurate classification of disease stage with good to excellent inter-observer agreement.
JCM, Vol. 9, Pages 3162: Application of A Convolutional Neural Network in The Diagnosis of Gastric Mesenchymal Tumors on Endoscopic Ultrasonography Images Journal of Clinical Medicine doi: 10.3390/jcm9103162 Authors: Kim Kim Kim Lee Lee Baek Kim Park Background and Aims: Endoscopic ultrasonography (EUS) is a useful diagnostic modality for evaluating gastric mesenchymal tumors; however, differentiating gastrointestinal stromal tumors (GISTs) from benign mesenchymal...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3161: Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose Journal of Clinical Medicine doi: 10.3390/jcm9103161 Authors: Katoh Peltonen Zeniya Sakamoto Utsunomiya Nishimura Tuomilehto Objective: We examined the association between non-alcoholic fatty liver disease (NAFLD) markers and fasting serum immunoreactive insulin (FIRI) and urinary albumin...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3150: Patient-Reported Outcomes Following Total Knee Replacement in Patients <65 Years of Age—A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9103150 Authors: Jason Trieu Daniel J. Gould Chris Schilling Tim Spelman Michelle M. Dowsey Peter F. Choong An increasing number of total knee replacements (TKRs) are being performed in response to the growing burden of osteoarthritis. Patients <65 years of age represent...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3159: Effects of Sacubitril/Valsartan on the Right Ventricular Arterial Coupling in Patients with Heart Failure with Reduced Ejection Fraction Journal of Clinical Medicine doi: 10.3390/jcm9103159 Authors: Daniele Masarone Vittoria Errigo Enrico Melillo Fabio Valente Rita Gravino Marina Verrengia Ernesto Ammendola Rossella Vastarella Giuseppe Pacileo Background: right ventricle-pulmonary artery (RV-PA) coupling assessed by measuring the tricuspid...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3152: Prognostic Relevance of the Eighth Edition of TNM Classification for Resected Perihilar Cholangiocarcinoma Journal of Clinical Medicine doi: 10.3390/jcm9103152 Authors: Hans-Michael Hau Felix Meyer Nora Jahn Sebastian Rademacher Robert Sucher Daniel Seehofer Objectives: In our study, we evaluated and compared the prognostic value and performance of the 6th, 7th, and 8th editions of the American Joint Committee on Cancer (AJCC) staging system in...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3157: Systemic Treatment for Advanced and Metastatic Malignant Peripheral Nerve Sheath Tumors—A Sarcoma Reference Center Experience Journal of Clinical Medicine doi: 10.3390/jcm9103157 Authors: Paweł Sobczuk Paweł Teterycz Anna M. Czarnecka Tomasz Świtaj Hanna Koseła-Paterczyk Katarzyna Kozak Sławomir Falkowski Piotr Rutkowski Malignant peripheral nerve sheath tumor (MPNST) is a rare type of soft tissue sarcomas. The localized disease is usually...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3154: Consideration of Migraines Among Risk Factors for Postoperative Nausea and Vomiting Journal of Clinical Medicine doi: 10.3390/jcm9103154 Authors: Jong-Ho Kim Man-sup Lim Sang-Hwa Lee Young-Suk Kwon Jae Jun Lee Jong-Hee Sohn The impact of migraine on postoperative nausea and vomiting (PONV) is controversial, and few studies have focused on their relationship. Thus, we investigated the impact of migraine, among other risk factors, on PONV in a large...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3153: Expression of MTDH and IL-10 Is an Independent Predictor of Worse Prognosis in ER-Negative or PR-Negative Breast Cancer Patients Journal of Clinical Medicine doi: 10.3390/jcm9103153 Authors: Pei-Yi Chu Shin-Mae Wang Po-Ming Chen Feng-Yao Tang En-Pei Isabel Chiang (1) Background: Tumor hypoxia leads to metastasis and certain immune responses, and interferes with normal biological functions. It also affects glucose intake, down-regulates oxidative phosphorylation,...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3158: Irisin in Liver Cirrhosis Journal of Clinical Medicine doi: 10.3390/jcm9103158 Authors: Michał Kukla Lubomir Skladany Tomasz Menżyk Aleksandra Derra Dominika Stygar Magdalena Skonieczna Dorota Hudy Katarzyna Nabrdalik Janusz Gumprecht Wojciech Marlicz Anastasios Koulaouzidis Tomas Koller Background: Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength,...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3151: The Effect of Virtual Reality on Preoperative Anxiety: A Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9103151 Authors: Chang-Hoon Koo Jin-Woo Park Jung-Hee Ryu Sung-Hee Han Virtual reality (VR), a technology that provides a stimulated sensory experience, has recently been implemented in various fields of medicine. Several studies have investigated the efficacy of VR on preoperative anxiety. The purpose of...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3156: Special Issue “Oral Health and Systemic Diseases” Journal of Clinical Medicine doi: 10.3390/jcm9103156 Authors: Schmalz Ziebolz With an enormous prevalence worldwide, diseases of the oral cavity and respective tissues are a highly relevant global health issue [1][...]
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3149: Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2 Journal of Clinical Medicine doi: 10.3390/jcm9103149 Authors: Roya Zandi Jessica Song Paul S. Micevych Amani A. Fawzi In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3155: A Deep Brain Stimulation Trial Period for Treating Chronic Pain Journal of Clinical Medicine doi: 10.3390/jcm9103155 Authors: Prasad Shirvalkar Kristin K. Sellers Ashlyn Schmitgen Jordan Prosky Isabella Joseph Philip A. Starr Edward F. Chang Early studies of deep brain stimulation (DBS) for various neurological disorders involved a temporary trial period where implanted electrodes were externalized, in which the electrical contacts exiting the...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3160: Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9103160 Authors: De Cannière Smeets Schoutteten Varon Morales Tellez Van Hoof Huffel Groenendaal Vandervoort Cardiac rehabilitation (CR) is a highly recommended secondary prevention measure for patients with diagnosed cardiovascular disease. Unfortunately, participation...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3148: Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France Journal of Clinical Medicine doi: 10.3390/jcm9103148 Authors: Pierre-Yves Boëlle Tristan Delory Xavier Maynadier Cécile Janssen Renaud Piarroux Marie Pichenot Xavier Lemaire Nicolas Baclet Pierre Weyrich Hugues Melliez Agnès Meybeck Jean-Philippe Lanoix Olivier Robineau Describing the characteristics of COVID-19 patients in the hospital is...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3146: Confocal Laser Endomicroscopy Assessment of Pituitary Tumor Microstructure: A Feasibility Study Journal of Clinical Medicine doi: 10.3390/jcm9103146 Authors: Evgenii Belykh Brandon Ngo Dara S. Farhadi Xiaochun Zhao Michael A. Mooney William L. White Jessica K. Daniels Andrew S. Little Jennifer M. Eschbacher Mark C. Preul This is the first study to assess confocal laser endomicroscopy (CLE) use within the transsphenoidal approach and...
Tue Sep 29, 2020 03:00
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