IJMS, Vol. 21, Pages 7215: Cardiac Fibroblast-Induced Pluripotent Stem Cell-Derived Exosomes as a Potential Therapeutic Mean for Heart Failure
International Journal of Molecular Sciences doi: 10.3390/ijms21197215
Authors:
Kurtzwald-Josefson
Zeevi-Levin
Rubchevsky
Bechar Erdman
Schwartz Rohaker
Nahum
Hochhauser
Ben-Avraham
Itskovitz-Eldor
Aravot
D. Barac
The limited regenerative capacity of the injured myocardium leads to remodeling and often heart failure. Novel therapeutic approaches are essential. Induced pluripotent stem cells (iPSC) differentiated into cardiomyocytes are a potential future therapeutics. We hypothesized that organ-specific reprogramed fibroblasts may serve an advantageous source for future cardiomyocytes. Moreover, exosomes secreted from those cells may have a beneficial effect on cardiac differentiation and/or function. We compared RNA from different sources of human iPSC using chip gene expression. Protein expression was evaluated as well as exosome micro-RNA levels and their impact on embryoid bodies (EBs) differentiation. Statistical analysis identified 51 genes that were altered (p ≤ 0.05), and confirmed in the protein level, cardiac fibroblasts-iPSCs (CF-iPSCs) vs. dermal fibroblasts-iPSCs (DF-iPSCs). Several miRs were altered especially miR22, a key regulator of cardiac hypertrophy and remodeling. Lower expression of miR22 in CF-iPSCs vs. DF-iPSCs was observed. EBs treated with these exosomes exhibited more beating EBs p = 0.05. vs. control. We identify CF-iPSC and its exosomes as a potential source for cardiac recovery induction. The decrease in miR22 level points out that our CF-iPSC-exosomes are naïve of congestive heart cell memory, making them a potential biological source for future therapy for the injured heart.
IJMS, Vol. 21, Pages 7216: NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms21197216 Authors: De Nuccio Bernardo Troiano Brignone Falchi Greco Rosini Basagni Lanni Serafini Minghetti Visentin An adequate protection from oxidative and inflammatory reactions, together with the promotion...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7214: Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy International Journal of Molecular Sciences doi: 10.3390/ijms21197214 Authors: Kralisch Hoffmann Estrada-Kunz Stumvoll Fasshauer Tönjes Miehle Objective. Similar to obesity, lipodystrophy (LD) causes adipose tissue dysfunction and severe metabolic complications. Growth differentiation factor 15 (GDF15) belongs to the transforming growth...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7193: Histone-Mutant Glioma: Molecular Mechanisms, Preclinical Models, and Implications for Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21197193 Authors: Maya S. Graham Ingo K. Mellinghoff Pediatric high-grade glioma (pHGG) is the leading cause of cancer death in children. Despite histologic similarities, it has recently become apparent that this disease is molecularly distinct from its adult counterpart. Specific hallmark oncogenic histone...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7212: Effects of Early-Life Stress on the Brain and Behaviors: Implications of Early Maternal Separation in Rodents International Journal of Molecular Sciences doi: 10.3390/ijms21197212 Authors: Nishi Early-life stress during the prenatal and postnatal periods affects the formation of neural networks that influence brain function throughout life. Previous studies have indicated that maternal separation (MS), a typical rodent model equivalent to early-life stress...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7210: Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38 International Journal of Molecular Sciences doi: 10.3390/ijms21197210 Authors: Liang-Yin Chou Chung-Hwan Chen Shu-Chun Chuang Tsung-Lin Cheng Yi-Hsiung Lin Hsin-Chiao Chou Yin-Chih Fu Yan-Hsiung Wang Chau-Zen Wang Discoidin domain receptor 1 (Drd1) is a collagen-binding membrane protein, but its role...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7213: The Interaction of Innate and Adaptive Immunity and Stabilization of Mast Cell Activation in Management of Infusion Related Reactions in Patients with Fabry Disease International Journal of Molecular Sciences doi: 10.3390/ijms21197213 Authors: Limgala Fikry Veligatla Goker-Alpan Fabry disease (FD) is an X-linked lysosomal disorder caused by mutations in GLA gene resulting in lack of or faulty α-galactosidase A (α-GalA) enzyme....
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7209: Functional Characterization of Gomisin N in High-Fat-Induced Drosophila Obesity Models International Journal of Molecular Sciences doi: 10.3390/ijms21197209 Authors: Lee Lee Cheon Gomisin N (GN) is lignin derived from Schisandra chinensis that has been reported to exhibit hepato-protective, anti-cancer, and anti-inflammatory effects. However, its role in whole-body energetic homeostasis remains unclear. In this study, we employed Drosophila melanogaster...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7211: Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature International Journal of Molecular Sciences doi: 10.3390/ijms21197211 Authors: Tzaridis Reiners Weller Bachurski Schäfer Schaub Hallek Scheffler Glas Herrlinger Wild Coch Hartmann Glioblastoma is a devastating disease, for which biomarkers allowing a prediction of...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7208: Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity International Journal of Molecular Sciences doi: 10.3390/ijms21197208 Authors: Damian Neubauer Maciej Jaśkiewicz Emilia Sikorska Sylwia Bartoszewska Marta Bauer Małgorzata Kapusta Magdalena Narajczyk Wojciech Kamysz Ultrashort cationic lipopeptides (USCLs) are considered to be a promising class of antimicrobials with high activity...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7207: Role of SGK1 in the Osteogenic Transdifferentiation and Calcification of Vascular Smooth Muscle Cells Promoted by Hyperglycemic Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21197207 Authors: Florian Poetsch Laura A. Henze Misael Estepa Barbara Moser Burkert Pieske Florian Lang Kai-Uwe Eckardt Ioana Alesutan Jakob Voelkl In diabetes mellitus, hyperglycemia promotes the osteogenic transdifferentiation of vascular...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7206: Self-Assembly of Supramolecular Architectures by the Effect of Amino Acid Residues of Quaternary Ammonium Pillar[5]arenes International Journal of Molecular Sciences doi: 10.3390/ijms21197206 Authors: Anastasia Nazarova Dmitriy Shurpik Pavel Padnya Timur Mukhametzyanov Peter Cragg Ivan Stoikov Novel water-soluble multifunctional pillar[5]arenes containing amide-ammonium-amino acid moiety were synthesized. The compounds demonstrated a superior...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7205: Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21197205 Authors: Susanne Feder Astrid Bruckmann Nichole McMullen Christopher J. Sinal Christa Buechler Murine chemerin is C-terminally processed to the bioactive isoforms, muChem-156 and muChem-155, among which the longer variant protects from hepatocellular carcinoma (HCC). However, the role of muChem-155...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7197: Angiopoietin-Like Protein 4 Overexpression in Visceral Adipose Tissue from Obese Subjects with Impaired Glucose Metabolism and Relationship with Lipoprotein Lipase International Journal of Molecular Sciences doi: 10.3390/ijms21197197 Authors: Ilaria Barchetta Caterina Chiappetta Valentina Ceccarelli Flavia Agata Cimini Laura Bertoccini Melania Gaggini Claudio Di Cristofano Gianfranco Silecchia Andrea Lenzi Frida Leonetti Marco Giorgio...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7199: Transcriptional and Metabolic Profiling of Potato Plants Expressing a Plastid-Targeted Electron Shuttle Reveal Modulation of Genes Associated to Drought Tolerance by Chloroplast Redox Poise International Journal of Molecular Sciences doi: 10.3390/ijms21197199 Authors: Juan J. Pierella Karlusich Rocío C. Arce Fahimeh Shahinnia Sophia Sonnewald Uwe Sonnewald Matias D. Zurbriggen Mohammad-Reza Hajirezaei Néstor Carrillo Water limitation represents...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7201: Placental Epigenome-Wide Association Study Identified Loci Associated with Childhood Adiposity at 3 Years of Age International Journal of Molecular Sciences doi: 10.3390/ijms21197201 Authors: Valérie Gagné-Ouellet Edith Breton Kathrine Thibeault Carol-Ann Fortin Véronique Desgagné Élise Girard Tremblay Andres Cardenas Renée Guérin Patrice Perron Marie-France Hivert Luigi Bouchard The aim of this study was to identify placental...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7203: Transient Changes of Metabolism at The Pronuclear Stage in Mice Influences Skeletal Muscle Phenotype in Adulthood International Journal of Molecular Sciences doi: 10.3390/ijms21197203 Authors: Christelle Bertrand-Gaday Martine Letheule Emilie Blanchet Barbara Vernus Laurence Pessemesse Amélie Bonnet-Garnier Anne Bonnieu François Casas Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7202: Age-Related Hearing Loss in C57BL/6J Mice Is Associated with Mitophagy Impairment in the Central Auditory System International Journal of Molecular Sciences doi: 10.3390/ijms21197202 Authors: Cha Kyung Youn Yonghyun Jun Eu-Ri Jo Sung Il Cho Aging is associated with functional and morphological changes in the sensory organs, including the auditory system. Mitophagy, a process that regulates the turnover of dysfunctional mitochondria, is impaired with...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7204: Modifying the Cyanobacterial Metabolism as a Key to Efficient Biopolymer Production in Photosynthetic Microorganisms International Journal of Molecular Sciences doi: 10.3390/ijms21197204 Authors: Maciej Ciebiada Katarzyna Kubiak Maurycy Daroch Cyanobacteria are photoautotrophic bacteria commonly found in the natural environment. Due to the ecological benefits associated with the assimilation of carbon dioxide from the atmosphere and utilization of light...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7198: Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21197198 Authors: Tania Maffucci Marco Falasca Signaling pathways regulated by the phosphoinositide 3-kinase (PI3K) enzymes have a well-established role in cancer development and progression. Over the past 30 years, the therapeutic potential of targeting this pathway has been well recognized, and...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7194: High Mannose N-Glycans Promote Migration of Bone-Marrow-Derived Mesenchymal Stromal Cells International Journal of Molecular Sciences doi: 10.3390/ijms21197194 Authors: Vivian Alonso-Garcia Cutter Chaboya Qiongyu Li Bryan Le Timothy J. Congleton Jose Florez Victoria Tran Gang-Yu Liu Wei Yao Carlito B. Lebrilla Fernando A. Fierro For hundreds of indications, mesenchymal stromal cells (MSCs) have not achieved the expected therapeutic...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7196: Comparable Effects of the Androgen Derivatives Danazol, Oxymetholone and Nandrolone on Telomerase Activity in Human Primary Hematopoietic Cells from Patients with Dyskeratosis Congenita International Journal of Molecular Sciences doi: 10.3390/ijms21197196 Authors: Margherita Vieri Martin Kirschner Mareike Tometten Anne Abels Benjamin Rolles Susanne Isfort Jens Panse Tim H. Brümmendorf Fabian Beier Dyskeratosis congenita (DKC) is a rare...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7200: Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells International Journal of Molecular Sciences doi: 10.3390/ijms21197200 Authors: Riad Ladjohounlou Safa Louati Alexandra Lauret Arnaud Gauthier Dominique Ardail Nicolas Magne Gersende Alphonse Claire Rodriguez-Lafrasse We investigated the potential involvement of ceramide-enriched membrane...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7187: Cross-Talk between P2X and NMDA Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21197187 Authors: Larry Rodriguez Catherine Yi Cameron Chu Quentin Duriez Sharyse Watanabe Megan Ryu Brandon Reyes Liana Asatryan Eric Boué-Grabot Daryl Davies Purinergic P2X receptors (P2X) are ATP-gated ion channels widely expressed in the CNS. While the direct contribution of P2X to synaptic transmission is uncertain, P2X reportedly...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7195: Immune Checkpoint Inhibitors and Cardiac Toxicity in Patients Treated for Non-Small Lung Cancer: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21197195 Authors: Grzegorz Sławiński Anna Wrona Alicja Dąbrowska-Kugacka Grzegorz Raczak Ewa Lewicka Lung cancer is a major cause of cancer-related mortality worldwide, both in men and women. The vast majority of patients are diagnosed with non-small-cell lung cancer (NSCLC, 80–85%...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7192: Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells International Journal of Molecular Sciences doi: 10.3390/ijms21197192 Authors: Paweł Leszczyński Magdalena Śmiech Aamir Salam Teeli Effi Haque Robert Viger Hidesato Ogawa Mariusz Pierzchała Hiroaki Taniguchi PRDM (PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain-containing)...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7190: Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States International Journal of Molecular Sciences doi: 10.3390/ijms21197190 Authors: Anna Maria Santoro Alessandro D’Urso Alessandra Cunsolo Danilo Milardi Roberto Purrello Diego Sbardella Grazia R. Tundo Donatella Diana Roberto Fattorusso Antonio Di Dato Antonella Paladino Marco Persico...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7191: The Class III Peroxidase Encoding Gene AtPrx62 Positively and Spatiotemporally Regulates the Low pH-Induced Cell Death in Arabidopsis thaliana Roots International Journal of Molecular Sciences doi: 10.3390/ijms21197191 Authors: Jonathas Pereira Graças Philippe Ranocha Victor Alexandre Vitorello Bruno Savelli Elisabeth Jamet Christophe Dunand Vincent Burlat Exogenous low pH stress causes cell death in root cells, limiting root development,...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7188: An Analysis of Clinical, Surgical, Pathological and Molecular Characteristics of Endometrial Cancer According to Mismatch Repair Status. A Multidisciplinary Approach International Journal of Molecular Sciences doi: 10.3390/ijms21197188 Authors: Giulia Dondi Sara Coluccelli Antonio De Leo Simona Ferrari Elisa Gruppioni Alessandro Bovicelli Lea Godino Camelia Alexandra Coadă Alessio Giuseppe Morganti Antonio Giordano Donatella Santini...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7186: Bioactive Ent-Kaurane Diterpenes Oridonin and Irudonin Prevent Cancer Cells Migration by Interacting with the Actin Cytoskeleton Controller Ezrin International Journal of Molecular Sciences doi: 10.3390/ijms21197186 Authors: Valentina Pagliara Giuliana Donadio Nunziatina De Tommasi Giuseppina Amodio Paolo Remondelli Ornella Moltedo Fabrizio Dal Piaz The ent-kaurane diterpene oridonin was reported to inhibit cell migration and invasion in several...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7189: Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19 International Journal of Molecular Sciences doi: 10.3390/ijms21197189 Authors: Eileen M McGowan Nahal Haddadi Najah T. Nassif Yiguang Lin The world is currently experiencing the worst health pandemic since the Spanish flu in 1918—the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7185: Autophagy Dynamics and Modulation in a Rat Model of Renal Ischemia-Reperfusion Injury International Journal of Molecular Sciences doi: 10.3390/ijms21197185 Authors: Jean-Paul Decuypere Shawn Hutchinson Diethard Monbaliu Wim Martinet Jacques Pirenne Ina Jochmans Renal ischemia-reperfusion (IR) injury leading to cell death is a major cause of acute kidney injury, contributing to morbidity and mortality. Autophagy counteracts cell death by removing...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7183: MCPIP1 RNase and Its Multifaceted Role International Journal of Molecular Sciences doi: 10.3390/ijms21197183 Authors: Richard Musson Weronika Szukała Jolanta Jura Inflammation is an organism’s physiological response to harmful septic and aseptic stimuli. This process begins locally through the influx of immune system cells to the damaged tissue and the subsequent activation and secretion of inflammatory mediators to restore homeostasis in the...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7184: The Potential Role of Irisin in Vascular Function and Atherosclerosis: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21197184 Authors: Kyeongho Byun Sewon Lee Exercise is an effective intervention for both the prevention and the treatment of obesity and insulin resistance because skeletal muscle secretes many bioactive proteins that contribute to the beneficial effect of exercise. It has been revealed that irisin plays an important...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7182: Imbalance of Lysine Acetylation Contributes to the Pathogenesis of Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21197182 Authors: Rui Wang Hongyang Sun Guanghui Wang Haigang Ren Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The neuropathological features of PD are selective and progressive loss of dopaminergic neurons in the substantia nigra pars compacta, deficiencies...
Tue Sep 29, 2020 03:00
IJMS, Vol. 21, Pages 7181: The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process International Journal of Molecular Sciences doi: 10.3390/ijms21197181 Authors: Chiara Lenzi Ileana Ramazzina Isabella Russo Alice Filippini Saverio Bettuzzi Federica Rizzi Parkinson’s Disease (PD) is a progressive neurodegenerative disease characterized by the presence of proteinaceous aggregates of αSynuclein (αSyn) in the dopaminergic...
Tue Sep 29, 2020 03:00
JCM, Vol. 9, Pages 3164: Atrial Substrate Underlies the Recurrence after Catheter Ablation in Patients with Atrial Fibrillation Journal of Clinical Medicine doi: 10.3390/jcm9103164 Authors: Yong-Soo Baek Jong-Il Choi Yun Gi Kim Kwang-No Lee Seung-Young Roh Jinhee Ahn Dong-Hyeok Kim Dae In Lee Sung Ho Hwang Jaemin Shim Jin Seok Kim Dae-Hyeok Kim Sang-Weon Park Young-Hoon Kim Prediction of recurrences after catheter ablation of atrial fibrillation...
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JCM, Vol. 9, Pages 3162: Application of A Convolutional Neural Network in The Diagnosis of Gastric Mesenchymal Tumors on Endoscopic Ultrasonography Images Journal of Clinical Medicine doi: 10.3390/jcm9103162 Authors: Kim Kim Kim Lee Lee Baek Kim Park Background and Aims: Endoscopic ultrasonography (EUS) is a useful diagnostic modality for evaluating gastric mesenchymal tumors; however, differentiating gastrointestinal stromal tumors (GISTs) from benign mesenchymal...
Tue Sep 29, 2020 03:00
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