Antibiotics, Vol. 9, Pages 45: Anti-Fungal Efficacy and Mechanisms of Flavonoids Antibiotics doi: 10.3390/antibiotics9020045 Authors: Aboody Mickymaray The prevalence of fungal infections is growing at an alarming pace and the pathogenesis is still not clearly understood. Recurrence of these fungal diseases is often due to their evolutionary avoidance of antifungal resistance. The development of suitable novel antimicrobial agents for fungal diseases continues to be a major problem...
Sun Jan 26, 2020 02:00
Antioxidants, Vol. 9, Pages 108: Hydrogen Peroxide Mediates Artemisinin-Derived C-16 Carba-Dimer-Induced Toxicity of Human Cancer Cells Antioxidants doi: 10.3390/antiox9020108 Authors: Kalen Wagner Sarsour Kumar Reedy Buettner Barua Goswami This study used a nitroaliphatic chemistry approach to synthesize a novel artemisinin-derived carba-dimer (AG-1) and determined its anti-proliferative effects in human normal and cancer cells. AG-1 treatments selectively...
Sun Jan 26, 2020 02:00
Antioxidants, Vol. 9, Pages 107: Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective Antioxidants doi: 10.3390/antiox9020107 Authors: Kim Lee Yoon Post-traumatic stress disorder (PTSD) is a chronic condition characterized by symptoms of physiological and psychosocial burden. While growing research demonstrated signs of inflammation in PTSD, specific biomarkers that may be representative of PTSD such...
Sun Jan 26, 2020 02:00
Antioxidants, Vol. 9, Pages 105: Antioxidants in Poultry Nutrition and Reproduction: An Update Antioxidants doi: 10.3390/antiox9020105 Authors: Surai For the last three decades poultry [...]
Sat Jan 25, 2020 02:00
Antioxidants, Vol. 9, Pages 106: Maslinic Acid Ameliorates Inflammation via the Downregulation of NF-κB and STAT-1 Antioxidants doi: 10.3390/antiox9020106 Authors: Lee Kim Park Bae Maslinic acid (MA), a natural compound of the triterpenoid group derived from olive, prevents the generation of pro-inflammatory cytokines and oxidative stress. In human umbilical vein endothelial cells (HUVECs) treated with lipopolysaccharide (LPS), we characterized the effects of MA on the regulation...
Sat Jan 25, 2020 02:00
Antioxidants, Vol. 9, Pages 104: Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension Antioxidants doi: 10.3390/antiox9020104 Authors: Varghese Niihori Eccles Kurdyukov James Rafikova Rafikov Pulmonary arterial hypertension (PAH) is a chronic cardiopulmonary disorder instigated by pulmonary vascular cell proliferation. Activation of Akt was previously reported to promote vascular remodeling. Also, the irreversible nitration...
Sat Jan 25, 2020 02:00
Antioxidants, Vol. 9, Pages 103: Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by Scaptotrigona affinis postica: in silico, in vitro, and in vivo Studies Antioxidants doi: 10.3390/antiox9020103 Authors: Lopes Vasconcelos Garcia Dória Pinheiro Pereira Camelo Morais Freitas Rocha de Sousa Ribeiro do Socorro de Sousa Cartágenes Bees are of great importance for plant diversity for being an important pollinating agents. Stingless...
Fri Jan 24, 2020 02:00
Antioxidants, Vol. 9, Pages 100: Glutathione S-Transferases Play a Crucial Role in Mitochondrial Function, Plasma Membrane Stability and Oxidative Regulation of Mammalian Sperm Antioxidants doi: 10.3390/antiox9020100 Authors: Llavanera Delgado-Bermúdez Olives Mateo-Otero Recuero Bonet Fernández-Fuertes Yeste Barranco Glutathione S-transferases (GSTs) are essential sperm antioxidant enzymes involved in cell protection against oxidative stress and toxic...
Fri Jan 24, 2020 02:00
Antioxidants, Vol. 9, Pages 101: Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds Antioxidants doi: 10.3390/antiox9020101 Authors: Balakrishnan Vijayraja Jo Ganesan Su-Kim Choi The discovery of several revitalizing molecules that can stop or reduce the pathology of a wide range of diseases will be considered a major breakthrough of the present time. Available synthetic compounds may provoke...
Fri Jan 24, 2020 02:00
Antioxidants, Vol. 9, Pages 99: Scrophularia koraiensis Nakai Attenuates Allergic Airway Inflammation via Suppression of NF-κB and Enhancement of Nrf2/HO-1 Signaling Antioxidants doi: 10.3390/antiox9020099 Authors: Jung Lee Song Lee Lim Lee Ko Shin Kim Shin Kim Scrophularia koraiensis Nakai (Scrophulariaceae) is a medicinal herb that grows in Korea and which has been widely used to treat fever, edema, neuritis and laryngitis. Hence, we evaluated...
Fri Jan 24, 2020 02:00
Antioxidants, Vol. 9, Pages 102: Ecotype-Specific Pathways of Reactive Oxygen Species Deactivation in Facultative Metallophyte Silene Vulgaris (Moench) Garcke Treated with Heavy Metals Antioxidants doi: 10.3390/antiox9020102 Authors: Muszyńska Labudda Kral This research aimed to indicate mechanisms involved in protection against the imbalanced generation of reactive oxygen species (ROS) during heavy metals (HMs) exposition of Silene vulgaris ecotypes with different levels of...
Fri Jan 24, 2020 02:00
Atmosphere, Vol. 11, Pages 139: Correction of Light Scattering-based Total Suspended Particulate Measurements through Machine Learning Atmosphere doi: 10.3390/atmos11020139 Authors: Guo Zhu Cheng Xu Wang Duan Instruments based on light scattering used to measure total suspended particulate (TSP) concentrations have the advantages of fast response, small size, and low cost compared to the gravimetric reference method. However, the relationship between scattering intensity...
Sun Jan 26, 2020 02:00
Atmosphere, Vol. 11, Pages 138: Study on the Sensitivity of Summer Ozone Density to the Enhanced Aerosol Loading over the Tibetan Plateau Atmosphere doi: 10.3390/atmos11020138 Authors: Yan Wang Yang The existence of the Asian tropopause aerosol layer (ATAL) and the influence of the heterogeneous chemistry of aerosols on the summer ozone valley over the Tibetan Plateau have received continuous attention. In this paper, based on the established box model of the heterogeneous chemical...
Sun Jan 26, 2020 02:00
Atmosphere, Vol. 11, Pages 137: Prediction of Aerosol Deposition in the Human Respiratory Tract via Computational Models: A Review with Recent Updates Atmosphere doi: 10.3390/atmos11020137 Authors: Bui Moon Chae Park Lee The measurement of deposited aerosol particles in the respiratory tract via in vivo and in vitro approaches is difficult due to those approaches’ many limitations. In order to overcome these obstacles, different computational models have been...
Sun Jan 26, 2020 02:00
Atmosphere, Vol. 11, Pages 136: Quantifying Extreme Precipitation Forecasting Skill in High-Resolution Models Using Spatial Patterns: A Case Study of the 2016 and 2018 Ellicott City Floods Atmosphere doi: 10.3390/atmos11020136 Authors: Zick Recent historic floods in Ellicott City, MD, on 30 July 2016 and 27 May 2018 provide stark examples of the types of floods that are expected to become more frequent due to urbanization and climate change. Given the profound impacts associated with...
Sat Jan 25, 2020 02:00
Atmosphere, Vol. 11, Pages 135: Stable Isotopes Reveal Climate Signal Hidden in Tree Rings of Endemic Balkan Pines Atmosphere doi: 10.3390/atmos11020135 Authors: Levanič Jevšenak Hafner Studies report the good potential of Pinus heldreichii (PIHE) and Pinus peuce (PIPE) for developing long chronologies from living trees and warn that the climate signal is weak in tree-ring widths of PIHE, and particularly PIPE. The goals of the study were to develop long chronologies, and to...
Fri Jan 24, 2020 02:00
Atmosphere, Vol. 11, Pages 134: Comparison of Methodologies for Assessing Desert Dust Contribution to Regional PM10 and PM2.5 Levels: A One-Year Study Over Portugal Atmosphere doi: 10.3390/atmos11020134 Authors: Gama Pio Monteiro Russo Fernandes Borrego Baldasano Tchepel Desert dust outbreaks may affect air quality. This study estimates the importance of African dust contribution to the PM10 and PM2.5 concentrations observed in rural regional background sites...
Fri Jan 24, 2020 02:00
Atmosphere, Vol. 11, Pages 133: Spectral Analysis of Gravity Waves from Near Space High-Resolution Balloon Data in Northwest China Atmosphere doi: 10.3390/atmos11020133 Authors: He Sheng He Using a set of near space high-resolution balloon data released in Hami, Xinjiang, we explored the spectral characteristics of temperature fluctuations and three-dimensional wind field fluctuations. As different from previous studies, which were based on radiosondes, we have increased the...
Fri Jan 24, 2020 02:00
Atmosphere, Vol. 11, Pages 132: Spring Season in Western Nepal Himalaya is not yet Warming: A 400-Year Temperature Reconstruction Based on Tree-Ring Widths of Himalayan Hemlock (Tsuga dumosa) Atmosphere doi: 10.3390/atmos11020132 Authors: Aryal Gaire Pokhrel Rana Sharma Kharal Poudel Dyola Fan Grießinger Bräuning The Himalayan region has already witnessed profound climate changes detectable in the cryosphere and the hydrological cycle, already...
Fri Jan 24, 2020 02:00
Atmosphere, Vol. 11, Pages 131: Aqueous-Phase Brown Carbon Formation from Aromatic Precursors under Sunlight Conditions Atmosphere doi: 10.3390/atmos11020131 Authors: Vidović Kroflič Šala Grgić At present, there are still numerous unresolved questions concerning the mechanisms of light-absorbing organic aerosol (brown carbon, BrC) formation in the atmosphere. Moreover, there is growing evidence that chemical processes in the atmospheric aqueous phase can be important. In...
Fri Jan 24, 2020 02:00
Atmosphere, Vol. 11, Pages 129: Observations of Atmospheric NO2 Using a New Low-Cost MAX-DOAS System
Atmosphere, Vol. 11, Pages 129: Observations of Atmospheric NO2 Using a New Low-Cost MAX-DOAS System Atmosphere doi: 10.3390/atmos11020129 Authors: Roşu Constantin Voiculescu Arseni Merlaud Van Roozendael Georgescu This article describes the prototype of a new MAX-DOAS (multi-axis differential optical absorption spectroscopy) system built at “Dunarea de Jos” University of Galati (UGAL), Romania, and the first results of its use to observe...
Fri Jan 24, 2020 02:00
Atmosphere, Vol. 11, Pages 130: Characteristics of Ground-Level Ozone from 2015 to 2018 in BTH Area, China Atmosphere doi: 10.3390/atmos11020130 Authors: Fang Xiao Sun Liu Zhang Xie Liang Wang With the ground-level ozone pollution problem increasingly prominent in recent years in China, it is particularly important in basic researches on ozone contamination characteristics. In this study, 13 cities in Beijing-Tianjin-Hebei (BTH) area were examined to determine...
Fri Jan 24, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 42: Formation of Future Educators’ Professional Training for Introducing Social Experience by Means of Innovative Technologies of Education to Senior Preschoolers Behavioral Sciences doi: 10.3390/bs10020042 Authors: Shkabarina Melnychuk Koval Stupnytska The purpose of the paper is to reveal the peculiarities of the introduction of innovative education technologies in the process of training future pre-school teachers in the field of the...
Sat Jan 25, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 41: A Short Empathy Paradigm to Assess Empathic Deficits in Schizophrenia Behavioral Sciences doi: 10.3390/bs10020041 Authors: Peveretou Radke Derntl Habel Empathy is important for successful social interaction and maintaining relationships. Several studies detected impairments in empathic abilities in schizophrenia, with some even indicating a broader deficit in several components, including emotion recognition, perspective taking, and...
Fri Jan 24, 2020 02:00
Biomedicines, Vol. 8, Pages 21: Circulating MyomiRs as Potential Biomarkers to Monitor Response to Nusinersen in Pediatric SMA Patients Biomedicines doi: 10.3390/biomedicines8020021 Authors: Bonanno Marcuzzo Malacarne Giagnorio Masson Zanin Arnoldi Andreetta Simoncini Venerando Gellera Pantaleoni Mantegazza Bernasconi Baranello Maggi Spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by mutations in survival...
Sun Jan 26, 2020 02:00
Biomedicines, Vol. 8, Pages 20: 2-deoxy-d-glucose Ameliorates Animal Models of Dermatitis Biomedicines doi: 10.3390/biomedicines8020020 Authors: Choi Heo Lee Choi An Bae An Jung Glucose metabolism is a key metabolic pathway that orchestrates cellular homeostasis by generating ATP, nucleotides, and amino acids. Abnormal glucose signaling has been found in many diseases including cancers and inflammatory diseases. According to recent report, glycolysis contributes...
Fri Jan 24, 2020 02:00
Biomolecules, Vol. 10, Pages 190: Enhancing Activity of Pleurotus sajor-caju (Fr.) Sing β-1,3-Glucanoligosaccharide (Ps-GOS) on Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells through the Involvement of BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway Biomolecules doi: 10.3390/biom10020190 Authors: Thanintorn Yodthong Ureporn Kedjarune-Leggat Carl Smythe Pannawich Sukprasirt Aratee Aroonkesorn Rapepun Wititsuwannakul Thanawat Pitakpornpreecha Osteoporosis...
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Biomolecules, Vol. 10, Pages 189: Sodium Chloride Induced Stress Responses of Antioxidative Activities in Leaves and Roots of Pistachio Rootstock Biomolecules doi: 10.3390/biom10020189 Authors: Akbari Katam Husain Farajpour Mazzuca Mahna Salinity substantially affects plant growth and crop productivity worldwide. Plants adopt several biochemical mechanisms including regulation of antioxidant biosynthesis to protect themselves against the toxic effects induced by...
Sun Jan 26, 2020 02:00
Biomolecules, Vol. 10, Pages 188: High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BKCa-Channel Activity and Inhibits IK(M) or Ih Biomolecules doi: 10.3390/biom10020188 Authors: Lu Gao Li Wu : GAL-021 has recently been developed as a novel breathing control modulator. However, modifications of ionic currents produced by this agent remain uncertain, although its efficacy in suppressing the activity of big-conductance Ca2+-activated...
Sat Jan 25, 2020 02:00
Biomolecules, Vol. 10, Pages 187: Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity Biomolecules doi: 10.3390/biom10020187 Authors: Sun Jiang Lv Liang Zhao Bian Zhang Jiang Zhang Heart failure (HF) is a deadly disease that is difficult to accurately diagnose. Circular RNAs (circRNAs) are a novel class of noncoding RNAs that might play important roles in many cardiovascular diseases. However, their...
Sat Jan 25, 2020 02:00
Biomolecules, Vol. 10, Pages 184: Asiatic Acid, Extracted from Centella asiatica and Induces Apoptosis Pathway through the Phosphorylation p38 Mitogen-Activated Protein Kinase in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells Biomolecules doi: 10.3390/biom10020184 Authors: Liu Chuang Lo Lin Hsi Hsieh Chen Nasopharyngeal carcinoma (NPC) is an important issue in Asia because of its unique geographical and ethnic distribution. Cisplatin-based regimens are commonly...
Sat Jan 25, 2020 02:00
Biomolecules, Vol. 10, Pages 185: Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release Biomolecules doi: 10.3390/biom10020185 Authors: Balkrishna Nain Chauhan Sharma Gupta Ranjan Varshney (1) Background: Withania somnifera Dunal (Ashwagandha) is a widely used medicinal herb in traditional medicinal systems with extensive research on various...
Sat Jan 25, 2020 02:00
Biomolecules, Vol. 10, Pages 183: Structure–Activity Relationship of HER2 Receptor Targeting Peptide and Its Derivatives in Targeted Tumor Therapy Biomolecules doi: 10.3390/biom10020183 Authors: Biri-Kovács Adorján Szabó Szeder Bősze Mező Human epidermal growth factor (HER2) is a transmembrane tyrosine kinase receptor that is frequently overexpressed in breast cancer. Its increased level prognoses a poor patient outcome and a high mortality rate. Despite the widening...
Sat Jan 25, 2020 02:00
Biomolecules, Vol. 10, Pages 186: Cytokinin Sensing in Bacteria Biomolecules doi: 10.3390/biom10020186 Authors: Kabbara Bidon Kilani Osman Hamze Stock Papon Although it has long been known that bacteria detect and react to plant chemicals to establish an interaction, the cellular signaling mechanisms involved in these perception processes have hitherto remained obscure. Some exciting recent advances in the field have described, for the first time, how some phytopathogenic...
Sat Jan 25, 2020 02:00
Biomolecules, Vol. 10, Pages 182: The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective Biomolecules doi: 10.3390/biom10020182 Authors: Nicolai P. Ostberg Mohammad A. Zafar Bulat A. Ziganshin John A. Elefteriades Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted the aorta due to high pressure and biomechanical stress,...
Fri Jan 24, 2020 02:00
Biomolecules, Vol. 10, Pages 181: Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities Biomolecules doi: 10.3390/biom10020181 Authors: Nugraha Triatmoko Wangchuk Keller This is an extensive review on epiphytic plants that have been used traditionally as medicines. It provides information on 185 epiphytes and their traditional medicinal uses, regions where Indigenous people use...
Fri Jan 24, 2020 02:00
Biomolecules, Vol. 10, Pages 180: Inhibitory Activity of Flavonoids, Chrysoeriol and Luteolin-7-O-Glucopyranoside, on Soluble Epoxide Hydrolase from Capsicum chinense Biomolecules doi: 10.3390/biom10020180 Authors: Kim Jin : Three flavonoids derived from the leaves of Capsicum chinense Jacq. were identified as chrysoeriol (1), luteolin-7-O-glucopyranoside (2), and isorhamnetin-7-O-glucopyranoside (3). They had IC50 values of 11.6±2.9, 14.4±1.5, and 42.7±3.5...
Fri Jan 24, 2020 02:00
Biomolecules, Vol. 10, Pages 179: FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions Biomolecules doi: 10.3390/biom10020179 Authors: Tapial Martínez López Navajas Lietha Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major driver of invasion and metastasis and its upregulation is associated with poor patient prognosis. FAK...
Fri Jan 24, 2020 02:00
Biomolecules, Vol. 10, Pages 178: The Stimulatory Effect of Purine-Type Cytokinins on Proliferation and Polyphenolic Compound Accumulation in Shoot Culture of Salvia Viridis Biomolecules doi: 10.3390/biom10020178 Authors: Grzegorczyk-Karolak Hnatuszko-Konka Zarzycka Kuźma The present study demonstrates hormonal control of Salvia viridis growth and development using four different purine-type cytokinins at different concentrations. The addition of cytokinins significantly...
Fri Jan 24, 2020 02:00
Biosensors, Vol. 10, Pages 8: Newly Developed System for Acetamiprid Residue Screening in the Lettuce Samples Based on a Bioelectric Cell Biosensor Biosensors doi: 10.3390/bios10020008 Authors: Apostolou Loizou Hadjilouka Inglezakis Kintzios Population growth and increased production demands on fruit and vegetables have driven agricultural production to new heights. Nevertheless, agriculture remains one of the least optimized industries, with laboratory tests that take...
Fri Jan 24, 2020 02:00
Brain Sciences, Vol. 10, Pages 67: Involvement of Centrally Projecting Edinger–Westphal Nucleus Neuropeptides in Actions of Addictive Drugs Brain Sciences doi: 10.3390/brainsci10020067 Authors: Zuniga Ryabinin The centrally-projecting Edinger–Westphal nucleus (EWcp) is a brain region distinct from the preganglionic Edinger–Westphal nucleus (EWpg). In contrast to the EWpg, the EWcp does not send projections to the ciliary ganglion and appears not to regulate oculomotor...
Sun Jan 26, 2020 02:00
Brain Sciences, Vol. 10, Pages 66: The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development Brain Sciences doi: 10.3390/brainsci10020066 Authors: Rebecca C. Shaffer Lauren Schmitt Angela John Thurman Leonard Abbeduto Michael Hong Ernest Pedapati Kelli Dominick John Sweeney Craig Erickson Language impairment is a core difficulty in fragile X syndrome (FXS), and yet standardized measures lack the sensitivity...
Sun Jan 26, 2020 02:00
Brain Sciences, Vol. 10, Pages 65: Neural Stem Cells/Neuronal Precursor Cells and Postmitotic Neuroblasts in Constitutive Neurogenesis and After ,Traumatic Injury to the Mesencephalic Tegmentum of Juvenile Chum Salmon, Oncorhynchus keta Brain Sciences doi: 10.3390/brainsci10020065 Authors: Pushchina Kapustyanov Varaksin The proliferation of neural stem cells (NSCs)/neuronal precursor cells (NPCs) and the occurrence of postmitotic neuroblasts in the mesencephalic tegmentum of...
Sat Jan 25, 2020 02:00
Brain Sciences, Vol. 10, Pages 64: CINET: A Brain-Inspired Deep Learning Context-Integrating Neural Network Model for Resolving Ambiguous Stimuli Brain Sciences doi: 10.3390/brainsci10020064 Authors: Amerineni Gupta Gupta The brain uses contextual information to uniquely resolve the interpretation of ambiguous stimuli. This paper introduces a deep learning neural network classification model that emulates this ability by integrating weighted bidirectional context into the classification...
Fri Jan 24, 2020 02:00
Brain Sciences, Vol. 10, Pages 63: Cerebellar Transcranial Magnetic Stimulation Reduces the Silent Period on Hand Muscle Electromyography During Force Control Brain Sciences doi: 10.3390/brainsci10020063 Authors: Matsugi Douchi Suzuki Oku Mori Tanaka Nishishita Bando Kikuchi Okada : This study aimed to investigate whether cerebellar transcranial magnetic stimulation (C-TMS) affected the cortical silent period (cSP) induced by TMS over the primary...
Fri Jan 24, 2020 02:00
Brain Sciences, Vol. 10, Pages 62: Surgery for Spine Disease and Intractable Pain Brain Sciences doi: 10.3390/brainsci10020062 Authors: Boling Painful conditions, particularly due to head pain, spinal disease, and neuropathic pain, are highly prevalent in modern society, resulting in a significant impact on the individual due to the disability of the condition and the direct cost of associated treatments [...]
Fri Jan 24, 2020 02:00
Cancers, Vol. 12, Pages 293: Early Changes in Circulating FGF19 and Ang-2 Levels as Possible Predictive Biomarkers of Clinical Response to Lenvatinib Therapy in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12020293 Authors: Chuma Uojima Numata Hidaka Toyoda Hiraoka Tada Hirose Atsukawa Itokawa Arai Kako Nakazawa Wada Iwasaki Miura Hishiki Nishigori Morimoto Hattori Ogushi Nozaki Fukuda Kagawa...
Sun Jan 26, 2020 02:00
Cancers, Vol. 12, Pages 292: The Spectrum of FANCM Protein Truncating Variants in European Breast Cancer Cases Cancers doi: 10.3390/cancers12020292 Authors: Figlioli Kvist Tham Soukupova Kleiblova Muranen Andrieu Azzollini Balmaña Barroso Benítez Bertelsen Blanco Bonanni Borg Brunet Calistri Calvello Chvojka Cortesi Darder Valle Diez Consortium Eon-Marchais Fostira Gensini Houdayer...
Sun Jan 26, 2020 02:00
Cancers, Vol. 12, Pages 290: A Comprehensive Review of Calcium Electroporation —A Novel Cancer Treatment Modality Cancers doi: 10.3390/cancers12020290 Authors: Frandsen Vissing Gehl Calcium electroporation is a potential novel anti-cancer treatment where high calcium concentrations are introduced into cells by electroporation, a method where short, high voltage pulses induce transient permeabilisation of the plasma membrane allowing passage of molecules into the cytosol. Calcium...
Sat Jan 25, 2020 02:00
Cancers, Vol. 12, Pages 291: Multifaceted Roles of Caveolin-1 in Lung Cancer: A New Investigation Focused on Tumor Occurrence, Development and Therapy Cancers doi: 10.3390/cancers12020291 Authors: Shi Li Lai Jiang Zhao Xiong Lung cancer is one of the most common and malignant cancers with extremely high morbidity and mortality in both males and females. Although traditional lung cancer treatments are fast progressing, there are still limitations. Caveolin-1 (Cav-1),...
Sat Jan 25, 2020 02:00
Cancers, Vol. 12, Pages 289: GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA Cancers doi: 10.3390/cancers12020289 Authors: Rice Cortes Lachowski Oertle Matellan Thorpe Ghose Wang Lee Plodinec del Río Hernández The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by...
Sat Jan 25, 2020 02:00
Cancers, Vol. 12, Pages 285: Independent Evaluation of the Respective Predictive Values for High-Grade Prostate Cancer of Clinical Information and RNA Biomarkers after Upfront MRI and Image-Guided Biopsies Cancers doi: 10.3390/cancers12020285 Authors: Roumiguié Ploussard Nogueira Bruguière Meyrignac Lesourd Péricart Malavaud Upfront MRI is taking the lead in the diagnosis of clinically significant prostate cancer, while few image-guided biopsies (IGBs) fail...
Fri Jan 24, 2020 02:00
Cancers, Vol. 12, Pages 287: Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers Cancers doi: 10.3390/cancers12020287 Authors: Do Lee Cho Chemokines are chemotactic cytokines that mediate immune cell chemotaxis and lymphoid tissue development. Recent advances have indicated that chemokines and their cognate receptors play critical roles in cancer-related inflammation and cancer progression. On the basis of...
Fri Jan 24, 2020 02:00
Cancers, Vol. 12, Pages 286: Smad Phospho-Isoforms for Hepatocellular Carcinoma Risk Assessment in Patients with Nonalcoholic Steatohepatitis Cancers doi: 10.3390/cancers12020286 Authors: Suwa Yamaguchi Yoshida Murata Ichimura Tsuneyama Seki Okazaki Nonalcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) sometimes occurs in mildly fibrotic livers, while HCC incidence in NASH-related cirrhosis is lower than and less predictable than in hepatitis...
Fri Jan 24, 2020 02:00
Cancers, Vol. 12, Pages 284: Mechanism- and Immune Landscape-Based Ranking of Therapeutic Responsiveness of 22 Major Human Cancers to Next Generation Anti-CTLA-4 Antibodies Cancers doi: 10.3390/cancers12020284 Authors: Zhang Xiong Rolfo Du Zhang Yang Russo Devenport Zhou Liu Zheng Background: CTLA-4 was the first immune checkpoint targeted for cancer therapy and the first target validated by the FDA (Food and Drug Administration) after approval...
Fri Jan 24, 2020 02:00
Cancers, Vol. 12, Pages 288: Novel Genetic Variants of ALG6 and GALNTL4 of the Glycosylation Pathway Predict Cutaneous Melanoma-Specific Survival Cancers doi: 10.3390/cancers12020288 Authors: Zhou Zhao Liu Luo Amos Lee Li Nan Wei Because aberrant glycosylation is known to play a role in the progression of melanoma, we hypothesize that genetic variants of glycosylation pathway genes are associated with the survival of cutaneous melanoma (CM) patients....
Fri Jan 24, 2020 02:00
Cells, Vol. 9, Pages 301: Bezafibrate Improves Mitochondrial Fission and Function in DNM1L-Deficient Patient Cells Cells doi: 10.3390/cells9020301 Authors: Liza Douiev Ruth Sheffer Gabriella Horvath Ann Saada Mitochondria are involved in many cellular processes and their main role is cellular energy production. They constantly undergo fission and fusion, and these counteracting processes are under strict balance. The cytosolic dynamin-related protein 1, Drp1, or dynamin-1-like...
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Cells, Vol. 9, Pages 300: Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b+ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40 Cells doi: 10.3390/cells9020300 Authors: Konstantina Antoniou Fanny Ender Tillman Vollbrandt Yves Laumonnier Franziska Rathmann Chandrashekhar Pasare Harinder Singh Jörg Köhl Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore...
Sun Jan 26, 2020 02:00
Cells, Vol. 9, Pages 299: Identification of Novel Rare ABCC1 Transporter Mutations in Tumor Biopsies of Cancer Patients Cells doi: 10.3390/cells9020299 Authors: Kadioglu Saeed Munder Spuller Greten Efferth : The efficiency of chemotherapy drugs can be affected by ATP-binding cassette (ABC) transporter expression or by their mutation status. Multidrug resistance is linked with ABC transporter overexpression. In the present study, we performed rare mutation analyses...
Sun Jan 26, 2020 02:00
Cells, Vol. 9, Pages 297: Regulation of Synaptic Development by Astrocyte Signaling Factors and Their Emerging Roles in Substance Abuse Cells doi: 10.3390/cells9020297 Authors: Walker Risher Risher Astrocytes have critical functions throughout the central nervous system (CNS) and have emerged as regulators of synaptic development and function. With their highly complex morphologies, they are able to interact with thousands of synapses via peripheral astrocytic processes (PAPs),...
Sun Jan 26, 2020 02:00
Cells, Vol. 9, Pages 298: A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease Cells doi: 10.3390/cells9020298 Authors: Liu Merrill Strack Best known as the powerhouse of the cell, mitochondria have many other important functions such as buffering intracellular calcium and reactive oxygen species levels, initiating apoptosis and supporting cell proliferation and survival. Mitochondria are also dynamic organelles that...
Sun Jan 26, 2020 02:00
Cells, Vol. 9, Pages 296: N6-Methyladenosine Regulates the Expression and Secretion of TGFβ1 to Affect the Epithelial–Mesenchymal Transition of Cancer Cells Cells doi: 10.3390/cells9020296 Authors: Li Chen Peng Lv Lin Chen Wang N6-methyladenosine (m6A) is the most abundant modification on eukaryotic mRNA, which regulates all steps of the mRNA life cycle. An increasing number of studies have shown that m6A methylation plays essential roles in tumor development....
Sat Jan 25, 2020 02:00
Cells, Vol. 9, Pages 294: Tumor-Educated Platelets and Angiogenesis in Glioblastoma: Another Brick in the Wall for Novel Prognostic and Targetable Biomarkers, Changing the Vision from a Localized Tumor to a Systemic Pathology Cells doi: 10.3390/cells9020294 Authors: Campanella Guarnaccia Cordiglieri Trombetta Caroli Carrabba La Verde Rampini Gaudino Costa Luzzi Mantovani Locatelli Riboni Navone Marfia : Circulating platelets...
Sat Jan 25, 2020 02:00
Cells, Vol. 9, Pages 295: Anti-CD3 Antibody Treatment Reduces Scar Formation in a Rat Model of Myocardial Infarction Cells doi: 10.3390/cells9020295 Authors: Wernly Paar Aigner Pilz Podesser Förster Jung Hofbauer Tockner Wimmer Kraus Motloch Hackl Hoppe Kiss Lichtenauer : Introduction: Antibody treatment with anti-thymocyte globulin (ATG) has been shown to be cardioprotective. We aimed to evaluate which single anti-T-cell epitope...
Sat Jan 25, 2020 02:00
Cells, Vol. 9, Pages 293: Zebrafish Avatars towards Personalized Medicine—A Comparative Review between Avatar Models Cells doi: 10.3390/cells9020293 Authors: Costa Estrada Mendes Fior Cancer frequency and prevalence have been increasing in the past decades, with devastating impacts on patients and their families. Despite the great advances in targeted approaches, there is still a lack of methods to predict individual patient responses, and therefore treatments are tailored...
Sat Jan 25, 2020 02:00
Cells, Vol. 9, Pages 292: The LisH Domain-Containing N-Terminal Fragment is Important for the Localization, Dimerization, and Stability of Katnal2 in Tetrahymena Cells doi: 10.3390/cells9020292 Authors: Joachimiak Waclawek Niziolek Osinka Fabczak Gaertig Wloga Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated...
Sat Jan 25, 2020 02:00
Cells, Vol. 9, Pages 291: Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer Cells doi: 10.3390/cells9020291 Authors: Mandelli Missale Bresciani Gatta Scapini Caveggion Roca Bugatti Monti Cristinelli Belotti Simeone Calza Melocchi Vermi Background: Urothelial bladder cancers (UBCs) are distinct in two main molecular subtypes, namely basal and luminal type. Subtypes are also diverse in term of immune...
Sat Jan 25, 2020 02:00
Cells, Vol. 9, Pages 290: Dynamic Changes in Function and Proteomic Composition of Extracellular Vesicles from Hepatic Stellate Cells during Cellular Activation Cells doi: 10.3390/cells9020290 Authors: Li Chen Kemper Brigstock : During chronic liver injury, hepatic stellate cells (HSC) undergo activation and are the principal cellular source of collagenous scar. In this study, we found that activation of mouse HSC (mHSC) was associated with a 4.5-fold increase in extracellular...
Sat Jan 25, 2020 02:00
Cells, Vol. 9, Pages 289: Urine microRNA Profiling Displays miR-125a Dysregulation in Children with Fragile X Syndrome Cells doi: 10.3390/cells9020289 Authors: Putkonen Laiho Ethell Pursiheimo Anttonen Pitkonen Gentile de Diego-Otero Castrén A triplet repeat expansion leading to transcriptional silencing of the FMR1 gene results in fragile X syndrome (FXS), which is a common cause of inherited intellectual disability and autism. Phenotypic variation requires...
Fri Jan 24, 2020 02:00
Cells, Vol. 9, Pages 288: Impact of Melatonin on Skeletal Muscle and Exercise Cells doi: 10.3390/cells9020288 Authors: Stacchiotti Favero Rodella Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life. Preventive and therapeutic tools to limit onset and progression of muscle frailty include nutrition and physical training. Melatonin, the indole produced at nighttime in pineal and extra-pineal sites...
Fri Jan 24, 2020 02:00
Cells, Vol. 9, Pages 286: Design and Synthesis of Arf1-Targeting γ-Dipeptides as Potential Agents against Head and Neck Squamous Cell Carcinoma Cells doi: 10.3390/cells9020286 Authors: Vo-Hoang Paiva He Estaran Teng Background: Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer-related deaths and calls for new druggable targets. We have previously highlighted the critical role of ADP-ribosylation factor-1 (Arf1) activation in HNSCC....
Fri Jan 24, 2020 02:00
Cells, Vol. 9, Pages 285: Extracellular Matrix Structure and Composition in the Early Four-Chambered Embryonic Heart Cells doi: 10.3390/cells9020285 Authors: Jallerat Feinberg During embryonic development, the heart undergoes complex morphogenesis from a liner tube into the four chambers consisting of ventricles, atria and valves. At the same time, the cardiomyocytes compact into a dense, aligned, and highly vascularized myocardium. The extracellular matrix (ECM) is known to play...
Fri Jan 24, 2020 02:00
Cells, Vol. 9, Pages 287: Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma Cells doi: 10.3390/cells9020287 Authors: Flynt Bisht Sridharan Ortiz Towfic Thakurta Multiple myeloma (MM) is the second most common hematological cancer and is characterized by genetic features including translocations, chromosomal copy number aberrations, and mutations in key oncogene and tumor suppressor genes. Dysregulation of the tumor suppressor TP53 is important...
Fri Jan 24, 2020 02:00
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