IJMS, Vol. 21, Pages 777: RNA editing as a therapeutic approach for retinal gene therapy requiring long coding sequences International Journal of Molecular Sciences doi: 10.3390/ijms21030777 Authors: Fry Peddle Barnard McClements MacLaren RNA editing aims to treat genetic disease through altering gene expression at the transcript level. Pairing site-directed RNA-targeting mechanisms with engineered deaminase enzymes allows for the programmable correction of G>A...
Sat Jan 25, 2020 02:00
IJMS, Vol. 21, Pages 776: Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine International Journal of Molecular Sciences doi: 10.3390/ijms21030776 Authors: Fresta Fidilio Lazzarino Musso Grasso Merlo Amorini Bucolo Tavazzi Lazzarino Lunte Caraci Caruso Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations...
Sat Jan 25, 2020 02:00
IJMS, Vol. 21, Pages 775: Noncovalent Sericin-Chitosan Scaffold: Physical Properties and Low Cytotoxicity Effect International Journal of Molecular Sciences doi: 10.3390/ijms21030775 Authors: Rungsima Chollakup Pimporn Uttayarat Arkadiusz Chworos Wirasak Smitthipong This research aims to utilize sericin, which is the waste from boiling silk cocoon, for the supramolecular scaffold preparation with chitosan. A suitable method for the self-assembled scaffold formation of sericin...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 774: Transcriptome Analysis Reveals the Different Response to Toxic Stress in Rootstock Grafted and Non-Grafted Cucumber Seedlings International Journal of Molecular Sciences doi: 10.3390/ijms21030774 Authors: Xuemei Xiao Jian Lv Jianming Xie Zhi Feng Ning Ma Ju Li Jihua Yu Alejandro Calderón-Urrea Autotoxicity of root exudates is one of the main reasons for consecutive monoculture problem (CMP) in cucumber under greenhouse cultivation. Rootstock...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 773: Evaluating the Combination of Radioimmunotherapy and Immunotherapy in a Melanoma Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21030773 Authors: Jiao Allen Malo Rickles Dadachova Immunotherapy has changed the oncology landscape during the last decade and become standard of care for several cancers. The combinations of immunotherapy with other treatment modalities are also being investigated. One of the challenges to...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 767: Characterization of a G-Quadruplex Structure in Pre-miRNA-1229 and in Its Alzheimer’s Disease-Associated Variant rs2291418: Implications for miRNA-1229 Maturation International Journal of Molecular Sciences doi: 10.3390/ijms21030767 Authors: Imperatore Then McDougal Mihailescu Alzheimer’s disease (AD), the most common age-related neurodegenerative disease, is associated with various forms of cognitive and functional impairment that worsen...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 769: Effects of Natural Progesterone and Synthetic Progestin on Germ Layer Gene Expression in a Human Embryoid Body Model International Journal of Molecular Sciences doi: 10.3390/ijms21030769 Authors: Yoon Young Kim Hoon Kim Chang Suk Suh Hung-Ching Liu Zev Rosenwaks Seung-Yup Ku Natural progesterone and synthetic progestin are widely used for the treatment of threatened abortion or in in vitro fertilization (IVF) cycles. This in vitro study aimed...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 763: Advanced Methodology and Preliminary Measurements of Molecular and Mechanical Properties of Heart Valves under Dynamic Strain International Journal of Molecular Sciences doi: 10.3390/ijms21030763 Authors: Madhurapantula Krell Morfin Roy Lister Orgel Mammalian heart valves are soft tissue assemblies with multi-scale material properties. This is because they are constructs comprising both muscle and non-contractile extracellular matrix proteins...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 765: The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis International Journal of Molecular Sciences doi: 10.3390/ijms21030765 Authors: Antonio Villalobo Martin W. Berchtold Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon binding to target proteins transduces signals encoded by global or subcellular-specific changes of Ca2+ concentration within the cell. The Ca2+/CaM complex as well as Ca2+-free...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 771: Activities of Chromatin Remodeling Factors and Histone Chaperones and Their Effects in Root Apical Meristem Development International Journal of Molecular Sciences doi: 10.3390/ijms21030771 Authors: Kang Wu Fan Zhu Eukaryotic genes are packaged into dynamic but stable chromatin structures to deal with transcriptional reprogramming and inheritance during development. Chromatin remodeling factors and histone chaperones are epigenetic factors that...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 768: Genomics Education in the Era of Personal Genomics: Academic, Professional, and Public Considerations International Journal of Molecular Sciences doi: 10.3390/ijms21030768 Authors: Whitley Tueller Weber Since the completion of the Human Genome Project in 2003, genomic sequencing has become a prominent tool used by diverse disciplines in modern science. In the past 20 years, the cost of genomic sequencing has decreased exponentially, making it affordable...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 770: Intracellular Calcium Dysregulation by the Alzheimer’s Disease-Linked Protein Presenilin 2 International Journal of Molecular Sciences doi: 10.3390/ijms21030770 Authors: Galla Redolfi Pozzan Pizzo Greotti Alzheimer’s disease (AD) is the most common form of dementia. Even though most AD cases are sporadic, a small percentage is familial due to autosomal dominant mutations in amyloid precursor protein (APP), presenilin-1 (PSEN1), and...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 766: Solubility Enhancement of Myricetin by Inclusion Complexation with Heptakis-O-(2-Hydroxypropyl)-β-Cyclodextrin: A Joint Experimental and Theoretical Study International Journal of Molecular Sciences doi: 10.3390/ijms21030766 Authors: Han Han Liu Wang Xin Zhang Yu Four cyclodextrins (CD) including β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), heptakis-O-(2-hydroxypropyl)-β-cyclodextrin (HP-β-CD),...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 764: Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21030764 Authors: Subedi Lee Madiha Gaire Jin Yumnam Kim Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible for the modulation of the immune system. TNF-α plays a critical role in almost every type of inflammatory disorder, including central nervous system...
Fri Jan 24, 2020 02:00
IJMS, Vol. 21, Pages 772: Transcriptome Analysis of Drought-Resistant and Drought-Sensitive Sorghum (Sorghum bicolor) Genotypes in Response to PEG-Induced Drought Stress International Journal of Molecular Sciences doi: 10.3390/ijms21030772 Authors: Abdel-Ghany Ullah Ben-Hur Reddy Drought is a major limiting factor of crop yields. In response to drought, plants reprogram their gene expression, which ultimately regulates a multitude of biochemical and physiological processes....
Fri Jan 24, 2020 02:00
IJNS, Vol. 6, Pages 5: Development of Newborn Screening for Pompe Disease International Journal of Neonatal Screening doi: 10.3390/ijns6010005 Authors: Hwu Chien Pompe disease is an inborn error of lysosomal degradation of glycogen. The responsible enzyme is acid alpha-glucosidase (GAA) [...]
Fri Jan 24, 2020 02:00
JCM, Vol. 9, Pages 343: MEWS++: Enhancing the Prediction of Clinical Deterioration in Admitted Patients through a Machine Learning Model Journal of Clinical Medicine doi: 10.3390/jcm9020343 Authors: Arash Kia Prem Timsina Himanshu N. Joshi Eyal Klang Rohit R. Gupta Robert M. Freeman David L Reich Max S Tomlinson Joel T Dudley Roopa Kohli-Seth Madhu Mazumdar Matthew A Levin Early detection of patients at risk for clinical deterioration is crucial for timely...
02:00
JCM, Vol. 9, Pages 340: Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice Journal of Clinical Medicine doi: 10.3390/jcm9020340 Authors: Liu Saul Pichavaram Xu Rudraraju Somanath Smith Caldwell Narayanan Diabetic retinopathy (DR) is a significant cause of blindness in working-age adults worldwide. Lack of effective strategies to prevent or reduce vision loss is a major problem. Since...
Sat Jan 25, 2020 02:00
JCM, Vol. 9, Pages 341: Polygenic Risk Scores Shed Light on the Relationship between Schizophrenia and Cognitive Functioning: Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9020341 Authors: Mallet Le Strat Dubertret Gorwood Schizophrenia is a multifactorial disease associated with widespread cognitive impairment. Although cognitive deficits are one of the factors most strongly associated with functional impairment in schizophrenia (SZ), current treatment...
Sat Jan 25, 2020 02:00
JCM, Vol. 9, Pages 342: Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants Journal of Clinical Medicine doi: 10.3390/jcm9020342 Authors: Piszczek Radtke Ehlert Jędrzejewski Sznarkowska Sadowska Bartmański Erdoğan Ercan Jedrzejczyk An increasing interest in the fabrication of implants made of titanium and its alloys results from their capacity to be integrated into the bone system. This integration is...
Sat Jan 25, 2020 02:00
JCM, Vol. 9, Pages 337: Fenofibrate Facilitates Post-Active Tuberculosis Infection in Macrophages and is Associated with Higher Mortality in Patients under Long-Term Treatment Journal of Clinical Medicine doi: 10.3390/jcm9020337 Authors: Liu Lu Tsai Wu Chien Chung Ma Background: Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects and persists in macrophages. This study aimed to investigate the effects of long-term fenofibrate treatment...
Sat Jan 25, 2020 02:00
JCM, Vol. 9, Pages 338: Arterial Hypertension as a Risk Factor for Reduced Glomerular Filtration Rate after Living Kidney Donation Journal of Clinical Medicine doi: 10.3390/jcm9020338 Authors: Kerschbaum Bitter Weitlaner Kienzl-Wagner Neuwirt Bösmüller Mayer Schneeberger Rudnicki Living kidney donation represents the optimal renal replacement therapy, but recent data suggest an increased long-term renal risk for the donor. Here, we evaluated the risk...
Sat Jan 25, 2020 02:00
JCM, Vol. 9, Pages 339: Unplanned Out-of-Hospital Birth—Short and Long-Term Consequences for the Offspring Journal of Clinical Medicine doi: 10.3390/jcm9020339 Authors: GUTVIRTZ WAINSTOCK LANDAU SHEINER The unpredictable nature of childbirth infrequently results in unplanned out-of-hospital birth, in a pre-hospital setting. We evaluated the perinatal and long-term outcome of children accidentally born out-of-hospital. This was a population-based analysis of singleton deliveries...
Sat Jan 25, 2020 02:00
JCM, Vol. 9, Pages 336: Association of Trimethylamine, Trimethylamine N-oxide, and Dimethylamine with Cardiovascular Risk in Children with Chronic Kidney Disease Journal of Clinical Medicine doi: 10.3390/jcm9020336 Authors: Hsu Chang-Chien Lin Hou Lu Tain Chronic kidney disease (CKD) is associated with high risk for cardiovascular disease (CVD). Gut microbiota-dependent metabolites trimethylamine (TMA), trimethylamine N-oxide (TMAO), and dimethylamine (DMA) have...
Sat Jan 25, 2020 02:00
JCM, Vol. 9, Pages 335: Cardiac Autonomic Dysfunction in Multiple Sclerosis: A Systematic Review of Current Knowledge and Impact of Immunotherapies Journal of Clinical Medicine doi: 10.3390/jcm9020335 Authors: Oliver Findling Larissa Hauer Thomas Pezawas Paulus S. Rommer Walter Struhal Johann Sellner Cardiac autonomic dysfunction (CAD) has been reported in patients with multiple sclerosis (MS). This systematic review summarizes the evidence for the types and prevalence...
Fri Jan 24, 2020 02:00
JCM, Vol. 9, Pages 333: Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations Journal of Clinical Medicine doi: 10.3390/jcm9020333 Authors: Beltrán Hernández Yu Ossendorp Korbelik Oliveira Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates...
Fri Jan 24, 2020 02:00
JCM, Vol. 9, Pages 334: Transdiagnostic or Disorder Specific? Indicators of Substance and Behavioral Addictions Nominated by People with Lived Experience Journal of Clinical Medicine doi: 10.3390/jcm9020334 Authors: Kim Hodgins Kim Wild Using a transdiagnostic perspective, the present research examined the prominent indicators of substance (alcohol, cocaine, marijuana, tobacco) and behavioral (gambling, video games, sex, shopping, work, eating) addictions nominated by people...
Fri Jan 24, 2020 02:00
JCM, Vol. 9, Pages 332: Head-to-Head Comparison of Consensus-Recommended Platelet Function Tests to Assess P2Y12 Inhibition—Insights for Multi-Center Trials Journal of Clinical Medicine doi: 10.3390/jcm9020332 Authors: Bélanger Bandeira Ferreira Welman Boulahya Tanguay So Lordkipanidzé The vasodilator-associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation...
Fri Jan 24, 2020 02:00
JCM, Vol. 9, Pages 331: Clinical Manifestations, Pathogenesis and Treatment of Hepatitis E Virus Infections Journal of Clinical Medicine doi: 10.3390/jcm9020331 Authors: Lhomme Marion Abravanel Izopet Kamar Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis throughout the world. Most infections are acute but they can become chronic in immunocompromised patients, such as solid organ transplant patients, patients with hematologic malignancy undergoing...
Fri Jan 24, 2020 02:00
JCM, Vol. 9, Pages 330: The Extent of Transmission of Novel Coronavirus in Wuhan, China, 2020 Journal of Clinical Medicine doi: 10.3390/jcm9020330 Authors: Nishiura Jung Linton Kinoshita Yang Hayashi Kobayashi Yuan Akhmetzhanov A cluster of pneumonia cases linked to a novel coronavirus (2019-nCoV) was reported by China in late December 2019. Reported case incidence has now reached the hundreds, but this is likely an underestimate. As of 24 January 2020,...
Fri Jan 24, 2020 02:00
JFMK, Vol. 5, Pages 8: The Effects of Augmented Eccentric Loading upon Kinematics and Muscle Activation in Bench Press Performance Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010008 Authors: van den Tillaar Kwan The aim of this study was to investigate the effects of an augmented eccentric load upon the kinematics and muscle activation of bench press, and to investigate possible mechanisms behind augmented eccentric loading during the lift. Sixteen resistance-trained...
Sun Jan 26, 2020 02:00
JFMK, Vol. 5, Pages 7: Oral Health and Fibromyalgia Syndrome: A Systemic Review Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5010007 Authors: De Stefano Bruno Muscatello Cedro Cicciù Rullo Gaeta Fiorillo Fibromyalgia is a syndrome currently considered idiopathic and multifactorial rheumatic that causes an increase in muscle tension and is characterized by muscle pain and chronic fibrous tissues—widespread, fluctuating and migrating—associated...
Sat Jan 25, 2020 02:00
Life, Vol. 10, Pages 10: Indexing Exoplanets with Physical Conditions Potentially Suitable for Rock-Dependent Extremophiles Life doi: 10.3390/life10020010 Authors: Jagadeesh Valluri Kari Kubska Kaczmarek The search for different life forms elsewhere in the universe is a fascinating area of research in astrophysics and astrobiology. Currently, according to the NASA Exoplanet Archive database, 3876 exoplanets have been discovered. The Earth Similarity Index (ESI) is defined...
Sun Jan 26, 2020 02:00
Medical Sciences, Vol. 8, Pages 6: Defining Community-Acquired Pneumonia as a Public Health Threat: Arguments in Favor from Spanish Investigators Medical Sciences doi: 10.3390/medsci8010006 Authors: Cillóniz Menéndez García-Vidal Péricas Torres Despite advances in its prevention, pneumonia remains associated with high morbidity, mortality, and health costs worldwide. Studies carried out in the last decade have indicated that more patients with community-acquired pneumonia...
Sat Jan 25, 2020 02:00
Medical Sciences, Vol. 8, Pages 5: Microscopic Observation Drug Susceptibility (MODS) Assay: A Convenient Method for Determining Antibiogram of Clinical Isolates of Mycobacterium tuberculosis in Ghana Medical Sciences doi: 10.3390/medsci8010005 Authors: Enid Owusu Mercy Jemima Newman (1) Background: Present methods for drug susceptibility tests (DST) rely on culture methods that are sophisticated and relatively faster, or a slow and cheaper option. These methods frustrate disease...
Sat Jan 25, 2020 02:00
Medicina, Vol. 56, Pages 52: Effects of Immunonutrition on Comprehensive Complication Index in Patients Undergoing Pancreatoduodenectomy Medicina doi: 10.3390/medicina56020052 Authors: Tumas Jasiūnas Strupas Šileikis Background and objectives: Immunonutrition is recommended by enhanced recovery after surgery in patients undergoing pancreatoduodenectomy for 5–7 days perioperatively as it may reduce the rate of infectious complications. However, data on effect of...
Fri Jan 24, 2020 02:00
Medicina, Vol. 56, Pages 51: Bisphosphonate’s Effect on Tongue Mucosa: An Experimental Electron Microscopy Study Medicina doi: 10.3390/medicina56020051 Authors: Papamitsou Morsi-Yeroyannis Papanastasiou Bakalopoulos Dietrich Karachrysafi Toskas Mareti Morsi-Yeroyanni Sioga Background and objectives: Bisphosphonates (BPs) are selective inhibitors of osteoclasts, used for the treatment of bone disorders. The objective of this study is to investigate...
Fri Jan 24, 2020 02:00
Metabolites, Vol. 10, Pages 47: Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function Metabolites doi: 10.3390/metabo10020047 Authors: Gardner Carpenter So Metabolomic profiling of biofluids, e.g., urine, plasma, has generated vast and ever-increasing amounts of knowledge over the last few decades. Paradoxically, metabolomic analysis of saliva, the most readily-available human biofluid, has lagged. This review explores the history of...
Sun Jan 26, 2020 02:00
Metabolites, Vol. 10, Pages 46: Changes in Metabolome and Nutritional Quality of Lycium barbarum Fruits from Three Typical Growing Areas of China as Revealed by Widely Targeted Metabolomics Metabolites doi: 10.3390/metabo10020046 Authors: Wang Liang Li Fan Li Cao An Shi Zhao Guo This study aimed at assessing the climatic factors influencing the wolfberry fruit morphology, and the composition of its nutritious metabolites. The cultivar Ningqi1, widely...
Sun Jan 26, 2020 02:00
Metabolites, Vol. 10, Pages 45: Special Issue on “NMR-Based Metabolomics and Its Applications Volume 2” Metabolites doi: 10.3390/metabo10020045 Authors: Cesare Marincola Mannina Over the last decade, the number of scientific publications in the metabolomics area has increased exponentially. The literature includes ~29,000 contributions (articles and reviews) during the period of 2009–2019, revealing metabolomics applications in a wide range of fields, including medical,...
Sun Jan 26, 2020 02:00
Metabolites, Vol. 10, Pages 44: A Case of Suspected Hyperphenylalaninemia at Newborn Screening by Tandem Mass Spectrometry during Total Parenteral Nutrition Metabolites doi: 10.3390/metabo10020044 Authors: Pieragostino Cicalini Di Michele Fusilli Cotugno Ferrante Bucci Dionisi-Vici Stuppia De Laurenzi Rossi Phenylketonuria (PKU) is a rare autosomal recessive condition affecting about 1 in 10,000 people in the Europe, with a higher rate in some...
Fri Jan 24, 2020 02:00
MPs, Vol. 3, Pages 12: Impedance Measures and a Mounting Technique for Drosophila: Larval Movements, Heart Rate, Imaging, and Electrophysiology Methods and Protocols doi: 10.3390/mps3010012 Authors: de Castro Cooper Monitoring movements of larval Drosophila with electrical detection allows one to record the behaviors without the use of lights and cameras. This is a suitable technique when studying the use of light-sensitive proteins in optogenetic studies. Electrical measures are...
Fri Jan 24, 2020 02:00
Microorganisms, Vol. 8, Pages 172: The Role of Selected Lactic Acid Bacteria on Organic Acid Accumulation during Wet and Spray-Dried Fish-based Silages. Contributions to the Winning Combination of Microbial Food Safety and Environmental Sustainability Microorganisms doi: 10.3390/microorganisms8020172 Authors: Kuley Özyurt Özogul Boga Akyol Rocha Özogul Organic acid contents of acidified and fermented fish silages made from gibel carp (Caracius gibelio) and klunzinger’s...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 175: Biostimulating Gut Microbiome with Bilberry Anthocyanin Combo to Enhance Anti-PD-L1 Efficiency against Murine Colon Cancer Microorganisms doi: 10.3390/microorganisms8020175 Authors: Liu Wang Jing Jiang Liu Recent advances have revealed the essential role of gut microbiomes in the therapeutic efficiency of immune checkpoint inhibitors (ICIs). Inspired by biostimulation, a method using nutrients to accelerate the growth of soil microorganisms...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 177: Evaluation of the Potential of Biofilm Formation of Bifidobacterium longum subsp. infantis and Lactobacillus reuteri as Competitive Biocontrol Agents Against Pathogenic and Food Spoilage Bacteria Microorganisms doi: 10.3390/microorganisms8020177 Authors: Speranza Liso Russo Corbo This study proposes to exploit the in vivo metabolism of two probiotics (Bifidobacterium longum subsp. infantis and Lactobacillus reuteri) which, upon adhesion...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 176: Adaptive and Innate Immune Cells in Fetal Human Cytomegalovirus-Infected Brains Microorganisms doi: 10.3390/microorganisms8020176 Authors: Sellier Marliot Bessières Stirnemann Encha-Razavi Guilleminot Haicheur Pages Ville Leruez-Ville Background: The understanding of the pathogenesis of cytomegalovirus (CMV)-induced fetal brain lesions is limited. We aimed to quantify adaptive and innate immune cells and CMV-infected...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 174: Stringent Selection of Knobby Plasmodium falciparum-Infected Erythrocytes during Cytoadhesion at Febrile Temperature Microorganisms doi: 10.3390/microorganisms8020174 Authors: Dörpinghaus Fürstenwerth Roth Bouws Rakotonirinalalao Jordan Sauer Rehn Pansegrau Höhn Mesén-Ramírez Bachmann Lorenzen Roeder Metwally Bruchhaus Changes in the erythrocyte membrane induced by Plasmodium falciparum invasion...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 173: Peritoneal Microbiome in End-Stage Renal Disease Patients and the Impact of Peritoneal Dialysis Therapy Microorganisms doi: 10.3390/microorganisms8020173 Authors: Liliana Simões-Silva Ricardo Araujo Manuel Pestana Isabel Soares-Silva Benedita Sampaio-Maia Factors influencing the occurrence of peritoneal dialysis (PD)-related infections are still far from fully understood. Recent studies described the existence of specific microbiomes in...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 178: Impact of Phosphorus Fertilization on Tomato Growth and Arbuscular Mycorrhizal Fungal Communities Microorganisms doi: 10.3390/microorganisms8020178 Authors: Higo Azuma Kamiyoshihara Kanda Tatewaki Isobe Understanding the impact of phosphorus (P) addition on arbuscular mycorrhizal fungi (AMF) is crucial to understanding tomato (Solanum lycopersicum L.) P nutrition. However, it remains unknown how P fertilization is associated with...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 171: Virulence Profiling and Molecular Typing of Shiga Toxin-Producing E. coli (STEC) from Human Sources in Brazil Microorganisms doi: 10.3390/microorganisms8020171 Authors: Cavalcanti Hernandes Takagi Guth Ori Pinheiro Andrade Oliveira Cergole-Novella Francisco Santos Since no recent data characterizing Shiga toxin-producing E. coli (STEC) from human infections in Brazil are available, the present study aimed to...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 170: Revealing the Variation and Stability of Bacterial Communities in Tomato Rhizosphere Microbiota Microorganisms doi: 10.3390/microorganisms8020170 Authors: Cheng Lei Li Huang Ma Xiong Zhang Jin Haq Xu Tian Microorganisms that colonize the plant rhizosphere can contribute to plant health, growth and productivity. Although the importance of the rhizosphere microbiome is known, we know little about the underlying...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 169: Effect of a Profound Feedstock Change on the Structure and Performance of Biogas Microbiomes Microorganisms doi: 10.3390/microorganisms8020169 Authors: Klang Szewzyk Bock Theuerl In this study the response of biogas-producing microbiomes to a profound feedstock change was investigated. The microbiomes were adapted to the digestion of either 100% sugar beet, maize silage, or of the silages with elevated amounts of total ammonium nitrogen...
Sat Jan 25, 2020 02:00
Microorganisms, Vol. 8, Pages 168: Drosophila Sexual Attractiveness in Older Males Is Mediated by Their Microbiota Microorganisms doi: 10.3390/microorganisms8020168 Authors: Heys Lizé Lewis Price Age is well known to be a basis for female preference of males. However, the mechanisms underlying age-based choices are not well understood, with several competing theories and little consensus. The idea that the microbiota can affect host mate choice is gaining traction, and in...
Fri Jan 24, 2020 02:00
Microorganisms, Vol. 8, Pages 167: Exploring the Ambiguous Status of Coagulase-Negative Staphylococci in the Biosafety of Fermented Meats: The Case of Antibacterial Activity Versus Biogenic Amine Formation Microorganisms doi: 10.3390/microorganisms8020167 Authors: Van der Veken Benhachemi Charmpi Ockerman Poortmans Van Reckem Michiels Leroy A total of 332 staphylococcal strains, mainly isolated from meat, were screened for antibacterial activity. Eighteen...
Fri Jan 24, 2020 02:00
Microorganisms, Vol. 8, Pages 166: Bacterial, Gut Microbiome-Modifying Therapies to Defend against Multidrug Resistant Organisms Microorganisms doi: 10.3390/microorganisms8020166 Authors: Feehan Garcia-Diaz Antibiotics have revolutionized human and animal healthcare, but their utility is reduced as bacteria evolve resistance mechanisms over time. Thankfully, there are novel antibiotics in the pipeline to overcome resistance, which are mentioned elsewhere in this special issue, but...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 541: Production of 5-Hydroxymethylfurfural from Chitin Biomass: A Review Molecules doi: 10.3390/molecules25030541 Authors: Dan Zhou Dongsheng Shen Wenjing Lu Tao Song Meizhen Wang Huajun Feng Jiali Shentu Yuyang Long Chitin biomass, a rich renewable resource, is the second most abundant natural polysaccharide after cellulose. Conversion of chitin biomass to high value-added chemicals can play a significant role in alleviating the global...
02:00
Molecules, Vol. 25, Pages 540: The Role of Salicylic Acid in Plants Exposed to Heavy Metals Molecules doi: 10.3390/molecules25030540 Authors: Sharma Sidhu Araniti Bali Shahzad Tripathi Brestic Skalicky Landi Salicylic acid (SA) is a very simple phenolic compound (a C7H6O3 compound composed of an aromatic ring, one carboxylic and a hydroxyl group) and this simplicity contrasts with its high versatility and the involvement of SA in several plant processes...
Sun Jan 26, 2020 02:00
Molecules, Vol. 25, Pages 539: TBAB-Catalyzed 1,6-Conjugate Sulfonylation of para-Quinone Methides: A Highly Efficient Approach to Unsymmetrical gem-Diarylmethyl Sulfones in Water Molecules doi: 10.3390/molecules25030539 Authors: Liu You Zhang Liu Liu Guan A highly efficient sulfonylation of para-quinone methides with sulfonyl hydrazines in water has been developed on the basis of the mode involving a tetrabutyl ammonium bromide (TBAB)-promoted sulfa-1,6-conjugated...
Sun Jan 26, 2020 02:00
Molecules, Vol. 25, Pages 538: Apoptotic Effects on HL60 Human Leukaemia Cells Induced by Lavandin Essential Oil Treatment Molecules doi: 10.3390/molecules25030538 Authors: Laghezza Masci Ovidi Taddei Turchetti Tiezzi Giacomello Garzoli Recent scientific investigations have reported a number of essential oils to interfere with intracellular signalling pathways and to induce apoptosis in different cancer cell types. In this paper, Lavandin Essential Oil (LEO),...
Sun Jan 26, 2020 02:00
Molecules, Vol. 25, Pages 537: Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives—An In Vitro Study Molecules doi: 10.3390/molecules25030537 Authors: Michalak Lach Antoszczak Huczyński Suchorska Polyether ionophore salinomycin (SAL) and its semi-synthetic derivatives are recognized as very promising anticancer drug candidates due to their activity against various types of cancer cells, including multidrug-resistant populations....
Sun Jan 26, 2020 02:00
Molecules, Vol. 25, Pages 536: Deep Oxidative Desulfurization of Fuels in the Presence of Brönsted Acidic Polyoxometalate-Based Ionic Liquids Molecules doi: 10.3390/molecules25030536 Authors: Akopyan Eseva Polikarpova Kedalo Vutolkina Glotov Polyoxometalate-based ionic liquid hybrid materials with a pyridinium cation, containing Brönsted acid sites, were synthesized and used as catalysts for the oxidation of model and real diesel fuels. Keggin-type polyoxometalates...
Sun Jan 26, 2020 02:00
Molecules, Vol. 25, Pages 535: Pharmacokinetic Characterization and Tissue Distribution of Fusion Protein Therapeutics by Orthogonal Bioanalytical Assays and Minimal PBPK Modeling Molecules doi: 10.3390/molecules25030535 Authors: Sugimoto Chen Qian Characterization of pharmacokinetic (PK) properties and target tissue distribution of therapeutic fusion proteins (TFPs) are critical in supporting in vivo efficacy. We evaluated the pharmacokinetic profile of an investigational TFP...
Sun Jan 26, 2020 02:00
Molecules, Vol. 25, Pages 533: Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase Molecules doi: 10.3390/molecules25030533 Authors: Biberoglu Tacal Schopfer Lockridge A newly recognized action of organophosphates (OP) is the ability to crosslink proteins through an isopeptide bond. The first step in the mechanism is covalent addition of the OP to the side chain of lysine. This activates OP-lysine for reaction with a nearby glutamic or aspartic...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 534: Characterization of Isolated Extracts from Justicia Plant Leaves used as Remedy for Anemia Molecules doi: 10.3390/molecules25030534 Authors: Wood Yasmin-Karim Moreau Kumar Akwanwi Derek Atoneche Kress Ngwa Indigenous populations use plants as an important healthcare resource or remedy for different diseases. Here, isolated extracts from Justicia (family Acanthanceae) plant leaves used in Africa as remedy for anemia are characterized...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 530: Theoretical Description of R–X⋯NH3 Halogen Bond Complexes: Effect of the R Group on the Complex Stability and Sigma-Hole Electron Depletion Molecules doi: 10.3390/molecules25030530 Authors: Juan Zurita Vladimir Rodriguez Cesar Zambrano Jose Ramón Mora Luis Rincón F. Javier Torres In the present work, a number of R–X⋯NH3 (X = Cl, Br, and I) halogen bonded systems were theoretical studied by means of DFT calculations performed at...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 531: Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry Molecules doi: 10.3390/molecules25030531 Authors: Jeong Baek Lee Kim Maeng Lee Suh Chung SH-1242, a novel inhibitor of heat shock protein 90 (HSP90), is a synthetic analog of deguelin: It was previously reported that the treatment of SH-1242 led to a strong suppression of hypoxia-mediated...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 527: Design, Synthesis, Molecular Modelling and Anticancer Activities of New Fused Phenanthrolines Molecules doi: 10.3390/molecules25030527 Authors: Al Matarneh Amarandi Craciun Mangalagiu Zbancioc Danac Three series of fused pyrrolophenanthroline derivatives were designed as analogues of phenstatin and synthesized in two steps starting with 1,7-phenanthroline, 4,7-phenanthroline and 1,10-phenanthroline, respectively. Two (Compounds 8a and...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 529: Aspidoptoids A–D: Four New Diterpenoids from Aspidopterys obcordata Vine Molecules doi: 10.3390/molecules25030529 Authors: Sun Cao Xiao Zhang Wang Shi Xiao Hu Xu Four new diterpenoids, named aspidoptoids A–D (1–4), together with two known analogues (5–6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A–B (1–2) are the first examples of phenylethylene-bearing...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 528: Microbial Transformation of Prenylquercetins by Mucor hiemalis Molecules doi: 10.3390/molecules25030528 Authors: Han Xiao Lee Quercetin, one of the most widely distributed flavonoids, has been found to show various biological activities including antioxidant, anticancer, and anti-inflammatory effects. It has been reported that bioactivity enhancement of flavonoids has often been closely associated with nuclear prenylation, as shown in 8-prenylquercetin...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 532: Substituted Piperazines as Novel Potential Radioprotective Agents Molecules doi: 10.3390/molecules25030532 Authors: Alzbeta Filipova Jan Marek Radim Havelek Jaroslav Pejchal Marcela Jelicova Jana Cizkova Martina Majorosova Lubica Muckova Tomas Kucera Lukas Prchal Miroslav Psotka Natalie Zivna Darja Koutova Zuzana Sinkorova Martina Rezacova Ales Tichy The increasing risk of radiation exposure underlines the need...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 524: Alkoxy- and Silanol-Functionalized Cage-Type Oligosiloxanes as Molecular Building Blocks to Construct Nanoporous Materials Molecules doi: 10.3390/molecules25030524 Authors: Shimojima Kuroda Siloxane-based materials have a wide range of applications. Cage-type oligosiloxanes have attracted significant attention as molecular building blocks to construct novel siloxane-based nanoporous materials with promising applications such as in catalysis and adsorption....
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 525: Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD Molecules doi: 10.3390/molecules25030525 Authors: Božič Zalar Rogelj Plavec Šket The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). Since the discovery one of the non-exclusive mechanisms of expanded hexanucleotide...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 526: Industrial Application of Nanocelluloses in Papermaking: A Review of Challenges, Technical Solutions, and Market Perspectives Molecules doi: 10.3390/molecules25030526 Authors: Balea Fuente Monte Merayo Campano Negro Blanco Nanocelluloses (NC) increase mechanical and barrier paper properties allowing the use of paper in applications actually covered by other materials. Despite the exponential increase of information, NC have not...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 522: Comparative Study of the Effect of 5,6-Dihydroergosterol and 3-epi-5,6-dihydroergosterol on Chemokine Expression in Human Keratinocytes Molecules doi: 10.3390/molecules25030522 Authors: Park Moon Ahn Lee Kim 5,6-Dihydroergosterol-glucose is an organic synthetic derivative of spinasterol-glucose, which has potent anti-inflammatory activity. We previously synthesized alpha and beta anomers of DHE-glycosides and compared their inhibitory activity...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 523: Dual Emission in a Ligand and Metal Co-Doped Lanthanide-Organic Framework: Color Tuning and Temperature Dependent Luminescence Molecules doi: 10.3390/molecules25030523 Authors: Andriotou Diamantis Zacharia Itskos Panagiotou Tasiopoulos Lazarides In this study, we report the luminescence color tuning in the lanthanide metal-organic framework (LnMOF) ([La(bpdc)Cl(DMF)] (1); bpdc2− = [1,1′-biphenyl]-4,4′-dicarboxylate,...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 521: Finger-Temperature-Detecting Liquid Crystal Composite Film for Anti-Counterfeiting Labels Molecules doi: 10.3390/molecules25030521 Authors: Yanzi Gao Ke Feng Jin Zhang Lanying Zhang The development of the economy has increased the demand for anti-counterfeiting technologies, and with the traditional ones becoming known to the public, new and more effective ones are needed. In this study, a series of liquid crystal mixtures containing side-chain...
Sat Jan 25, 2020 02:00
Molecules, Vol. 25, Pages 520: Fast Isolation of Flavonoids from the Endemic Species Nolana ramosissima I.M. Johnst and Its Endothelium-Independent Relaxation Effect in Rat Aorta Molecules doi: 10.3390/molecules25030520 Authors: Fredi Cifuentes Javier Palacios Jorge Bórquez Adrián Paredes Claudio Parra Alejandra Bravo Mario J. Simirgiotis The infusion of the desertic plant Nolana ramosissima I.M. Johnst showed vascular smooth muscle relaxation in rat aorta and the presence...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 519: Exopolyhedral Ligand Orientation Controls Diastereoisomer in Mixed-Metal Bis(carboranes) Molecules doi: 10.3390/molecules25030519 Authors: Chan Rosair Welch Heterobimetallic derivatives of a bis(carborane), [μ7,8-(1′,3′−3′-Cl-3′-PPh3-closo-3′,1′,2′-RhC2B9H10)-2-(p-cymene)-closo-2,1,8-RuC2B9H10] (1) and [μ7,8-(1′,3′−3′-Cl-3′-PPh3-closo-3′,1′,2′-RhC2B9H10)-2-Cp-closo-2,1,8-CoC2B9H10]...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 515: The Effect of Polyphenols on Pomegranate Fruit Susceptibility to Pilidiella granati Provides Insights into Disease Tolerance Mechanisms Molecules doi: 10.3390/molecules25030515 Authors: Annamaria Mincuzzi Antonio Ippolito Virginia Brighenti Lucia Marchetti Stefania Benvenuti Angela Ligorio Federica Pellati Simona Marianna Sanzani Pilidiella granati, also known as Coniella granati, is the etiological agent of pomegranate fruit dry rot....
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 512: A Non-Targeted Capillary Electrophoresis-Mass Spectrometry Strategy to Study Metabolic Differences in an In vitro Model of High-Glucose Induced Changes in Human Proximal Tubular HK-2 Cells Molecules doi: 10.3390/molecules25030512 Authors: Bernardo-Bermejo Sánchez-López Castro-Puyana Benito-Martínez Lucio-Cazaña Marina Diabetic nephropathy is characterized by the chronic loss of kidney function due to high glucose renal levels. HK-2...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 518: Development and Validation of Methods for the Determination of Anthocyanins in Physiological Fluids via UHPLC-MSn Molecules doi: 10.3390/molecules25030518 Authors: Kaiser Müller-Ehl Passon Schieber Recent in vitro and in vivo studies on anthocyanins confirmed numerous health-promoting effects in humans. Daily anthocyanin intake can be estimated via food databases, but the amount absorbed by the organism still remains uncertain because anthocyanin...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 516: Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment Molecules doi: 10.3390/molecules25030516 Authors: Liang Peng Zhou Zou Cheng The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota,...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 514: Binaphthyl-Based Macrocycles as Optical Sensors for Aromatic Diphenols Molecules doi: 10.3390/molecules25030514 Authors: Piacentini Caricato Pacini Nitti Pasini The synthesis of several rigid, homochiral organic macrocycles possessing, respectively, average molecular D2 and D3 symmetries, is described. They have been obtained from aromatic dicarboxylic acids, in combination with an axially-chiral, suitable dibenzylic alcohol, derived from...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 517: Bioassay-Guided Different Extraction Techniques of Carica papaya (Linn.) Leaves on In Vitro Wound-Healing Activities Molecules doi: 10.3390/molecules25030517 Authors: Husnul Hanani Soib Hassan Fahmi Ismail Fitrien Husin Mohamad Hafizi Abu Bakar Harisun Yaakob Mohamad Roji Sarmidi Herbal plants are traditionally utilized to treat various illnesses. They contain phytochemicals that can be extracted using conventional methods such as maceration,...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 510: Bioactives From Agri-Food Wastes: Present Insights and Future Challenges Molecules doi: 10.3390/molecules25030510 Authors: Ben-Othman Jõudu Bhat Sustainable utilization of agri-food wastes and by-products for producing value-added products (for cosmetic, pharmaceutical or food industrial applications) provides an opportunity for earning additional income for the dependent industrial sector. Besides, effective valorisation of wastes/by-products...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 513: Novel Approaches Utilizing Metal-Organic Framework Composites for the Extraction of Organic Compounds and Metal Traces from Fish and Seafood Molecules doi: 10.3390/molecules25030513 Authors: Vardali Manousi Barczak Giannakoudakis The determination of organic and inorganic pollutants in fish samples is a complex and demanding process, due to their high protein and fat content. Various novel sorbents including graphene, graphene oxide, molecular...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 511: Understanding the Solution Behavior of Epinephrine in the Presence of Toxic Cations: A Thermodynamic Investigation in Different Experimental Conditions Molecules doi: 10.3390/molecules25030511 Authors: Crea De Stefano Irto Lando Materazzi Milea Pettignano Sammartano The interactions of epinephrine ((R)-(−)-3,4-dihydroxy-α-(methylaminomethyl)benzyl alcohol; Eph-) with different toxic cations (methylmercury(II):...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 505: Synthesis of Biologically Active Molecules through Multicomponent Reactions Molecules doi: 10.3390/molecules25030505 Authors: Insuasty Castillo Becerra Rojas Abonia Focusing on the literature progress since 2002, the present review explores the highly significant role that multicomponent reactions (MCRs) have played as a very important tool for expedite synthesis of a vast number of organic molecules, but also, highlights the fact that...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 508: Visible-light Promoted Atom Transfer Radical Addition−Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-Donor Molecules doi: 10.3390/molecules25030508 Authors: Xu Wang Mao Gu Li He Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor−acceptor (EDA) complex between...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 507: From Dermal Patch to Implants—Applications of Biocomposites in Living Tissues Molecules doi: 10.3390/molecules25030507 Authors: Karolina Papera Valente Alexandre Brolo Afzal Suleman Composites are composed of two or more materials, displaying enhanced performance and superior mechanical properties when compared to their individual components. The use of biocompatible materials has created a new category of biocomposites. Biocomposites can be applied...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 506: Berberine Impairs the Survival of Triple Negative Breast Cancer Cells: Cellular and Molecular Analyses Molecules doi: 10.3390/molecules25030506 Authors: Lamyae El Khalki Virginie Maire Thierry Dubois Abdelmajid Zyad Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Non-available targeted therapy for TNBC represents its biggest treatment challenge. Thus, finding new promising effective drugs is urgently needed. In the...
Fri Jan 24, 2020 02:00
Molecules, Vol. 25, Pages 509: Production of Prenylated Stilbenoids in Hairy Root Cultures of Peanut (Arachis hypogaea) and its Wild Relatives A. ipaensis and A. duranensis via an Optimized Elicitation Procedure Molecules doi: 10.3390/molecules25030509 Authors: Fang Yang Medina-Bolivar Prenylated stilbenoids are phenolic compounds produced in a small number of plants such as peanut (Arachis hypogaea) to counteract biotic and abiotic stresses. In addition to their role in plant...
Fri Jan 24, 2020 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου