Epigenomic profiling of primate LCLs reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures [NEW RESULTS]: To gain insight into the evolution of the epigenetic regulation of gene expression in primates, we extensively profiled a new panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone marks, ATAC-seq and RNA-seq, further complemented with WGS and WGBS. We annotated regulatory elements and integrated chromatin contact maps to define gene regulatory architectures, creating the largest catalog of regulatory elements in primates to date. We report that epigenetic conservation and its correlation with sequence conservation in primates depends on the activity state of the regulatory element. Our gene regulatory architectures reveal the coordination of different types of components and highlight the role of promoters and intragenic enhancers in the regulation of gene expression. We observed that most regulatory changes occur in weakly active intragenic enhancers. Remarkably, novel human-specific intragenic enhancers with weak activities are enriched in human-specific mutations. These elements appear in genes with signals of positive selection, tissue-specific expression and particular functional enrichments, suggesting that the regulatory evolution of these genes may have contributed to human adaptation.
Medicine RSS-Feeds by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com
Πληροφορίες
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(366)
- ► Φεβρουαρίου (184)
- ► Ιανουαρίου (182)
-
►
2022
(2814)
- ► Δεκεμβρίου (182)
- ► Σεπτεμβρίου (213)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (262)
-
►
2021
(3815)
- ► Δεκεμβρίου (229)
- ► Σεπτεμβρίου (276)
- ► Φεβρουαρίου (64)
-
▼
2020
(5754)
- ► Δεκεμβρίου (401)
-
▼
Σεπτεμβρίου
(365)
-
▼
Σεπ 30
(57)
- Medicine by Alexandros G. SfakianakisMedicine by A...
- International Journal of Molecular Sciences
- Antibiotics
- Evidence
- Carotid petrous segment aneurysm presenting as hyp...
- Assessme
- A Review of the Effects of Abacus Trainin
- An Invited Commentary on "One-stitch vers
- Patients with Early-Onset Rectal Cancer Aged 40 Ye...
- Tumour-associated tissue eosinophilia (TATE) in or...
- Application of platelet-rich plasma (PRP) improves...
- Tumor-associated macrophages derived from cancer s...
- Immunotherapy for primary and secondary brain tumors
- Current research progress in allergic conjunctival...
- The Effects of Respiratory Training in Parkinson's...
- Platelets in Sepsis:
- Liquid biopsy for ALK-positive early non-small-cel...
- Epigenomic profiling of primate Lymphoblastoid cel...
- Treadmill exercise ameliorates memory deficits and...
- Bulbocodin D as a potential multi-target agent for...
- Chediak Higashi disease ....present in early child...
- Effectiveness of myringoplasty in patients with eo...
- Effectiveness of intraoperative facial nerve monit...
- Necroptotic neuronal cell death in amyotrophic lat...
- Host – virus – drug interactions as determinants o...
- Advanced drug delivery systems can assist in manag...
- Can palatovaginal canal be the site of origin of j...
- Smart polymeric eye gear: A possible preventive me...
- Role of testosterone in COVID-19 patients
- Potential role of GcMAF in suppressing the severit...
- Factors related to asymptomatic or severe COVID-19...
- Role of inositol to improve surfactant functions a...
- The COVID-19 Score can predict the need for trache...
- Nerve regeneration and ischemia based on the sciat...
- Intranasal Tofacitinib on Chronic Rhinosinusitis w...
- Incidence of metastasis to level V lymph nodes in ...
- Tendon function after replantation of complete thu...
- Cholesteatoma Classification
- Narcolepsy type 2
- Cold atmospheric plasma on bacterial contamination...
- Clear cell acanthoma...............a red papule a ...
- Transposition flap plastic to cover an extensive d...
- Eyelid reconstruction with modified Tenzel flap af...
- Subantimicrobial dose doxycycline in rosacea
- Hypersensitivity reactions to non‐steroidal anti‐i...
- Severe skin fragility with postnatal lethal outcom...
- Rapid recurrence in head and neck cancer
- Tooth ultrastructure of a novel COL1A2 mutation ex...
- SNHG3/miR‐2682‐5p/HOXB8 promotes cell proliferatio...
- DNA methylation alterations and their potential in...
- Low-level laser therapy (LLLT) and piezocision on ...
- Oxaliplatin-Induced Thrombotic Microangiopathy
- Frameless Stereotactic Brain Biopsy
- COVID‐19 and immunological dysregulation: can auto...
- COVID‐19 and venous thromboembolism
- Restraint stress abates the antioxidant potential ...
-
▼
Σεπ 30
(57)
- ► Φεβρουαρίου (754)
- ► Ιανουαρίου (894)
-
►
2019
(146)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου