Evidence for the Utility of Actuarial Neuropsychological Criteria Across the Continuum of Normal Aging, Mild Cognitive Impairment, and Dementia. J Alzheimers Dis. 2020 Sep 25;: Authors: Graves LV, Edmonds EC, Thomas KR, Weigand AJ, Cooper S, Bondi MW Abstract BACKGROUND: Research suggests that actuarial neuropsychological criteria improve the accuracy of mild cognitive impairment (MCI) diagnoses relative to conventional diagnostic methods....
Tue Sep 29, 2020 19:06
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06793
Tue Sep 29, 2020 07:00
Related Articles Antibacterial and antibiofilm activities of ceragenins against Achromobacter species isolated from cystic fibrosis patients. J Chemother. 2020 Sep 26;:1-12 Authors: Damar-Çelik D, Mataracı-Kara E, Savage PB, Özbek-Çelik B Abstract Achromobacter species, which are recognized as emerging pathogens isolated from patients with cystic fibrosis, are capable of forming biofilm in the respiratory tract in patients and innate multidrug...
Tue Sep 29, 2020 19:20
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:To investigate the pathologic complete response (pCR) rates of dual human epidermal growth factor receptor 2 (HER2) blockade in a neoadjuvant setting for HER2+ breast cancer.Methods:We searched randomized clinical trials (RCTs) using dual HER2 blockade in a neoadjuvant setting for HER2+ breast cancer in PubMed, the Cochrane Library, Embase and ClinicalTrials.gov up to July 5, 2020, and all included...
Tue Sep 29, 2020 13:10
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Aim:This study aims to evaluate the safety and efficacy of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) guided intensity-modulated radiation therapy (IMRT) for patients with peritoneal metastases.Patients and Methods:A total of 55 patients with peritoneal metastases were treated with 18F-FDG-PET/CT-guided IMRT (BIMRT) from January 2012 to January 2019. They were prescribed...
Tue Sep 29, 2020 13:12
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08639
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05587
Tue Sep 29, 2020 07:00
Related Articles Comparison of screening methods for obstructive sleep apnea in the context of dental clinics: A systematic review. Cranio. 2020 Sep 26;:1-19 Authors: Rossi C, Templier L, Miguez M, De La Cruz J, Curto A, Albaladejo A, Lagravère Vich M Abstract OBJECTIVE: To review the available bibliographic data to identify the best screening methods to detect potential obstructive sleep apnea (OSA) patients during dental clinical practice....
Tue Sep 29, 2020 19:29
Baclofen destabilises breathing during sleep in healthy humans: a randomised, controlled, double-blind crossover trial. Br J Clin Pharmacol. 2020 Sep 28;: Authors: Straus C, Teulier M, Morel S, Wattiez N, Hajage D, Giboin C, Charbit B, Dasque E, Bodineau L, Chenuel B, Straus N, Attali V, Similowski T Abstract AIM: Periodic breathing is frequent in patients with severe heart failure. Apart from being an indicator of severity, periodic breathing...
Tue Sep 29, 2020 19:29
A prospective controlled study about sleep disorders in drug resistant epilepsy. Sleep Med. 2020 Sep 10;75:434-440 Authors: Bergmann M, Prieschl M, Stefani A, Heidbreder A, Walser G, Frauscher B, Unterberger I, Högl B Abstract OBJECTIVE: To evaluate sleep disorders and chronotype in patients with drug resistant focal and generalised epilepsy compared to healthy controls. METHODS: Sixty four patients with focal and six with generalised,...
Tue Sep 29, 2020 19:29
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Justin Cottrell, Siraj K. Zahr, Evan J. Propst, Indra Narang, Reshma Amin, Jackie Chiang, Suhail Al-Saleh, Nikolaus E. Wolter
Tue Sep 29, 2020 19:31
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Yue Fan, Xiaomin Niu, Yushan Chen, Lu Ping, Tengyu Yang, Xiaowei Chen
Tue Sep 29, 2020 19:31
Publication date: Available online 28 September 2020Source: Human PathologyAuthor(s): Annika L. Windon, Erik Almazan, Maria Oliva-Hemker, Danielle Hutchings, Naziheh Assarzadegan, Kevan Salimian, Elizabeth A. Montgomery, Lysandra Voltaggio
Tue Sep 29, 2020 19:36
Publication date: Available online 28 September 2020Source: Human PathologyAuthor(s): Wenchang Guo, Whayoung Lee, Yunxia Lu, Xiaodong Li, Vishal S. Chandan
Tue Sep 29, 2020 19:36
Publication date: Available online 28 September 2020Source: Human PathologyAuthor(s): Iván A. González, Philip S. Bauer, Jingxia Liu, Deyali Chatterjee
Tue Sep 29, 2020 19:36
Indianapolis-based Redux has partnered with hearing aid manufacturer, Signia, making its professional drying and cleaning system for personal electronics available through Signia's Aspire Rewards Program. With the push of a button, the Redux system safely removes all moisture from hearing aids in a matter of minutes while providing real-time verification. Redux's patented technology creates a vacuum to lower the evaporation point of water and remove all moisture from both traditionally powered and...
Mon Sep 28, 2020 18:33
Related Articles Genes, culture, and the human niche: An overview. Evol Anthropol. 2020 Sep 28;: Authors: O'Brien MJ, Bentley RA Abstract The sharp distinction between biological traits and culturally based traits, which had long been standard in evolutionary approaches to behavior, was blurred in the early 1980s by mathematical models that allowed a co-dependent evolution of genetic transmission and cultural information. Niche-construction...
Tue Sep 29, 2020 19:58
Speciation is driven by traits that can act to prohibit mating between nascent lineages, including male courtship and female preference for male traits. Mating barriers involving these traits evolve quickly because there is strong selection on males and females to maximize reproductive success, and the tight co-evolution of mating interactions can lead to rapid diversification of sexual behavior. Using lineages of D. melanogaster that show strong asymmetrical reproductive isolation, we ask two key...
Tue Sep 29, 2020 03:00
Several human monoclonal antibodies directed against immune checkpoints, including T lymphocyte antigen 4 and programmed cell death protein 1, have been implemented for cancer treatment in order to promote eff...
Tue Sep 29, 2020 03:00
Related Articles Long non-coding RNA ARAP1-AS1 promotes the proliferation and migration in cervical cancer through epigenetic regulation of DUSP5. . 2020 Sep 28;:1-8 Authors: Min H, He W Abstract Emerging reports have indicated that long non-coding RNAs (lncRNAs) play pivotal roles in multiple cancers, containing cervical cancer. LncRNA ARAP1 antisense RNA 1 (ARAP1-AS1) was previously identified as a tumor-promoter in bladder cancer. However,...
Tue Sep 29, 2020 20:09
Several human monoclonal antibodies directed against immune checkpoints, including T lymphocyte antigen 4 and programmed cell death protein 1, have been implemented for cancer treatment in order to promote eff...
Tue Sep 29, 2020 03:00
Related Articles Long non-coding RNA ARAP1-AS1 promotes the proliferation and migration in cervical cancer through epigenetic regulation of DUSP5. . 2020 Sep 28;:1-8 Authors: Min H, He W Abstract Emerging reports have indicated that long non-coding RNAs (lncRNAs) play pivotal roles in multiple cancers, containing cervical cancer. LncRNA ARAP1 antisense RNA 1 (ARAP1-AS1) was previously identified as a tumor-promoter in bladder cancer. However,...
Tue Sep 29, 2020 20:09
Abstract Aim To report the clinical and radiographic outcomes of implant‐supported fixed dental prostheses with cantilever extensions (FDPCs) after a function time ≥ 10 years. Material and methods Patients with FDPCs in posterior areas were clinically and radiographically re‐evaluated. Mesial and distal radiographic marginal bone levels (mBLs) from baseline (i.e. delivery of FDPC) to the follow‐up examination were calculated and compared between implant surfaces adjacent to and distant...
Tue Sep 29, 2020 19:25
Spectral variability of sws1 opsin gene in humans and New World monkeys. Abstract Vision is a major sense for Primates and the ability to perceive colors has great importance for the species ecology and behavior. Visual processing begins with the activation of the visual opsins in the retina, and the spectral absorption peaks are highly variable among species. In most Primates, LWS/MWS opsins are responsible for sensitivity to long/middle wavelengths within the visible light spectrum, and SWS1...
Tue Sep 29, 2020 18:33
Related Articles Commentary: Compulsive drug use is associated with imbalance of orbitofrontal- and prelimbic-striatal circuits in punishment-resistant individuals. Front Neural Circuits. 2020;14:49 Authors: Zhang HB, Zheng H, Zhang Y, Zhao D PMID: 32982697 [PubMed - in process]
Tue Sep 29, 2020 20:26
Related Articles Why Brain Criticality Is Clinically Relevant: A Scoping Review. Front Neural Circuits. 2020;14:54 Authors: Zimmern V Abstract The past 25 years have seen a strong increase in the number of publications related to criticality in different areas of neuroscience. The potential of criticality to explain various brain properties, including optimal information processing, has made it an increasingly exciting area of investigation...
Tue Sep 29, 2020 20:26
Related Articles Subpopulations of Projection Neurons in the Olfactory Bulb. Front Neural Circuits. 2020;14:561822 Authors: Imamura F, Ito A, LaFever BJ Abstract Generation of neuronal diversity is a biological strategy widely used in the brain to process complex information. The olfactory bulb is the first relay station of olfactory information in the vertebrate central nervous system. In the olfactory bulb, axons of the olfactory sensory neurons...
Tue Sep 29, 2020 20:26
Abstract Transcranial magnetic stimulation (TMS) is a non‐invasive method to assess neurophysiology of the primary motor cortex in humans. Dystonia is a poorly understood neurological movement disorder, often presenting in an idiopathic, isolated form across different parts of the body. The neurophysiological profile of isolated dystonia compared to healthy adults remains unclear. We conducted a systematic review with meta‐analysis of neurophysiologic TMS measures in people with isolated dystonia...
Tue Sep 29, 2020 19:24
Surgical Infections, Ahead of Print.
Tue Sep 29, 2020 10:00
Publication date: Available online 28 September 2020Source: NeuroImageAuthor(s): Vionnet Laetitia, Aranovitch Alexander, Duerst Yolanda, Haeberlin Maximilian, Dietrich Benjamin Emmanuel, Gross Simon, Pruessmann Klaas Paul
Tue Sep 29, 2020 21:08
Publication date: Available online 28 September 2020Source: NeuroImageAuthor(s): Giorgia Cona, Martin Wiener, Cristina Scarpazza
Tue Sep 29, 2020 21:08
Publication date: Available online 28 September 2020Source: NeuroImageAuthor(s): Meichao Zhang, Dominika Varga, Xiuyi Wang, Katya Krieger-Redwood, Andre Gouws, Jonathan Smallwood, Elizabeth Jefferies
Tue Sep 29, 2020 21:08
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has currently infected over 6.5 million people worldwide. In response to the pandemic, numerous studies have tried to identify causes and symptoms of the disease. Emerging evidence supports recently acquired anosmia (complete loss of smell) and hyposmia (partial loss of smell) as symptoms of COVID-19, but studies of olfactory dysfunction show a wide range of prevalence, from 5%...
Tue Sep 29, 2020 03:00
Thyroid, Ahead of Print.
Tue Sep 29, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Tue Sep 29, 2020 10:00
Related Articles Use of auditory evoked potentials with electrical stimulation at the round window niche pre-operatively on a brain-injured patient: A case study. Cochlear Implants Int. 2020 Sep 27;:1-7 Authors: Huen M, Lee J, Westerberg BD Abstract OBJECTIVES: To highlight the effectiveness of using PS testing in conjunction with electrically evoked auditory evoked potentials (eAEPs) to help guide treatment plans in patients with limited behavioural...
Tue Sep 29, 2020 22:04
A novel IDA-LaNDT derivative was able to reach the highest productivity in the biosynthesis of a well-known antitumoral agent called decitabine. However, the combination of two simple and inexpensive techniques s...
Tue Sep 29, 2020 03:00
Bacteria mineralization is a promising biotechnological approach to apply in biomaterials development. In this investigation, we demonstrate that Bacillus subtilis 168 induces and influences CaCO3 composites prec...
Tue Sep 29, 2020 03:00
Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, was quickly identified as the cause of COVID-19 disease soon after its earliest reports. Global sequencing of thousands of genomes has revealed many common genetic variants, which are the key to unraveling the early evolutionary history of SARS-CoV-2 and tracking its global spread over time. However, our knowledge of fundamental events in the genome evolution and spread of this coronavirus remains grossly incomplete and highly uncertain....
Tue Sep 29, 2020 03:00
Scientists have found that although male and female birds have an almost identical set of genes, they function differently in each sex through a mechanism called alternative splicing.
Sat Sep 26, 2020 21:52
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08179
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08458
Tue Sep 29, 2020 07:00
Zusammenfassung Hintergrund Die Therapie mit einem Immuncheckpointinhibitor (ICI) hat, als Monotherapie oder in Kombination mit etablierten Verfahren, die Therapie der Kopf-Hals-Karzinome revolutioniert. Die Verbesserung der Therapien macht aber auch eine Reevaluation und Weiterentwicklung prädiktiver und prognostischer Marker notwendig, denn trotz aller Fortschritte bleibt die Überlebensrate fortgeschrittener und insbesondere der gegen...
Tue Sep 29, 2020 03:00
Disc repositioning to re-establish the relationship of the condylar head with the fossa is a common step in several temporomandibular joint (TMJ) surgical procedures. Discopexy has been described both as part of an open procedure, and endoscopically.1 Multiple techniques and systems such as the Mitek system2 (mini anchor, Mitex Products Inc) and Arthrex system3 (Arthrex Corkscrew® mini anchor system) have been described. These devices have limitations in the requirement for specialised equipment...
Tue Sep 29, 2020 03:00
Today immersive environments such as Virtual Reality (VR) offer new opportunities for serious gaming in exercise therapy and psychoeducation. Chronic back pain (CBP) patients could benefit from exergames in VR...
Tue Sep 29, 2020 03:00
After stroke, kinematic measures obtained with non-robotic and robotic devices are highly recommended to precisely quantify the sensorimotor impairments of the upper-extremity and select the most relevant ther...
Tue Sep 29, 2020 03:00
Accurate prediction of motor recovery after stroke is critical for treatment decisions and planning. Machine learning has been proposed to be a promising technique for outcome prediction because of its high ac...
Tue Sep 29, 2020 03:00
Rejuvenation Research, Ahead of Print.
Tue Sep 29, 2020 10:00
Researchers have sequenced and analyzed complete genomes from two very different millipede species. The study provides important insights into arthropod evolution, and highlights the genetic underpinnings of unique features of millipede physiology.
Tue Sep 29, 2020 22:21
Theatre actors use voice in virtually any physical position, moving or still, and perform in a wide range of venues. The present study investigated acoustic qualities required to perform classical material without electronic amplification in outdoor spaces.
Tue Sep 29, 2020 03:00
Isolated aspergillus laryngitis is rare and often diagnosed after surgical excision or biopsy for a suspected premalignant or malignant pathology. Unlike other systemic or localized aspergillosis, there are no specific guidelines for isolated laryngeal aspergillosis. Our experience of dealing with a wide variety of isolated laryngeal aspergillosis showed that this entity is very responsive to medical therapy, making extensive debridement (as often carried out in surgically accessible aspergillosis)...
Tue Sep 29, 2020 03:00
Abnormal esophageal motility is prevalent in gastroesophageal reflux disease patients; however, its relationship with laryngopharyngeal reflux (LPR) symptom severity remains unclear. Altered esophageal transit may contribute to LPR symptoms. We aimed to examine the relationship between reflux symptom index (RSI), a validated questionnaire for LPR symptoms, and abnormal esophageal motility on high-resolution manometry (HRM).
Tue Sep 29, 2020 03:00
COVID-19 in Italy has led to the need to reorganize hospital protocols with a significant risk of interruption to cancer treatment programs. In this report, we will focus on a management model covering the two...
Tue Sep 29, 2020 03:00
Stereotactic radiosurgery (SRS) has been increasingly applied for up to 10 brain metastases instead of whole brain radiation therapy (WBRT) to achieve local tumor control while reducing neurotoxicity. Furtherm...
Tue Sep 29, 2020 03:00
The coronavirus disease 2019 (Covid-19) pandemic is an international public health emergency with major social and economic disruptions and devastating health consequences. The rapid development of vaccines is imperative. More than 30 vaccine candidates against severe acute respiratory syndrome…
Tue Sep 29, 2020 03:00
Abstract Due to drastic changes in pollinators between native and invaded habitats, we might expect that pollinator-mediated selection on floral traits of alien plants differ from that in their native ranges. Here, through geometric morphometric tools and phenotypic selection analyses, we examined whether adaptation in flower shape and length occurred in Nicotiana glauca as a response to pollinator selection in contrasting pollination environments. We assessed populations of this...
Tue Sep 29, 2020 03:00
Abstract Purpose Children with a history of brain tumors do not appear to be at a significantly higher risk of sports-related injuries. Nevertheless, according to the systematic review and survey conducted by Perreault et al., 75% of healthcare professionals restrict their patients’ participation in physical activities after brain tumor surgery. The aim of our study was to verify whether children after brain tumor surgery return to...
Tue Sep 29, 2020 03:00
Related Articles Long non-coding RNA ARAP1-AS1 promotes the proliferation and migration in cervical cancer through epigenetic regulation of DUSP5. . 2020 Sep 28;:1-8 Authors: Min H, He W Abstract Emerging reports have indicated that long non-coding RNAs (lncRNAs) play pivotal roles in multiple cancers, containing cervical cancer. LncRNA ARAP1 antisense RNA 1 (ARAP1-AS1) was previously identified as a tumor-promoter in bladder cancer. However,...
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New England Journal of Medicine, Ahead of Print.
Tue Sep 29, 2020 12:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1247-4651 Purpose To present a systematic review of the presence and severity of neuropsychological impairment in the six main neuropsychological domains (attention, executive function, language, visuospatial processing, intelligence, and memory) in patients with Cushing’s disease (CD) and/or Cushing’s Syndrome (CS) at various stages of the illness. The work aims to identify neuropsychological leverage points for focused diagnosis and rehabilitation in...
Tue Sep 29, 2020 02:00
Researchers found that a range of factors affected the fidelity and parenting behavior of plovers, rather than being defined by the species.
Mon Sep 28, 2020 19:50
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06919
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09797
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08773
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08289
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05365
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06419
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09466
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08437
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c10357
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07347
Tue Sep 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08137
Tue Sep 29, 2020 07:00
Abstract As classical transplantation repopulation assays for studying the radiobiology of rat mammary stem/progenitor cells are extremely time-consuming, this study aimed to characterize the radiobiological properties of mammospheres, spherical clumps of mammary cells formed under non-adherent culture conditions, which are a simple and widely used technique for assessing progenitor cell activity. Rat mammary cells were dissociated and used in transplantation repopulation assays...
Tue Sep 29, 2020 03:00
AbstractHypocalcaemia is a well-recognized complication of total thyroidectomy surgery. Patients who develop post-operative hypocalcaemia often report symptoms of neuromuscular instability including peripheral numbness and/or tingling. In severe cases, larygospasm with stridor and bronchospasm can occur. We present the first reported case in the literature, to our knowledge, of a 58-year-old male presenting with intermittent exertional stridor, dysphonia and dysphagia following thyroid surgery 2...
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Zusammenfassung Die Anwendung neuer molekularbiologischer Techniken hat in den letzten Jahren zu einem deutlichen Erkenntnisgewinn hinsichtlich der Komposition des humanen Mikrobioms geführt. So lassen sich sowohl inter- als auch intraindividuelle Unterschiede nachweisen, welche teils mit dem Auftreten bestimmter Krankheiten korrelieren. Für einige sog. Onkomikroben wurde ein direkter Zusammenhang zwischen deren Einflussnahme auf den Wirtsorganismus und der Karzinogenese nachgewiesen,...
Tue Sep 29, 2020 03:00
Zusammenfassung Hintergrund In der ästhetischen und funktionellen Nasenchirurgie ist die Höhenreduzierung des Nasenrückens ein wichtiges Werkzeug. Hierfür stehen mehrere technische Optionen zur Verfügung, bisherige Verfahren haben gemeinsam, dass diese, nach der Abtragung von Knochen und Knorpel, eine Rekonstruktion dieser wichtigen Region notwendig machen. Das Konzept der nasenrückenerhaltenden oder Dorsal-Preservation(DP)-Rhinoplastik...
Tue Sep 29, 2020 03:00
Abstract Purpose Superagers are older adults presenting excellent memory performance that may reflect resilience to the conventional pathways of aging. Our contribution aims to shape the evidence body of the known distinctive biomarkers of superagers and their connections with the Brain and Cognitive Reserve and Brain Maintenance concepts. Methods ...
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Purpose: Debio 1143 is an oral antagonist of inhibitor of apoptosis proteins which enhances tumour response with concomitant chemoradiotherapy. Addition of Debio 1143 to cisplatin-based chemoradiotherapy in locally-advanced (LA)-SCCHN was evaluated in a phase I/II study to determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D). Phase I results are reported. Experimental design: Treatment-naive LA-SCCHN patients (stages III/IVA/IVB) received Debio 1143 (100/200/300mg/day),...
Tue Sep 29, 2020 17:00
To improve and complete our knowledge of archaeal tRNA modification patterns, we have identified and compared the modification pattern (type and location) in tRNAs of three very different archaeal species, Methanococcus maripaludis (a mesophilic methanogen), Pyrococcus furiosus (a hyperthermophile thermococcale) and Sulfolobus acidocaldarius (an acidophilic thermophilic sulfolobale). Most abundant isoacceptor tRNAs (79 in total) for each of the 20 amino acids were isolated by two-dimensional gel...
Tue Sep 29, 2020 18:30
The Microprocessor complex of DROSHA and DGCR8 initiates the biosynthesis of microRNAs (miRNAs) by processing primary miRNAs (pri-miRNAs). Microprocessor can be oriented on pri-miRNAs in opposite directions to generate productive and unproductive cleavages at their basal and apical junctions, respectively. However, only the productive cleavage gives rise to miRNAs. A single nucleotide polymorphism (SNP, rs2910164) in pri-mir-146a is associated with various human diseases. Although this SNP was found...
Tue Sep 29, 2020 19:13
Exposure to the mycotoxin aflatoxin B1 (AFB1) strongly correlates with hepatocellular carcinoma (HCC). P450 enzymes convert AFB1 into a highly reactive epoxide that forms unstable 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) DNA adducts, which convert to stable mutagenic AFB1 formamidopyrimidine (FAPY) DNA adducts. In CYP1A2-expressing budding yeast, AFB1 is a weak mutagen but a potent recombinagen. However, few genes have been identified that confer AFB1 resistance. Here, we profiled...
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British Journal of Cancer, Published online: 30 September 2020; doi:10.1038/s41416-020-01098-8A multicentre, randomised, open-label, parallel-group Phase 2b study of belotecan versus topotecan for recurrent ovarian cancer
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Clitoris is a leading player in female sexuality. Women glans clitoris contains free nerve endings, genital endbulbs, Meissner‐like corpuscles and Pacinian corpuscles, but not Ruffini corpuscles. The basic composition and immunohistochemical profile of glans clitoris corpuscles is superimposable with counterpart digital sensory corpuscles, including the occurrence of an endoneurium‐related capsule y about 65%. Most corpuscles in the glans clitoris showed axonal Piezo2 immunoreactivity, thus, suggesting...
Tue Sep 29, 2020 18:13
BACKGROUND: Plasmodium falciparum resistance to chloroquine (CQ), the most widely used antimalarial drug, has historically posed a major threat to malaria control in Angola and throughout the world. Although Angola replaced CQ with artemisinin combination therapy (ACT) as a frontline treatment in 2006, malaria cases and deaths have recently been rising. CQ-resistance mutations may still be a contributing factor, given that (1) some also modulate resistance to ACT partner drugs and (2) ACT is not...
Tue Sep 29, 2020 03:00
Simulation of genomic data is one of the key tool in population genetics, yet, to date, there is no forward-in-time simulator of bacterial populations that is both computationally efficient and adaptable to a wide range of scenarios. Here we demonstrate how to simulate bacterial populations with SLiM, a forward-in-time simulator built for eukaryotes. SLiM gained lots of traction in the past years, and has exhaustive documentation showcasing the various scenarios that are possible to simulate. This...
Tue Sep 29, 2020 03:00
An amendment to this paper has been published and can be accessed via the original article.
Tue Sep 29, 2020 03:00
Little is known about hepatitis A virus (HAV) prevalence in indigenous communities. This study aims to evaluate the prevalence of HAV in indigenous community compared to urban population located at Western Ama...
Tue Sep 29, 2020 03:00
Restriction-Modification (R-M) systems are ubiquitous in bacteria and were considered for years as rudimentary immune systems that protect bacterial cells from foreign DNA. Currently, these R-M systems are rec...
Tue Sep 29, 2020 03:00
Rodents play an important role to spread zoonotic diseases through society. The current study was carried out to collect informative data on the intestinal helminthic infections of wild rodents in Taleqan Coun...
Tue Sep 29, 2020 03:00
Due to the allergic nature of the pollen of Cryptomeria japonica, the most important Japanese forestry conifer, a pollen-free cultivar is preferred. Mutant trees detected in nature have been used to produce a pol...
Tue Sep 29, 2020 03:00
Natural populations are often exposed to temporally varying environments. Evolutionary dynamics in periodically or stochastically modulated environments have been extensively studied, both theoretically and experimentally, though understanding the effects of temporally varying selection pressures remains challenging. Here we investigate how periodic cycling between a pair of statistically related fitness landscapes affects the evolved fitness of an asexually reproducing population. Inspired by collateral...
Tue Sep 29, 2020 03:00
Tissue Engineering Part A, Ahead of Print.
Tue Sep 29, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Tue Sep 29, 2020 10:00
Phylogenetic networks provide a powerful framework for modeling and analyzing reticulate evolutionary histories. While polyploidy has been shown to be prevalent not only in plants but also in other groups of eukaryotic species, most work done thus far on phylogenetic network inference assumes diploid hybridization. These inference methods have been applied, with varying degrees of success, to data sets with polyploid species, even though polyploidy violates the mathematical assumptions underlying...
Tue Sep 29, 2020 03:00
Authors: Beatriz do Vale, Ana Patrícia Lopes, Maria da Conceição Fontes, Mário Silvestre, Luís Cardoso and Ana Cláudia Coelho.<br />Parasite Vol. 27 , page 52<br />Published online: 29/09/2020<br /> Keywords: Companion animals ; Europe ; Systematic review ; Thelazia callipaeda ; Thelaziosis ; Wildlife.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/xnO7CrFWgvA" height="1" width="1" alt=""/>
Tue Sep 29, 2020 03:00
It is a putatively understood phenomenon that the overall prevalence of allergic disease has been increasing in recent decades—particularly in industrialized nations. Despite this, there is a relative scarcity...
Tue Sep 29, 2020 03:00
Intensive and trait-selective harvesting of fish and wildlife can cause evolutionary changes in a range of life-history and behavioural traits. These changes might in turn alter the circadian system both at behavioral and molecular levels, with knock-on effects on daily physiological processes and behavioural outputs. We examined the evolutionary impact of size-selective mortality on collective risk-taking behavior and the circadian system in a model fish species. We exposed zebrafish (Danio rerio)...
Tue Sep 29, 2020 03:00
Retention of participants is essential to ensure the statistical power and internal validity of clinical trials. Poor participant retention reduces power and can bias the estimates of intervention effect. Ther...
Tue Sep 29, 2020 03:00
Abstract Chemosensitive dysfunctions are now considered as frequent and early symptoms of coronavirus disease 2019 (COVID-19). In the last few weeks, researchers' greatest efforts have been focusing mainly on the analysis of olfactory disorders, neglecting taste dysfunctions. According to our psychophysical evaluations, it can be inferred that the pathogenesis of taste disorders in COVID-19 patients is largely smell-independent. Moreover, isolated gustatory disorders are highly...
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Abstract Angiotensin‐converting enzyme 2 (ACE2) has been identified as the functional receptor of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and a target for disease prevention. However, the relationship between ACE2 expression and its clinical implications in SARS‐CoV‐2 pathogenesis remain unknown. Here, we explored the location and expression of ACE2, and its correlation with gender, age and cigarette smoke (CS), in a CS‐exposed mouse model and 224 non‐malignant lung tissues...
Tue Sep 29, 2020 18:52
Abstract Background Approximately 50% of patients with head and neck cancer (HNC) initially were seen with advanced disease. We aimed to evaluate the association of epidemiologic factors with advanced HNC at diagnosis. Methods The OraRad multicenter prospective cohort study enrolled HNC patients receiving curative‐intent radiation therapy. Factors assessed for association with advanced HNC presentation at diagnosis included demographics, social and medical history, cancer characteristics,...
Tue Sep 29, 2020 17:51
Abstract Aneurysm in the petrous segment of the internal carotid artery is extremely rare, and symptoms are usually derived from compression of neighbor structures such as nerve palsies. Clinical symptoms can be nonspecific and imaging findings are complex, making the diagnosis of this kind of aneurysms extremely challenging. CT angiography is the best diagnostic tool, and treatment options include surgical and endovascular approaches, the latest being preferred. We report an...
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