Publication date: November 2020
Source: Medical Hypotheses, Volume 144
Author(s):
Author links open overlay panelEduardo Pérez-CamposMayoralaeMaría TeresaHernández-HuertabeLauraPérez-Campos Mayoralae1Carlos AlbertoMatias-CervantesbeGabrielMayoral-AndradeaeLuis Ángel LagunaBarriosceEduardoPérez-Camposcde1
a
Centro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68020, Mexico
b
CONACyT, Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68020, Mexico
c
Facultad de Medicina y Cirugía, Universidad Autónoma “Benito Juárez” de Oaxaca, Oaxaca 68020, Mexico
d
Tecnológico Nacional de México/IT Oaxaca, Oaxaca 68020, Mexico
e
Laboratorio de Patología Clinica “Eduardo Pérez Ortega”, Oaxaca 68000, Mexico
Received 26 August 2020, Revised 11 September 2020, Accepted 18 September 2020, Available online 24 September 2020.
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Abstract
The factors that may contribute to a COVID-19 patient remaining in the asymptomatic stage, or to the infection evolving into the more serious stages are examined. In particular, we refer to the TMPRSS2 expression profile, balance of androgen and estrogen, blood group-A and/or B, nonsynonymous mutations in ORF3, and proteins NS7b and NS8 in SARS-CoV-2. Also, we review other factors related to the susceptibility and pathogenicity of SARS-CoV-2.
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