Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): Kunjian Liu, Guofeng Li, Wenjin Guo, Jiao Zhang
Thu Sep 24, 2020 19:46
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): He Ye, Liyan Sun, Jun Li, Yayun Wang, Junzhe Bai, Liang Wu, Qi Han, Zhiping Yang, Li Li
Thu Sep 24, 2020 19:46
Publication date: Available online 23 September 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Hu Xu, Hao Liu, Ying Hong, Xin Rong, Kangkang Huang, Pu Dan, Beiyu Wang
Thu Sep 24, 2020 19:48
Publication date: November 2020Source: Clinical Neurology and Neurosurgery, Volume 198Author(s): Mohammad Etoom, Mohammad Alwardat, Ala’ S. Aburub, Francesco Lena, Roberto Fabbrizo, Nicola Modugno, Diego Centonze
Thu Sep 24, 2020 19:48
Publication date: November 2020Source: Clinical Neurology and Neurosurgery, Volume 198Author(s): Catherine Peterson, Ben Waldau
Thu Sep 24, 2020 19:48
Despite booming consumer interest in online hearing testing, none of the leading tests consistently use best practices to encourage patients to pursue treatment with hearing aids, according to new research from Auditory Insight. In a study examining the online hearing tests from eight leading direct-to-consumer hearing aid brands, including Audicus, Eargo, and MDHearingAid, as well as those from eight leading brands retailed through audiologists, including Phonak, GN Resound, and Starkey, Auditory...
Wed Sep 23, 2020 14:45
Oticon Medical has launched the Ponto Care™ app, a supportive and easy-to-use mobile application for all bone-anchored hearing device users. It expands on the previously released Ponto Trial Companion app by adding a second section, Aftercare.The goal of creating the Ponto Care app was to support users becoming more engaged, independent, and involved in their bone anchored hearing treatment. The app provides them with the self-help tools needed for more insightful conversations with their hearing...
Wed Sep 23, 2020 18:53
Publication date: Available online 23 September 2020Source: Pathology - Research and PracticeAuthor(s): Gabriella Pasqual-Melo, Sara S. Bernardes, Fernando P. Souza-Neto, Iriana M. Carrara, Leandra N.Z. Ramalho, Poliana C. Marinello, Rodrigo C. Luiz, Rubens Cecchini, Sander Bekeschus, Alessandra L. Cecchini
Thu Sep 24, 2020 20:01
Publication date: Available online 23 September 2020Source: American Journal of OtolaryngologyAuthor(s): Conor H. Blanco, John B. Stein, Gregory L. Barinsky, Christina H. Fang, Jordon G. Grube, Roger E. Turbin, Jean Anderson Eloy
Thu Sep 24, 2020 20:04
Background Standard nasal steroid sprays are often first‐line treatment for chronic rhinosinusitis (CRS), but many patients remain symptomatic despite their use. The exhalation delivery system with fluticasone (EDS‐FLU) has been shown to be efficacious in mixed populations of symptomatic patients, but the question remains whether benefits would be similar in those already on traditional steroid sprays. The goal of this study was to compare EDS‐FLU treatment outcomes in patients who have previously...
Thu Sep 24, 2020 18:15
Publication date: October 2020Source: Annals of Diagnostic Pathology, Volume 48Author(s): Koichi Sato, Takeshi Uehara, Mai Iwaya, Tomoyuki Nakajima, Yusuke Miyagawa, Tomoaki Suga, Hiroyoshi Ota, Eiji Tanaka
Thu Sep 24, 2020 20:17
Related Articles ExActa HIF prolyl hydroxylase inhibitors-The new lifestyle drug? Acta Physiol (Oxf). 2019 11;227(3):e13370 Authors: Sciesielski LK, Kirschner KM PMID: 31465609 [PubMed - indexed for MEDLINE]
Thu Sep 24, 2020 20:29
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Oncol Lett"[jour] These pubmed results were generated on 2020/09/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 24, 2020 20:44
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Tulio A. Valdez, Sahith Kudaravalli, Katherine R. Kavanagh
Thu Sep 24, 2020 20:46
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Kubilay Kınoğlu, Kadir Serkan Orhan, Hakan Kara, Oğuz Öztürk, Beldan Polat, Hülya Aydoğan, Mehmet Çelik, Ayşe Begüm Ceviz, Yahya Güldiken
Thu Sep 24, 2020 20:46
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Ryan Puccia, Kelly Staricha, Valerie M. Carlberg, David Moe, Robert Chun
Thu Sep 24, 2020 20:46
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Mehmet Erkan Kaplama, Ahmet Yukkaldiran, Semih Ak
Thu Sep 24, 2020 20:46
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Hemawathiy Sundagumaran, Jayashree Seethapathy
Thu Sep 24, 2020 20:46
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Meng-Xue Li, Zheng Li, Rui Zhang, Yue Yu, Lu-Shan Wang, Qi Wang, Zhen Ding, Jin-Peng Zhang, Mei-Rong Zhang, Li-Chun Xu
Thu Sep 24, 2020 20:46
Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): David Hui, Signe Søvik
Thu Sep 24, 2020 20:46
After performing my beachside neurologic exam, complete with lobster hammer to check reflexes, I made a mistake I would never have made with a patient. "Mom," I said, "There are some subtle findings. You need an MRI, but don’t worry — it’s not like you have a brain tumor." I advised my mother to…
Thu Sep 24, 2020 03:00
Presentation of Case. Dr. Jacqueline B. Henson (Medicine): A 54-year-old man was evaluated at this hospital after cardiac arrest associated with ventricular fibrillation. The patient had been in his usual state of health until midday on the day of admission, when he was in a fast-food restaurant…
Thu Sep 24, 2020 03:00
Organelle identity depends on protein composition. How mistargeted proteins are selectively recognized and removed from organelles is incompletely understood. Here, we found that the orphan P5A–adenosine triphosphatase (ATPase) transporter ATP13A1 (Spf1 in yeast) directly interacted with the transmembrane segment (TM) of mitochondrial tail–anchored proteins. P5A-ATPase activity mediated the extraction of mistargeted proteins from the endoplasmic reticulum (ER). Cryo–electron microscopy structures...
Thu Sep 24, 2020 20:40
Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology...
Thu Sep 24, 2020 20:40
Schistosome parasites kill 250,000 people every year. Treatment of schistosomiasis relies on the drug praziquantel. Unfortunately, a scarcity of molecular tools has hindered the discovery of new drug targets. Here, we describe a large-scale RNA interference (RNAi) screen in adult Schistosoma mansoni that examined the function of 2216 genes. We identified 261 genes with phenotypes affecting neuromuscular function, tissue integrity, stem cell maintenance, and parasite survival. Leveraging these data,...
Thu Sep 24, 2020 20:40
Precise cell targeting is challenging because most mammalian cell types lack a single surface marker that distinguishes them from other cells. A solution would be to target cells using specific combinations of proteins present on their surfaces. In this study, we design colocalization-dependent protein switches (Co-LOCKR) that perform AND, OR, and NOT Boolean logic operations. These switches activate through a conformational change only when all conditions are met, generating rapid, transcription-independent...
Thu Sep 24, 2020 20:40
Addressing the ultrafast coherent evolution of electronic wave functions has long been a goal of nonlinear x-ray physics. A first step toward this goal is the investigation of stimulated x-ray Raman scattering (SXRS) using intense pulses from an x-ray free-electron laser. Earlier SXRS experiments relied on signal amplification during pulse propagation through dense resonant media. By contrast, our method reveals the fundamental process in which photons from the primary radiation source directly interact...
Thu Sep 24, 2020 20:40
Marine heatwaves (MHWs)—periods of extremely high ocean temperatures in specific regions—have occurred in all of Earth’s ocean basins over the past two decades, with severe negative impacts on marine organisms and ecosystems. However, for most individual MHWs, it is unclear to what extent they have been altered by human-induced climate change. We show that the occurrence probabilities of the duration, intensity, and cumulative intensity of most documented, large, and impactful MHWs have increased...
Thu Sep 24, 2020 20:40
Sexual parasitism has evolved as a distinctive mode of reproduction among deep-sea anglerfishes. The permanent attachment of males to host females observed in these species represents a form of anatomical joining, which is otherwise unknown in nature. Pronounced modifications to immune facilities are associated with this reproductive trait. The genomes of species with temporarily attaching males lack functional aicda genes that underpin affinity maturation of antibodies. Permanent attachment is associated...
Thu Sep 24, 2020 20:40
The design and fabrication of robust metallic states in graphene nanoribbons (GNRs) are challenging because lateral quantum confinement and many-electron interactions induce electronic band gaps when graphene is patterned at nanometer length scales. Recent developments in bottom-up synthesis have enabled the design and characterization of atomically precise GNRs, but strategies for realizing GNR metallicity have been elusive. Here we demonstrate a general technique for inducing metallicity in GNRs...
Thu Sep 24, 2020 20:40
Intervention strategies are urgently needed to control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The trimeric viral spike (S) protein catalyzes fusion between viral and target cell membranes to initiate infection. Here, we report two cryo–electron microscopy structures derived from a preparation of the full-length S protein, representing its prefusion (2.9-angstrom resolution) and postfusion (3.0-angstrom resolution) conformations, respectively. The spontaneous transition...
Thu Sep 24, 2020 20:40
Although the avian pallium seems to lack an organization akin to that of the cerebral cortex, birds exhibit extraordinary cognitive skills that are comparable to those of mammals. We analyzed the fiber architecture of the avian pallium with three-dimensional polarized light imaging and subsequently reconstructed local and associative pallial circuits with tracing techniques. We discovered an iteratively repeated, column-like neuronal circuitry across the layer-like nuclear boundaries of the hyperpallium...
Thu Sep 24, 2020 20:40
Ancient DNA has provided new insights into many aspects of human history. However, we lack comprehensive studies of the Y chromosomes of Denisovans and Neanderthals because the majority of specimens that have been sequenced to sufficient coverage are female. Sequencing Y chromosomes from two Denisovans and three Neanderthals shows that the Y chromosomes of Denisovans split around 700 thousand years ago from a lineage shared by Neanderthals and modern human Y chromosomes, which diverged from each...
Thu Sep 24, 2020 20:40
Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs’ cycle intermediates that alter transcription of immune response genes. We extended these observations by defining fumarate as an inhibitor of pyroptotic cell death. We found that dimethyl fumarate (DMF) delivered to cells or endogenous fumarate reacts with gasdermin D (GSDMD) at critical cysteine residues to form S-(2-succinyl)-cysteine. GSDMD succination prevents its interaction with caspases, limiting its...
Thu Sep 24, 2020 20:40
Further improvement and stabilization of perovskite solar cell (PSC) performance are essential to achieve the commercial viability of next-generation photovoltaics. Considering the benefits of fluorination to conjugated materials for energy levels, hydrophobicity, and noncovalent interactions, two fluorinated isomeric analogs of the well-known hole-transporting material (HTM) Spiro-OMeTAD are developed and used as HTMs in PSCs. The structure–property relationship induced by constitutional isomerism...
Thu Sep 24, 2020 20:40
Since its discovery 16 years ago, roaming has become a ubiquitous mechanism in molecular photochemistry. Its general features are now understood, but little detail is known about how the potential energy surface (PES) determines reaction outcomes. We performed detailed experiments on formaldehyde (H2CO) photodissociation and determined fully correlated quantum state distributions of the molecular hydrogen and carbon monoxide products. These experiments reveal previously undetected bimodal carbon...
Thu Sep 24, 2020 20:40
The challenge of prebiotic chemistry is to trace the syntheses of life’s key building blocks from a handful of primordial substrates. Here we report a forward-synthesis algorithm that generates a full network of prebiotic chemical reactions accessible from these substrates under generally accepted conditions. This network contains both reported and previously unidentified routes to biotic targets, as well as plausible syntheses of abiotic molecules. It also exhibits three forms of nontrivial chemical...
Thu Sep 24, 2020 20:40
Subjective experiences that can be consciously accessed and reported are associated with the cerebral cortex. Whether sensory consciousness can also arise from differently organized brains that lack a layered cerebral cortex, such as the bird brain, remains unknown. We show that single-neuron responses in the pallial endbrain of crows performing a visual detection task correlate with the birds’ perception about stimulus presence or absence and argue that this is an empirical marker of avian consciousness....
Thu Sep 24, 2020 20:40
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice. The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal...
Thu Sep 24, 2020 20:40
Schistosomiasis is a neglected tropical disease that infects 240 million people. With no vaccines and only one drug available, new therapeutic targets are needed. The causative agents, schistosomes, are intravascular flatworm parasites that feed on blood and lay eggs, resulting in pathology. The function of the parasite’s various tissues in successful parasitism are poorly understood, hindering identification of therapeutic targets. Using single-cell RNA sequencing (RNA-seq), we characterize 43,642...
Thu Sep 24, 2020 20:40
Mean percent relative abundance changes in marmoset gut miocrobiota Phyla from baseline to 6 months post fecal transplant. Abstract Disruption of microbial communities within human hosts has been associated with infection, obesity, cognitive decline, cancer risk and frailty, suggesting that microbiome‐targeted therapies may be an option for improving healthspan and lifespan. The objectives of this study were to determine the feasibility of delivering fecal microbiota transplants (FMTs) to...
Thu Sep 24, 2020 19:03
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Hiromitsu Yamashita, Yoshimitsu Takahashi, Tatsuro Ishizaki, Haruki Imura, Takeo Nakayama
Thu Sep 24, 2020 21:30
Abstract Background Although melanoma brain metastases (MBM) tend to respond to systemic therapy concordantly with extracranial metastases, little is known about differences in immune cell and vascular content between the brain and other metastatic sites. Here we studied infiltrating immune cell subsets and microvessel density (MVD) in paired intracerebral and extracerebral melanoma metastases. ...
Thu Sep 24, 2020 03:00
Mucosal Immunology, Published online: 24 September 2020; doi:10.1038/s41385-020-00345-8Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets
Thu Sep 24, 2020 03:00
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Melika Lotfi, Nima Rezaei
Thu Sep 24, 2020 22:57
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