Iodine ‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma.

Iodine ‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma.: Iodine‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma.
Int J Oncol. 2020 Jan 10;:
Authors: Brito AF, Abrantes AM, Teixo R, Pires AS, Ribeiro AC, Ferreira RF, Fernandes A, Puga T, Laranjo M, Caramelo F, Boin I, Jefferson DM, Gonçalves AC, Martins R, Rodrigues J, Ribeiro IP, Barbosa De Melo J, Sarmento-Ribeiro AB, Carreira IM, Souza D, Tralhão JG, Botelho MF
Abstract
Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, providing the o...