Antioxidants, Vol. 9, Pages 69: Contribution of Individual Polyphenols to Antioxidant Activity of Cotoneaster bullatus and Cotoneaster zabelii Leaves—Structural Relationships, Synergy Effects and Application for Quality Control Antioxidants doi: 10.3390/antiox9010069 Authors: Agnieszka Kicel Aleksandra Owczarek Paulina Kapusta Joanna Kolodziejczyk-Czepas Monika A. Olszewska Cotoneaster plants are sources of traditional medicines and dietary products, with health benefits...
Sun Jan 12, 2020 02:00
Antioxidants, Vol. 9, Pages 68: Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells Antioxidants doi: 10.3390/antiox9010068 Authors: Namrata Khurana Partha K. Chandra Hogyoung Kim Asim B. Abdel-Mageed Debasis Mondal Suresh C. Sikka Androgen receptor (AR) signaling is fundamental to prostate cancer (PC) progression, and hence, androgen deprivation therapy (ADT) remains a mainstay...
Sun Jan 12, 2020 02:00
Antioxidants, Vol. 9, Pages 67: The Apoplastic and Symplastic Antioxidant System in Onion: Response to Long-Term Salt Stress Antioxidants doi: 10.3390/antiox9010067 Authors: Grisaly García María José Clemente-Moreno Pedro Díaz-Vivancos Marina García José Antonio Hernández The response of apoplastic antioxidant systems in root and leaf tissues from two onion genotypes (‘Texas 502’, salt-sensitive and ‘Granex 429’, salt-resistant) in...
Sun Jan 12, 2020 02:00
Antioxidants, Vol. 9, Pages 66: Up-Regulation of Superoxide Dismutase 2 in 3D Spheroid Formation Promotes Therapeutic Potency of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Antioxidants doi: 10.3390/antiox9010066 Authors: Lee Song Kim Ha Lee Choi Oh Um Jin Umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are accessible, available in abundance, and have been shown to be a promising source that can regenerate cartilage in patients...
Sat Jan 11, 2020 02:00
Antioxidants, Vol. 9, Pages 65: Pholiota nameko Polysaccharides Promotes Cell Proliferation and Migration and Reduces ROS Content in H2O2-Induced L929 Cells Antioxidants doi: 10.3390/antiox9010065 Authors: Sung Wang Liu Chou Lai Hsieh Pholiota nameko, a type of edible and medicinal fungus, is currently grown extensively for food and traditional medicine in China and Japan. It possesses various biological activities, such as anti-inflammatory, anti-hyperlipidemia...
Fri Jan 10, 2020 02:00
Antioxidants, Vol. 9, Pages 64: The Influence of In Vitro Gastrointestinal Digestion on the Anticancer Activity of Manuka Honey Antioxidants doi: 10.3390/antiox9010064 Authors: Cianciosi Forbes-Hernández Afrin Gasparrini Quiles Gil Bompadre Simal-Gandara Battino Giampieri : Manuka honey (MH) is a natural food with many beneficial properties to human health, thanks to its high variety of bioactive compounds; however, little is known about its bioaccessibility....
Fri Jan 10, 2020 02:00
Antioxidants, Vol. 9, Pages 63: The Skin-Whitening Effects of Ectoine via the Suppression of α-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes Antioxidants doi: 10.3390/antiox9010063 Authors: You-Cheng Hseu Xuan-Zao Chen Yugandhar Vudhya Gowrisankar Hung-Rong Yen Jing-Yuan Chuang Hsin-Ling Yang Ultraviolet A (UVA)-irradiation induced reactive oxygen species (ROS) production mediates excessive melanogenesis in...
Fri Jan 10, 2020 02:00
Antioxidants, Vol. 9, Pages 62: Rosmarinus officinalis Essential Oil Improves Scopolamine-Induced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio) Antioxidants doi: 10.3390/antiox9010062 Authors: Luminita Capatina Razvan Stefan Boiangiu Gabriela Dumitru Edoardo Marco Napoli Giuseppe Ruberto Lucian Hritcu Elena Todirascu-Ciornea Rosmarinus officinalis L. is a traditional herb with various therapeutic...
Fri Jan 10, 2020 02:00
Antioxidants, Vol. 9, Pages 61: Polyphenols from Food and Natural Products: Neuroprotection and Safety Antioxidants doi: 10.3390/antiox9010061 Authors: Rui F. M. Silva Lea Pogačnik Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties. Many studies have highlighted their potential role in the prevention and treatment of various pathological conditions...
Fri Jan 10, 2020 02:00
Arts, Vol. 9, Pages 9: The Medieval Synagogue of Molina de Aragón: Architecture and Decoration Arts doi: 10.3390/arts9010009 Authors: Daniel Muñoz-Garrido The remains of a medieval synagogue, in addition to numerous fragments of plaster decoration, have been found as a result of the excavation work done at the Prao de los Judíos archaeological site in the town of Molina de Aragón (Guadalajara, Spain). These remains suggest that the synagogue was built in the second...
Sun Jan 12, 2020 02:00
Arts, Vol. 9, Pages 8: The Great Orbital Run (or the M25 in 4000 Images) Arts doi: 10.3390/arts9010008 Authors: Chance The Great Orbital Run was a solitary run/artwork that took place over nine days around the inside boundary of the M25 London Orbital. The journey was mapped through a stream of photographs and GPS coordinates relayed live from a mobile phone to a web interface and shown as a projected artwork at the University of Greenwich, London. It was later re-configured as the...
Sun Jan 12, 2020 02:00
Arts, Vol. 9, Pages 7: Mapping a New Humanism in the 1940s: Thelma Johnson Streat between Dance and Painting Arts doi: 10.3390/arts9010007 Authors: Schriber Thelma Johnson Streat is perhaps best known as the first African American woman to have work acquired by the Museum of Modern Art. However, in the 1940s–1950s she inhabited multiple coinciding roles: painter, performer, choreographer, cultural ethnographer, and folklore collector. As part of this expansive practice, her...
Sat Jan 11, 2020 02:00
Arts, Vol. 9, Pages 6: Ana-Ethnographic Representation: Early Modern Pueblo Painters, Scientific Colonialism, and Tactics of Refusal Arts doi: 10.3390/arts9010006 Authors: Sascha T. Scott In 1918, San Ildefonso Pueblo artist Crescencio Martinez completed two commissions for the anthropologist Edgar L. Hewett: A set of paintings and a series of tiles. The paintings, called the Crescencio Set, mark a formative moment in the development of a new genre of art, modern Pueblo painting. Before...
Sat Jan 11, 2020 02:00
Arts, Vol. 9, Pages 5: Maribor Synagogue: Between Facts and Reinterpretation Arts doi: 10.3390/arts9010005 Authors: Janez Premk Maribor Synagogue is one of the few preserved medieval synagogues in Central Europe. The renovation of the building between 1992 and 1999, undertaken by the Institute for the Protection of Cultural Heritage of Slovenia, proved to be much more demanding than originally foreseen. Its architectural shell and architectural elements have served as a reference point...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 90: An Extensive Collection of Evaluation Indicators to Assess Occupants’ Health and Comfort in Indoor Environment Atmosphere doi: 10.3390/atmos11010090 Authors: Fantozzi Rocca Today, the effects of the indoor environment on occupants’ health and comfort represent a very important topic and requires a holistic approach in which the four main environmental factors (thermal comfort, air quality, acoustics, and lighting) should be simultaneously...
Sun Jan 12, 2020 02:00
Atmosphere, Vol. 11, Pages 91: High-Resolution Biomass Burning Aerosol Transport Simulations in the Tropics Atmosphere doi: 10.3390/atmos11010091 Authors: Nurzahziani Surussavadee Noosook This study evaluates the performance of the Weather Research and Forecasting Model with Chemistry (WRF-Chem) for simulating biomass burning aerosol transport at high resolution in the tropics using two different biomass burning emission inventories. Hourly, daily, and monthly average PM10 dry...
Sun Jan 12, 2020 02:00
Atmosphere, Vol. 11, Pages 88: Spatial Particulate Fields during High Winds in the Imperial Valley, California Atmosphere doi: 10.3390/atmos11010088 Authors: Freedman English Wagner Liu Venkatram Tong Al-Hamdan Sorek-Hamer Chatfield Rivera Kinney We examined windblown dust within the Imperial Valley (CA) during strong springtime west-southwesterly (WSW) wind events. Analysis of routine agency meteorological and ambient particulate matter (PM)...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 89: Improving WRF Typhoon Precipitation and Intensity Simulation Using a Surrogate-Based Automatic Parameter Optimization Method Atmosphere doi: 10.3390/atmos11010089 Authors: Di Duan Shen Xie Typhoon precipitation and intensity forecasting plays an important role in disaster prevention and mitigation in the typhoon landfall area. However, the issue of improving forecast accuracy is very challenging. In this study, the Weather Research and Forecasting...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 86: Modelling the Optical Properties of Soot Particles under Various Aging Conditions Atmosphere doi: 10.3390/atmos11010086 Authors: Li Yan Shen Zhang Geng Yang Azzi As atmospheric fresh soot particles age, they become coated with other chemical species. This transforms their physicochemical properties and affects their optical characteristics, which is of great importance to air quality, the environment and climate change. One of the...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 85: Numerical Study of the Interaction between Oasis and Urban Areas within an Arid Mountains-Desert System in Xinjiang, China Atmosphere doi: 10.3390/atmos11010085 Authors: Peng Cai Rafiq Hamdi Huili He Geping Luo Jin Wang Miao Zhang Chaofan Li Piet Termonia Philippe De Maeyer The rapid oasis expansion and urbanization that occurred in Xinjiang province (China) in the last decades have greatly modified the land surface energy balance...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 87: Monitoring and Modeling Roof-Level Wind Speed in a Changing City Atmosphere doi: 10.3390/atmos11010087 Authors: Baumann-Stanzer Stenzel Rau Piringer Feichtinger Costabloz Results of an observational campaign and model study are presented demonstrating how the wind field at roof-level in the urban area of Vienna changed due to the construction of a new building nearby. The investigation was designed with a focus on the wind energy yield...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 84: Study of Chemical and Optical Properties of Biomass Burning Aerosols during Long-Range Transport Events toward the Arctic in Summer 2017 Atmosphere doi: 10.3390/atmos11010084 Authors: Tymon Zielinski Ezio Bolzacchini Marco Cataldi Luca Ferrero Sandra Graßl Georg Hansen David Mateos Mauro Mazzola Roland Neuber Paulina Pakszys Michal Posyniak Christoph Ritter Mirko Severi Piotr Sobolewski Rita Traversi Christian Velasco-Merino...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 83: Global Monitoring and Characterization of Infrasound Signatures by Large Fireballs Atmosphere doi: 10.3390/atmos11010083 Authors: Christoph Pilger Peter Gaebler Patrick Hupe Theresa Ott Esther Drolshagen Large meteoroids can be registered in infrasound recordings during their entry into the Earth’s atmosphere. A comprehensive study of 10 large fireball events of the years 2018 and 2019 highlights their detection and characterization...
Fri Jan 10, 2020 02:00
Atmosphere, Vol. 11, Pages 82: Spatial Variability in Years of Abrupt Seasonal Temperature Changes and Warming (Cooling) Hiatuses in China from 1951–2018 and the Variation Trends before and after These Years Atmosphere doi: 10.3390/atmos11010082 Authors: Xing Huang Long Ma Tingxi Liu Bolin Sun Ying Zhou Yang Chen Zixu Qiao Abrupt temperature changes and warming (cooling) hiatuses have an impact on the ecological environment. Currently, research findings for the spatial...
Fri Jan 10, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 33: Associations of Patient Mood, Modulators of Quality of Life, and Pharmaceuticals with Amyotrophic Lateral Sclerosis Survival Duration Behavioral Sciences doi: 10.3390/bs10010033 Authors: Bond Bowen Mertens Denson Jordan Vidakovic Mitchell Associations of modulators of quality of life (QoL) and survival duration are assessed in the fatal motor neuron disease, Amyotrophic Lateral Sclerosis. Major categories include clinical...
Fri Jan 10, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 32: Coping Strategies and Personality Profile Characteristics of People Whose Parents Were Alcohol Addicts Behavioral Sciences doi: 10.3390/bs10010032 Authors: Anna M. Lutsenko The relevance of this research is due to the wide prevalence of addictive behavior and the insufficient knowledge of the coping strategies of patients and their families. The purpose of this research was to investigate the resource factors and coping strategies of adults with...
Fri Jan 10, 2020 02:00
Behavioral Sciences, Vol. 10, Pages 31: The Effect of Eating Habits’ Quality on Scholastic Performance in Turkish Adolescents Behavioral Sciences doi: 10.3390/bs10010031 Authors: Aleksandra S. Kristo Büşra Gültekin Merve Öztağ Angelos K. Sikalidis Evidence associates scholastic performance to quality of eating habits. However, there is limited information on this topic in Turkey, an emerging economy with notable disparities. Our work aimed to evaluate the effect of eating habits...
Fri Jan 10, 2020 02:00
Bioengineering, Vol. 7, Pages 9: S-Nitroso-N-Acetyl-D-Penicillamine Modified Hyperbranched Polyamidoamine for High-Capacity Nitric Oxide Storage and Release Bioengineering doi: 10.3390/bioengineering7010009 Authors: Sean P. Hopkins Megan C. Frost Synthetic nitric oxide (NO)-donating materials have been shown to have many beneficial effects when incorporated into biomedical materials. When released in the correct dosage, NO has been shown to increase the biocompatibility of blood and...
Fri Jan 10, 2020 02:00
Biology, Vol. 9, Pages 16: Glucose Favors Lipid Anabolic Metabolism in the Invasive Breast Cancer Cell Line MDA-MB-231 Biology doi: 10.3390/biology9010016 Authors: Ocaña Martínez-Poveda Quesada Medina Metabolic reprogramming in tumor cells is considered one of the hallmarks of cancer. Many studies have been carried out in order to elucidate the effects of tumor cell metabolism on invasion and tumor progression. However, little is known about the immediate substrate preference...
Fri Jan 10, 2020 02:00
Biomedicines, Vol. 8, Pages 12: Combined Effects of NMES and Mendelsohn Maneuver on the Swallowing Function and Swallowing–Quality of Life of Patients with Stroke-Induced Sub-Acute Swallowing Disorders Biomedicines doi: 10.3390/biomedicines8010012 Authors: Byeon It is necessary to identify how to improve the swallowing-related quality of life, as well as the swallowing function, in order to evaluate the effect of treatments on swallowing disorders. This study aimed to prove the effects...
Sun Jan 12, 2020 02:00
Biomedicines, Vol. 8, Pages 11: Anti-Inflammatory Effects of Diospyrin on Lipopolysaccharide-Induced Inflammation Using RAW 264.7 Mouse Macrophages Biomedicines doi: 10.3390/biomedicines8010011 Authors: Shahidullah Lee Kim Halimi Rauf Kim Kim Park Diospyrin is a bisnaphthoquinonoid medicinal compound derived from Diospyros lotus, with known anti-cancer, anti-tubercular, and anti-leishmanial activities against Leishmania donovani. However, the effects of diospyrin...
Sat Jan 11, 2020 02:00
Biomolecules, Vol. 10, Pages 128: The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms Biomolecules doi: 10.3390/biom10010128 Authors: Suresh Banjara Chathura D. Suraweera Mark G. Hinds Marc Kvansakul Intrinsic apoptosis, the response to intracellular cell death stimuli, is regulated by the interplay of the B-cell lymphoma 2 (Bcl-2) family and their membrane interactions. Bcl-2 proteins mediate a number of processes including development, homeostasis,...
Sun Jan 12, 2020 02:00
Biomolecules, Vol. 10, Pages 127: Host-Induced Gene Silencing of an Adenylate Kinase Gene Involved in Fungal Energy Metabolism Improves Plant Resistance to Verticillium dahliae Biomolecules doi: 10.3390/biom10010127 Authors: Xiaofeng Su Guoqing Lu Xiaokang Li Latifur Rehman Wende Liu Guoqing Sun Huiming Guo Guoliang Wang Hongmei Cheng Verticillium wilt, caused by the ascomycete fungus Verticillium dahliae (Vd), is a devastating disease of numerous plant species....
Sun Jan 12, 2020 02:00
Biomolecules, Vol. 10, Pages 126: In Vitro Autonomous Construction of the Flagellar Axial Structure in Inverted Membrane Vesicles Biomolecules doi: 10.3390/biom10010126 Authors: Hiroyuki Terashima Chinatsu Tatsumi Akihiro Kawamoto Keiichi Namba Tohru Minamino Katsumi Imada The bacterial flagellum is a filamentous organelle extending from the cell surface. The axial structure of the flagellum consists of the rod, hook, junction, filament, and cap. The axial structure is...
Sat Jan 11, 2020 02:00
Biomolecules, Vol. 10, Pages 125: Design and Rationale of the ERA-CVD Consortium PREMED-CAD—Precision Medicine in Coronary Artery Disease Biomolecules doi: 10.3390/biom10010125 Authors: Apurva Shrivastava Vincenzo Marzolla Henri Weidmann Massimiliano Caprio David-Alexandre Tregouet Tanja Zeller Mahir Karakas Cardiovascular diseases (CVDs) comprise 45% of all deaths in Europe and causes 3.9 million deaths annually. Coronary artery disease (CAD) which includes myocardial...
Sat Jan 11, 2020 02:00
Biomolecules, Vol. 10, Pages 124: Improved Pullulan Production and Process Optimization Using Novel GA–ANN and GA–ANFIS Hybrid Statistical Tools Biomolecules doi: 10.3390/biom10010124 Authors: Badhwar Kumar Yadav Kumar Siwach Chhabra Dubey Pullulan production from Aureobasidium pullulans was explored to increase yield. Non-linear hybrid mathematical tools for optimization of process variables as well as the pullulan yield were analyzed. The one variable at a...
Fri Jan 10, 2020 02:00
Biomolecules, Vol. 10, Pages 123: Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers Through an Intrinsic Apoptosis Pathway Biomolecules doi: 10.3390/biom10010123 Authors: Sheng Zhang Li Xie Wen Cheng In order to discover novel derivatives in the anti-tumor field, reported anti-tumor pharmacophores (uridine, uracil, and thymine) were combined with 2-methoxyestradiol, which has been characterized as having excellent biological...
Fri Jan 10, 2020 02:00
Biomolecules, Vol. 10, Pages 121: Protein Backbone and Average Particle Dynamics in Reconstituted Discoidal and Spherical HDL Probed by Hydrogen Deuterium Exchange and Elastic Incoherent Neutron Scattering Biomolecules doi: 10.3390/biom10010121 Authors: Gogonea Peters Gerstenecker Topbas Hou Combet DiDonato Smith Rye Hazen Lipoproteins are supramolecular assemblies of proteins and lipids with dynamic characteristics critically linked to their biological...
Fri Jan 10, 2020 02:00
Biomolecules, Vol. 10, Pages 122: A Critical Regulation of Th17 Cell Responses and Autoimmune Neuro-Inflammation by Ginsenoside Rg3 Biomolecules doi: 10.3390/biom10010122 Authors: Park Cho Choi Na Chung Among diverse helper T-cell subsets, Th17 cells appear to be pathogenic in diverse autoimmune diseases, and thus, targeting Th17 cells could be beneficial for the treatment of the diseases in humans. Ginsenoside Rg3 is one of the most potent components in Korean Red Ginseng...
Fri Jan 10, 2020 02:00
Biomolecules, Vol. 10, Pages 120: Exploring the Potential of Nitric Oxide and Hydrogen Sulfide (NOSH)-Releasing Synthetic Compounds as Novel Priming Agents against Drought Stress in Medicago sativa Plants Biomolecules doi: 10.3390/biom10010120 Authors: Antoniou Xenofontos Chatzimichail Christou Kashfi Fotopoulos Land plants are continuously exposed to multiple abiotic stress factors like drought, heat, and salinity. Nitric oxide (NO) and hydrogen sulfide (H2S) are...
Fri Jan 10, 2020 02:00
Biomolecules, Vol. 10, Pages 119: Structural and Functional Aspects of G-Quadruplex Aptamers Which Bind a Broad Range of Influenza A Viruses Biomolecules doi: 10.3390/biom10010119 Authors: Novoseltseva Ivanov Novikov Tkachev Bunin Gambaryan Tashlitsky Arutyunyan Kopylov Zavyalova An aptamer is a synthetic oligonucleotide with a unique spatial structure that provides specific binding to a target. To date, several aptamers to hemagglutinin of the influenza...
Fri Jan 10, 2020 02:00
Biomolecules, Vol. 10, Pages 118: A Simple and Direct Assay for Monitoring Fatty Acid Synthase Activity and Product-Specificity by High-Resolution Mass Spectrometry Biomolecules doi: 10.3390/biom10010118 Authors: Topolska Martínez-Montañés Ejsing De novo fatty acid synthesis is a pivotal enzymatic process in all eukaryotic organisms. It is involved in the conversion of glucose and other nutrients to fatty acyl (FA) chains, that cells use as building blocks for membranes, energy...
Fri Jan 10, 2020 02:00
Brain Sciences, Vol. 10, Pages 43: Therapeutic Advances for Huntington’s Disease Brain Sciences doi: 10.3390/brainsci10010043 Authors: Ashok Kumar Vijay Kumar Kritanjali Singh Sukesh Kumar You-Sam Kim Yun-Mi Lee Jong-Joo Kim Huntington’s disease (HD) is a progressive neurological disease that is inherited in an autosomal fashion. The cause of disease pathology is an expansion of cytosine-adenine-guanine (CAG) repeats within the huntingtin gene (HTT) on chromosome...
Sun Jan 12, 2020 02:00
Brain Sciences, Vol. 10, Pages 42: Toward Improving Diagnostic Strategies in Chronic Disorders of Consciousness: An Overview on the (Re-)Emergent Role of Neurophysiology Brain Sciences doi: 10.3390/brainsci10010042 Authors: Billeri Filoni Russo Portaro Militi Calabrò Naro The differential diagnosis of patients with Disorder of Consciousness (DoC), in particular in the chronic phase, is significantly difficult. Actually, about 40% of patients with unresponsive...
Fri Jan 10, 2020 02:00
Brain Sciences, Vol. 10, Pages 41: Insights from a Bibliometric Analysis of Vividness and Its Links with Consciousness and Mental Imagery Brain Sciences doi: 10.3390/brainsci10010041 Authors: Haustein Vellino D’Angiulli We performed a bibliometric analysis of the peer-reviewed literature on vividness between 1900 and 2019 indexed by the Web of Science and compared it with the same analysis of publications on consciousness and mental imagery. While we observed a similarity between...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 190: In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate Cancers doi: 10.3390/cancers12010190 Authors: Wei Peng Henriette S. de Bruijn Timo L. M. ten Hagen Kristian Berg Jan L. N. Roodenburg Go M. van Dam Max J. H. Witjes Dominic J. Robinson Targeted photodynamic therapy (PDT) has the potential to improve the therapeutic effect of PDT due to significantly...
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Cancers, Vol. 12, Pages 191: Multiple Myeloma and Thrombosis: Prophylaxis and Risk Prediction Tools Cancers doi: 10.3390/cancers12010191 Authors: Despina Fotiou Maria Gavriatopoulou Evangelos Terpos Thromboembolism in multiple myeloma (MM) patients remains a common complication that renders the optimization of our thromboprophylaxis practice necessary. This review aims to make clear the need for the development of more accurate risk assessment tools and means of thrombosis prevention....
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Cancers, Vol. 12, Pages 189: Influence of Baseline Cardiovascular Comorbidities on Mortality after Androgen Deprivation Therapy for Metastatic Prostate Cancer Cancers doi: 10.3390/cancers12010189 Authors: Wu Fang Hwang Shih Shao Few studies have assessed the benefits of androgen deprivation therapy (ADT) in men with metastatic prostate cancer (PC; mPC) at an old age or with major cardiovascular conditions. A retrospective cohort consisted of 3835 men with newly diagnosed...
Sun Jan 12, 2020 02:00
Cancers, Vol. 12, Pages 188: Small RNA Profiling of piRNAs in Colorectal Cancer Identifies Consistent Overexpression of piR-24000 That Correlates Clinically with an Aggressive Disease Phenotype Cancers doi: 10.3390/cancers12010188 Authors: Deepak Narayanan Iyer Timothy Ming-Hun Wan Johnny Hon-Wai Man Ryan Wai-Yan Sin Xue Li Oswens Siu-Hung Lo Dominic Chi-Chung Foo Roberta Wen-Chi Pang Wai-Lun Law Lui Ng Piwi-interacting RNAs (piRNAs) represent a novel class...
Sun Jan 12, 2020 02:00
Cancers, Vol. 12, Pages 187: Multifunctional Silica-Based Nanoparticles with Controlled Release of Organotin Metallodrug for Targeted Theranosis of Breast Cancer Cancers doi: 10.3390/cancers12010187 Authors: Karina Ovejero Paredes Diana Díaz-García Victoria García-Almodóvar Laura Lozano Chamizo Marzia Marciello Miguel Díaz-Sánchez Sanjiv Prashar Santiago Gómez-Ruiz Marco Filice Three different multifunctional nanosystems based on the tethering onto mesoporous...
Sun Jan 12, 2020 02:00
Cancers, Vol. 12, Pages 186: Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance Cancers doi: 10.3390/cancers12010186 Authors: Zhuo-Xun Wu Yuqi Yang Qiu-Xu Teng Jing-Quan Wang Zi-Ning Lei Jing-Qiu Wang Sabrina Lusvarghi Suresh V. Ambudkar Dong-Hua Yang Zhe-Sheng Chen Tivantinib, also known as ARQ-197, is a potent non-ATP competitive selective c-Met inhibitor currently under phase 3 clinical trial evaluation for...
Sun Jan 12, 2020 02:00
Cancers, Vol. 12, Pages 183: PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation Cancers doi: 10.3390/cancers12010183 Authors: Zoltán G. Páhi Barbara N. Borsos Vasiliki Pantazi Zsuzsanna Ujfaludi Tibor Pankotai Transcription is a multistep, tightly regulated process. During transcription initiation, promoter recognition and pre-initiation complex (PIC) formation take place, in which dynamic recruitment or exchange of transcription activators...
Sat Jan 11, 2020 02:00
Cancers, Vol. 12, Pages 184: Vimentin Intermediate Filaments as Potential Target for Cancer Treatment Cancers doi: 10.3390/cancers12010184 Authors: Katerina Strouhalova Magdalena Přechová Aneta Gandalovičová Jan Brábek Martin Gregor Daniel Rosel Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of structurally related proteins showing distinct...
Sat Jan 11, 2020 02:00
Cancers, Vol. 12, Pages 185: Molecular Complexity of Diffuse Large B-Cell Lymphoma: Can It Be a Roadmap for Precision Medicine? Cancers doi: 10.3390/cancers12010185 Authors: Nicoletta Coccaro Luisa Anelli Antonella Zagaria Tommasina Perrone Giorgina Specchia Francesco Albano Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma; it features extreme molecular heterogeneity regardless of the classical cell-of-origin (COO) classification. Despite this,...
Sat Jan 11, 2020 02:00
Cancers, Vol. 12, Pages 182: Predictors of Response and Survival in Immune Checkpoint Inhibitor-Treated Unresectable Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12010182 Authors: Pei-Chang Lee Yee Chao Ming-Huang Chen Keng-Hsin Lan Chieh-Ju Lee I-Cheng Lee San-Chi Chen Ming-Chih Hou Yi-Hsiang Huang Immune checkpoint inhibitors (ICIs) with nivolumab and pembrolizumab are promising agents for advanced hepatocellular carcinoma (HCC) but lack of effective...
Sat Jan 11, 2020 02:00
Cancers, Vol. 12, Pages 180: Oxidation-Triggerable Liposome Incorporating Poly(Hydroxyethyl Acrylate-co-Allyl methyl sulfide) as an Anticancer Carrier of Doxorubicin Cancers doi: 10.3390/cancers12010180 Authors: Kim Yoon Kim Since cancer cells are oxidative in nature, anti-cancer agents can be delivered to cancer cells specifically without causing severe normal cell toxicity if the drug carriers are designed to be sensitive to the intrinsic characteristic. Oxidation-sensitive...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 181: Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy Cancers doi: 10.3390/cancers12010181 Authors: Huang Hsu Chen Chang Chang Hung Liu Kao Targeted therapy is an efficient treatment for patients with epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC). Therapeutic resistance invariably occurs in NSCLC patients....
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 179: Evaluation of Calcium Electroporation for the Treatment of Cutaneous Metastases: A Double Blinded Randomised Controlled Phase II Trial Cancers doi: 10.3390/cancers12010179 Authors: Ágoston Baltás Ócsai Rátkai Lázár Korom Varga Németh Dósa-Rácz Viharosné Gehl Oláh Kemény Kis Calcium electroporation (Ca-EP) is a new anticancer treatment providing similar features to electrochemotherapy (ECT). The aim of our study...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 177: Contribution of mTOR and PTEN to Radioresistance in Sporadic and NF2-Associated Vestibular Schwannomas: A Microarray and Pathway Analysis Cancers doi: 10.3390/cancers12010177 Authors: Gugel Ebner Grimm Czemmel Paulsen Hagel Tatagiba Nahnsen Tabatabai The use of radiation treatment has increased for both sporadic and neurofibromatosis type 2 (NF2)-associated vestibular schwannoma (VS). However, there are a subset of radioresistant...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 178: Erratum: Passardi, A. et al. Chemoradiotherapy (Gemox Plus Helical Tomotherapy) for Unresectable Locally Advanced Pancreatic Cancer: A Phase II Study. Cancers 2019, 11, 663 Cancers doi: 10.3390/cancers12010178 Authors: Passardi Scarpi Neri Parisi Ghigi Ercolani Gardini Barba Pagan Casadei-Gardini Valgiusti Ferroni Frassineti Romeo The authors wish to make the following corrections to this paper [...]
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 172: Triple-Negative Primary Breast Tumors Induce Supportive Premetastatic Changes in the Extracellular Matrix and Soluble Components of the Lung Microenvironment Cancers doi: 10.3390/cancers12010172 Authors: Braeden Medeiros David Goodale Carl Postenka Lori E. Lowes Patti Kiser Stephen Hearn Nikki Salmond Karla C. Williams Alison L. Allan The lung is one of the deadliest sites of breast cancer metastasis, particularly in patients with...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 175: Polymeric Nanoparticles for the Treatment of Malignant Gliomas Cancers doi: 10.3390/cancers12010175 Authors: Basant Salah Mahmoud Ali Hamod AlAmri Christopher McConville Malignant gliomas are one of the deadliest forms of brain cancer and despite advancements in treatment, patient prognosis remains poor, with an average survival of 15 months. Treatment using conventional chemotherapy does not deliver the required drug dose to the tumour site, owing...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 174: The MicroRNA-23b/27b/24 Cluster Facilitates Colon Cancer Cell Migration by Targeting FOXP2 Cancers doi: 10.3390/cancers12010174 Authors: Kensei Nishida Yuki Kuwano Kazuhito Rokutan Acquisition of cell migration capacity is an early and essential process in cancer development. The aim of this study was to identify microRNA gene expression networks that induced high migration capacity. Using colon cancer HCT116 cells subcloned by transwell-based migrated...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 176: A Novel Prostate Cell Type-Specific Gene Signature to Interrogate Prostate Tumor Differentiation Status and Monitor Therapeutic Response (Running Title: Phenotypic Classification of Prostate Tumors) Cancers doi: 10.3390/cancers12010176 Authors: Sarah N. Mapelli Domenico Albino Maurizia Mello-Grand Dheeraj Shinde Manuel Scimeca Rita Bonfiglio Elena Bonanno Giovanna Chiorino Ramon Garcia-Escudero Carlo V. Catapano Giuseppina M. Carbone...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 171: Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity Cancers doi: 10.3390/cancers12010171 Authors: Donatella Lucchetti Claudio Ricciardi Tenore Filomena Colella Alessandro Sgambato A better understanding of the mechanisms of cell communication between cancer cells and the tumor microenvironment is crucial to develop personalized therapies. It has been known for a while that cancer cells are metabolically distinct from...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 170: Candidate Causal Variants at the 8p12 Breast Cancer Risk Locus Regulate DUSP4 Cancers doi: 10.3390/cancers12010170 Authors: Dylan M. Glubb Wei Shi Jonathan Beesley Laura Fachal Jayne-Louise Pritchard Karen McCue Daniel R. Barnes Antonis C. Antoniou Alison M. Dunning Douglas F. Easton Georgia Chenevix-Trench Genome-wide association studies have revealed a locus at 8p12 that is associated with breast cancer risk. Fine-mapping of...
Fri Jan 10, 2020 02:00
Cancers, Vol. 12, Pages 173: HB-EGF–EGFR Signaling in Bone Marrow Endothelial Cells Mediates Angiogenesis Associated with Multiple Myeloma Cancers doi: 10.3390/cancers12010173 Authors: Luigia Rao Donato Giannico Patrizia Leone Antonio Giovanni Solimando Eugenio Maiorano Concetta Caporusso Loren Duda Roberto Tamma Rosanna Mallamaci Nicola Susca Alessio Buonavoglia Matteo Claudio Da Vià Domenico Ribatti Vallì De Re Angelo Vacca Vito Racanelli ...
Fri Jan 10, 2020 02:00
Cells, Vol. 9, Pages 193: Visfatin Induces Senescence of Human Dental Pulp Cells Cells doi: 10.3390/cells9010193 Authors: Chang Youp Ok Sera Park Hye-Ock Jang Takashi Takata Moon-Kyoung Bae Yong-Deok Kim Mi Heon Ryu Soo-Kyung Bae Dental pulp plays an important role in the health of teeth. The aging of teeth is strongly related to the senescence of dental pulp cells. A novel adipokine, visfatin, is closely associated with cellular senescence. However, little is known...
Sun Jan 12, 2020 02:00
Cells, Vol. 9, Pages 194: Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections Cells doi: 10.3390/cells9010194 Authors: Adriely Goes Philipp Lapuhs Thomas Kuhn Eilien Schulz Robert Richter Fabian Panter Charlotte Dahlem Marcus Koch Ronald Garcia Alexandra K. Kiemer Rolf Müller Gregor Fuhrmann In 2019, it was estimated that 2.5 million people die from lower tract respiratory infections annually. One of...
Sun Jan 12, 2020 02:00
Cells, Vol. 9, Pages 192: FAK-Dependent Cell Motility and Cell Elongation Cells doi: 10.3390/cells9010192 Authors: Katoh Fibroblastic cells show specific substrate selectivity for typical cell–substrate adhesion. However, focal adhesion kinase (FAK) contributes to controlling the regulation of orientation and polarity. When fibroblasts attach to micropatterns, tyrosine-phosphorylated proteins and FAK are both detected along the inner border between the adhesive micropatterns...
Sun Jan 12, 2020 02:00
Cells, Vol. 9, Pages 189: Spectral Characterization of Stem Cell-Derived Myelination within the Injured Adult PNS Using the Solvatochromic Dye Nile Red Cells doi: 10.3390/cells9010189 Authors: Joey Grochmal Wulin Teo Hardeep Gambhir Ranjan Kumar Jo Anne Stratton Raveena Dhaliwal Craig Brideau Jeff Biernaskie Peter Stys Rajiv Midha Background: Myelin is an essential component of the peripheral and central nervous system, enabling fast axonal conduction and supporting...
Sat Jan 11, 2020 02:00
Cells, Vol. 9, Pages 190: Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions Cells doi: 10.3390/cells9010190 Authors: Xiaojiaoyang Li Runping Liu Yanyan Wang Weiwei Zhu Derrick Zhao Xuan Wang Hang Yang Emily C. Gurley Weidong Chen Phillip B. Hylemon Huiping Zhou Activation of hepatic macrophages represents the critical driving force to promote cholestatic liver injury. Exosomes,...
Sat Jan 11, 2020 02:00
Cells, Vol. 9, Pages 191: Cytokine Directed Chondroblast Trans-Differentiation: JAK Inhibition Facilitates Direct Reprogramming of Fibroblasts to Chondroblasts Cells doi: 10.3390/cells9010191 Authors: Perla Cota Summer A. Helmi Charlie Hsu Derrick E. Rancourt Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including...
Sat Jan 11, 2020 02:00
Cells, Vol. 9, Pages 187: The Ebola Virus Nucleoprotein Recruits the Nuclear RNA Export Factor NXF1 into Inclusion Bodies to Facilitate Viral Protein Expression Cells doi: 10.3390/cells9010187 Authors: Lisa Wendt Janine Brandt Bianca S. Bodmer Sven Reiche Marie Luisa Schmidt Shelby Traeger Thomas Hoenen Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is only limited...
Sat Jan 11, 2020 02:00
Cells, Vol. 9, Pages 188: Are Liver Pericytes Just Precursors of Myofibroblasts in Hepatic Diseases? Insights from the Crosstalk between Perivascular and Inflammatory Cells in Liver Injury and Repair Cells doi: 10.3390/cells9010188 Authors: Lindolfo da Silva Meirelles Renan Fava Marson Maria Inês Gonzalez Solari Nance Beyer Nardi Cirrhosis, a late form of liver disease, is characterized by extensive scarring due to exacerbated secretion of extracellular matrix proteins by myofibroblasts...
Sat Jan 11, 2020 02:00
Cells, Vol. 9, Pages 186: Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing Cells doi: 10.3390/cells9010186 Authors: Thomas Wallach Max Wetzel Paul Dembny Ori Staszewski Christina Krüger Alice Buonfiglioli Marco Prinz Seija Lehnardt Toll-like receptors (TLRs) belong to pattern recognition receptors, which respond to danger signals such as pathogen-associated molecular patterns or damage-associated...
Sat Jan 11, 2020 02:00
Cells, Vol. 9, Pages 185: TGF-β1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells Cells doi: 10.3390/cells9010185 Authors: Jingwen Yin Hsun-Ming Chang Yuyin Yi Yuanqing Yao Peter C.K. Leung Glial cell line-derived neurotrophic factor (GDNF) is expressed at a high level in the human ovary and GDNF signaling is involved in the direct control of follicular activation and oocyte maturation. Transforming growth factor-β1...
Fri Jan 10, 2020 02:00
Cells, Vol. 9, Pages 183: Missing Information from the Estrogen Receptor Puzzle: Where Are They Localized in Bull Reproductive Tissues and Spermatozoa? Cells doi: 10.3390/cells9010183 Authors: Antalikova Secova Horovska Krejcirova Simonik Jankovicova Bartokova Tumova Manaskova-Postlerova Estrogens are steroid hormones that affect a wide range of physiological functions. The effect of estrogens on male reproductive tissues and sperm cells through specific...
Fri Jan 10, 2020 02:00
Cells, Vol. 9, Pages 182: LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells Cells doi: 10.3390/cells9010182 Authors: Actis Dato Benitez-Amaro Gonzalo-Calvo Vazquez Bonacci Llorente-Cortés Chiabrando Abstract: The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated...
Fri Jan 10, 2020 02:00
Cells, Vol. 9, Pages 181: Understanding Calcium-Dependent Conformational Changes in S100A1 Protein: A Combination of Molecular Dynamics and Gene Expression Study in Skeletal Muscle Cells doi: 10.3390/cells9010181 Authors: Chaturvedi Ahmad Yadav Lee Sonkar Marina Choi The S100A1 protein, involved in various physiological activities through the binding of calcium ions (Ca2+), participates in several protein-protein interaction (PPI) events after Ca2+-dependent...
Fri Jan 10, 2020 02:00
Cells, Vol. 9, Pages 180: Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac Cells doi: 10.3390/cells9010180 Authors: Sánchez Clares Rodríguez-Lagunas Fábrega Calpena Safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) has been widely studied and both therapeutic and side effects at the gastric and cardiovascular level have been generally associated with the inhibitory effect of isoform 1 (COX-1) and 2 (COX-2) cyclooxygenase...
Fri Jan 10, 2020 02:00
Cells, Vol. 9, Pages 184: A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries Cells doi: 10.3390/cells9010184 Authors: Peng Li Hou Huang FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several...
Fri Jan 10, 2020 02:00
Cells, Vol. 9, Pages 179: Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle Cells doi: 10.3390/cells9010179 Authors: Baudel Shi Large Albert In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the development of vascular diseases. It...
Fri Jan 10, 2020 02:00
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