IJMS, Vol. 21, Pages 457: DM1 Phenotype Variability and Triplet Repeat Instability: Challenges in the Development of New Therapies International Journal of Molecular Sciences doi: 10.3390/ijms21020457 Authors: Tomé Gourdon Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disease caused by an unstable cardiotocography (CTG) repeat expansion in the DMPK gene. This disease is characterized by high clinical and genetic variability, leading to some difficulties in the diagnosis...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 453: Full-Length Transcriptome Analysis of the ABCB, PIN/PIN-LIKES, and AUX/LAX Families Involved in Somatic Embryogenesis of Lilium pumilum DC. Fisch International Journal of Molecular Sciences doi: 10.3390/ijms21020453 Authors: Song Wang Ren Sun Plant cell totipotency is one of the 25 major topics in current scientific research, and somatic embryos are good experimental material for studying cell totipotency. Polar auxin transport plays an important...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 456: Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21020456 Authors: André F. Gabriel Marina C. Costa Francisco J. Enguita Non-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 455: Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21020455 Authors: Mukherjee Madamsetty Paul Mukherjee Angiogenesis is a process of generation of de-novo blood vessels from already existing vasculature. It has a crucial role in different physiological process including wound healing, embryonic development, and tumor growth. The methods by which therapeutic...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 454: Overexpression of Rice Expansin7 (Osexpa7) Confers Enhanced Tolerance to Salt Stress in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21020454 Authors: Chuluuntsetseg Jadamba Kiyoon Kang Nam-Chon Paek Soo In Lee Soo-Cheul Yoo Expansins are key regulators of cell-wall extension and are also involved in the abiotic stress response. In this study, we evaluated the function of OsEXPA7 involved in salt stress tolerance. Phenotypic...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 452: Regulation of CFTR Biogenesis by the Proteostatic Network and Pharmacological Modulators International Journal of Molecular Sciences doi: 10.3390/ijms21020452 Authors: Estabrooks Brodsky Cystic fibrosis (CF) is the most common lethal inherited disease among Caucasians in North America and a significant portion of Europe. The disease arises from one of many mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator, or CFTR. The...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 451: Neurogenesis and Specification of Retinal Ganglion Cells International Journal of Molecular Sciences doi: 10.3390/ijms21020451 Authors: Nguyen-Ba-Charvet Rebsam Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated during development, followed by the other retinal cell types. How are retinal progenitor cells (RPCs) able to produce these cell types in a specific and timely order? Here, we will review the different models...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 449: Biological Functions of HMGN Chromosomal Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21020449 Authors: Nanduri Furusawa Bustin Chromatin plays a key role in regulating gene expression programs necessary for the orderly progress of development and for preventing changes in cell identity that can lead to disease. The high mobility group N (HMGN) is a family of nucleosome binding proteins that preferentially binds to chromatin...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 450: Conflicting Actions of Inhalational Anesthetics, Neurotoxicity and Neuroprotection, Mediated by the Unfolded Protein Response International Journal of Molecular Sciences doi: 10.3390/ijms21020450 Authors: Hiroshi Kokubun Hisayo Jin Mari Komita Tomohiko Aoe Preclinical studies have shown that exposure of the developing brain to inhalational anesthetics can cause neurotoxicity. However, other studies have claimed that anesthetics can exert neuroprotective...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 448: Immune Checkpoint Inhibitors in Pre-Treated Gastric Cancer Patients: Results from a Literature-Based Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21020448 Authors: Giandomenico Roviello Silvia Paola Corona Alberto D’Angelo Pietro Rosellini Stefania Nobili Enrico Mini Immunotherapy has recently changed the treatment of several cancers. We performed a literature-based meta-analysis of randomised controlled trials to...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 447: Comparison of The Sorption Kinetics of Lead(II) and Zinc(II) on Titanium Phosphate Ion-Exchanger International Journal of Molecular Sciences doi: 10.3390/ijms21020447 Authors: Marina V. Maslova Vladimir I. Ivanenko Nataliya Yu. Yanicheva Natalia V. Mudruk The treatment of heavy metal-contaminated wastewater is an important action to reduce The negative impacts of industrial wastes on water bodies. This work focuses on The application of a low-cost titanium...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 445: Production, Structural Characterization, and In Vitro Assessment of the Prebiotic Potential of Butyl-Fructooligosaccharides International Journal of Molecular Sciences doi: 10.3390/ijms21020445 Authors: Sini Kang Hyun Ju You Yeong-Geun Lee Yunju Jeong Tony V. Johnston Nam-In Baek Seockmo Ku Geun Eog Ji Short-chain fatty acids (SCFAs), especially butyrate, produced in mammalian intestinal tracts via fermentation of dietary fiber, are known...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 446: Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins International Journal of Molecular Sciences doi: 10.3390/ijms21020446 Authors: Adrián Campos Andrés Clemente-Blanco Cells are constantly suffering genotoxic stresses that affect the integrity of our genetic material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission of the genetic information, a situation that could lead to...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 444: Transcription Factor CaSBP12 Negatively Regulates Salt Stress Tolerance in Pepper (Capsicum annuum L.) International Journal of Molecular Sciences doi: 10.3390/ijms21020444 Authors: Huai-Xia Zhang Wen-Chao Zhu Xiao-Hui Feng Jing-Hao Jin Ai-Min Wei Zhen-Hui Gong SBP-box (Squamosa-promoter binding protein) genes are a type of plant-specific transcription factor and play important roles in plant growth, signal transduction, and stress response. However,...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 443: Does Maternal Stress Affect the Early Embryonic Microenvironment? Impact of Long-Term Cortisol Stimulation on the Oviduct Epithelium International Journal of Molecular Sciences doi: 10.3390/ijms21020443 Authors: Shuaizhi Du Nares Trakooljul Jennifer Schoen Shuai Chen Maternal stress before or during the sensitive preimplantation phase is associated with reproduction failure. Upon real or perceived threat, glucocorticoids (classic stress hormones) as...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 210: Impact of Right Atrial Physiology on Heart Failure and Adverse Events after Myocardial Infarction Journal of Clinical Medicine doi: 10.3390/jcm9010210 Authors: Schuster Backhaus Stiermaier Navarra Uhlig Rommel Koschalka Kowallick Bigalke Kutty Gutberlet Hasenfuß Thiele Eitel Background: Right ventricular (RV) function is a known predictor of adverse events in heart failure and following acute myocardial infarction...
Sun Jan 12, 2020 02:00
JCM, Vol. 9, Pages 209: The Effectiveness of Psychological Treatments in Women with Breast Cancer: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9010209 Authors: Angela Guarino Cristina Polini Giuseppe Forte Francesca Favieri Ilaria Boncompagni Maria Casagrande Breast cancer is the most prevalent oncological disease among women, and it represents the second oncological cause of death. Many studies have considered the quality of life...
Sun Jan 12, 2020 02:00
JCM, Vol. 9, Pages 208: A Comparison of Cervical and Thoracolumbar Fractures Associated with Diffuse Idiopathic Skeletal Hyperostosis—A Nationwide Multicenter Study Journal of Clinical Medicine doi: 10.3390/jcm9010208 Authors: Katoh Okada Yoshii Yamada Watanabe Katsumi Hiyama Nakagawa Okada Endo Takeuchi Matsunaga Maruo Sakai Kobayashi Ohba Wada Ohya Mori Tsushima Nishimura Tsuji Watanabe Matsumoto...
Sun Jan 12, 2020 02:00
JCM, Vol. 9, Pages 206: The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence Journal of Clinical Medicine doi: 10.3390/jcm9010206 Authors: Elena Kosenko Lyudmila Tikhonova Gubidat Alilova Amparo Urios Carmina Montoliu Alzheimer’s disease (AD) is a fatal form of dementia of unknown etiology. Although amyloid plaque accumulation in the brain has been the subject of intensive research in disease...
Sun Jan 12, 2020 02:00
JCM, Vol. 9, Pages 207: Relationship between the Thickness of the Coracoid Process and Latarjet Graft Positioning—An Anatomical Study on 70 Embalmed Scapulae Journal of Clinical Medicine doi: 10.3390/jcm9010207 Authors: Markus Gregori Lukas Eichelberger Claudia Gahleitner Stefan Hajdu Michael Pretterklieber Background: The Latarjet procedure is a popular technique with the aim of the reconstruction of glenoid cavity bone defects in patients with chronic anterior shoulder...
Sun Jan 12, 2020 02:00
JCM, Vol. 9, Pages 205: Does Beta-Trace Protein (BTP) Outperform Cystatin C as a Diagnostic Marker of Acute Kidney Injury Complicating the Early Phase of Acute Pancreatitis? Journal of Clinical Medicine doi: 10.3390/jcm9010205 Authors: Justyna Wajda Paulina Dumnicka Mateusz Sporek Barbara Maziarz Witold Kolber Anna Ząbek-Adamska Piotr Ceranowicz Marek Kuźniewski Beata Kuśnierz-Cabala Acute pancreatitis (AP) belongs to the commonest acute gastrointestinal conditions...
Sat Jan 11, 2020 02:00
JCM, Vol. 9, Pages 204: Unravelling the Pathogenetic Mechanisms in Congenital Aortopathies: Need for an Integrative Translational Approach Journal of Clinical Medicine doi: 10.3390/jcm9010204 Authors: Evaldas Girdauskas Harald Kaemmerer Yskert von Kodolitsch Congenital heart disease (CHD)-associated aortopathy is a very heterogeneous entity with a wide spectrum of clinical presentations. The pathogenesis of aortopathy is still incompletely understood, and, therefore, the best prevention...
Sat Jan 11, 2020 02:00
JCM, Vol. 9, Pages 200: Nasal Nitric Oxide in Chronic Rhinosinusitis with or without Nasal Polyps: A Systematic Review with Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9010200 Authors: Pasquale Ambrosino Antonio Molino Giorgio Alfredo Spedicato Paolo Parrella Roberto Formisano Andrea Motta Matteo Nicola Dario Di Minno Mauro Maniscalco Background and Aims: There has been a recent growing interest in the role of nasal nitric oxide (nNO) as a biomarker...
Sat Jan 11, 2020 02:00
JCM, Vol. 9, Pages 202: Isolated Anti-HBc: Significance and Management Journal of Clinical Medicine doi: 10.3390/jcm9010202 Authors: Florian MORETTO François-Xavier CATHERINE Clémentine ESTEVE Mathieu BLOT Lionel PIROTH Hepatitis B virus (HBV) infection is prevalent worldwide and is associated with dramatic levels of morbidity and mortality. Isolated anti-HBc (IAHBc) is a particular serological pattern that is commonly found in immunocompromised patients. There is ongoing...
Sat Jan 11, 2020 02:00
JCM, Vol. 9, Pages 203: Resting Energy Expenditure and Body Composition in Overweight Men and Women Living in a Temperate Climate Journal of Clinical Medicine doi: 10.3390/jcm9010203 Authors: Marcos Martin-Rincon Mario Perez-Valera David Morales-Alamo Ismael Perez-Suarez Cecilia Dorado Juan J. Gonzalez-Henriquez Julian W. Juan-Habib Cristian Quintana-Garcia Victor Galvan-Alvarez Pablo B. Pedrianes-Martin Carmen Acosta David Curtelin Jose A.L. Calbet Pedro...
Sat Jan 11, 2020 02:00
JCM, Vol. 9, Pages 201: Alternative Applications of Trans-Oral Robotic Surgery (TORS): A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9010201 Authors: Giovanni Cammaroto Luigi Marco Stringa Henry Zhang Pasquale Capaccio Francesco Galletti Bruno Galletti Giuseppe Meccariello Giannicola Iannella Stefano Pelucchi Ahmed Baghat Claudio Vicini Background: The role of robotic surgery in the field of oncology has been widely described, in particular...
Sat Jan 11, 2020 02:00
JCM, Vol. 9, Pages 199: The Predictive Value of Low Muscle Mass as Measured on CT Scans for Postoperative Complications and Mortality in Gastric Cancer Patients: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9010199 Authors: Alicia S. Borggreve Robin B. den Boer Gijs I. van Boxel Pim A. de Jong Wouter B. Veldhuis Elles Steenhagen Richard van Hillegersberg Jelle P. Ruurda Risk assessment is relevant to predict outcomes in patients...
Sat Jan 11, 2020 02:00
JCM, Vol. 9, Pages 198: Novel Biochemical Markers of Neurovascular Complications in Type 1 Diabetes Patients Journal of Clinical Medicine doi: 10.3390/jcm9010198 Authors: Falkowski Rogowicz-Frontczak Szczepanek-Parulska Krygier Wrotkowska Uruska Araszkiewicz Ruchala Zozulinska-Ziolkiewicz Type 1 diabetes mellitus (T1DM) is associated with chronic complications, which are the result of neurovascular changes. There is still a lack of universal biochemical...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 196: Jejunal Insulin Signalling Is Increased in Morbidly Obese Subjects with High Insulin Resistance and Is Regulated by Insulin and Leptin Journal of Clinical Medicine doi: 10.3390/jcm9010196 Authors: Gutierrez-Repiso Ho-Plagaro Santiago-Fernandez Garcia-Serrano Rodríguez-Pacheco Valdes Garrido-Sanchez Rodríguez-Díaz López-Gómez Moreno-Ruiz Alcain-Martinez Gautier-Stein Mithieux Garcia-Fuentes Little is known about...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 194: Platelet Function Test Use for Patients with Coronary Artery Disease in the Early 2020s Journal of Clinical Medicine doi: 10.3390/jcm9010194 Authors: Fontana Roffi Reny In the field of antithrombotics, precision medicine is of particular interest, as it may lower the incidence of potentially life-threatening side effects. Indeed, antiplatelet drugs such as P2Y12 inhibitors are one of the most common causes of emergency admissions for drug-related adverse...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 197: Efficacy of Different Chemotherapy Regimens in Patients with Locally Advanced Synchronous Esophageal and Head/Neck Squamous Cell Carcinoma Receiving Curative Concurrent Chemoradiotherapy Journal of Clinical Medicine doi: 10.3390/jcm9010197 Authors: Chen Lu Chien Lo Wang Chou Li Esophageal squamous cell carcinoma (ESCC) and head/neck squamous cell carcinoma (HNSCC) are very common cancers worldwide, and there is higher incidence of synchronous...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 193: Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock Journal of Clinical Medicine doi: 10.3390/jcm9010193 Authors: Jong Eun Park Tae Gun Shin Ik Joon Jo Kyeongman Jeon Gee Young Suh Minsu Park Hojeong Won Chi Ryang Chung Sung Yeon Hwang Sepsis is a common cause of delirium in the intensive care unit (ICU). Recently, vitamin C and thiamine administration has been gaining interest as a potential...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 195: Circulating Biomarkers of Cell Adhesion Predict Clinical Outcome in Patients with Chronic Heart Failure Journal of Clinical Medicine doi: 10.3390/jcm9010195 Authors: Bouwens van den Berg Akkerhuis Baart Caliskan Brugts Mouthaan Ramshorst Germans Umans Boersma Kardys Cardiovascular inflammation and vascular endothelial dysfunction are involved in chronic heart failure (CHF), and cellular adhesion molecules are considered...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 192: An Efficient Photodynamic Therapy Treatment for Human Pancreatic Adenocarcinoma Journal of Clinical Medicine doi: 10.3390/jcm9010192 Authors: Alexandre Quilbe Olivier Moralès Martha Baydoun Abhishek Kumar Rami Mustapha Takashi Murakami Bertrand Leroux Clémentine de Schutter Elise Thecua Laurine Ziane Ludovic Colombeau Céline Frochot Serge Mordon Nadira Delhem To date, pancreatic adenocarcinoma (ADKP) is a devastating disease...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 190: Diagnostic Accuracy of Stool Tests for Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Journal of Clinical Medicine doi: 10.3390/jcm9010190 Authors: Berbel Ykema Lisanne Rigter Manon Spaander Leon Moons Tanya Bisseling Berthe Aleman Jan Paul de Boer Pieternella Lugtenburg Cecile Janus Eefke Petersen Judith Roesink John Raemaekers Richard van der Maazen Iris Lansdorp-Vogelaar Andrea Gini Wieke Verbeek Margriet...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 191: Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) after Polytrauma: A Rare Syndrome with Major Consequences Journal of Clinical Medicine doi: 10.3390/jcm9010191 Authors: Lillian Hesselink Ruben J. Hoepelman Roy Spijkerman Mark C. H. de Groot Karlijn J. P. van Wessem Leo Koenderman Luke P. H. Leenen Falco Hietbrink Nowadays, more trauma patients develop chronic critical illness (CCI), a state characterized by prolonged...
Fri Jan 10, 2020 02:00
JCM, Vol. 9, Pages 189: Sensitivity of Viscoelastic Tests to Platelet Function Journal of Clinical Medicine doi: 10.3390/jcm9010189 Authors: Marco Ranucci Ekaterina Baryshnikova Viscoelastic tests provide a dynamic assessment of coagulation, by exploring the time to clot formation and the clot strength. Using specific activators or inhibitors, additional factors can be explored, like the fibrinogen contribution to clot strength. Since the early days, various attempts have been done...
Fri Jan 10, 2020 02:00
JoF, Vol. 6, Pages 13: A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species Journal of Fungi doi: 10.3390/jof6010013 Authors: David Kadosh Vasanthakrishna Mundodi Many pathogenic Candida species possess the ability to undergo a reversible morphological transition from yeast to filamentous cells. In Candida albicans, the most frequently isolated human fungal pathogen, multiple lines of evidence strongly suggest that this transition is associated...
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JoF, Vol. 6, Pages 12: Detecting Azole-Antifungal Resistance in Aspergillus fumigatus by Pyrosequencing Journal of Fungi doi: 10.3390/jof6010012 Authors: van der Torre Novak-Frazer Rautemaa-Richardson Guidelines on the diagnosis and management of Aspergillus disease recommend a multi-test approach including CT scans, culture, fungal biomarker tests, microscopy and fungal PCR. The first-line treatment of confirmed invasive aspergillosis (IA) consists of drugs in the azole family;...
Fri Jan 10, 2020 02:00
JoF, Vol. 6, Pages 11: Molecular Detection of Aspergillus: Application of a Real-Time PCR Multiplex Assay in Tissue Samples Journal of Fungi doi: 10.3390/jof6010011 Authors: Raquel Sabino Helena Simões Cristina Veríssimo Diagnosis of invasive fungal infections is complex, and the lack of standardization of molecular methods is still a challenge. Several methods are available for the diagnosis of invasive aspergillosis, but their effectiveness will depend on the studied population,...
Fri Jan 10, 2020 02:00
Medicina, Vol. 56, Pages 30: Illnesses Encountered During Medical Volunteering in Takeo Province, Cambodia Medicina doi: 10.3390/medicina56010030 Authors: Lee Choi Rim Lim Heo Shin Aieng Rim Background and Objectives: Medical volunteering seeks to meet the clinical needs of underserved areas, but has been criticized for difficulties in addressing local health issues and resultant lack of sustainability. Our team has visited rural Cambodia annually since 2012....
Fri Jan 10, 2020 02:00
Medicina, Vol. 56, Pages 28: Nutrition for Female Soccer Players—Recommendations Medicina doi: 10.3390/medicina56010028 Authors: Hubert Dobrowolski Aleksandra Karczemna Dariusz Włodarek Soccer is one of the most popular sports in the world. As its number of players is increasing, the number of female players is also on the rise. However, there are limited data about how the diets of female soccer players should be designed. Thus, the aim of our work is to deliver concise nutritional...
Fri Jan 10, 2020 02:00
Medicina, Vol. 56, Pages 29: Analysis of Extemporaneous Prescriptions Prescribed by Dermatovenerologists in Latvia and Comparison with Standardized Compounded Preparation Monographs of Germany and USA Medicina doi: 10.3390/medicina56010029 Authors: Olga Kiseļova Baiba Mauriņa Venta Šidlovska Background and objectives: Even though many industrially manufactured medicines are available, extemporaneous preparations still have their niche in dermatology. In several countries, dermatovenerologists...
Fri Jan 10, 2020 02:00
Membranes, Vol. 10, Pages 14: Systematic Study of the Impact of Pulsed Electric Field Parameters (Pulse/Pause Duration and Frequency) on ED Performances during Acid Whey Treatment Membranes doi: 10.3390/membranes10010014 Authors: Guillaume Dufton Sergey Mikhaylin Sami Gaaloul Laurent Bazinet Processing acid whey is still a challenge for the dairy industry due to its high lactic acid and mineral contents. Their removal processes represent a high investment and running cost in...
Sat Jan 11, 2020 02:00
Membranes, Vol. 10, Pages 13: A Novel Cellulose-Based Polymer for Efficient Removal of Methylene Blue Membranes doi: 10.3390/membranes10010013 Authors: Gago Chagas Ferreira Velizarov Coelhoso A novel cellulose-based cross-linked polymer, dicarboxymethyl cellulose (DCMC), has been synthesized and used for methylene blue (MB) removal. Inductively coupled plasma atomic emission spectrometry (ICP-AES), Fourier-transform infrared spectroscopy (FTIR), nitrogen porosimetry,...
Fri Jan 10, 2020 02:00
Metabolites, Vol. 10, Pages 32: Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease Metabolites doi: 10.3390/metabo10010032 Authors: Camila Weschenfelder Alexandre Schaan de Quadros Julia Lorenzon dos Santos Silvia Bueno Garofallo Aline Marcadenti Adipose tissue is a complex structure responsible for fat storage and releasing polypeptides (adipokines) and metabolites, with systemic actions including body weight balance, appetite regulation,...
Sat Jan 11, 2020 02:00
Metabolites, Vol. 10, Pages 31: Testicular Caspase-3 and β-Catenin Regulators Predicted via Comparative Metabolomics and Docking Studies Metabolites doi: 10.3390/metabo10010031 Authors: Mohammed S. Hifnawy Mahmoud A. Aboseada Hossam M. Hassan Asmaa M. AboulMagd Adel F. Tohamy Samraa H. Abdel-Kawi Mostafa E. Rateb El Moataz Bellah El Naggar Miaomiao Liu Ronald J. Quinn Hani A. Alhadrami Usama Ramadan Abdelmohsen Many routes have been explored to search...
Sat Jan 11, 2020 02:00
Metabolites, Vol. 10, Pages 30: Liquid Chromatography Tandem Mass Spectrometry Quantification of 13C-Labeling in Sugars Metabolites doi: 10.3390/metabo10010030 Authors: Jean-Christophe Cocuron Zacchary Ross Ana P. Alonso Subcellular compartmentation has been challenging in plant 13C-metabolic flux analysis. Indeed, plant cells are highly compartmented: they contain vacuoles and plastids in addition to the regular organelles found in other eukaryotes. The distinction of reactions...
Fri Jan 10, 2020 02:00
MPs, Vol. 3, Pages 5: Dissection of Larval and Pupal Wings of Bicyclus anynana Butterflies Methods and Protocols doi: 10.3390/mps3010005 Authors: Tirtha Das Banerjee Antónia Monteiro The colorful wings of butterflies are emerging as model systems for evolutionary and developmental studies. Some of these studies focus on localizing gene transcripts and proteins in wings at the larval and pupal stages using techniques such as immunostaining and in situ hybridization. Other studies quantify...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 108: Comparative Transcriptome Analyses during the Vegetative Cell Cycle in the Mono-Cellular Organism Pseudokeronopsis erythrina (Alveolata, Ciliophora) Microorganisms doi: 10.3390/microorganisms8010108 Authors: Yiwei Xu Zhuo Shen Eleni Gentekaki Jiahui Xu Zhenzhen Yi Studies focusing on molecular mechanisms of cell cycles have been lagging in unicellular eukaryotes compared to other groups. Ciliates, a group of unicellular eukaryotes, have...
Sun Jan 12, 2020 02:00
Microorganisms, Vol. 8, Pages 106: Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of Staphylococcus aureus Microorganisms doi: 10.3390/microorganisms8010106 Authors: Kirsi Savijoki Ilkka Miettinen Tuula A. Nyman Maarit Kortesoja Leena Hanski Pekka Varmanen Adyary Fallarero The present study investigated Staphylococcus aureus ATCC25923 surfaceomes (cell surface proteins) during prolonged growth by subjecting...
Sun Jan 12, 2020 02:00
Microorganisms, Vol. 8, Pages 107: Temporal Variability of Virioplankton during a Gymnodinium catenatum Algal Bloom Microorganisms doi: 10.3390/microorganisms8010107 Authors: Du Cai Zuo Meng Zhu Zhou Viruses are key biogeochemical engines in the regulation of the dynamics of phytoplankton. However, there has been little research on viral communities in relation to algal blooms. Using the virMine tool, we analyzed viral information from metagenomic data of field dinoflagellate...
Sun Jan 12, 2020 02:00
Microorganisms, Vol. 8, Pages 105: Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes Microorganisms doi: 10.3390/microorganisms8010105 Authors: Kawalek Wawrzyniak Bartosik Jagura-Burdzy The segregation of newly replicated chromosomes in bacterial cells is a highly coordinated spatiotemporal process. In the majority of bacterial species, a tripartite ParAB-parS system, composed of an ATPase (ParA), a DNA-binding protein (ParB),...
Sat Jan 11, 2020 02:00
Microorganisms, Vol. 8, Pages 104: Modulation of Campylobacter jejuni Motility, Adhesion to Polystyrene Surfaces, and Invasion of INT407 Cells by Quorum-Sensing Inhibition Microorganisms doi: 10.3390/microorganisms8010104 Authors: Katarina Šimunović Dina Ramić Changyun Xu Sonja Smole Možina Campylobacter jejuni is a major foodborne pathogen, and the LuxS-mediated quorum-sensing (QS) system influences its motility, biofilm formation, invasion, host colonization, and virulence....
Sat Jan 11, 2020 02:00
Microorganisms, Vol. 8, Pages 103: Assessment of a Loop-Mediated Isothermal Amplification (LAMP) Assay for the Rapid Detection of Pathogenic Bacteria from Respiratory Samples in Patients with Hospital-Acquired Pneumonia Microorganisms doi: 10.3390/microorganisms8010103 Authors: Andrea Vergara Hervé Boutal Adrián Ceccato Míriam López Adrià Cruells Leticia Bueno-Freire Javier Moreno-Morales Jorge Puig de la Bellacasa Pedro Castro Antoni Torres Francesc Marco Climent...
Sat Jan 11, 2020 02:00
Microorganisms, Vol. 8, Pages 102: Genome Improvement and Core Gene Set Refinement of Fugacium kawagutii Microorganisms doi: 10.3390/microorganisms8010102 Authors: Tangcheng Li Liying Yu Bo Song Yue Song Ling Li Xin Lin Senjie Lin Cataloging an accurate functional gene set for the Symbiodiniaceae species is crucial for addressing biological questions of dinoflagellate symbiosis with corals and other invertebrates. To improve the gene models of Fugacium kawagutii, we...
Sat Jan 11, 2020 02:00
Microorganisms, Vol. 8, Pages 101: Isolation and Identification of Microvirga thermotolerans HR1, a Novel Thermo-Tolerant Bacterium, and Comparative Genomics among Microvirga Species Microorganisms doi: 10.3390/microorganisms8010101 Authors: Li Gao Chen Xue Han Wang Dai Lin Ke Zhang Members of the Microvirga genus are metabolically versatile and widely distributed in Nature. However, knowledge of the bacteria that belong to this genus is currently...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 99: Thymol Inhibits Biofilm Formation, Eliminates Pre-Existing Biofilms, and Enhances Clearance of Methicillin-Resistant Staphylococcus aureus (MRSA) in a Mouse Peritoneal Implant Infection Model Microorganisms doi: 10.3390/microorganisms8010099 Authors: Yuan Dai Ouyang Rehman Hussain Zhang Yin Fu Lin He Lv Liang Shu Song Li Zou Yin Methicillin-resistant Staphylococcus aureus (MRSA) is a common...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 100: Simulating Extracellular Glucose Signals Enhances Xylose Metabolism in Recombinant Saccharomyces cerevisiae Microorganisms doi: 10.3390/microorganisms8010100 Authors: Wu Li Wei Wu Wu Bao Hou Liu Shen Efficient utilization of both glucose and xylose from lignocellulosic biomass would be economically beneficial for biofuel production. Recombinant Saccharomyces cerevisiae strains with essential genes and metabolic networks...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 98: Differential Genotyping of Mycobacterium avium Complex and Its Implications in Clinical and Environmental Epidemiology Microorganisms doi: 10.3390/microorganisms8010098 Authors: Jeong-Ih Shin Sung Jae Shin Min-Kyoung Shin In recent decades, the incidence and prevalence of nontuberculous mycobacteria (NTM) have greatly increased, becoming a major worldwide public health problem. Among numerous NTM species, the Mycobacterium avium complex (MAC) is...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 95: Isolation of a Psychrotolerant and UV-C-Resistant Bacterium from Elephant Island, Antarctica with a Highly Thermoactive and Thermostable Catalase Microorganisms doi: 10.3390/microorganisms8010095 Authors: María T. Monsalves Gabriela P. Ollivet-Besson Maximiliano J. Amenabar Jenny M. Blamey Microorganisms present in Antarctica have to deal not only with cold temperatures but also with other environmental conditions, such as high UV radiation,...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 96: Protective Effects of Tropical Fruit Processing Coproducts on Probiotic Lactobacillus Strains during Freeze-Drying and Storage Microorganisms doi: 10.3390/microorganisms8010096 Authors: Caroliny Mesquita Araújo Karoliny Brito Sampaio Francisca Nayara Dantas Duarte Menezes Erika Tayse da Cruz Almeida Marcos dos Santos Lima Vanessa Bordin Viera Estefânia Fernandes Garcia Andrea Gómez-Zavaglia Evandro Leite de Souza Maria Elieidy Gomes...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 94: Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host Microorganisms doi: 10.3390/microorganisms8010094 Authors: Alejandra Chávez-Carbajal María Luisa Pizano-Zárate Fernando Hernández-Quiroz Guillermo Federico Ortiz-Luna Rosa María Morales-Hernández Amapola De Sales-Millán María Hernández-Trejo Angelina García-Vite Luis Beltrán-Lagunes Carlos Hoyo-Vadillo Jaime...
Fri Jan 10, 2020 02:00
Microorganisms, Vol. 8, Pages 97: Bacterial Biodiversity of Extra Virgin Olive Oils and Their Potential Biotechnological Exploitation Microorganisms doi: 10.3390/microorganisms8010097 Authors: Francesco Fancello Chiara Multineddu Mario Santona Pierfrancesco Deiana Giacomo Zara Ilaria Mannazzu Marilena Budroni Sandro Dettori Severino Zara Bacterial diversity of 15 extra virgin olive oils, obtained from different Italian varieties, including Frantoio, Coratina,...
Fri Jan 10, 2020 02:00
Molbank, Vol. 2020, Article M1106: 2-(Bicyclo[4.2.0]octa-1,3,5-trien-3-yl)-adamantan-2-ol Molbank doi: 10.3390/M1106 Authors: Konstantin S. Levchenko Konstantin A. Chudov Dmitri Yu. Demin Konstantin A. Lyssenko Pavel S. Shmelin A new adamantan-2-ol with a 2-bicyclo[4.2.0]octa-1,3,5-trien-3-yl substituent in the position 2 was synthesized via two stage synthesis starting from benzocyclobutene and adamatan-2-one. The structure of the title compound was determined using 1H-and...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 312: Preparation of Chitosan Molecularly Imprinted Polymers and the Recognition Mechanism for Adsorption of Alpha-Lipoic Acid Molecules doi: 10.3390/molecules25020312 Authors: Long Xu Ze-Xin Zhao Yun-An Huang Qiu-Jin Zhu Two effective molecularly imprinted polymers for the adsorption of alpha-lipoic acid (ALA) were synthesized by the cross-linking of chitosan with epichlorohydrin (ECH) and glutaraldehyde (GLU), respectively, in the presence of ALA as...
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Molecules, Vol. 25, Pages 311: LC-MS/MS-Based Profiling of Tryptophan-Related Metabolites in Healthy Plant Foods Molecules doi: 10.3390/molecules25020311 Authors: Sara Vitalini Michele Dei Cas Federico Maria Rubino Ileana Vigentini Roberto Foschino Marcello Iriti Rita Paroni Food plants contain hundreds of bioactive phytochemicals arising from different secondary metabolic pathways. Among these, the metabolic route of the amino acid Tryptophan yields a large number...
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Molecules, Vol. 25, Pages 310: Occurrence of the Persistent Antimicrobial Triclosan in Microwave Pretreated and Anaerobically Digested Municipal Sludges under Various Process Conditions Molecules doi: 10.3390/molecules25020310 Authors: Kor-Bicakci Abbott Ubay-Cokgor Eskicioglu Treatment of emerging contaminants, such as antimicrobials, has become a priority topic for environmental protection. As a persistent, toxic, and bioaccumulative antimicrobial, the accumulation of...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 307: Application of Conducting Polymer Nanostructures to Electrochemical Biosensors Molecules doi: 10.3390/molecules25020307 Authors: Waleed A. El-Said Muhammad Abdelshakour Jin-Ha Choi Jeong-Woo Choi Over the past few decades, nanostructured conducting polymers have received great attention in several application fields, including biosensors, microelectronics, polymer batteries, actuators, energy conversion, and biological applications due to their...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 306: The Synthesis and Functional Study of Multicolor Nitrogen-Doped Carbon Dots for Live Cell Nuclear Imaging Molecules doi: 10.3390/molecules25020306 Authors: Yanan Zhang Xingwei Zhang Yanping Shi Chao Sun Nan Zhou Haixia Wen The nitrogen-doped carbon dots (N-CQDs) were synthesized by citric acid as a raw material and propylene diamine as a passivation agent. Structure, optical properties and biocompatibility of N-CQDs were analyzed. It was...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 309: Innovative Approaches for Recovery of Phytoconstituents from Medicinal/Aromatic Plants and Biotechnological Production Molecules doi: 10.3390/molecules25020309 Authors: Radu Claudiu Fierascu Irina Fierascu Alina Ortan Milen I. Georgiev Elwira Sieniawska Continuously growing demand for plant derived therapeutic molecules obtained in a sustainable and eco-friendly manner favors biotechnological production and development of innovative extraction...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 308: Oxidations of Benzhydrazide and Phenylacetic Hydrazide by Hexachloroiridate(IV): Reaction Mechanism and Structure–Reactivity Relationship Molecules doi: 10.3390/molecules25020308 Authors: Xiaolai Zhang Benz(o)hydrazide (BH) is the basic aryl hydrazide; aryl hydrazides have been pursued in the course of drug discovery. Oxidations of BH and phenylacetic hydrazide (PAH) by hexachloroiridate(IV) ([IrCl6]2−) were investigated by use of stopped-flow...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 303: Voltammetry and Spectroelectrochemistry of TCNQ in Acetonitrile/RTIL Mixtures Molecules doi: 10.3390/molecules25020303 Authors: Abderrahman Atifi Michael D. Ryan Understanding the solvation and ion-pairing interactions of anionic substrates in room-temperature ionic liquids (RTIL) is key for the electrochemical applications of these new classes of solvents. In this work, cyclic voltammetry and visible and infrared spectroelectrochemistry of tetracyanoquinodimethane...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 305: Chemistry and Some Biological Potential of Bismuth and Antimony Dithiocarbamate Complexes Molecules doi: 10.3390/molecules25020305 Authors: Jerry O. Adeyemi Damian C. Onwudiwe Interest in the synthesis of Bi(III) and Sb(III) dithiocarbamate complexes is on the rise, and this has been attributed to their wide structural diversity and their interesting application as biological agents and in solid state/materials chemistry. The readily available binding...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 304: A Preliminary Study on Metabolome Profiles of Buffalo Milk and Corresponding Mozzarella Cheese: Safeguarding the Authenticity and Traceability of Protected Status Buffalo Dairy Products Molecules doi: 10.3390/molecules25020304 Authors: Angela Salzano Gelsomina Manganiello Gianluca Neglia Francesco Vinale Donato De Nicola Michael D’Occhio Giuseppe Campanile The aim of this study is to combine advanced GC-MS and metabolite identification...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 302: The Emulsifying Properties of Hydrogenated Rosin Xylitol Ester as a Biomass Surfactant for Food: Effect of pH and Salts Molecules doi: 10.3390/molecules25020302 Authors: Qiu Chen Wei Liang Zhou Wang The xylitol ester of hydrogenated rosin (XEHR) was obtained for the first time from biomass-based hydrogenated rosin and xylitol using an environmentally friendly, high-pressure CO2 catalytic synthesis. This compound is intended for use...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 301: Ammi Visnaga L., a Potential Medicinal Plant: A Review Molecules doi: 10.3390/molecules25020301 Authors: Khalil Bishr Desouky Salama Ammi visnaga L. (Visnaga daucoides Gaertn., Family Apiaceae), also known as Khella Baldi or toothpick weed, is an annual or biennial herb indigenous to the Mediterranean region of North Africa, Asia, and Europe. The plant is known to have been used in traditional medicine a long time ago. Nowadays, it is used...
Sun Jan 12, 2020 02:00
Molecules, Vol. 25, Pages 300: Charge Displacement Analysis—A Tool to Theoretically Characterize the Charge Transfer Contribution of Halogen Bonds Molecules doi: 10.3390/molecules25020300 Authors: Ciancaleoni Nunzi Belpassi Theoretical bonding analysis is of prime importance for the deep understanding of the various chemical interactions, covalent or not. Among the various methods that have been developed in the last decades, the analysis of the Charge Displacement function...
Sat Jan 11, 2020 02:00
Molecules, Vol. 25, Pages 299: Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives Molecules doi: 10.3390/molecules25020299 Authors: Rokhyatou Seck Abdoulaye Gassama Sandrine Cojean Christian Cavé In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting...
Sat Jan 11, 2020 02:00
Molecules, Vol. 25, Pages 296: Biogas Production from Physicochemically Pretreated Grass Lawn Waste: Comparison of Different Process Schemes Molecules doi: 10.3390/molecules25020296 Authors: Georgia Antonopoulou Dimitrios Vayenas Gerasimos Lyberatos Various pretreatment methods, such as thermal, alkaline and acid, were applied on grass lawn (GL) waste and the effect of each pretreatment method on the Biochemical Methane Potential was evaluated for two options, namely using the...
Sat Jan 11, 2020 02:00
Molecules, Vol. 25, Pages 298: Tautomerism and Self-Association in the Solution of New Pinene-Bipyridine and Pinene-Phenanthroline Derivatives Molecules doi: 10.3390/molecules25020298 Authors: Solea Cornu Deneva Crochet Fromm Antonov Allemann Mamula Two novel pinene-type ligands have been synthesized and their tautomeric and self-associating behavior studied in solution and in the solid state. The first ligand, an acetylated derivative of 5,6-pinene-bipyridine,...
Sat Jan 11, 2020 02:00
Molecules, Vol. 25, Pages 297: Synthesis of Highly Crystalline Graphite from Spontaneous Ignition of In Situ Derived Acetylene and Chlorine at Ambient Conditions Molecules doi: 10.3390/molecules25020297 Authors: Nikolaos Chalmpes Konstantinos Spyrou Athanasios B. Bourlinos Dimitrios Moschovas Apostolos Avgeropoulos Michael A. Karakassides Dimitrios Gournis We exploited a classic chemistry demonstration experiment based on the reaction of acetylene with chlorine to obtain...
Sat Jan 11, 2020 02:00
Molecules, Vol. 25, Pages 295: Considerations for Docking of Selective Angiotensin-Converting Enzyme Inhibitors Molecules doi: 10.3390/molecules25020295 Authors: Julio Caballero The angiotensin-converting enzyme (ACE) is a two-domain dipeptidylcarboxypeptidase, which has a direct involvement in the control of blood pressure by performing the hydrolysis of angiotensin I to produce angiotensin II. At the same time, ACE hydrolyzes other substrates such as the vasodilator peptide bradykinin...
Sat Jan 11, 2020 02:00
Molecules, Vol. 25, Pages 294: Assaying Chlamydia pneumoniae Persistence in Monocyte-Derived Macrophages Identifies Dibenzocyclooctadiene Lignans as Phenotypic Switchers Molecules doi: 10.3390/molecules25020294 Authors: Eveliina Taavitsainen Maarit Kortesoja Tanja Bruun Niklas G. Johansson Leena Hanski Antibiotic-tolerant persister bacteria involve frequent treatment failures, relapsing infections and the need for extended antibiotic treatment. The virulence of an intracellular...
Sat Jan 11, 2020 02:00
Molecules, Vol. 25, Pages 291: The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective? Molecules doi: 10.3390/molecules25020291 Authors: Petralia Battaglia Bruno Pennisi Mangano Lombardo Fagone Cavalli Saraceno Nicoletti Basile Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer′s disease...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 292: Evaluation of Fungistatic Activity of Eight Selected Essential Oils on Four Heterogeneous Fusarium Isolates Obtained from Cereal Grains in Southern Poland Molecules doi: 10.3390/molecules25020292 Authors: Krzyśko-Łupicka Sokół Piekarska-Stachowiak The aim of the study was to determine the relationship between the chemical composition of eight commercial essential oils (EsO) (garlic, grapefruit, lemon grass, tea tree, thyme, verbena, cajeput, and...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 289: Effects of Oil Droplet Size and Interfacial Protein Film on the Properties of Fish Myofibrillar Protein–Oil Composite Gels Molecules doi: 10.3390/molecules25020289 Authors: Xu Chen Zhang Lyu Ding Zhou The effects of oil droplet size and the formation of an interfacial protein film (IPF) on silver carp myofibrillar protein (MP)–oil composite gels were studied. MP- or Tween 80-stabilized camellia seed oil emulsions with different...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 290: Cobalt Catalyzed C-P Bond Formation by Cross-Coupling of Boronic Acids with P(O)H Compounds in Presence of Zinc Molecules doi: 10.3390/molecules25020290 Authors: Hicks McTague Hapatsha Teriak Kaur In our current work, we have reported the first cobalt-catalyzed cross-coupling of arylboronic acid with alkyl/aryl phosphites under mild conditions. The reaction was carried out in the presence of zinc powder as an additive and ter-pyridine as...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 293: Antimicrobial Activity of Protein Fraction from Naja ashei Venom Against Staphylococcus epidermidis Molecules doi: 10.3390/molecules25020293 Authors: Bocian Ciszkowicz Hus Buczkowicz Lecka-Szlachta Pietrowska Petrilla Petrillova Legáth Legáth One of the key problems of modern infectious disease medicine is the growing number of drug-resistant and multi-drug-resistant bacterial strains. For this reason, many studies are...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 287: Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics Molecules doi: 10.3390/molecules25020287 Authors: Wang Gong Bo Zhang Zhang Zang Zhang Li Iridoids are a class of active compounds that widely exist in the plant kingdom. In recent years, with advances in phytochemical research, many compounds with novel structure and outstanding activity have been identified. Iridoid compounds have...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 288: Phytochemical Characterization and In Vitro Anti-Inflammatory, Antioxidant and Antimicrobial Activity of Combretum collinum Fresen Leaves Extracts from Benin Molecules doi: 10.3390/molecules25020288 Authors: Marquardt Seide Vissiennon Schubert Birkemeyer Ahyi Fester Leaves from Combretum collinum Fresen (Combretaceae) are commonly used for the treatment of inflammatory conditions, wound healing and bacterial infections in traditional...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 286: The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives Molecules doi: 10.3390/molecules25020286 Authors: Natalia Treder Tomasz Bączek Katarzyna Wychodnik Justyna Rogowska Lidia Wolska Alina Plenis Recent years have seen the increased utilization of ionic liquids (ILs) in the development and optimization...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 285: Synthesis, X-ray Characterization and Density Functional Theory (DFT) Studies of Two Polymorphs of the α,α,α,α, Isomer of Tetra-p-Iodophenyl Tetramethyl Calix[4]pyrrole: On the Importance of Halogen Bonds Molecules doi: 10.3390/molecules25020285 Authors: Dragoș Dăbuleanu Antonio Bauzá Joaquín Ortega-Castro Eduardo C. Escudero-Adán Pablo Ballester Antonio Frontera This manuscript reports the improved synthesis of the α,α,α,α...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 283: Synthesis and Thermal Investigations of Eleven-Membered Ring Systems Containing One of the Heavier Group 14 Element Atoms Si, Ge, and Sn Molecules doi: 10.3390/molecules25020283 Authors: Nadi Eleya Clement Appiah Enno Lork Mathias Gogolin Thorsten M. Gesing Tim Stauch Anne Staubitz Unique eleven-membered rings containing silicon, germanium, and tin were synthesized in good yields by the reactions of the corresponding 1,2-bis((2-bromothiophen-3-yl)methoxy)benzenes...
Fri Jan 10, 2020 02:00
Molecules, Vol. 25, Pages 284: Revisiting the Rearrangement of Dewar Thiophenes Molecules doi: 10.3390/molecules25020284 Authors: Sara Gómez Edison Osorio Eugenia Dzib Rafael Islas Albeiro Restrepo Gabriel Merino The mechanism for the walk rearrangement in Dewar thiophenes has been clarified theoretically by studying the evolution of chemical bonds along the intrinsic reaction coordinates. Substituent effects on the overall mechanism are assessed by using combinations...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 472: Tumor-Stroma Crosstalk Enhances REG3A Expressions that Drive the Progression of Hepatocellular Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21020472 Authors: Yuri Cho Min Ji Park Koeun Kim Jae-Young Park Jihye Kim Wonjin Kim Jung-Hwan Yoon Abstract: Background: Crosstalk between tumors and their microenvironment plays a crucial role in the progression of hepatocellular carcinoma (HCC). However, there is little existing...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 468: Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1 International Journal of Molecular Sciences doi: 10.3390/ijms21020468 Authors: Denise Hoch Martina Bachbauer Caroline Pöchlauer Francisco Algaba-Chueca Veronika Tandl Boris Novakovic Ana Megia Martin Gauster Richard Saffery Andreas Glasner Gernot Desoye Alejandro Majali-Martinez In the first trimester of pregnancy,...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 470: Epimers of Vitamin D: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21020470 Authors: Bashar Al-Zohily Asma Al-Menhali Salah Gariballa Afrozul Haq Iltaf Shah In this review, we discuss the sources, formation, metabolism, function, biological activity, and potency of C3-epimers (epimers of vitamin D). We also determine the role of epimerase in vitamin D-binding protein (DBP) and vitamin D receptors (VDR) according to different...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 471: The Influence of Met Receptor Level on HGF-Induced Glycolytic Reprogramming in Head and Neck Squamous Cell Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21020471 Authors: Verena Boschert Nicola Klenk Alexander Abt Sudha Janaki Raman Markus Fischer Roman C. Brands Axel Seher Christian Linz Urs D. A. Müller-Richter Thorsten Bischler Stefan Hartmann Head and neck squamous cell carcinoma (HNSCC) is known to...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 467: Prediction of Protein–Protein Interaction Sites Using Convolutional Neural Network and Improved Data Sets International Journal of Molecular Sciences doi: 10.3390/ijms21020467 Authors: Zengyan Xie Xiaoya Deng Kunxian Shu Protein–protein interaction (PPI) sites play a key role in the formation of protein complexes, which is the basis of a variety of biological processes. Experimental methods to solve PPI sites are expensive and time-consuming,...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 469: Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21020469 Authors: Gustav Holmgren Benjamin Ulfenborg Annika Asplund Karin Toet Christian X Andersson Ann Hammarstedt Roeland Hanemaaijer Barbara Küppers-Munther Jane Synnergren There is a strong anticipated future for human induced pluripotent...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 466: Identification of 56 Proteins Involved in Embryo–Maternal Interactions in the Bovine Oviduct International Journal of Molecular Sciences doi: 10.3390/ijms21020466 Authors: Charles Banliat Guillaume Tsikis Valérie Labas Ana-Paula Teixeira-Gomes Emmanuelle Com Régis Lavigne Charles Pineau Benoit Guyonnet Pascal Mermillod Marie Saint-Dizier The bovine embryo develops in contact with the oviductal fluid (OF) during the first 4–5...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 464: Mast Cells: Fascinating but Still Elusive after 140 Years from Their Discovery International Journal of Molecular Sciences doi: 10.3390/ijms21020464 Authors: Gilda Varricchi Gianni Marone Some of the basic characteristics of tissue mast cells were described over 140 years ago by Paul Ehrlich, the founder of modern immunology [...]
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 465: Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1β Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21020465 Authors: Yun Gao Dezhen Tu Ru Yang Chun-Hsien Chu Jau-Shyong Hong Hui-Ming Gao Chronic neuroinflammation contributes to the pathogenesis of Parkinson’s disease (PD). However, cellular and molecular mechanisms by...
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 463: Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength International Journal of Molecular Sciences doi: 10.3390/ijms21020463 Authors: Christian Schwiebert Peter Kühnen Niels-Peter Becker Tim Welsink Theresa Keller Waldemar B. Minich Susanna Wiegand Lutz Schomburg Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves’ ophthalmopathy....
Sat Jan 11, 2020 02:00
IJMS, Vol. 21, Pages 462: Divergent Evolution of Eukaryotic CC- and A-Adding Enzymes International Journal of Molecular Sciences doi: 10.3390/ijms21020462 Authors: Erber Franz Betat Prohaska Mörl Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria,...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 458: Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21020458 Authors: Evrova Kellenberger Calcagni Vogel Buschmann Cell-based tendon therapies with tenocytes as a cell source need effective tenocyte in vitro expansion before application for tendinopathies and tendon injuries. Supplementation of tenocyte culture with biomolecules...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 460: Ergosterol Peroxide from the Medicinal Mushroom Ganoderma lucidum Inhibits Differentiation and Lipid Accumulation of 3T3-L1 Adipocytes International Journal of Molecular Sciences doi: 10.3390/ijms21020460 Authors: Jeong Park Ergosterol peroxide is a natural compound of the steroid family found in many fungi, and it possesses antioxidant, anti-inflammatory, anticancer and antiviral activities. The anti-obesity activity of several edible and medicinal mushrooms...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 459: Molecular Psychiatry: Trends and Study Examples International Journal of Molecular Sciences doi: 10.3390/ijms21020459 Authors: Rein Fries In contrast to about 20–30 years ago, the concept that psychiatric diseases have a molecular basis is now widely accepted [...]
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 461: Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2 International Journal of Molecular Sciences doi: 10.3390/ijms21020461 Authors: Toto Malagrinò Visconti Troilo Gianni Noonan syndrome (NS) is a genetic disorder caused by the hyperactivation of the RAS-MAPK molecular pathway. About 50% of NS cases are caused by mutations affecting the SHP2 protein, a multi-domain phosphatase with a fundamental role in the regulation...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 457: DM1 Phenotype Variability and Triplet Repeat Instability: Challenges in the Development of New Therapies International Journal of Molecular Sciences doi: 10.3390/ijms21020457 Authors: Tomé Gourdon Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disease caused by an unstable cardiotocography (CTG) repeat expansion in the DMPK gene. This disease is characterized by high clinical and genetic variability, leading to some difficulties in the diagnosis...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 453: Full-Length Transcriptome Analysis of the ABCB, PIN/PIN-LIKES, and AUX/LAX Families Involved in Somatic Embryogenesis of Lilium pumilum DC. Fisch International Journal of Molecular Sciences doi: 10.3390/ijms21020453 Authors: Song Wang Ren Sun Plant cell totipotency is one of the 25 major topics in current scientific research, and somatic embryos are good experimental material for studying cell totipotency. Polar auxin transport plays an important...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 456: Circular RNA-Centered Regulatory Networks in the Physiopathology of Cardiovascular Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21020456 Authors: André F. Gabriel Marina C. Costa Francisco J. Enguita Non-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 455: Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21020455 Authors: Mukherjee Madamsetty Paul Mukherjee Angiogenesis is a process of generation of de-novo blood vessels from already existing vasculature. It has a crucial role in different physiological process including wound healing, embryonic development, and tumor growth. The methods by which therapeutic...
Fri Jan 10, 2020 02:00
IJMS, Vol. 21, Pages 454: Overexpression of Rice Expansin7 (Osexpa7) Confers Enhanced Tolerance to Salt Stress in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21020454 Authors: Chuluuntsetseg Jadamba Kiyoon Kang Nam-Chon Paek Soo In Lee Soo-Cheul Yoo Expansins are key regulators of cell-wall extension and are also involved in the abiotic stress response. In this study, we evaluated the function of OsEXPA7 involved in salt stress tolerance. Phenotypic...
Fri Jan 10, 2020 02:00
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