ConclusionsCT ‐guided biopsy is a safe and highly accurate diagnostic method for SCLNs. (Source: The Clinical Respiratory Journal)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
05:03
Contributors : Samuel Jacques ; Almer M van der Sloot ; Caroline Huard ; Jasmin Coulombe-Huntington ; Sarah Tsao ; Sylvain Tollis ; Thierry Bertomeu ; Elizabeth J Culp ; Daniel Pallant ; Michael A Cook ; Eric Bonneil ; Pierre Thibault ; Gerard D Wright ; Michael TyersSeries Type : OtherOrganism : Homo sapiensSystematic genetic interaction profiles can reveal the mechanism-of-action of bioactivecompounds. The imipridone ONC201, which is currently in cancer clinical trials, has beenascribed a variety...
03:58
Conclusion Sarcopenia was found to be a predictor of postoperative complications in H&N free flap reconstruction, signifying its value as a negative prognostic factor in surgical outcomes. This study reflects level of evidence IV. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Reconstructive Microsurgery)
Sun Feb 23, 2020 00:00
Conclusion This review and institutional series demonstrate the versatility of FVFG to facilitate limb reconstruction in large defects or serve as a salvage option in complex cases. While immediate and donor-site complications are uncommon, delayed recipient-site complications are frequent, and patients and families should be counseled regarding this expectation. Though technically challenging, excellent long-term graft viability and functional recovery can be achieved in the large majority of patients....
Sun Feb 23, 2020 00:00
Authors: Rossi RE, Monteleone M, Altomare M, Cattaneo L, Torchio M, Coppa J, Mazzaferro V PMID: 32083410 [PubMed - as supplied by publisher] (Source: Minerva Chirurgica)
03:44
ConclusionCompounds 1, 2, 5, and 6 showed anti-prostate cancer activities using the LNCaP prostate cancer cells with IC50 values of 17.84, 33.26, 54.13, and 81.55 μg/mL, and compounds 3, 4, 8, and 9 exhibited moderate hepatoprotective activities, respectively. A preliminary structure-activity relation was summarized in this paper.Graphical abstract (Source: Journal of Ethnopharmacology)
01:36
Publication date: Available online 22 February 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Laura Torres Royo, Gabriela Antelo Redondo, Miguel Árquez Pianetta, Meritxell Arenas PratAbstractRadiotherapy (RT) has always been a mainstay for malignant tumors therapy, but it is also used for benign pathology. The application of low or intermediate doses of RT has been widely studied. This topic was presented and discussed in the last XX GOCO (Grup Oncològic Català-Occità) meeting....
00:38
Publication date: Available online 4 February 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Divaya Bhutani, Amer Assal, Markus Y. Mapara, Samantha Prinzing, Suzanne Lentzsch (Source: Clinical Lymphoma Myeloma and Leukemia)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
00:38
Authors: Gholami A, Mousavi SM, Hashemi SA, Ghasemi Y, Chiang WH, Parvin N Abstract Nowadays, magnetic nanoparticles (MNPs) have been rapidly investigated and attracted worldwide attention due to their great potential as mediators of heat for treating hyperthermia and their possibility to deliver drugs at specific locations, which can thereby limit systematic effects. Cancer therapy via MNPs proposes novel properties rather than normal methods such as almost zero side effects and a high-efficiency...
00:06
In this study we tried to explore Diazepam as a repurposed drug and tested it in Neuroblastoma (Neuro 2a) cells. Diazepam loaded Poly Lactic Acid Nanoparticles were developed (D-PLA-NPs) using nanoprecipitation method. Entrapment efficiency was found to be ± 99.7% and drug loading was ± 12.88%. The particle size developed was 188.8 nm and zeta potential was −25.6 millivolt. Dissolution profiles were studied in PBS (pH 7.4) or simulated media, almost 50% release was observed within 6 h. In vitro,...
Sun Feb 23, 2020 23:02
This study provides a powerful approach for detection of highly reactive and unstable H2S biomolecules in live systems. PMID: 32081180 [PubMed - in process] (Source: Analytica Chimica Acta)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Sun Feb 23, 2020 21:42
Authors: Yang Q, Wang S, Li D, Yuan J, Xu J, Shao S Abstract Development of a mitochondria-targeting fluorescent probe with large Stokes shift and long-wavelength emission was benefit for accurate detection of hypoxic status, which was known as a major factor of the tumor physiology and influence important pathological processes. However, an efficient optical approach for simultaneously achieving such merits was still lacking. In this work, a turn-on fluorescence probe (HBT-NP) was designed...
Sun Feb 23, 2020 21:42
Authors: Wang Z, Xue Z, Hao X, Miao C, Zhang J, Zheng Y, Zheng Z, Lin X, Weng S Abstract The expression level of miRNA-21 is closely related to the occurrence and development of cancer, especially in gastrointestinal cancer. Monitoring miRNA-21 has clinical application in the diagnosis and evaluation of gastrointestinal cancer. A turn-on ratiometric fluorescence bioassay based on the T7 exonuclease-mediated cyclic enzymatic amplification method was developed for miRNA-21 determination by...
Sun Feb 23, 2020 21:42
Authors: Chen Y, Sun L, Qiao X, Zhang Y, Li Y, Ma F Abstract Two novel electrochemiluminescence (ECL) deoxyribosensors are designed for assay of early lung cancer biomarker (NAP2) using the DNA three-way junction (DNA-TWJ) inserted NAP2 binding aptamer between two double-helical stems and labeled with ruthenium (II) complex (Ru) (NBAT-Ru) taken as molecular recognition element. The signal-off ECL deoxyribosensor was fabricated by covalently coupling the 5'-NH2-(CH2)6-NBAT-Ru to glassy carbon...
Sun Feb 23, 2020 21:42
Publication date: July 2020Source: Radiation Physics and Chemistry, Volume 172Author(s): A.S. Mustaqim, N.Z. Yahaya, N.N.A. Razak, H. ZinAbstractThe cancer treatment modalities have been developed rapidly with the aim to maximize the absorbed dose toward the cancer cells while sparing the healthy tissues. The use of high atomic number, Z nanomaterials has become interest as it offers the possibilities such as destroying cancer tumor with minimal damage to the healthy tissues. The study aimed to evaluate...
Sun Feb 23, 2020 19:12
CONCLUSION: Complications remain hard to predict and there are continuing causes of morbidity. Additionally, prior treatment continues to affect surgical outcomes. PMID: 32079554 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Sun Feb 23, 2020 17:41
CONCLUSION: Repeat transoral laser microsurgery can be an oncologically safe alternative to other salvage therapies for glottic squamous cell carcinoma recurrence, without sacrificing functional outcomes. PMID: 32079549 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Sun Feb 23, 2020 17:41
CONCLUSIONS: Non-functional, metastatic Pan-NETs may transform to insulin secreting lesions, with negative impact on prognosis. Therefore, if symptoms as hypoglycemia develops continuous follow-up of clinical parameters, biochemical profiles of pancreatic hormones and histopathological evaluation of proliferation is suggested to detect changes in characteristics of these malignant neoplasms. PMID: 32087093 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)MedWorm Message:...
Sun Feb 23, 2020 17:19
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Heba A. Hassan, Naglaa M. Ammar, Ahmed Serag, Olfat G. Shaker, Abdel Nasser El Gendy, Abdel-Hamid Z. Abdel-HamidAbstractColorectal cancer (CRC) is a major public health concern and one of the main causes of cancer-related deaths worldwide. Of different risk factors for developing CRC, obesity plays a vital key role in colorectal carcinogenesis due to the perturbation in the metabolic and lipid profiles of obese candidates....
Sun Feb 23, 2020 17:12
Publication date: Available online 22 February 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Sirirat Boondireke, Chunyue Liu, Benjamas T. Wongsatayanon, Michèle Léonard, Alain DurandAbstractMonomyristin (MM), a monoacylglycerol with very low water solubility, has been reported to exhibit anti-proliferative property against cervical cancer cells. In order to increase its bioavailability, MM was encapsulated for the first time inside dextran-covered poly(lactic...
Sun Feb 23, 2020 17:12
We presented a simple and efficient strategy to prepare magnetic DNA nanocompartments for encapsulation of enzymes through self-assembly, which can control and adjust the location orientation and microenvironment of the enzymes. (Source: Chemical Engineering Journal)
Sun Feb 23, 2020 17:12
In this study, we design and synthesize a hybrid nanoplatform (HNP) that is made of photothermal nanomaterials, gold nanostars, and glycopolymer that is thermoresponsive and contains glucose and galactose. The glucose groups can specifically recognize Concanavalin A (ConA), being cytotoxic to hepatoma (HepG2) cells, and the galactose groups can target asialoglycoprotein receptor. Thus, a HNP-ConA system with synergistic effects for photothermal therapy of HepG2 Cells is formed. It is found that the...
Sun Feb 23, 2020 17:12
Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Qiaojuan Jia, Zhenzhen Li, Chuanpan Guo, Xiaoyu Huang, Mengmeng Kang, Yingpan Song, Linghao He, Nan Zhou, Minghua Wang, Zhihong Zhang, Guodong Fu, Miao DuAbstractA novel drug nanocarrier system based on bimetallic NiCo Prussian blue analogue (NiCo-PBA) was constructed for targeted anticancer drug delivery and cancer therapy. Rare earth Tb3+ ion was doped in NiCo-PBA to prepare a complex with strong fluorescence...
Sun Feb 23, 2020 17:12
Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Weiwei Zeng, Hanjie Zhang, Yimin Deng, Aiting Jiang, Xiaoyan Bao, Minqi Guo, Zimu Li, Meiying Wu, Xiaoyuan Ji, Xiaowei Zeng, Lin MeiAbstractPhotonic therapy (e.g., photodynamic therapy (PDT) and photothermal therapy (PTT)), features easy handling, good targeting, high curative effect and lower side effects compared to other treatments, thus showing considerable potential in cancer treatment. However, adverse tumor...
Sun Feb 23, 2020 17:12
ConclusionsThe single-port approach has advantages as easier surgical planning and transition for combined and multi-quadrants surgeries: faster recovery, minimal postoperative pain and need for opioids, and excellent cosmetic outcome. We suggest that combined procedures should be performed only in high volume institutions by surgeons with vast experience in robotic surgery in selected patients.ResumenIntroducciónPresentar el primer caso de cirugía multicuadrante concomitante —prostatectomía radical...
Sun Feb 23, 2020 15:42
Publication date: Available online 22 February 2020Source: Actas Urológicas Españolas (English Edition)Author(s): A. Vives, M. Cosentino, J. PalouAbstractHuman papilloma virus infection is the most common sexually transmitted infection worldwide. There is a high detection rate in sexually active young people but the risk, in males, persists over years. Currently, the American Center for Disease Control and Prevention does not recommend the evaluation of men for HPV and, the extant bibliography, backs...
Sun Feb 23, 2020 15:42
In conclusion, even within an integrated health care system, there remains significant heterogeneity in the uptake of conservative management for low-risk prostate cancer. Both guideline-concordant factors and other factors not discussed in the guidelines were associated with conservative management use.Patient summaryIn the US Veterans Affairs health care system the vast majority of men with low-risk prostate cancer were managed conservatively by 2016, although there was significant variation by...
Sun Feb 23, 2020 15:41
ConclusionsFunctional outcomes after treatment for localized prostate cancer can be predicted at the time of diagnosis based on age, race, PSA, biopsy grade, baseline function, and a general question regarding overall health. Providers and patients can use this prediction tool to inform shared decision making.Patient summaryIn this report, we studied patient-reported sexual, urinary, hormonal, and bowel function through 5 yr after treatment with radical prostatectomy, radiation therapy, or active...
Sun Feb 23, 2020 15:41
Publication date: Available online 22 February 2020Source: Preventive MedicineAuthor(s): Junxiu Liu, Yanan Zhang, Carl J. Lavie, Fred K. Tabung, Jiting Xu, Qingwei Hu, Lixia He, Yunxiang ZhangAbstractC-reactive protein (CRP) and fibrinogen are associated with an increased risk of death with suggested differences by gender, diet quality and race/ethnicity. However, the current evidence is limited. We used data including 8646 men and 9880 women from the National Health and Nutrition Examination Survey...
Sun Feb 23, 2020 15:38
ConclusionNo modifiable risk factors were identified, but patients with positive margins receiving adjuvant radiation or chemo-radiation had the longest survival. (Source: The American Journal of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Sun Feb 23, 2020 15:13
ConclusionsUS may underestimate breast tumor size. Treatment decisions that take into account tumor size can be made equally reliably in patients with high or low breast density. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 15:13
Authors: Khrystyna Zhurakivska Giuseppe Troiano Marco Montella Lorenzo Lo Muzio Luca Fiorillo Gabriele Cervino Marco Cicciù Cesare D’Amico Rosario Rullo Gregorio Laino Dario Di Stasio Luigi Laino Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous...
Sun Feb 23, 2020 00:00
Authors: Francesco Izzo Franco Ionna Vincenza Granata Vittorio Albino Renato Patrone Francesco Longo Agostino Guida Paolo Delrio Daniela Rega Dario Scala Roberto Pezzuto Roberta Fusco Elio Di Bernardo Valeria D’Alessio Roberto Grassi Deyanira Contartese Raffaele Palaia The aim of the study is to evaluate the usability aspects of new deployable, expandable, electrode prototypes, in terms of suitability solutions for laparoscopic applications...
Sun Feb 23, 2020 00:00
Authors: Cao M, Zhou M, Zhang J Abstract Patients with metastatic colorectal cancer (mCRC) beyond second line treatment have a poor prognosis. Regorafenib, TAS-102, fruquintinib, panitumumab and cetuximab are recommended single-agent chemotherapy regimens for patients exhibiting disease progression, this meta-analysis aimed to evaluate the efficacy and safety of these regimens in randomized controlled trials (RCTs). Eight RCTs with 3,832 cancer patients were included. Results showed that...
Sun Feb 23, 2020 05:56
CONCLUSION: The best of our knowledge it is the third description of brachial plexus schwannoma associated with breast cancer and the first with a synchronous association. The knowledge of this pathology and its potential to alter treatment justify the reporting of the present case. PMID: 32083563 [PubMed - as supplied by publisher] (Source: Breast Disease)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Sun Feb 23, 2020 05:53
Sun Feb 23, 2020 05:15
Conclusion: Cytokine-induced killer cell immunotherapy combined with first-line chemotherapy could significantly improve the OS and PFS of patients with mCRC, particularly for patients with metastatic colon cancer. PMID: 32076550 [PubMed] (Source: Clinical Colorectal Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Sun Feb 23, 2020 04:05
Authors: Herold A Abstract Hemorrhoidal disease is one of the most common illnesses in industrialized nations. Up to 70% of adults suffer from the disease once in their lifetime. This underlines the necessity and importance of knowing about the differential diagnosis of hemorrhoids. One can differentiate between differential diagnoses of symptoms (bleeding, pain, itching, tumor) and differential diagnoses of the phenotype findings (anal prolapse, mucosal prolapse and rectal prolapse, skin...
Sun Feb 23, 2020 03:47
Authors: Hessam S, Bechara FG Abstract Hidradenitis suppurativa/acne inversa (HS/AI) is a chronic inflammatory skin disease. Several studies showed that perianal, perineal and gluteal involvement is more common in men. Axillary, submammary and inguinal localizations seem to be more prevalent in women. Involvement of the genitoanal region is associated with a higher reduced quality of live and sexual health compared to other locations. Moreover HS/AI in the genitoanal region can lead to...
Sun Feb 23, 2020 03:47
Publication date: Available online 22 February 2020Source: Life SciencesAuthor(s): Ning Zhou, Xiao-Bing Zhang, Cheng Chen, Xin-Yu Chen, Bo Kang, Jian-Qin He, Guo-Zhong Gong, Ying-Jie Wang, Yan-Wen ZhouAbstractAimsTo compare how OCT4A proteins interact with and regulate multiple OCT4A-octamer motifs (OMs) in different regions of the FOS gene expressed in somatic cancer cells versus pluripotent stem cells.Materials and methodsTwo FOS reporter gene systems harboring predicted OMs or their mutational...
Sun Feb 23, 2020 03:41
In this study, fluorescence emission spectroscopy and mass spectrometry (MALDI-TOF) were employed to define the putative interaction sites and their accessibility for the biologically important metals of Irving William Series.Key findingsSeveral hotspot residues in the ZAG scaffold involved in these interactions were mapped and their binding affinity score for each metal has been determined. Their binding abilities of these sites and aggregation propensities of ZAG were monitored by fluorescence...
Sun Feb 23, 2020 03:41
Publication date: Available online 22 February 2020Source: Life SciencesAuthor(s): Maryam Ezzati, Bahman Yousefi, Kobra Velaei, Amin SafaAbstractBreast cancer is one of the well-known malignant tumors among women. In spite of attempts to classifying breast cancer according to its histological and molecular properties, it is almost considered as a dilemma in treatment. Nowadays, public and medical attentions have primary focused on foods with anti-cancer properties to alleviate the cancer problems....
Sun Feb 23, 2020 03:41
Publication date: Available online 21 February 2020Source: PolymerAuthor(s): Inès Hamouda, Cédric Labay, Maria Pau Ginebra, Erwan Nicol, Cristina CanalAbstractAtmospheric pressure plasma jets (APPJ) have great potential in wound healing, bacterial disinfection and in cancer therapy. Recent studies pointed out that hydrogels can be used as screens during APPJ treatment, or even be used as reservoirs for reactive oxygen and nitrogen species generated by APPJ in liquids. Thus, novel applications are...
Sun Feb 23, 2020 03:16
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Yiju Song, Kaihang Cao, Wenjun Li, Chaoyun Ma, Xiuwen Qiao, Hongling Li, Chenglin HongAbstractA three-dimensional array of reduced graphene oxide/MoS2 @ polyaniline-layered nanosheets (denoted as rGO/MoS2 @ PANI) has a novel structure of intercalated MoS2/PANI nanosheets arrays arranged on rGO that can be used as carcinoembryonic antigen (CEA) electrochemical immunosensors (detectors). In this graded nanosheet, the PANI...
Sun Feb 23, 2020 03:15
Publication date: Available online 21 February 2020Source: Chinese Chemical LettersAuthor(s): Lei Zhou, Chang Du, Rong Zhang, Changming DongAbstractWe developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm2, 10 min), PDOXCBs gradually heated aqueous...
Sun Feb 23, 2020 03:15
Antidepressant Effect of the VA Weight Management Program (MOVE) Among Veterans With Severe Obesity.
CONCLUSIONS: Depressed veterans with severe obesity improved their depressive symptoms by participating in the MOVE program. Veterans in the IMP had greater but short-term antidepressant effect as compared to educational intervention for obesity. Future studies with larger sample size may elucidate the underlying mechanisms of weight reduction to improve depression and, more importantly, sustain response among veterans with severe obesity. PMID: 32077960 [PubMed - as supplied by publisher] (Source:...
Sun Feb 23, 2020 03:11
In conclusion, women with a history of bone, breast, brain or kidney cancer have reduced chances of childbirth. Thyroid cancer, melanoma and Non-Hodgkin lymphoma survivors can conversely be reassured. (Source: Reproductive BioMedicine Online)
Sun Feb 23, 2020 03:05
Authors: Puri BK PMID: 32075573 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Sun Feb 23, 2020 02:36
Publication date: Available online 22 February 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Berwin Singh Swami Vetha, Phil-Sun Oh, Suhn Hee Kim, Hwan-Jeong JeongAbstractUnlike normal cells, cancer cells mutate to thrive in exaggerated levels of reactive oxygen species (ROS). This potentially makes them more susceptible to small molecule-induced oxidative stress. The intracellular ROS increase in cancer cells is a potential area under investigation for the development...
Sun Feb 23, 2020 02:35
Publication date: Available online 22 February 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Cosmin Butnarasu, Nadia Barbero, Claudia Barolo, Sonja VisentinAbstractMucins glycoproteins are the principal components of mucus which cover all the mucosal surfaces of the human body. The mucus and mucins are essential mediators of the innate immune system, however in the last decades mucins have been identified even as an important class of cancer biomarkers. Luminogenic materials...
Sun Feb 23, 2020 02:35
Conclusions: Preoperative blood transfusion is associated with severe postoperative complications following colectomy in moderate and severe anemic cancer patients. Further studies are needed to establish an optimal preoperative transfusional cutoff value to optimize postoperative outcomes and balance clinical costs. PMID: 32075458 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)
Sun Feb 23, 2020 02:04
Conclusions.</b> Female survivors of DTC who received 131-I treatment during childhood do not appear to have major abnormalities in reproductive characteristics nor in predictors of ovarian failure. PMID: 32079487 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Sun Feb 23, 2020 01:59
Conclusions Surufatinib demonstrated promising efficacy with a tolerable and manageable safety profile for patients with locally advanced or metastatic MTC, RAI-refractory DTC, or locally advanced, unresectable recurrences unable to receive RAI. PMID: 32075524 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
Sun Feb 23, 2020 01:59
Authors: Wang C, Zhang R, Wei X, Lv M, Jiang Z Abstract Metals are essential components in all forms of life required for the function of nearly half of all enzymes and are critically involved in virtually all fundamental biological processes. Especially, the transition metals iron (Fe), zinc (Zn), manganese (Mn), nickel (Ni), copper (Cu) and cobalt (Co) are crucial micronutrients known to play vital roles in metabolism as well due to their unique redox properties. Metals carry out three...
Sun Feb 23, 2020 01:58
Authors: Siedlecka-Kroplewska K, Wozniak M, Kmiec Z Abstract Resveratrol is a naturally occurring polyphenolic compound present in many plant species and wine. It possesses a wide range of beneficial biological properties including anticancer activity. Resveratrol has been demonstrated to induce both autophagy and apoptosis in several human cancer cell lines. The aim of this study was to investigate whether resveratrol modulates autophagy and apoptosis in MOLT-4 human lymphoblastic leukemia...
Sun Feb 23, 2020 01:43
Conclusion: This is the first meta-analysis of the relationship between tumour-infiltrating immune cells and the prognosis of EC. High CD8+ and CD45RO+ T cell densities in tumours were associated with favorable outcomes in EC patients. PMID: 32076456 [PubMed - in process] (Source: Disease Markers)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps...
Sun Feb 23, 2020 01:25
Conclusion: ZNF143, as a tumor oncogene, promoted the proliferation of GC cells both in vitro and in vivo, indicating that ZNF143 might function as a novel target for GC therapy.in vitro. The downregulation of ZNF143 facilitated cell apoptosis. ZNF143 decreased the ROS level in GC cells, resulting in the reduction of cell apoptosis. Transfection with p53 reversed the antiapoptotic effect of ZNF143, while pifithrin-in vivo was examined using tumor xenograft assay. PMID: 32076462 [PubMed - in...
Sun Feb 23, 2020 01:25
In conclusion, the LINC00284-related ceRNA network may provide valuable information on the mechanisms of SOC initiation and progression. Importantly, LINC00284 proved to be a new potential prognostic biomarker for SOC. PMID: 32076467 [PubMed - in process] (Source: Disease Markers)
Sun Feb 23, 2020 01:25
Conclusions: PCT was helpful in recognizing GNBSI, but the test results should be interpreted carefully with knowledge of patients' medical condition and should not serve as the only criterion for GNBSI. Further prospective studies are warranted for comparisons between different clinical settings. PMID: 32076461 [PubMed - in process] (Source: Disease Markers)
Sun Feb 23, 2020 01:25
Conclusion: The results of our unsupervised classification algorithm based on three variables of laboratory tests correlated well with the neurologists' diagnoses. PMID: 32076460 [PubMed - in process] (Source: Disease Markers)
Sun Feb 23, 2020 01:25
In conclusion, our findings widen the genotypic spectrum of MLH1 mutations responsible for LS. This study increases the phenotypic spectrum of LS which will certainly help the clinicians in diagnosing LS in multigeneration families. This study also puts emphasis on the importance of genetic counselling for the benefit of asymptomatic carriers of MMR gene variants who are at higher risk of LS. PMID: 32076465 [PubMed - in process] (Source: Disease Markers)
Sun Feb 23, 2020 01:25
Conclusions: PON1 could act as a biomarker for HCC to assist in the diagnosis of HCC. PMID: 32076459 [PubMed - in process] (Source: Disease Markers)
Sun Feb 23, 2020 01:25
ConclusionsComplete resection is vital for local control in pancreatic metastasis of UPS. Sites of recurrence are rare; hence, patients must be carefully followed up. (Source: International Journal of Surgery Case Reports)
Sun Feb 23, 2020 01:16
ConclusionThe role of neoadjuvant chemotherapy in the treatment of angiosarcoma should be reconsidered considering its ability to provide important prognostic information and improve the likelihood of curative surgery. (Source: International Journal of Surgery Case Reports)
Sun Feb 23, 2020 01:16
Publication date: March 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 3Author(s): Sara Hägg, Juulia JylhäväAbstractColorectal cancer (CRC) is a chronic disease of the old population with slow development progressing into clinical signs and symptoms. Biological aging is characterized by e.g. mitochondrial dysfunction and epigenetic alterations (e.g. methylation) - mechanisms that are also important in cancer development. For CRC, specific types of tumors are distinguishable by...
Sun Feb 23, 2020 01:16
ConclusionUsing the obstruction protocol in patients with bowel obstruction reduced emergency surgery and postoperative morbidity and mortality in this pilot study. This protocol seems to be a viable and efficient alternative to emergency surgery. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
Publication date: March 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 3Author(s): (Source: European Journal of Surgical Oncology (EJSO))MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Sun Feb 23, 2020 01:16
ConclusionThis audit revealed large numbers of cases of femoral metastases. Although the use of endoprostheses may be increasing in Trauma Units, intramedullary nailing still predominates. Future pathways may benefit from referring patients directly to arthroplasty surgeons. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
This article describes our thoughts on, and first experience with the development and implementation of an alternative, remote follow-up plan for colorectal cancer patients. Within remote follow-up, patients have access to test results, and are supported with self-management information. They have access to telemedicine applications such as video-consultation, text messaging, and telephone services to contact their physician and nurse practitioner. Routine outpatient clinical visits are abandoned....
Sun Feb 23, 2020 01:16
ConclusionThis study is the first, to the best of our knowledge, to show that anterior LARC exhibited the highest pCR rate after neoadjuvant CRT. Patients with anterior rectal cancers do not have different prognoses from those with non-anterior cancers if they undergo neoadjuvant CRT. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
ConclusionFrail older adults with colorectal cancer need a tailored approach from pre-treatment assessment until discharge after surgery, and co-management with a geriatrician is recommended. If this is not possible, surgeons treating frail older patients may improve care by adapting some geriatric principles. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
Publication date: March 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 3Author(s): (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
ConclusionCompared with the CRT group, the SCRT group had a similar treatment response, local control and long-term prognosis, and more importantly, a portion of the patients in the SCRT group were exempted from excessive radiation. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
Publication date: Available online 8 February 2020Source: European Journal of Surgical OncologyAuthor(s): Tibor Kovacs, Isabel T. Rubio, Christos Markopoulos, Riccardo A. Audisio, Susan Knox, Thorsten Kühn, Robert Mansel, Zoltan Matrai, Francesco Meani, Maurizio Nava, Lynda Wyld, Karen Benn, Maria Joao Cardoso, Giuseppe Catanuto, Alberto Costa, Giuseppe Curigliano, Gabor Cserni, Sarah Downey, Jian Farhadi, Oreste GentiliniExecutive summaryThe Breast Surgery theoretical and practical knowledge curriculum...
Sun Feb 23, 2020 01:16
ConclusionSub-groups at risk for relapses and nodal metastasis were identified. A global variation exists also when benchmarking a rectal cancer complete regression. (Source: European Journal of Surgical Oncology (EJSO))MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Sun Feb 23, 2020 01:16
ConclusionsThe PE MDT meeting is a critical step in the patient care pathway and facilitates critical decision making. Anatomically-based contraindications to surgery (i.e. involvement of adjacent organs, bone and neurovascular structures) do not appear to influence MDT decision making regarding resectability. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
ConclusionHistologic subtype had no prognostic relevance in locoregional or systemic metastatic disease in appendiceal adenocarcinoma. In peritoneal metastases, mucinous histologic subtype was a favorable prognostic factor, compared to non-mucinous and signet ring cell subtype. (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
Publication date: March 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 3Author(s): (Source: European Journal of Surgical Oncology (EJSO))
Sun Feb 23, 2020 01:16
Authors: Yasuda D, Ohe T, Takahashi K, Imamura R, Kojima H, Okabe T, Ichimura Y, Komatsu M, Yamamoto M, Nagano T, Mashino T Abstract Resistance to anticancer agents has been an obstacle to developing therapeutics and reducing medical costs. Whereas sorafenib is used for the treatment of human hepatocellular carcinoma (HCC), resistance limits its efficacy. p62, a multifunctional protein, is overexpressed in several HCC cell lines, such as Huh-1 cells. Phosphorylated p62 (p-p62) inhibits...
Sun Feb 23, 2020 00:40
ConclusionsLI-RADS shows high diagnostic accuracy in diagnosing of HCC with a pooled sensitivity of 0.86 and specificity of 0.85, and specificity is higher for LR-5 or LR ≥ 5. However, further prospective studies of LI-RADS are needed to elucidate its value for diagnosing of small HCCs (≤20 mm). (Source: European Journal of Radiology)
Sun Feb 23, 2020 00:36
ConclusionsCT angiography imaging findings have the potential to identify patients with head and neck cancer at higher risk of bleeding. (Source: European Journal of Radiology)
Sun Feb 23, 2020 00:36
ConclusionsHigh image quality can be obtained with SSDE-CT of the abdomen. Lowest monoenergetic reconstructions provide the highest image contrast and should be used for vessel evaluation. The best trade-off between artifacts and parenchymal contrast can be obtained with 80 keV images. (Source: European Journal of Radiology)
Sun Feb 23, 2020 00:36
CONCLUSIONS: For peripheral lung cancer, the measurement on CT and routine MRI sequences can potentially replace each other after comprehensive consideration of examination purposes, but for central lung cancer, alternative use of CT and MRI in evaluating treatment responses for lung cancer should needs extra attention. The diameter measurement of lung cancer on DWI is consistent with that on T1WI and T2WI, suggesting that DWI can provide functional and morphological information. PMID: 32083610...
Sat Feb 22, 2020 23:36
Authors: Jabalee J, Towle R, Lawson J, Dickman C, Garnis C Abstract Neutral sphingomyelinase 2 (nSMase2), the product of the sphingomyelin phosphodiesterase 3 (SMPD3) gene, catalyzes the hydrolysis of sphingomyelin to ceramide. Ceramide acts on various signaling pathways to influence cell proliferation, survival, and stress response. Altered levels of sphingolipids and ceramides have been reported in various cancer types, including oral squamous cell carcinoma (OSCC). OSCC patients exhibit...
Sat Feb 22, 2020 23:30
Authors: Filippou PS, Karagiannis GS PMID: 32076483 [PubMed] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
CONCLUSIONS: TP53 co-mutations are frequent in EGFR mt+ NSCLC and have a strong negative impact on all clinical endpoints of TKI therapy. PMID: 32076486 [PubMed] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
CONCLUSIONS: The presence of a VHL mutation in virtually all renal tumor subtypes suggests that VHL analysis cannot be used to distinguish between renal tumor subtypes. Consequently, anti-VHL treatment strategies should not be limited to patients with clear cell cancer. PMID: 32076485 [PubMed] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
Authors: Yang H, Hui H, Wang Q, Li H, Zhao K, Zhou Y, Zhu Y, Wang X, You Q, Guo Q, Lu N Abstract [This corrects the article DOI: 10.18632/oncotarget.2340.]. PMID: 32076490 [PubMed - in process] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
Authors: Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH, Ouellette MM Abstract [This corrects the article DOI: 10.18632/oncotarget.2500.]. PMID: 32076492 [PubMed - in process] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
Authors: Smith AM, Zhang CRC, Cristino AS, Grady JP, Fink JL, Moore AS Abstract [This corrects the article DOI: 10.18632/oncotarget.27206.]. PMID: 32076493 [PubMed - in process] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
Conclusions: Niche mutations exhibited an increased risk of death when compared with EGFR mutations and a similar risk of death when compared with KRAS mutations. PMID: 32082488 [PubMed] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
We describe below a patient who has shown a response to combination of chemotherapy with Elenagen, a plasmid encoding p62. Elenagen was tested in a previous phase I/II study in patients with refractory solid tumors and shown to be safe. Also, plasmid ability to halt tumor progression and restore sensitivity to chemotherapy was found. Preclinical data supports effects on tumor grade and change the tumor's microenvironment in spontaneous canine breast cancers. We describe here a 48-year old female...
Sat Feb 22, 2020 23:30
Authors: Lu H, Liu C, Huynh H, Le TBU, LaMarche MJ, Mohseni M, Engelman JA, Hammerman PS, Caponigro G, Hao HX Abstract SHP2 mediates RAS activation downstream of multiple receptor tyrosine kinases (RTKs) and cancer cell lines dependent on RTKs are in general dependent on SHP2. Profiling of the allosteric SHP2 inhibitor SHP099 across cancer cell lines harboring various RTK dependencies reveals that FGFR-dependent cells are often insensitive to SHP099 when compared to EGFR-dependent cells....
Sat Feb 22, 2020 23:30
Authors: Merrigan SL, Park B, Ali Z, Jensen LD, Corson TW, Kennedy BN Abstract Aberrant ocular angiogenesis can underpin vision loss in leading causes of blindness, including neovascular age-related macular degeneration and proliferative diabetic retinopathy. Current pharmacological interventions require repeated invasive administrations, may lack efficacy and are associated with poor patient compliance and tachyphylaxis. Vitamin D has de novo anti-angiogenic properties. Here, our aim was...
Sat Feb 22, 2020 23:30
Authors: Timmermans-Sprang E, Collin RWJ, Henkes A, Philipsen M, Mol JA Abstract [This corrects the article DOI: 10.18632/oncotarget.26873.]. PMID: 32082491 [PubMed - in process] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
Authors: Zhang J, He P, Xi Y, Geng M, Chen Y, Ding J Abstract [This corrects the article DOI: 10.18632/oncotarget.2784.]. PMID: 32076491 [PubMed - in process] (Source: Oncotarget)
Sat Feb 22, 2020 23:30
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