Induction chemotherapy in sinonasal malignancies: A review of literature

Induction chemotherapy in sinonasal malignancies: A review of literature: Narayana Subramanian, Filippo Marchi, Andrea Luigi Camillo Carobbio, Francesco Missale, Deepak Balasubramanian, Krishnakumar Thankappan, Subramania Iyer



Journal of Head & Neck Physicians and Surgeons 2019 7(2):52-61



Sinonasal cancers form a distinct subset of head-and-neck tumors. They exhibit varied histologies with different clinical outcomes. These tumors are rare, and there exists no randomized trial identifying the ideal treatment for these patients. Induction chemotherapy (CT) has been tried with varying success for different purposes such as bioselection, improving outcomes, orbital preservation, and reduction in the extent of surgery. The purpose of this review is to examine and present the literature regarding the use of induction CT in sinonasal cancers and their outcomes.