TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits

TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits:



Nature Communications, Published online: 07 April 2020; doi:10.1038/s41467-020-15537-w

The TrkB receptor is known to regulate obesity via appetite control, but the underlying neural circuits are not known. Here, the authors show that selective modulation of TrkB+ neurons in the paraventricular hypothalamus regulates food intake via circuits to ventromedial hypothalamus and lateral parabrachial nucleus.