Whole lung irradiation for completely responding pulmonary metastases in pediatric Ewing sarcoma.

Whole lung irradiation for completely responding pulmonary metastases in pediatric Ewing sarcoma.:

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Whole lung irradiation for completely responding pulmonary metastases in pediatric Ewing sarcoma.

Future Oncol. 2020 Apr 06;:

Authors: Elghazawy H, Nasr A, Zaky I, Zamzam M, Elgammal A, Farid N, Zaghloul MS

Abstract

Aim: Scarce data assessing the real value of whole lung irradiation (WLI) in Ewing's sarcoma (ES) with lung-only metastasis, with published conflicting results. We studied the impact of WLI in a homogenous pediatric population. Materials & methods: Retrospective study evaluating the survival outcomes of WLI in these patients. Results: Out of 163 metastatic ES; 41 patients were eligible for WLI. 30 patients (73.1%) received WLI (+ve) while 11 patients (26.8%) did not receive WLI (-ve). Five-year event-free survival was statistically significant in WLI (+ve). Five-year pulmonary relapse-free survival showed trend for improvement with WLI (+ve), while 5-year overall survival was not statistically significant between the two arms. Conclusion: WLI added significantly to the long term clinical outcome of metastatic ES patients, with no irreversible toxicity.

PMID: 32250164 [PubMed - as supplied by publisher]