Cancers, Vol. 12, Pages 1309: Metagenomic Analysis of Serum Microbe-Derived Extracellular Vesicles and Diagnostic Models to Differentiate Ovarian Cancer and Benign Ovarian Tumor Cancers doi: 10.3390/cancers12051309 Authors: Se Ik Kim Nayeon Kang Sangseob Leem Jinho Yang HyunA Jo Maria Lee Hee Seung Kim Danny N. Dhanasekaran Yoon-Keun Kim Taesung Park Yong Sang Song We aimed to develop a diagnostic model identifying ovarian cancer (OC) from benign ovarian...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1308: Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup Cancers doi: 10.3390/cancers12051308 Authors: Joline Roze Glen Monroe Joachim Kutzera Jolijn Groeneweg Ellen Stelloo Sterre Paijens Hans Nijman Hannah van Meurs Luc van Lonkhuijzen Jurgen Piek Christianne Lok Geertruida Jonges Petronella Witteveen René Verheijen Gijs van Haaften Ronald Zweemer ...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1306: Clinical Characteristics of Korean Breast Cancer Patients Who Carry Pathogenic Germline Mutations in Both BRCA1 and BRCA2: A Single-Center Experience Cancers doi: 10.3390/cancers12051306 Authors: Joon Young Hur Ji-Yeon Kim Jin Seok Ahn Young-Hyuck Im Jiyun Lee Minsuk Kwon Yeon Hee Park There are few reports of breast cancer patients who carry germline mutations in both germline breast cancer susceptibility genes 1 (gBRCA1) and 2 (gBRCA2)....
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1305: Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture Model Cancers doi: 10.3390/cancers12051305 Authors: Seul-Ki Kim So Dam Jang Hyunho Kim Seok Chung Jong Kook Park Hyo-Jeong Kuh Invasive cancer cell migration is a key feature of metastatic human pancreatic ductal adenocarcinoma (PDAC), yet the underlying mechanisms remain poorly understood. Here, we investigated modes of cancer...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1302: Adaptor CAR Platforms—Next Generation of T Cell-Based Cancer Immunotherapy Cancers doi: 10.3390/cancers12051302 Authors: Claudia Arndt Frederick Fasslrinner Liliana R. Loureiro Stefanie Koristka Anja Feldmann Michael Bachmann The success of conventional chimeric antigen receptor (CAR) therapy in the treatment of refractory hematologic malignancies has triggered the development of novel exciting experimental CAR technologies. Among them, adaptor...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1307: Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer Cancers doi: 10.3390/cancers12051307 Authors: Aimy Sebastian Nicholas R. Hum Kelly A. Martin Sean F. Gilmore Ivana Peran Stephen W. Byers Elizabeth K. Wheeler Matthew A. Coleman Gabriela G. Loots Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1303: Novel Nuclear Medicine Imaging Applications in Immuno-Oncology Cancers doi: 10.3390/cancers12051303 Authors: Stefano Frega Alessandro Dal Maso Giulia Pasello Lea Cuppari Laura Bonanno PierFranco Conte Laura Evangelista The global immuno-oncology pipeline has grown progressively in recent years, leading cancer immunotherapy to become one of the main issues of the healthcare industry. Despite their success in the treatment of several malignancies,...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1311: The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe? Cancers doi: 10.3390/cancers12051311 Authors: Kelsey A. Roelofs Roderick O’Day Lamis Al Harby Amit K. Arora Victoria M.L. Cohen Mandeep S. Sagoo Bertil Damato Purpose: To evaluate the MOLES system for identifying malignancy in melanocytic choroidal tumors in patients treated for choroidal melanoma. Methods: Records of 615 patients treated for choroidal...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1299: HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth Cancers doi: 10.3390/cancers12051299 Authors: Janika K. Liebig Silke Kuphal Anja Katrin Bosserhoff In addition to genetic changes, post-transcriptional events strongly contribute to the progression of malignant tumors. The RNA-binding protein HuR (ELAVL1) is able to bind and stabilize a large group of target mRNAs, which contain AU-rich elements (ARE)...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1295: Adenovirus and Immunotherapy: Advancing Cancer Treatment by Combination Cancers doi: 10.3390/cancers12051295 Authors: Mizuho Sato-Dahlman Christopher J. LaRocca Chikako Yanagiba Masato Yamamoto Gene therapy with viral vectors has significantly advanced in the past few decades, with adenovirus being one of the most commonly employed vectors for cancer gene therapy. Adenovirus vectors can be divided into 2 groups: (1) replication-deficient viruses;...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1298: Targeting Protein Synthesis in Colorectal Cancer Cancers doi: 10.3390/cancers12051298 Authors: Stefanie Schmidt Sarah Denk Armin Wiegering Under physiological conditions, protein synthesis controls cell growth and survival and is strictly regulated. Deregulation of protein synthesis is a frequent event in cancer. The majority of mutations found in colorectal cancer (CRC), including alterations in the WNT pathway as well as activation of RAS/MAPK and...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1297: Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner Cancers doi: 10.3390/cancers12051297 Authors: Manale El Kharbili Muriel Cario Nicolas Béchetoille Catherine Pain Claude Boucheix Françoise Degoul Ingrid Masse Odile Berthier-Vergnes Melanoma is the most aggressive skin cancer with an extremely challenging therapy. The dermal-epidermal junction (DEJ)...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1296: Dysregulation of Redox Status in Urinary Bladder Cancer Patients Cancers doi: 10.3390/cancers12051296 Authors: Edyta Reszka Monika Lesicka Edyta Wieczorek Ewa Jabłońska Beata Janasik Maciej Stępnik Tomasz Konecki Zbigniew Jabłonowski The alteration of redox homeostasis constitutes an important etiological feature of common human malignancies. We investigated DNA damage, selenium (Se) levels and the expression of cytoprotective genes...
Thu May 21, 2020 03:00
Cancers, Vol. 12, Pages 1300: Clinical Significance of Systemic Inflammation Markers in Newly Diagnosed, Previously Untreated Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12051300 Authors: Jeong Il Yu Hee Chul Park Gyu Sang Yoo Seung Woon Paik Moon Suk Choi Hye-Seung Kim Insuk Sohn Heerim Nam This study aimed to investigate the clinical significance of systemic inflammation markers (SIMs)—including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1285: stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae Cells doi: 10.3390/cells9051285 Authors: Iga Wasilewska Rishikesh Kumar Gupta Bartosz Wojtaś Oksana Palchevska Jacek Kuźnicki In neurons, stromal interaction molecule (STIM) proteins regulate store-operated Ca2+ entry (SOCE) and are involved in calcium signaling pathways. However, STIM activity in neurological diseases is unclear and should be clarified by studies...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1287: Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer Cells doi: 10.3390/cells9051287 Authors: D’Aguanno Del Bufalo The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is responsible for a cell’s fate. Due to the recognized relevance of this family in cancer progression and response to therapy, different efforts have made in recent years in order to develop small...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1284: In-Vitro-Generated Hypertrophic-Like Adipocytes Displaying PPARG Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo Cells doi: 10.3390/cells9051284 Authors: Marianna Aprile Simona Cataldi Caterina Perfetto Maria Rosaria Ambrosio Paola Italiani Rosarita Tatè Matthias Blüher Alfredo Ciccodicola Valerio Costa Reduced neo-adipogenesis and dysfunctional lipid-overloaded adipocytes are hallmarks of hypertrophic obesity linked to...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1286: Consequences of Lmna Exon 4 Mutations in Myoblast Function Cells doi: 10.3390/cells9051286 Authors: Gómez-Domínguez Epifano Miguel Castaño Vilaplana-Martí Martín Amarilla-Quintana Bertrand Bonne Ramón-Azcón Rodríguez-Milla Pérez de Castro Laminopathies are causally associated with mutations on the Lamin A/C gene (LMNA). To date, more than 400 mutations in LMNA have been reported in patients. These mutations are widely...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1279: A Clonal NG2-Glia Cell Response in a Mouse Model of Multiple Sclerosis Cells doi: 10.3390/cells9051279 Authors: Sonsoles Barriola Fernando Pérez-Cerdá Carlos Matute Ana Bribián Laura López-Mascaraque NG2-glia, also known as oligodendrocyte precursor cells (OPCs), have the potential to generate new mature oligodendrocytes and thus, to contribute to tissue repair in demyelinating diseases like multiple sclerosis (MS). Once activated in response to...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1276: Silibinin Upregulates CXCR4 Expression in Cultured Bone Marrow Cells (BMCs) Especially in Pulmonary Arterial Hypertension Rat Model Cells doi: 10.3390/cells9051276 Authors: Tingting Zhang Nanako Kawaguchi Kunikazu Tsuji Emiko Hayama Yoshiyuki Furutani Hisashi Sugiyama Toshio Nakanishi Previously we reported that silibinin ameliorated pulmonary arterial hypertension (PAH) in rat PAH models, possibly through the suppression of the CXCR4/SDF-1,...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1278: MicrobioLink: An Integrated Computational Pipeline to Infer Functional Effects of Microbiome–Host Interactions Cells doi: 10.3390/cells9051278 Authors: Tahila Andrighetti Balazs Bohar Ney Lemke Padhmanand Sudhakar Tamas Korcsmaros Microbiome–host interactions play significant roles in health and in various diseases including autoimmune disorders. Uncovering these inter-kingdom cross-talks propels our understanding of disease pathogenesis...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1282: Integrating Biophysics in Toxicology Cells doi: 10.3390/cells9051282 Authors: Giorgia Del Del Favero Annette Kraegeloh Integration of biophysical stimulation in test systems is established in diverse branches of biomedical sciences including toxicology. This is largely motivated by the need to create novel experimental setups capable of reproducing more closely in vivo physiological conditions. Indeed, we face the need to increase predictive power and experimental...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1281: YRNAs: New Insights and Potential Novel Approach in Head and Neck Squamous Cell Carcinoma Cells doi: 10.3390/cells9051281 Authors: Kacper Guglas Tomasz Kolenda Maciej Stasiak Magda Kopczyńska Anna Teresiak Matthew Ibbs Renata Bliźniak Katarzyna Lamperska YRNAs are a class of non-coding RNAs that are components of the Ro60 ribonucleoprotein particle and are essential for initiation of DNA replication. Ro60 ribonucleoprotein particle is a...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1277: Evaluation of a Novel Boron-Containing α-D-Mannopyranoside for BNCT Cells doi: 10.3390/cells9051277 Authors: Takao Tsurubuchi Makoto Shirakawa Wataru Kurosawa Kayo Matsumoto Risa Ubagai Hiroshi Umishio Yasuyo Suga Junko Yamazaki Akihiro Arakawa Yutaka Maruyama Takuya Seki Yusuke Shibui Fumiyo Yoshida Alexander Zaboronok Minoru Suzuki Yoshinori Sakurai Hiroki Tanaka Kei Nakai Eiichi Ishikawa Akira Matsumura...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1280: HDAC3–ERα Selectively Regulates TNF-α-Induced Apoptotic Cell Death in MCF-7 Human Breast Cancer Cells via the p53 Signaling Pathway Cells doi: 10.3390/cells9051280 Authors: Park Kim Kwak Jeong Lee Hwang Choi Choi Tumor necrosis factor-α (TNF-α) plays a significant role in inflammation and cancer-related apoptosis. We identified a TNF-α-mediated epigenetic mechanism of apoptotic cell death regulation...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1275: SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer’s Disease Mouse Model Cells doi: 10.3390/cells9051275 Authors: Soo Yong Park Joo Yeong Kang Taehee Lee Donggyu Nam Chang-Jin Jeon Jeong Beom Kim Alzheimer’s disease (AD) is a complex, age-related neurodegenerative disease that is the most common form of dementia. However, the cure for AD has not yet been founded. The accumulation of amyloid...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1283: Multi-Omics Analysis of Diabetic Heart Disease in the db/db Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene Cells doi: 10.3390/cells9051283 Authors: Ashton Faulkner Zexu Dang Elisa Avolio Anita C Thomas Thomas Batstone Gavin R Lloyd Ralf JM Weber Lukáš Najdekr Andris Jankevics Warwick B Dunn Gaia Spinetti Carmine Vecchione Annibale A Puca Paolo Madeddu Characterisation of animal models of diabetic...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1274: Evidence for Overlapping and Distinct Biological Activities and Transcriptional Targets Triggered by Fibroblast Growth Factor Receptor 2b Signaling between Mid- and Early Pseudoglandular Stages of Mouse Lung Development Cells doi: 10.3390/cells9051274 Authors: Matthew R. Jones Arun Lingampally Jin Wu Jamschid Sedighi Negah Ahmadvand Jochen Wilhelm Ana Ivonne Vazquez-Armendariz Susanne Herold Chengshui Chen Jin-San Zhang Saverio Bellusci...
Thu May 21, 2020 03:00
Cells, Vol. 9, Pages 1265: Human Cumulus Cells in Long-Term In Vitro Culture Reflect Differential Expression Profile of Genes Responsible for Planned Cell Death and Aging—A Study of New Molecular Markers Cells doi: 10.3390/cells9051265 Authors: Błażej Chermuła Wiesława Kranc Karol Jopek Joanna Budna-Tukan Greg Hutchings Claudia Dompe Lisa Moncrieff Krzysztof Janowicz Małgorzata Józkowiak Michal Jeseta Jim Petitte Paul Mozdziak Leszek Pawelczyk Robert...
Thu May 21, 2020 03:00
Cosmetics, Vol. 7, Pages 38: Tracking Bacterial Spoilage in Cosmetics by a New Bioanalytical Approach: API-SPME-GC-MS to Monitor MVOCs Cosmetics doi: 10.3390/cosmetics7020038 Authors: Maria Celeiro Esther Varela Rocio Rodriguez Manuel Penedo Marta Lores The main goal of this work was the use of the powerful solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) technique to unequivocally identify microbial volatile organic compounds (MVOCs) derived...
Thu May 21, 2020 03:00
Cosmetics, Vol. 7, Pages 37: Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers Cosmetics doi: 10.3390/cosmetics7020037 Authors: Da Jung Kim Seul Bi Lee Song Sun Chang Jungsun Lee This letter is intended to clarify the clinical effectiveness of neuropeptide substance P (SP) in reducing age-related skin wrinkling. This is the first clinical study to evaluate the efficacy of the topical application of SP on wrinkle reduction. For the clinical...
Thu May 21, 2020 03:00
Dentistry Journal, Vol. 8, Pages 53: Novel Coronavirus (COVID-19) and Dentistry–A Comprehensive Review of Literature Dentistry Journal doi: 10.3390/dj8020053 Authors: Poyan Barabari Keyvan Moharamzadeh The novel coronavirus (COVID-19) pandemic has become a real challenge for healthcare providers around the world and has significantly affected the dental professionals in practices, universities and research institutions. The aim of this article was to review the available literature...
Thu May 21, 2020 03:00
Diagnostics, Vol. 10, Pages 333: Optimization of the CDC Protocol of Molecular Diagnosis of COVID-19 for Timely Diagnosis Diagnostics doi: 10.3390/diagnostics10050333 Authors: Chao-Ju Chen Li-Ling Hsieh Shu-Kai Lin Chu-Feng Wang Yi-Hui Huang Shang-Yi Lin Po-Liang Lu Coronavirus disease 2019 (COVID-19), the current uncontrolled outbreak of infectious disease, has caused significant challenges throughout the world. A reliable rapid diagnostic test for COVID-19 is demanded...
Thu May 21, 2020 03:00
Diagnostics, Vol. 10, Pages 331: Subjective Versus Quantitative Methods of Assessing Breast Density Diagnostics doi: 10.3390/diagnostics10050331 Authors: Wijdan Alomaim Desiree O’Leary John Ryan Louise Rainford Michael Evanoff Shane Foley In order to find a consistent, simple and time-efficient method of assessing mammographic breast density (MBD), different methods of assessing density comparing subjective, quantitative, semi-subjective and semi-quantitative methods were...
Thu May 21, 2020 03:00
Diagnostics, Vol. 10, Pages 332: Diagnosis of Parkinson’s Disease by A Metabolomics-Based Laboratory-Developed Test (LDT) Diagnostics doi: 10.3390/diagnostics10050332 Authors: Petr G. Lokhov Oxana P. Trifonova Dmitry L. Maslov Steven Lichtenberg Elena E. Balashova A laboratory-developed test (LDT) is a type of in vitro diagnostic test that is designed, manufactured and used in the same laboratory (i.e., an in-house test). In this study, a metabolomics-based LDT was developed....
Thu May 21, 2020 03:00
Foods, Vol. 9, Pages 666: Influence of Different Dehydration Levels on Volatile Profiles, Phenolic Contents and Skin Hardness of Alkaline Pre-Treated Grapes cv Muscat of Alexandria (Vitis vinifera L.) Foods doi: 10.3390/foods9050666 Authors: Onofrio Corona Diego Planeta Paola Bambina Simone Giacosa Maria Alessandra Paissoni Margherita Squadrito Fabrizio Torchio Susana Río Segade Luciano Cinquanta Vincenzo Gerbi Luca Rolle A dehydration experiment was carried...
Thu May 21, 2020 03:00
Foods, Vol. 9, Pages 667: Effects of the Incorporation of Tannin Extract from Quebracho Colorado Wood on Color Parameters, Lipid Oxidation, and Sensory Attributes of Beef Patties Foods doi: 10.3390/foods9050667 Authors: Ana Paula B. Fruet Francine M. Giotto Mozart A. Fonseca José Laerte Nörnberg Amilton S. de de Mello The tannin extract of Quebracho Colorado wood (Schinopsis balansae and Schinopsis lorentzii) is rich in proanthocyanidins with demonstrated powerful scavenging...
Thu May 21, 2020 03:00
Foods, Vol. 9, Pages 665: A Review of Coffee By-Products Including Leaf, Flower, Cherry, Husk, Silver Skin, and Spent Grounds as Novel Foods within the European Union Foods doi: 10.3390/foods9050665 Authors: Tizian Klingel Jonathan I. Kremer Vera Gottstein Tabata Rajcic de Rezende Steffen Schwarz Dirk W. Lachenmeier The coffee plant Coffea spp. offers much more than the well-known drink made from the roasted coffee bean. During its cultivation and production, a wide variety...
Thu May 21, 2020 03:00
Healthcare, Vol. 8, Pages 140: Effect of Anxiety on Empathy: An Observational Study Among Nurses Healthcare doi: 10.3390/healthcare8020140 Authors: Ayuso-Murillo Colomer-Sánchez Santiago-Magdalena Lendínez-Mesa Gracia López-Peláez Herrera-Peco Empathy, defined as an emotional ability to put oneself in the place of others, read their state of mind, and think how they are feeling, is an essential pillar of nursing care. On the other hand, anxiety is a frequent...
Thu May 21, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου