IJERPH, Vol. 17, Pages 3604: The Psychological Impact of Confinement Linked to the Coronavirus Epidemic COVID-19 in Algeria International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17103604 Authors: Azzeddine Madani Saad Eddine Boutebal Christopher Robin Bryant The COVID-19 pandemic continues to spread in countries around the world. The impact of this virus is very great on populations following the application of total and partial containment measures....
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3650: The Role of Immune Checkpoints after Cellular Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21103650 Authors: Friederike Schmitz Dominik Wolf Tobias A.W. Holderried Cellular therapies utilize the powerful force of the human immune system to target malignant cells. Allogeneic hematopoietic stem cell transplantation (allo-HCT) is the most established cellular therapy, but chimeric antigen receptor (CAR) T cell therapies have gained...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3654: Differential ESR1 Promoter Methylation in the Peripheral Blood—Findings from the Women 40+ Healthy Aging Study International Journal of Molecular Sciences doi: 10.3390/ijms21103654 Authors: Elena S. Gardini Gary G. Chen Serena Fiacco Laura Mernone Jasmine Willi Gustavo Turecki Ulrike Ehlert Background Estrogen receptor α (ERα) contributes to maintaining biological processes preserving health during aging. DNA methylation...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3652: Roles of Actin in the Morphogenesis of the Early Caenorhabditis elegans Embryo International Journal of Molecular Sciences doi: 10.3390/ijms21103652 Authors: Samandar Eweis Plastino The cell shape changes that ensure asymmetric cell divisions are crucial for correct development, as asymmetric divisions allow for the formation of different cell types and therefore different tissues. The first division of the Caenorhabditis elegans embryo has emerged as...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3651: ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS International Journal of Molecular Sciences doi: 10.3390/ijms21103651 Authors: Bonafede Turano Scambi Busato Bontempi Virla Schiaffino Marzola Bonetti Mariotti Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motoneurons. To...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3653: Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21103653 Authors: Cheleschi Barbarino Gallo Tenti Bottaro Frati Giannotti Fioravanti Hydrostatic pressure (HP) modulates chondrocytes metabolism, however, its ability to regulate oxidative stress and microRNAs (miRNA) has not been clarified. The aim of this study was to...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3649: Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis International Journal of Molecular Sciences doi: 10.3390/ijms21103649 Authors: Michal Duliban Ewelina Gorowska-Wojtowicz Waclaw Tworzydlo Agnieszka Rak Malgorzata Brzoskwinia Izabella Krakowska Jan K. Wolski Malgorzata Kotula-Balak Bartosz J. Płachno Barbara Bilinska Although epidemiological studies from...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3638: Antioxidant Strategy to Prevent Simulated Microgravity-Induced Effects on Bone Osteoblasts International Journal of Molecular Sciences doi: 10.3390/ijms21103638 Authors: Caterina Morabito Simone Guarnieri Alessandra Cucina Mariano Bizzarri Maria A. Mariggiò The effects induced by microgravity on human body functions have been widely described, in particular those on skeletal muscle and bone tissues. This study aims to implement information on the...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3635: Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21103635 Authors: Undral Buyandelger Douglas G. Walker Daijiro Yanagisawa Toshifumi Morimura Ikuo Tooyama Aberrant angiogenesis is a pathological feature of a number of diseases and arises from the uncoordinated expression of angiogenic factors as response to different cellular stresses. Age-related...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3636: Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha International Journal of Molecular Sciences doi: 10.3390/ijms21103636 Authors: Ya-Ling Yang Feng-Sheng Wang Hung-Yu Lin Ying-Hsien Huang Recent studies have found that microRNA-29a (miR-29a) levels are significantly lower in fibrotic livers, as shown with human liver cirrhosis. Such...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3644: Development of 3D Hepatic Constructs Within Polysaccharide-Based Scaffolds with Tunable Properties International Journal of Molecular Sciences doi: 10.3390/ijms21103644 Authors: Labour Le Guilcher Aid-Launais El Samad Lanouar Simon-Yarza Letourneur Organoids production is a key tool for in vitro studies of physiopathological conditions, drug-induced toxicity assays, and for a potential use in regenerative medicine. Hence, it prompted...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3647: Genetics and Sex in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS): Is There a Link? International Journal of Molecular Sciences doi: 10.3390/ijms21103647 Authors: Francesca Trojsi Giulia D’Alvano Simona Bonavita Gioacchino Tedeschi Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known cure. Approximately 90% of ALS cases are sporadic, although multiple genetic risk factors have been recently revealed also...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3648: SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner International Journal of Molecular Sciences doi: 10.3390/ijms21103648 Authors: Moroni Barbaro Caiment Coleman Costagliola Conza Elviri Giselbrecht Krause Mota Nazzari Pennington Ringwald Sandri Thomas Waddington Toni Endocrine disruptors (EDs) are chemicals...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3646: The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21103646 Authors: Jung Yun Kang Namju Kang Yu-Mi Yang Jeong Hee Hong Dong Min Shin The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin,...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3645: Melatonin from an Antioxidant to a Classic Hormone or a Tissue Factor: Experimental and Clinical Aspects 2019 International Journal of Molecular Sciences doi: 10.3390/ijms21103645 Authors: Juan C. Mayo Rosa M. Sainz During the last 25 years we have accomplished great advances in melatonin research, regarding antioxidant or anti-inflammatory functions, oncostatic actions, glucose metabolism regulation or plant physiology, among others. Of course, we should...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3637: The Role of LIN28-let-7-ARID3B Pathway in Placental Development International Journal of Molecular Sciences doi: 10.3390/ijms21103637 Authors: Asghar Ali Gerrit J. Bouma Russell V. Anthony Quinton A. Winger Placental disorders are a major cause of pregnancy loss in humans, and 40–60% of embryos are lost between fertilization and birth. Successful embryo implantation and placental development requires rapid proliferation, invasion, and migration...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3642: Structural Mechanisms of Store-Operated and Mitochondrial Calcium Regulation: Initiation Points for Drug Discovery International Journal of Molecular Sciences doi: 10.3390/ijms21103642 Authors: Megan Noble Qi-Tong Lin Christian Sirko Jacob A. Houpt Matthew J. Novello Peter B. Stathopulos Calcium (Ca2+) is a universal signaling ion that is essential for the life and death processes of all eukaryotes. In humans, numerous cell stimulation pathways...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3640: Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein but not α-fetoprotein as a Long-Term Hepatocellular Carcinoma Predictor International Journal of Molecular Sciences doi: 10.3390/ijms21103640 Authors: Osawa Tamaki Kurosaki Kirino Watakabe Wang Okada Shimizu Higuchi Takaura Takada Kaneko Yasui Tsuchiya Nakanishi Itakura Takahashi Enomoto Izumi Identification of high-risk patients...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3641: Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release International Journal of Molecular Sciences doi: 10.3390/ijms21103641 Authors: Cardoso Rodrigues Almeida Amorim Amaral Castanheira Coutinho Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3639: Preparation of Biphenyl-Conjugated Bromotyrosine for Inhibition of PD-1/PD-L1 Immune Checkpoint Interactions International Journal of Molecular Sciences doi: 10.3390/ijms21103639 Authors: Kim Kawamoto Dharmatti Kobatake Ito Miyatake Cancer immunotherapy has been revolutionized by the development of monoclonal antibodies (mAbs) that inhibit interactions between immune checkpoint molecules, such as programmed cell-death 1 (PD-1), and its...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3643: High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21103643 Authors: Ricobaraza Gonzalez-Aparicio Mora-Jimenez Lumbreras Hernandez-Alcoceba The adaptation of adenoviruses as gene delivery tools has resulted in the development of high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or “gutless”. Compared with earlier generations...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3633: The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21103633 Authors: Primer Psaltis Tan Bursill Diabetes mellitus affects millions of people worldwide and is associated with devastating vascular complications. A number of these complications, such as impaired wound healing and poor coronary collateral circulation, are characterised...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3634: KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGFβ1 Activation International Journal of Molecular Sciences doi: 10.3390/ijms21103634 Authors: Rutger A. F. Gjaltema Désirée Goubert Christian Huisman Consuelo del Pilar García Tobilla Mihály Koncz Pytrick G. Jellema Dandan Wu Uilke Brouwer Antal Kiss Pernette J. Verschure Ruud A. Bank Marianne G. Rots Epigenetic editing,...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3632: Isolation and Characterization of Antibodies Induced by Immunization with TNF-α Inducible Globotetraosylceramide International Journal of Molecular Sciences doi: 10.3390/ijms21103632 Authors: Tetsuya Okuda Glycosphingolipids containing very-long-chain fatty acids (VLCFAs) regulate several immune responses, such as cytokine production, immune signaling, and antibody induction. We previously reported that stimulation with an inflammatory mediator, TNF-α,...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3631: Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion International Journal of Molecular Sciences doi: 10.3390/ijms21103631 Authors: Raffaella Boggia Federica Turrini Alessandra Roggeri Guendalina Olivero Francesca Cisani Tommaso Bonfiglio Maria Summa Massimo Grilli Gabriele Caviglioli Silvana Alfei Paola Zunin Rosalia Bertorelli Anna Pittaluga The immune system and the central...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3630: FAK Family Kinases in Vascular Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21103630 Authors: James M. Murphy Kyuho Jeong Ssang-Taek Steve Lim In various vascular diseases, extracellular matrix (ECM) and integrin expression are frequently altered, leading to focal adhesion kinase (FAK) or proline-rich tyrosine kinase 2 (Pyk2) activation. In addition to the major roles of FAK and Pyk2 in regulating adhesion dynamics via integrins,...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3628: Three-Dimensional Printed Porous Titanium Screw with Bioactive Surface Modification for Bone–Tendon Healing: A Rabbit Animal Model International Journal of Molecular Sciences doi: 10.3390/ijms21103628 Authors: Yu-Min Huang Chih-Chieh Huang Pei-I Tsai Kuo-Yi Yang Shin-I Huang Hsin-Hsin Shen Hong-Jen Lai Shu-Wei Huang San-Yuan Chen Feng-Huei Lin Chih-Yu Chen The interference screw fixation method is used to secure a graft in the...
Thu May 21, 2020 03:00
IJMS, Vol. 21, Pages 3629: Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole International Journal of Molecular Sciences doi: 10.3390/ijms21103629 Authors: Karolina Stryjska Lidia Radko Lilianna Chęcińska Joachim Kusz Andrzej Posyniak Justyn Ochocki Two novel silver(I) complexes of the biologically active ligand miconazole in the form of Ag(MCZ)2X (MCZ...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1567: Short-Term Effects of Comprehensive Pulmonary Rehabilitation and its Maintenance in Patients with Idiopathic Pulmonary Fibrosis: A Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9051567 Authors: Inga Jarosch Tessa Schneeberger Rainer Gloeckl Michael Kreuter Marion Frankenberger Claus Neurohr Antje Prasse Julia Freise Juergen Behr Wolfgang Hitzl Andreas R. Koczulla Klaus Kenn The recommendation for pulmonary...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1566: Timing of Transfusion, not Hemoglobin Variability, is Associated with 3-Month Outcomes in Acute Ischemic Stroke Journal of Clinical Medicine doi: 10.3390/jcm9051566 Authors: Chulho Kim Sang-Hwa Lee Jae-Sung Lim Mi Sun Oh Kyung-Ho Yu Yerim Kim Ju-Hun Lee Min Uk Jang San Jung Byung-Chul Lee Objectives: This study aimed to investigate whether transfusions and hemoglobin variability affects the outcome of stroke after an acute ischemic...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1565: The Role of Optical Coherence Tomography in Differential Diagnosis of Multiple Sclerosis and Autoimmune Connective Tissue Diseases with CNS Involvement Journal of Clinical Medicine doi: 10.3390/jcm9051565 Authors: Paula Wildner Ewa Zydorczak Magdalena Oset Małgorzata Siger Michał Wilczyński Mariusz Stasiołek Mariola Matysiak The purpose of this study was to examine whether application of optical coherence tomography (OCT) measurements can provide...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1562: Heme Oxygenase-1 in Central Nervous System Malignancies Journal of Clinical Medicine doi: 10.3390/jcm9051562 Authors: Giuseppe Sferrazzo Michelino Di Rosa Eugenio Barone Giovanni Li Volti Nicolò Musso Daniele Tibullo Ignazio Barbagallo Central nervous system tumors are the most common pediatric solid tumors and account for 20%–25% of all childhood malignancies. Several lines of evidence suggest that brain tumors show altered redox...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1560: Body Composition Impact on Sleep in Young Adults: The Mediating Role of Sedentariness, Physical Activity, and Diet Journal of Clinical Medicine doi: 10.3390/jcm9051560 Authors: Almudena Carneiro-Barrera Francisco J. Amaro-Gahete Francisco M. Acosta Jonatan R. Ruiz Obesity and sleep disturbances are both related to endocrine and metabolic alterations, cardiovascular disease, and impaired daytime functioning and mood. However, the bidirectional relationship...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1564: The COVID-19 Infection in Italy: A Statistical Study of an Abnormally Severe Disease Journal of Clinical Medicine doi: 10.3390/jcm9051564 Authors: Giuseppe De Natale Valerio Ricciardi Gabriele De Luca Dario De Natale Giovanni Di Meglio Antonio Ferragamo Vito Marchitelli Andrea Piccolo Antonio Scala Renato Somma Emanuele Spina Claudia Troise We statistically investigate the Coronavirus Disease 19 (COVID-19) pandemic, which...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1563: Do Centenarians Die Healthier than Younger Elders? A Comparative Epidemiological Study in Spain Journal of Clinical Medicine doi: 10.3390/jcm9051563 Authors: Mercedes Clerencia-Sierra Ignatios Ioakeim-Skoufa Beatriz Poblador-Plou Francisca González-Rubio Mercedes Aza-Pascual-Salcedo Mónica Machón Antonio Gimeno-Miguel Alexandra Prados-Torres This study aims to describe the clinical course, drug use, and health services use characteristics during...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1561: Determinants of Performance in the Timed Up-and-Go and Six-Minute Walk Tests in Young and Old Healthy Adults Journal of Clinical Medicine doi: 10.3390/jcm9051561 Authors: Montgomery McPhee Pääsuke Sipilä Maier Hogrel Degens The aim of this study was to assess associations between performance in the timed up-and-go (TUG) and six-minute walk distance (6MWD) with physiological characteristics in young and old healthy adults. Thereto, we...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1558: Quantified Vascular Calcification at the Dialysis Access Site: Correlations with the Coronary Artery Calcium Score and Survival Analysis of Access and Cardiovascular Outcomes Journal of Clinical Medicine doi: 10.3390/jcm9051558 Authors: Hyunsuk Kim Bom Lee Gwangho Choi Ho Yong Jin Houn Jung Sunghyun Hwang Hojung Yoon Seok hyung Kim Hoon Suk Park Jongseok Lee Jong-Woo Yoon Vascular calcification is a major contributor to mortality...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1559: Biomechanical and Clinical Effect of Patient-Specific or Customized Knee Implants: A Review Journal of Clinical Medicine doi: 10.3390/jcm9051559 Authors: Lee Koh Kang (1) Background: Although knee arthroplasty or knee replacement is already an effective clinical treatment, it continues to undergo clinical and biomechanical improvements. For an increasing number of conditions, prosthesis based on an individual patient’s anatomy is a promising...
Thu May 21, 2020 03:00
JCM, Vol. 9, Pages 1556: Preoperative, Intraoperative and Postoperative Corticosteroid Use as an Adjunctive Treatment for Rhegmatogenous Retinal Detachment Journal of Clinical Medicine doi: 10.3390/jcm9051556 Authors: Vincenza Bonfiglio Michele Reibaldi Iacopo Macchi Matteo Fallico Corrado Pizzo Clara Patane Andrea Russo Antonio Longo Alessandra Pizzo Giovanni Cillino Salvatore Cillino Maria Vadalà Michele Rinaldi Robert Rejdak Katarzyna Nowomiejska...
Thu May 21, 2020 03:00
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